GREMLIN Database
HEPS2 - Heptaprenyl diphosphate synthase component 2
UniProt: P31114 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 348 (310)
Sequences: 7174 (4901)
Seq/√Len: 278.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_Y319_K3.2261.00
217_D220_I3.0881.00
321_F341_K3.0251.00
274_N308_A3.0191.00
230_Y316_Y3.0181.00
298_E302_K2.9841.00
312_V315_M2.7121.00
289_T292_Q2.7011.00
321_F337_A2.6831.00
270_Y308_A2.6161.00
84_G94_I2.4621.00
196_K229_Y2.4501.00
208_Q225_Y2.4181.00
204_A225_Y2.4061.00
226_W323_K2.3631.00
304_D307_E2.3601.00
119_E129_A2.3541.00
270_Y305_A2.3261.00
318_Q322_Q2.3031.00
325_N337_A2.2261.00
208_Q221_H2.1681.00
279_N302_K2.1281.00
241_I309_S2.0891.00
115_I174_E2.0081.00
222_K226_W1.9891.00
83_S224_L1.9621.00
333_R337_A1.9561.00
307_E311_A1.9451.00
315_M319_K1.8691.00
314_E318_Q1.8621.00
322_Q325_N1.8301.00
211_A224_L1.7761.00
162_I212_I1.7751.00
276_A279_N1.7611.00
301_K306_I1.7571.00
237_I309_S1.7571.00
204_A229_Y1.7541.00
110_V127_I1.7501.00
162_I208_Q1.7421.00
83_S207_C1.7321.00
307_E310_M1.7111.00
271_A300_I1.7061.00
41_D85_M1.7011.00
96_Y153_R1.6931.00
311_A315_M1.6831.00
247_T250_E1.6811.00
159_A209_L1.6771.00
48_E51_Q1.6721.00
174_E177_Q1.6501.00
329_R333_R1.6501.00
226_W230_Y1.6391.00
46_E74_R1.5881.00
111_H141_D1.5841.00
241_I306_I1.5841.00
188_L273_K1.5761.00
187_N190_T1.5681.00
241_I310_M1.5591.00
158_K221_H1.5541.00
87_G220_I1.5491.00
114_V133_N1.5451.00
300_I305_A1.5421.00
223_A326_T1.5391.00
216_A220_I1.5391.00
270_Y273_K1.5271.00
295_P298_E1.5221.00
311_A314_E1.5141.00
312_V316_Y1.5041.00
108_S170_V1.5011.00
321_F340_A1.4981.00
149_E165_Q1.4881.00
328_P333_R1.4541.00
111_H140_G1.4371.00
330_G333_R1.4361.00
202_L206_S1.4351.00
158_K218_E1.4311.00
207_C228_G1.4301.00
188_L312_V1.4121.00
295_P299_E1.4041.00
246_S251_L1.4031.00
323_K326_T1.3981.00
233_M316_Y1.3941.00
270_Y274_N1.3841.00
273_K308_A1.3781.00
227_F324_L1.3391.00
169_E197_R1.3381.00
230_Y323_K1.3341.00
46_E49_L1.3331.00
317_L321_F1.3311.00
218_E222_K1.3301.00
45_I49_L1.3271.00
153_R161_R1.3151.00
260_L290_Q1.3111.00
271_A305_A1.3081.00
211_A216_A1.3061.00
204_A208_Q1.3041.00
297_I301_K1.2961.00
191_Y195_I1.2961.00
166_T205_V1.2951.00
158_K161_R1.2891.00
282_K295_P1.2811.00
193_R196_K1.2791.00
308_A311_A1.2771.00
118_A257_G1.2771.00
317_L344_G1.2711.00
238_I310_M1.2671.00
193_R197_R1.2631.00
87_G210_G1.2491.00
196_K233_M1.2491.00
294_E298_E1.2451.00
291_E294_E1.2431.00
48_E99_V1.2411.00
275_P279_N1.2401.00
