HEPS2 - BACSU - GREMLIN Contacts

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HEPS2 - Heptaprenyl diphosphate synthase component 2

UniProt:	P31114	Sequences: MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDVIERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLEMIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAHRILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADEKIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPALKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARSSLAAIAKYIGKRKF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	348 (310)
Sequences:	7174 (4901)
Seq/√Len:	278.3

ECOLI - ISPB ISPA
BACSU - HEPS2 ISPA COMQ
HALSA - Q9HQI3 Q9HND0
SULSO - GGPS HEXPP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
230_Y	319_K	3.226	1.00
217_D	220_I	3.088	1.00
321_F	341_K	3.025	1.00
274_N	308_A	3.019	1.00
230_Y	316_Y	3.018	1.00
298_E	302_K	2.984	1.00
312_V	315_M	2.712	1.00
289_T	292_Q	2.701	1.00
321_F	337_A	2.683	1.00
270_Y	308_A	2.616	1.00
84_G	94_I	2.462	1.00
196_K	229_Y	2.450	1.00
208_Q	225_Y	2.418	1.00
204_A	225_Y	2.406	1.00
226_W	323_K	2.363	1.00
304_D	307_E	2.360	1.00
119_E	129_A	2.354	1.00
270_Y	305_A	2.326	1.00
318_Q	322_Q	2.303	1.00
325_N	337_A	2.226	1.00
208_Q	221_H	2.168	1.00
279_N	302_K	2.128	1.00
241_I	309_S	2.089	1.00
115_I	174_E	2.008	1.00
222_K	226_W	1.989	1.00
83_S	224_L	1.962	1.00
333_R	337_A	1.956	1.00
307_E	311_A	1.945	1.00
315_M	319_K	1.869	1.00
314_E	318_Q	1.862	1.00
322_Q	325_N	1.830	1.00
211_A	224_L	1.776	1.00
162_I	212_I	1.775	1.00
276_A	279_N	1.761	1.00
301_K	306_I	1.757	1.00
237_I	309_S	1.757	1.00
204_A	229_Y	1.754	1.00
110_V	127_I	1.750	1.00
162_I	208_Q	1.742	1.00
83_S	207_C	1.732	1.00
307_E	310_M	1.711	1.00
271_A	300_I	1.706	1.00
41_D	85_M	1.701	1.00
96_Y	153_R	1.693	1.00
311_A	315_M	1.683	1.00
247_T	250_E	1.681	1.00
159_A	209_L	1.677	1.00
48_E	51_Q	1.672	1.00
174_E	177_Q	1.650	1.00
329_R	333_R	1.650	1.00
226_W	230_Y	1.639	1.00
46_E	74_R	1.588	1.00
111_H	141_D	1.584	1.00
241_I	306_I	1.584	1.00
188_L	273_K	1.576	1.00
187_N	190_T	1.568	1.00
241_I	310_M	1.559	1.00
158_K	221_H	1.554	1.00
87_G	220_I	1.549	1.00
114_V	133_N	1.545	1.00
300_I	305_A	1.542	1.00
223_A	326_T	1.539	1.00
216_A	220_I	1.539	1.00
270_Y	273_K	1.527	1.00
295_P	298_E	1.522	1.00
311_A	314_E	1.514	1.00
312_V	316_Y	1.504	1.00
108_S	170_V	1.501	1.00
321_F	340_A	1.498	1.00
149_E	165_Q	1.488	1.00
