GREMLIN Database
MENG - Demethylmenaquinone methyltransferase
UniProt: P31113 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (203)
Sequences: 12958 (9854)
Seq/√Len: 691.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_K74_E3.2201.00
82_E104_H2.8961.00
67_K95_G2.7661.00
139_M149_V2.6751.00
76_K117_F2.6661.00
55_C125_G2.6131.00
56_C77_G2.5861.00
118_D144_K2.5761.00
138_E141_R2.5681.00
62_T75_I2.4501.00
78_L105_G2.4261.00
52_L117_F2.3261.00
82_E86_S2.2541.00
49_A119_Y2.2411.00
85_L102_L2.2101.00
87_V90_Q2.1871.00
133_L210_E2.1781.00
85_L104_H2.1121.00
74_E101_E2.1041.00
112_F117_F2.0851.00
76_K103_L2.0771.00
54_V139_M2.0691.00
88_G102_L2.0551.00
200_G203_E1.9961.00
69_A73_G1.9951.00
32_H35_W1.9701.00
120_V139_M1.9571.00
85_L89_E1.9311.00
92_V102_L1.9051.00
51_A65_L1.8961.00
140_R213_L1.8671.00
205_A209_E1.8481.00
138_E142_V1.7951.00
63_I92_V1.7821.00
133_L137_K1.7371.00
63_I91_K1.7131.00
120_V143_V1.6491.00
143_V149_V1.6461.00
50_K144_K1.6041.00
79_D85_L1.5861.00
46_K49_A1.5611.00
50_K76_K1.5571.00
56_C62_T1.5491.00
78_L110_L1.5241.00
133_L207_L1.5231.00
14_E83_N1.5191.00
76_K101_E1.4911.00
105_G111_P1.4851.00
131_D134_T1.4831.00
62_T77_G1.4761.00
77_G102_L1.4501.00
80_F106_N1.4471.00
111_P138_E1.4381.00
180_L184_S1.4381.00
14_E81_S1.4021.00
31_Q35_W1.3971.00
55_C122_I1.3931.00
64_A67_K1.3581.00
37_D64_A1.3471.00
132_Y207_L1.3321.00
143_V147_G1.3261.00
83_N86_S1.3221.00
129_V135_V1.3211.00
21_D58_T1.3111.00
37_D41_R1.3111.00
134_T137_K1.2951.00
54_V107_A1.2871.00
51_A119_Y1.2521.00
50_K117_F1.2411.00
50_K118_D1.2211.00
37_D68_A1.2181.00
120_V142_V1.2161.00
49_A73_G1.2111.00
206_G210_E1.1951.00
86_S89_E1.1851.00
206_G209_E1.1831.00
90_Q94_D1.1691.00
107_A125_G1.1681.00
64_A68_A1.1591.00
39_T150_V1.1581.00
63_I95_G1.1571.00
52_L120_V1.1561.00
66_A99_Q1.1531.00
50_K116_T1.1391.00
56_C88_G1.1291.00
110_L138_E1.1171.00
63_I67_K1.0911.00
139_M143_V1.0891.00
106_N109_E1.0861.00
61_W123_G1.0841.00
38_K42_I1.0831.00
135_V139_M1.0721.00
124_F128_N1.0641.00
143_V213_L1.0621.00
92_V100_I1.0591.00
59_A88_G1.0511.00
126_L153_E1.0381.00
174_M177_F1.0371.00
124_F127_R1.0301.00
87_V91_K1.0261.00
168_M172_Y1.0251.00
173_I177_F1.0251.00
108_M131_D1.0141.00
21_D91_K1.0101.00
30_Q34_K1.0101.00
116_T144_K1.0001.00
114_D141_R0.9931.00
89_E93_K0.9911.00
51_A75_I0.9871.00
30_Q35_W0.9861.00
126_L129_V0.9751.00
110_L142_V0.9711.00
125_G129_V0.9641.00
19_N22_Q0.9621.00
90_Q93_K0.9591.00
62_T100_I0.9591.00
112_F142_V0.9591.00
78_L103_L0.9521.00
91_K95_G0.9521.00
201_M205_A0.9481.00
81_S84_M0.9431.00
203_E206_G0.9401.00
86_S90_Q0.9291.00
127_R153_E0.9221.00
92_V97_F0.9191.00
205_A218_Y0.9131.00
122_I125_G0.9081.00
60_D91_K0.8871.00
168_M171_K0.8861.00
38_K41_R0.8841.00
45_V49_A0.8821.00
32_H36_R0.8741.00
59_A102_L0.8711.00
67_K97_F0.8621.00
77_G88_G0.8551.00
58_T84_M0.8551.00
134_T138_E0.8491.00
62_T102_L0.8451.00
48_G73_G0.8451.00
51_A121_T0.8251.00
119_Y147_G0.8241.00
173_I176_F0.8221.00
49_A118_D0.8221.00
107_A129_V0.8181.00
31_Q36_R0.8141.00
61_W65_L0.8131.00
133_L211_A0.8071.00
53_D77_G0.8031.00
165_A170_F0.8021.00
114_D142_V0.8011.00
30_Q33_K0.8011.00
124_F154_T0.7981.00
181_F185_Y0.7951.00
53_D121_T0.7901.00
179_K182_A0.7881.00
165_A169_Y0.7811.00
137_K141_R0.7811.00
180_L183_K0.7791.00
165_A171_K0.7761.00
41_R68_A0.7701.00