149_E168_V1.2291.00
223_A323_K1.2221.00
132_D135_I1.2211.00
48_E96_Y1.2091.00
271_A303_T1.2041.00
305_A308_A1.2041.00
334_S338_A1.2021.00
334_S337_A1.1871.00
40_D43_D1.1831.00
188_L308_A1.1801.00
238_I313_S1.1801.00
245_T306_I1.1771.00
195_I233_M1.1731.00
329_R334_S1.1681.00
100_T151_M1.1641.00
227_F340_A1.1461.00
266_L312_V1.1461.00
126_T129_A1.1411.00
71_G74_R1.1401.00
210_G214_S1.1381.00
191_Y269_L1.1341.00
201_L204_A1.1341.00
208_Q222_K1.1341.00
183_N190_T1.1341.00
256_G293_L1.1331.00
115_I138_Y1.1321.00
275_P303_T1.1291.00
85_M332_A1.1291.00
86_F327_L1.1281.00
97_V159_A1.1161.00
188_L270_Y1.1151.00
242_L251_L1.1131.00
146_G149_E1.1131.00
316_Y319_K1.1071.00
275_P299_E1.1041.00
128_K133_N1.1001.00
266_L309_S1.0971.00
277_L280_Q1.0971.00
87_G216_A1.0911.00
47_R51_Q1.0891.00
117_D133_N1.0881.00
180_D194_R1.0871.00
271_A299_E1.0861.00
341_K345_K1.0801.00
192_L316_Y1.0751.00
87_G214_S1.0741.00
114_V137_M1.0731.00
227_F323_K1.0621.00
81_L98_A1.0561.00
65_L69_Q1.0511.00
50_E65_L1.0501.00
83_S87_G1.0451.00
192_L233_M1.0421.00
318_Q321_F1.0371.00
194_R263_N1.0361.00
325_N333_R1.0341.00
70_A124_K1.0241.00
337_A341_K1.0191.00
52_T153_R1.0051.00
314_E345_K1.0051.00
256_G297_I0.9971.00
177_Q263_N0.9971.00
298_E301_K0.9941.00
44_V47_R0.9881.00
319_K322_Q0.9871.00
211_A221_H0.9871.00
285_N292_Q0.9861.00
279_N303_T0.9831.00
79_F231_V0.9831.00
292_Q295_P0.9771.00
330_G334_S0.9731.00
97_V209_L0.9721.00
86_F224_L0.9691.00
48_E52_T0.9671.00
152_T160_H0.9661.00
64_G143_M0.9641.00
176_E193_R0.9561.00
226_W319_K0.9531.00
270_Y312_V0.9441.00
79_F207_C0.9431.00
192_L312_V0.9411.00
219_K223_A0.9371.00
229_Y233_M0.9301.00
120_L125_P0.9291.00
80_V101_L0.9271.00
66_H131_W0.9241.00
294_E297_I0.9241.00
61_S65_L0.9201.00
158_K212_I0.9181.00
290_Q294_E0.9171.00
212_I221_H0.9131.00
188_L269_L0.9111.00
180_D190_T0.9081.00
76_R235_Y0.9071.00
108_S202_L0.9071.00
39_N43_D0.9031.00
127_I131_W0.8971.00
159_A213_A0.8931.00
46_E50_E0.8881.00
161_R165_Q0.8831.00
146_G168_V0.8761.00
176_E197_R0.8761.00
326_T333_R0.8751.00
75_I343_I0.8731.00
38_L78_V0.8721.00
310_M314_E0.8701.00
99_V150_M0.8661.00
92_N96_Y0.8651.00
80_V98_A0.8611.00
317_L340_A0.8581.00
110_V136_A0.8561.00
44_V92_N0.8481.00
204_A228_G0.8391.00
110_V143_M0.8381.00
218_E221_H0.8381.00
105_H108_S0.8361.00
281_L284_I0.8291.00
338_A341_K0.8261.00
151_M159_A0.8261.00
248_E254_P0.8220.99
301_K307_E0.8200.99
89_Y94_I0.8180.99
306_I310_M0.8170.99
220_I223_A0.8160.99
223_A227_F0.8160.99
254_P257_G0.8100.99