328_P	333_R	1.454	1.00
111_H	140_G	1.437	1.00
330_G	333_R	1.436	1.00
202_L	206_S	1.435	1.00
158_K	218_E	1.431	1.00
207_C	228_G	1.430	1.00
188_L	312_V	1.412	1.00
295_P	299_E	1.404	1.00
246_S	251_L	1.403	1.00
323_K	326_T	1.398	1.00
233_M	316_Y	1.394	1.00
270_Y	274_N	1.384	1.00
273_K	308_A	1.378	1.00
227_F	324_L	1.339	1.00
169_E	197_R	1.338	1.00
230_Y	323_K	1.334	1.00
46_E	49_L	1.333	1.00
317_L	321_F	1.331	1.00
218_E	222_K	1.330	1.00
45_I	49_L	1.327	1.00
153_R	161_R	1.315	1.00
260_L	290_Q	1.311	1.00
271_A	305_A	1.308	1.00
211_A	216_A	1.306	1.00
204_A	208_Q	1.304	1.00
297_I	301_K	1.296	1.00
191_Y	195_I	1.296	1.00
166_T	205_V	1.295	1.00
158_K	161_R	1.289	1.00
282_K	295_P	1.281	1.00
193_R	196_K	1.279	1.00
308_A	311_A	1.277	1.00
118_A	257_G	1.277	1.00
317_L	344_G	1.271	1.00
238_I	310_M	1.267	1.00
193_R	197_R	1.263	1.00
87_G	210_G	1.249	1.00
196_K	233_M	1.249	1.00
294_E	298_E	1.245	1.00
291_E	294_E	1.243	1.00
48_E	99_V	1.241	1.00
275_P	279_N	1.240	1.00
149_E	168_V	1.229	1.00
223_A	323_K	1.222	1.00
132_D	135_I	1.221	1.00
48_E	96_Y	1.209	1.00
271_A	303_T	1.204	1.00
305_A	308_A	1.204	1.00
334_S	338_A	1.202	1.00
334_S	337_A	1.187	1.00
40_D	43_D	1.183	1.00
188_L	308_A	1.180	1.00
238_I	313_S	1.180	1.00
245_T	306_I	1.177	1.00
195_I	233_M	1.173	1.00
329_R	334_S	1.168	1.00
100_T	151_M	1.164	1.00
227_F	340_A	1.146	1.00
266_L	312_V	1.146	1.00
126_T	129_A	1.141	1.00
71_G	74_R	1.140	1.00
210_G	214_S	1.138	1.00
191_Y	269_L	1.134	1.00
201_L	204_A	1.134	1.00
208_Q	222_K	1.134	1.00
183_N	190_T	1.134	1.00
256_G	293_L	1.133	1.00
115_I	138_Y	1.132	1.00
275_P	303_T	1.129	1.00
85_M	332_A	1.129	1.00
86_F	327_L	1.128	1.00
97_V	159_A	1.116	1.00
188_L	270_Y	1.115	1.00
242_L	251_L	1.113	1.00
146_G	149_E	1.113	1.00
316_Y	319_K	1.107	1.00
275_P	299_E	1.104	1.00
128_K	133_N	1.100	1.00
266_L	309_S	1.097	1.00
277_L	280_Q	1.097	1.00
87_G	216_A	1.091	1.00
47_R	51_Q	1.089	1.00
117_D	133_N	1.088	1.00
180_D	194_R	1.087	1.00
271_A	299_E	1.086	1.00
341_K	345_K	1.080	1.00
192_L	316_Y	1.075	1.00
87_G	214_S	1.074	1.00
114_V	137_M	1.073	1.00
227_F	323_K	1.062	1.00
81_L	98_A	1.056	1.00
65_L	69_Q	1.051	1.00
50_E	65_L	1.050	1.00
83_S	87_G	1.045	1.00
192_L	233_M	1.042	1.00
318_Q	321_F	1.037	1.00
194_R	263_N	1.036	1.00
325_N	333_R	1.034	1.00
70_A	124_K	1.024	1.00
337_A	341_K	1.019	1.00
52_T	153_R	1.005	1.00
314_E	345_K	1.005	1.00
256_G	297_I	0.997	1.00