103_L112_F0.7681.00
109_E134_T0.7681.00
189_S193_E0.7661.00
164_Q167_F0.7651.00
116_T142_V0.7641.00
176_F179_K0.7641.00
66_A100_I0.7571.00
160_F163_R0.7571.00
31_Q34_K0.7541.00
91_K94_D0.7531.00
123_G152_L0.7451.00
202_K205_A0.7401.00
44_N148_Q0.7381.00
55_C80_F0.7341.00
76_K112_F0.7301.00
61_W121_T0.7291.00
13_F16_I0.7261.00
184_S187_E0.7251.00
50_K115_D0.7231.00
43_M119_Y0.7231.00
166_Y170_F0.7221.00
181_F184_S0.7221.00
65_L121_T0.7221.00
54_V120_V0.7201.00
165_A172_Y0.7201.00
60_D64_A0.7161.00
105_G110_L0.7151.00
207_L211_A0.7141.00
166_Y169_Y0.7101.00
40_M68_A0.7041.00
126_L135_V0.7011.00
175_P179_K0.6961.00
153_E204_L0.6891.00
54_V135_V0.6841.00
164_Q168_M0.6831.00
69_A75_I0.6831.00
79_D84_M0.6831.00
84_M124_F0.6731.00
54_V78_L0.6711.00
85_L88_G0.6711.00
53_D56_C0.6711.00
124_F152_L0.6701.00
30_Q36_R0.6691.00
202_K206_G0.6681.00
188_Y191_L0.6631.00
169_Y172_Y0.6591.00
117_F142_V0.6591.00
119_Y148_Q0.6531.00
185_Y189_S0.6521.00
116_T141_R0.6511.00
89_E102_L0.6491.00
66_A97_F0.6481.00
187_E190_W0.6481.00
73_G76_K0.6451.00
127_R154_T0.6431.00
92_V96_G0.6431.00
203_E207_L0.6401.00
18_K87_V0.6401.00
112_F116_T0.6351.00
166_Y172_Y0.6331.00
165_A168_M0.6291.00
207_L210_E0.6271.00
110_L117_F0.6271.00
141_R144_K0.6271.00
79_D104_H0.6241.00
39_T123_G0.6211.00
122_I129_V0.6181.00
108_M135_V0.6111.00
122_I135_V0.6101.00
82_E89_E0.6081.00
126_L204_L0.6081.00
53_D128_N0.6031.00
58_T91_K0.6021.00
172_Y175_P0.6001.00
52_L142_V0.6001.00
63_I66_A0.6001.00
188_Y192_Q0.5981.00
208_F212_G0.5961.00
189_S192_Q0.5941.00
126_L151_C0.5851.00
172_Y176_F0.5851.00
184_S188_Y0.5831.00
169_Y173_I0.5831.00
114_D138_E0.5821.00
77_G100_I0.5811.00
187_E191_L0.5771.00
63_I102_L0.5761.00
40_M64_A0.5751.00
92_V98_S0.5741.00
198_F204_L0.5741.00
83_N87_V0.5741.00
179_K183_K0.5681.00
164_Q170_F0.5651.00
165_A176_F0.5651.00
111_P142_V0.5621.00
125_G128_N0.5621.00
45_V48_G0.5611.00
14_E17_Y0.5591.00
56_C79_D0.5581.00
116_T145_P0.5571.00
149_V213_L0.5551.00
132_Y136_L0.5541.00
53_D75_I0.5541.00
178_G182_A0.5531.00
61_W64_A0.5521.00
13_F17_Y0.5521.00
141_R145_P0.5501.00
178_G181_F0.5481.00
51_A61_W0.5481.00
51_A69_A0.5471.00
13_F127_R0.5461.00
66_A75_I0.5411.00
40_M65_L0.5411.00
92_V99_Q0.5381.00
109_E138_E0.5371.00
209_E216_V0.5351.00
93_K96_G0.5351.00
199_P203_E0.5331.00
123_G127_R0.5331.00
209_E215_N0.5321.00
161_G164_Q0.5321.00
185_Y203_E0.5321.00
164_Q171_K0.5301.00
205_A216_V0.5281.00
65_L69_A0.5251.00
182_A185_Y0.5251.00
171_K175_P0.5241.00
156_Q200_G0.5221.00
58_T87_V0.5191.00
160_F164_Q0.5170.99
166_Y171_K0.5170.99
196_R199_P0.5150.99
36_R60_D0.5130.99
25_S32_H0.5120.99
175_P178_G0.5110.99
187_E192_Q0.5080.99
42_I45_V0.5080.99
80_F108_M0.5070.99
128_N153_E0.5050.99
89_E101_E0.5030.99
56_C78_L0.5010.99
172_Y177_F0.5010.99
25_S28_S0.5010.99
166_Y175_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.9356 100 0.292 Contact Map
4pneA 2 0.8841 100 0.385 Contact Map
2o57A 2 0.8927 100 0.403 Contact Map
3dtnA 2 0.9442 100 0.404 Contact Map
3bkxA 2 0.9313 100 0.413 Contact Map
3busA 1 0.8197 100 0.414 Contact Map
1vl5A 1 0.7725 100 0.419 Contact Map
2yqzA 1 0.8841 100 0.425 Contact Map
3ujcA 1 0.8627 100 0.429 Contact Map
1y8cA 1 0.9227 100 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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