188_L266_L0.8080.99
308_A312_V0.8060.99
118_A243_D0.8060.99
97_V213_A0.8030.99
90_D93_K0.7970.99
242_L246_S0.7930.99
63_A127_I0.7900.99
293_L297_I0.7880.99
69_Q124_K0.7860.99
226_W229_Y0.7850.99
305_A309_S0.7850.99
241_I245_T0.7850.99
169_E196_K0.7820.99
300_I303_T0.7810.99
266_L270_Y0.7810.99
84_G214_S0.7810.99
222_K225_Y0.7800.99
315_M318_Q0.7780.99
162_I205_V0.7780.99
241_I313_S0.7760.99
322_Q326_T0.7760.99
332_A335_S0.7710.99
280_Q284_I0.7700.99
271_A296_I0.7670.99
43_D47_R0.7650.99
66_H130_K0.7640.99
235_Y239_D0.7630.99
285_N288_T0.7590.99
288_T292_Q0.7580.99
58_P62_E0.7570.99
245_T301_K0.7560.99
245_T310_M0.7550.99
45_I81_L0.7540.99
76_R105_H0.7520.99
82_L335_S0.7500.99
207_C227_F0.7460.99
86_F332_A0.7440.99
227_F336_L0.7420.99
50_E69_Q0.7390.99
274_N304_D0.7380.99
74_R77_P0.7370.99
43_D46_E0.7340.99
119_E128_K0.7330.99
47_R50_E0.7330.99
296_I300_I0.7330.99
230_Y233_M0.7270.99
114_V134_R0.7260.99
199_T235_Y0.7190.99
276_A280_Q0.7190.99
73_K239_D0.7190.99
81_L94_I0.7160.99
234_S320_A0.7150.99
84_G89_Y0.7150.99
110_V114_V0.7140.99
291_E295_P0.7110.99
234_S313_S0.7100.99
93_K154_I0.7100.99
40_D44_V0.7080.98
50_E54_R0.7060.98
243_D251_L0.7040.98
200_A233_M0.7040.98
82_L85_M0.7020.98
125_P129_A0.7000.98
38_L41_D0.6950.98
150_M153_R0.6890.98
314_E344_G0.6890.98
115_I171_C0.6880.98
244_F267_P0.6880.98
94_I213_A0.6870.98
299_E302_K0.6850.98
234_S317_L0.6840.98
100_T154_I0.6780.98
199_T203_I0.6750.98
101_L209_L0.6750.98
54_R57_Y0.6730.98
268_V296_I0.6720.98
63_A139_T0.6700.98
278_K281_L0.6690.98
64_G67_L0.6690.98
42_I46_E0.6690.98
63_A66_H0.6670.98
221_H225_Y0.6660.98
251_L255_V0.6640.98
112_D116_D0.6630.98
331_R334_S0.6620.98
247_T251_L0.6620.98
64_G139_T0.6620.98
275_P278_K0.6610.98
56_D193_R0.6600.98
206_S210_G0.6590.98
289_T294_E0.6580.98
120_L248_E0.6580.98
38_L45_I0.6570.98
72_G76_R0.6570.98
176_E179_K0.6570.98
287_E290_Q0.6550.97
311_A318_Q0.6520.97
257_G261_Q0.6500.97
177_Q264_V0.6460.97
220_I328_P0.6450.97
115_I178_I0.6440.97
107_A115_I0.6430.97
162_I166_T0.6430.97
207_C224_L0.6430.97
166_T201_L0.6410.97
155_N161_R0.6390.97
96_Y150_M0.6360.97
83_S210_G0.6350.97
148_L164_S0.6350.97
329_R332_A0.6350.97
100_T163_L0.6340.97
54_R65_L0.6340.97
103_M143_M0.6340.97
38_L42_I0.6280.97
37_F335_S0.6270.97
145_A171_C0.6260.97
197_R201_L0.6250.97
170_V203_I0.6240.97
304_D308_A0.6230.97
113_D121_R0.6230.97
246_S250_E0.6230.97
75_I339_I0.6220.97
73_K235_Y0.6210.97
237_I313_S0.6170.96
152_T161_R0.6160.96
177_Q181_K0.6140.96
109_L122_R0.6140.96