177_Q	263_N	0.997	1.00
298_E	301_K	0.994	1.00
44_V	47_R	0.988	1.00
319_K	322_Q	0.987	1.00
211_A	221_H	0.987	1.00
285_N	292_Q	0.986	1.00
279_N	303_T	0.983	1.00
79_F	231_V	0.983	1.00
292_Q	295_P	0.977	1.00
330_G	334_S	0.973	1.00
97_V	209_L	0.972	1.00
86_F	224_L	0.969	1.00
48_E	52_T	0.967	1.00
152_T	160_H	0.966	1.00
64_G	143_M	0.964	1.00
176_E	193_R	0.956	1.00
226_W	319_K	0.953	1.00
270_Y	312_V	0.944	1.00
79_F	207_C	0.943	1.00
192_L	312_V	0.941	1.00
219_K	223_A	0.937	1.00
229_Y	233_M	0.930	1.00
120_L	125_P	0.929	1.00
80_V	101_L	0.927	1.00
66_H	131_W	0.924	1.00
294_E	297_I	0.924	1.00
61_S	65_L	0.920	1.00
158_K	212_I	0.918	1.00
290_Q	294_E	0.917	1.00
212_I	221_H	0.913	1.00
188_L	269_L	0.911	1.00
180_D	190_T	0.908	1.00
76_R	235_Y	0.907	1.00
108_S	202_L	0.907	1.00
39_N	43_D	0.903	1.00
127_I	131_W	0.897	1.00
159_A	213_A	0.893	1.00
46_E	50_E	0.888	1.00
161_R	165_Q	0.883	1.00
146_G	168_V	0.876	1.00
176_E	197_R	0.876	1.00
326_T	333_R	0.875	1.00
75_I	343_I	0.873	1.00
38_L	78_V	0.872	1.00
310_M	314_E	0.870	1.00
99_V	150_M	0.866	1.00
92_N	96_Y	0.865	1.00
80_V	98_A	0.861	1.00
317_L	340_A	0.858	1.00
110_V	136_A	0.856	1.00
44_V	92_N	0.848	1.00
204_A	228_G	0.839	1.00
110_V	143_M	0.838	1.00
218_E	221_H	0.838	1.00
105_H	108_S	0.836	1.00
281_L	284_I	0.829	1.00
338_A	341_K	0.826	1.00
151_M	159_A	0.826	1.00
248_E	254_P	0.822	0.99
301_K	307_E	0.820	0.99
89_Y	94_I	0.818	0.99
306_I	310_M	0.817	0.99
220_I	223_A	0.816	0.99
223_A	227_F	0.816	0.99
254_P	257_G	0.810	0.99
188_L	266_L	0.808	0.99
308_A	312_V	0.806	0.99
118_A	243_D	0.806	0.99
97_V	213_A	0.803	0.99
90_D	93_K	0.797	0.99
242_L	246_S	0.793	0.99
63_A	127_I	0.790	0.99
293_L	297_I	0.788	0.99
69_Q	124_K	0.786	0.99
226_W	229_Y	0.785	0.99
305_A	309_S	0.785	0.99
241_I	245_T	0.785	0.99
169_E	196_K	0.782	0.99
300_I	303_T	0.781	0.99
266_L	270_Y	0.781	0.99
84_G	214_S	0.781	0.99
222_K	225_Y	0.780	0.99
315_M	318_Q	0.778	0.99
162_I	205_V	0.778	0.99
241_I	313_S	0.776	0.99
322_Q	326_T	0.776	0.99
332_A	335_S	0.771	0.99
280_Q	284_I	0.770	0.99
271_A	296_I	0.767	0.99
43_D	47_R	0.765	0.99
66_H	130_K	0.764	0.99
235_Y	239_D	0.763	0.99
285_N	288_T	0.759	0.99
288_T	292_Q	0.758	0.99
58_P	62_E	0.757	0.99
245_T	301_K	0.756	0.99
245_T	310_M	0.755	0.99
45_I	81_L	0.754	0.99
76_R	105_H	0.752	0.99
82_L	335_S	0.750	0.99
207_C	227_F	0.746	0.99
86_F	332_A	0.744	0.99
227_F	336_L	0.742	0.99
50_E	69_Q	0.739	0.99
274_N	304_D	0.738	0.99