148_L151_M0.6130.96
145_A167_I0.6120.96
335_S338_A0.6110.96
135_I175_I0.6110.96
41_D44_V0.6080.96
189_R193_R0.6070.96
149_E153_R0.6070.96
66_H124_K0.6040.96
239_D242_L0.6020.96
198_K236_Q0.6010.96
125_P130_K0.6010.96
331_R335_S0.6000.96
208_Q212_I0.5990.96
278_K282_K0.5980.96
62_E66_H0.5980.96
180_D186_Q0.5950.96
338_A342_Y0.5940.96
73_K76_R0.5930.96
97_V154_I0.5910.95
108_S206_S0.5900.95
38_L46_E0.5900.95
76_R109_L0.5870.95
329_R337_A0.5860.95
314_E341_K0.5860.95
192_L237_I0.5840.95
80_V206_S0.5840.95
306_I309_S0.5830.95
49_L52_T0.5830.95
93_K155_N0.5810.95
227_F231_V0.5810.95
312_V319_K0.5810.95
63_A135_I0.5790.95
248_E251_L0.5770.95
44_V48_E0.5750.95
76_R199_T0.5690.94
149_E161_R0.5680.94
324_L337_A0.5680.94
190_T193_R0.5650.94
266_L308_A0.5640.94
48_E95_K0.5620.94
245_T251_L0.5620.94
45_I99_V0.5570.94
44_V95_K0.5550.94
104_I147_S0.5540.94
299_E303_T0.5530.94
144_L171_C0.5530.94
60_L63_A0.5490.93
144_L148_L0.5490.93
177_Q194_R0.5490.93
72_G235_Y0.5480.93
238_I343_I0.5480.93
169_E172_L0.5460.93
105_H202_L0.5460.93
81_L85_M0.5460.93
163_L209_L0.5450.93
67_L265_T0.5450.93
49_L56_D0.5440.93
148_L167_I0.5430.93
176_E190_T0.5420.93
274_N303_T0.5400.93
314_E317_L0.5370.93
130_K133_N0.5360.92
186_Q190_T0.5340.92
190_T194_R0.5330.92
192_L196_K0.5330.92
105_H199_T0.5320.92
196_K201_L0.5300.92
227_F320_A0.5270.92
112_D240_D0.5270.92
142_Y177_Q0.5240.92
118_A126_T0.5240.92
112_D258_D0.5240.92
271_A275_P0.5240.92
199_T239_D0.5230.92
67_L106_M0.5220.92
223_A226_W0.5220.92
238_I241_I0.5220.92
68_L106_M0.5210.91
104_I107_A0.5210.91
38_L49_L0.5190.91
93_K156_E0.5190.91
277_L281_L0.5190.91
238_I344_G0.5180.91
64_G142_Y0.5180.91
216_A221_H0.5180.91
170_V201_L0.5160.91
63_A67_L0.5140.91
257_G260_L0.5110.91
237_I316_Y0.5110.91
279_N282_K0.5090.90
104_I167_I0.5080.90
96_Y154_I0.5080.90
42_I78_V0.5080.90
148_L163_L0.5070.90
104_I205_V0.5060.90
267_P309_S0.5060.90
87_G224_L0.5030.90
253_K258_D0.5030.90
167_I171_C0.5000.90
120_L254_P0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wjkA 2 0.8966 100 0.141 Contact Map
3oyrA 2 0.931 100 0.143 Contact Map
1wy0A 2 0.9138 100 0.146 Contact Map
3mzvA 2 0.9195 100 0.146 Contact Map
4jxyA 5 0.8851 100 0.147 Contact Map
3aqbB 1 0.9167 100 0.148 Contact Map
4lobA 2 0.9282 100 0.151 Contact Map
3pkoA 2 0.9397 100 0.153 Contact Map
3rmgA 2 0.8707 100 0.153 Contact Map
3apzA 2 0.8276 100 0.158 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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