74_R	77_P	0.737	0.99
43_D	46_E	0.734	0.99
119_E	128_K	0.733	0.99
47_R	50_E	0.733	0.99
296_I	300_I	0.733	0.99
230_Y	233_M	0.727	0.99
114_V	134_R	0.726	0.99
199_T	235_Y	0.719	0.99
276_A	280_Q	0.719	0.99
73_K	239_D	0.719	0.99
81_L	94_I	0.716	0.99
234_S	320_A	0.715	0.99
84_G	89_Y	0.715	0.99
110_V	114_V	0.714	0.99
291_E	295_P	0.711	0.99
234_S	313_S	0.710	0.99
93_K	154_I	0.710	0.99
40_D	44_V	0.708	0.98
50_E	54_R	0.706	0.98
243_D	251_L	0.704	0.98
200_A	233_M	0.704	0.98
82_L	85_M	0.702	0.98
125_P	129_A	0.700	0.98
38_L	41_D	0.695	0.98
150_M	153_R	0.689	0.98
314_E	344_G	0.689	0.98
115_I	171_C	0.688	0.98
244_F	267_P	0.688	0.98
94_I	213_A	0.687	0.98
299_E	302_K	0.685	0.98
234_S	317_L	0.684	0.98
100_T	154_I	0.678	0.98
199_T	203_I	0.675	0.98
101_L	209_L	0.675	0.98
54_R	57_Y	0.673	0.98
268_V	296_I	0.672	0.98
63_A	139_T	0.670	0.98
278_K	281_L	0.669	0.98
64_G	67_L	0.669	0.98
42_I	46_E	0.669	0.98
63_A	66_H	0.667	0.98
221_H	225_Y	0.666	0.98
251_L	255_V	0.664	0.98
112_D	116_D	0.663	0.98
331_R	334_S	0.662	0.98
247_T	251_L	0.662	0.98
64_G	139_T	0.662	0.98
275_P	278_K	0.661	0.98
56_D	193_R	0.660	0.98
206_S	210_G	0.659	0.98
289_T	294_E	0.658	0.98
120_L	248_E	0.658	0.98
38_L	45_I	0.657	0.98
72_G	76_R	0.657	0.98
176_E	179_K	0.657	0.98
287_E	290_Q	0.655	0.97
311_A	318_Q	0.652	0.97
257_G	261_Q	0.650	0.97
177_Q	264_V	0.646	0.97
220_I	328_P	0.645	0.97
115_I	178_I	0.644	0.97
107_A	115_I	0.643	0.97
162_I	166_T	0.643	0.97
207_C	224_L	0.643	0.97
166_T	201_L	0.641	0.97
155_N	161_R	0.639	0.97
96_Y	150_M	0.636	0.97
83_S	210_G	0.635	0.97
148_L	164_S	0.635	0.97
329_R	332_A	0.635	0.97
100_T	163_L	0.634	0.97
54_R	65_L	0.634	0.97
103_M	143_M	0.634	0.97
38_L	42_I	0.628	0.97
37_F	335_S	0.627	0.97
145_A	171_C	0.626	0.97
197_R	201_L	0.625	0.97
170_V	203_I	0.624	0.97
304_D	308_A	0.623	0.97
113_D	121_R	0.623	0.97
246_S	250_E	0.623	0.97
75_I	339_I	0.622	0.97
73_K	235_Y	0.621	0.97
237_I	313_S	0.617	0.96
152_T	161_R	0.616	0.96
177_Q	181_K	0.614	0.96
109_L	122_R	0.614	0.96
148_L	151_M	0.613	0.96
145_A	167_I	0.612	0.96
335_S	338_A	0.611	0.96
135_I	175_I	0.611	0.96
41_D	44_V	0.608	0.96
189_R	193_R	0.607	0.96
149_E	153_R	0.607	0.96
66_H	124_K	0.604	0.96
239_D	242_L	0.602	0.96
198_K	236_Q	0.601	0.96
125_P	130_K	0.601	0.96
331_R	335_S	0.600	0.96
208_Q	212_I	0.599	0.96
278_K	282_K	0.598	0.96
62_E	66_H	0.598	0.96
180_D	186_Q	0.595	0.96
338_A	342_Y	0.594	0.96
73_K	76_R	0.593	0.96
97_V	154_I	0.591	0.95
108_S	206_S	0.590	0.95
38_L	46_E	0.590	0.95
76_R	109_L	0.587	0.95
329_R	337_A	0.586	0.95
314_E	341_K	0.586	0.95
192_L	237_I	0.584	0.95
80_V	206_S	0.584	0.95
306_I	309_S	0.583	0.95
49_L	52_T	0.583	0.95
93_K	155_N	0.581	0.95
227_F	231_V	0.581	0.95
312_V	319_K	0.581	0.95
63_A	135_I	0.579	0.95
248_E	251_L	0.577	0.95
44_V	48_E	0.575	0.95
76_R	199_T	0.569	0.94
149_E	161_R	0.568	0.94
324_L	337_A	0.568	0.94
190_T	193_R	0.565	0.94
266_L	308_A	0.564	0.94
48_E	95_K	0.562	0.94
245_T	251_L	0.562	0.94
45_I	99_V	0.557	0.94
44_V	95_K	0.555	0.94
104_I	147_S	0.554	0.94
299_E	303_T	0.553	0.94
144_L	171_C	0.553	0.94
60_L	63_A	0.549	0.93
144_L	148_L	0.549	0.93
177_Q	194_R	0.549	0.93
72_G	235_Y	0.548	0.93
238_I	343_I	0.548	0.93
169_E	172_L	0.546	0.93
105_H	202_L	0.546	0.93
81_L	85_M	0.546	0.93
163_L	209_L	0.545	0.93
67_L	265_T	0.545	0.93
49_L	56_D	0.544	0.93
148_L	167_I	0.543	0.93
176_E	190_T	0.542	0.93
274_N	303_T	0.540	0.93
314_E	317_L	0.537	0.93
130_K	133_N	0.536	0.92
186_Q	190_T	0.534	0.92
190_T	194_R	0.533	0.92
192_L	196_K	0.533	0.92
105_H	199_T	0.532	0.92
196_K	201_L	0.530	0.92
227_F	320_A	0.527	0.92
112_D	240_D	0.527	0.92
142_Y	177_Q	0.524	0.92
118_A	126_T	0.524	0.92
112_D	258_D	0.524	0.92
271_A	275_P	0.524	0.92
199_T	239_D	0.523	0.92
67_L	106_M	0.522	0.92
223_A	226_W	0.522	0.92
238_I	241_I	0.522	0.92
68_L	106_M	0.521	0.91
104_I	107_A	0.521	0.91
38_L	49_L	0.519	0.91
93_K	156_E	0.519	0.91
277_L	281_L	0.519	0.91
238_I	344_G	0.518	0.91
64_G	142_Y	0.518	0.91
216_A	221_H	0.518	0.91
170_V	201_L	0.516	0.91
63_A	67_L	0.514	0.91
257_G	260_L	0.511	0.91
237_I	316_Y	0.511	0.91
279_N	282_K	0.509	0.90
104_I	167_I	0.508	0.90
96_Y	154_I	0.508	0.90
42_I	78_V	0.508	0.90
148_L	163_L	0.507	0.90
104_I	205_V	0.506	0.90
267_P	309_S	0.506	0.90
87_G	224_L	0.503	0.90
253_K	258_D	0.503	0.90
167_I	171_C	0.500	0.90
120_L	254_P	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wjkA	2	0.8966	100	0.141	Contact Map
3oyrA	2	0.931	100	0.143	Contact Map
1wy0A	2	0.9138	100	0.146	Contact Map
3mzvA	2	0.9195	100	0.146	Contact Map
4jxyA	5	0.8851	100	0.147	Contact Map
3aqbB	1	0.9167	100	0.148	Contact Map
4lobA	2	0.9282	100	0.151	Contact Map
3pkoA	2	0.9397	100	0.153	Contact Map
3rmgA	2	0.8707	100	0.153	Contact Map
3apzA	2	0.8276	100	0.158	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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