GREMLIN Database
HEPS1 - Heptaprenyl diphosphate synthase component 1
UniProt: P31112 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (233)
Sequences: 204 (167)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_A119_L4.7341.00
64_L98_Y3.3430.97
61_T120_A3.1500.96
73_D196_I2.9340.94
70_D127_N2.7620.91
18_K61_T2.6610.90
66_Q70_D2.6470.89
101_G131_I2.6120.89
19_L175_F2.4920.86
36_D179_K2.3690.83
42_H105_S2.3510.83
166_P192_I2.1840.78
63_M120_A2.0860.74
31_P98_Y2.0510.73
66_Q71_T1.9690.70
73_D118_T1.9010.67
41_F119_L1.8910.66
11_L101_G1.8580.65
44_L168_W1.8390.64
61_T123_I1.8320.64
15_L176_F1.8130.63
64_L168_W1.8070.63
125_E140_D1.7980.62
23_Y28_I1.7970.62
64_L70_D1.7610.61
76_T89_R1.7550.60
66_Q127_N1.7460.60
64_L127_N1.7380.59
207_E210_F1.7320.59
176_F180_R1.7040.58
151_V155_L1.7000.58
108_S198_L1.6670.56
68_A162_H1.6470.55
101_G124_K1.6400.55
40_L172_S1.6370.55
146_E173_S1.6300.54
22_P89_R1.6270.54
128_E152_E1.6260.54
61_T108_S1.6200.54
177_V184_G1.6150.54
122_A158_R1.6080.53
90_Q107_L1.5960.53
31_P89_R1.5900.52
64_L106_L1.5870.52
37_K159_V1.5470.50
15_L60_V1.5240.49
131_I135_D1.5090.49
62_A98_Y1.4900.48
177_V194_S1.4630.46
26_K108_S1.4630.46
63_M124_K1.4570.46
63_M67_S1.4510.46
21_H117_R1.4390.45
62_A88_N1.4290.45
26_K123_I1.4050.44
24_L176_F1.4030.44
142_N220_L1.3830.43
45_F169_K1.3790.42
115_M160_A1.3730.42
59_I108_S1.3710.42
12_N35_E1.3690.42
44_L160_A1.3630.42
223_L226_P1.3600.42
124_K131_I1.3500.41
119_L122_A1.3490.41
126_I162_H1.3480.41
103_Y180_R1.3450.41
70_D89_R1.3410.41
153_S193_G1.3320.40
233_N236_K1.3290.40
28_I37_K1.3150.39
31_P134_Y1.3070.39
113_I156_F1.2990.39
101_G176_F1.2940.39
188_F194_S1.2910.38
9_A13_T1.2700.37
67_S87_K1.2680.37
68_A95_A1.2580.37
15_L63_M1.2550.37
75_V123_I1.2480.36
15_L19_L1.2460.36
51_K181_L1.2380.36
66_Q168_W1.2170.35
131_I154_A1.2160.35
72_H94_L1.2100.35
72_H96_G1.2100.35
74_E170_K1.1970.34
41_F62_A1.1890.34
54_D115_M1.1730.33
11_L89_R1.1690.33
131_I147_S1.1630.33
181_L202_K1.1580.33
99_F220_L1.1560.32
44_L155_L1.1510.32
39_L73_D1.1510.32
76_T122_A1.1500.32
12_N21_H1.1470.32
122_A178_F1.1450.32
68_A201_T1.1240.31
158_R203_E1.1220.31
66_Q106_L1.1180.31
42_H68_A1.1120.31
230_I234_R1.0870.30
69_L152_E1.0820.29
13_T145_F1.0760.29
70_D95_A1.0710.29
221_L233_N1.0700.29
108_S157_H1.0670.29
30_A99_F1.0660.29
161_E169_K1.0650.29
190_D229_N1.0650.29
59_I115_M1.0640.29
176_F179_K1.0600.29
103_Y152_E1.0500.28
76_T120_A1.0450.28
45_F168_W1.0450.28
79_R167_R1.0330.28
206_L239_S1.0290.27
91_L97_D1.0260.27
64_L93_V1.0200.27
26_K161_E1.0160.27
194_S228_Q1.0110.27
61_T119_L1.0020.26
67_S71_T1.0010.26
35_E123_I0.9940.26
71_T122_A0.9930.26
52_N143_D0.9900.26
58_Y63_M0.9900.26
23_Y103_Y0.9860.26
14_K56_E0.9840.26
73_D182_M0.9840.26
143_D203_E0.9820.26
204_E235_L0.9690.25
115_M186_D0.9670.25
21_H102_L0.9570.25
34_D124_K0.9560.25
33_I99_F0.9560.25
96_G100_S0.9500.24
72_H100_S0.9500.24
94_L100_S0.9500.24
65_V155_L0.9490.24
172_S176_F0.9480.24
59_I63_M0.9470.24
199_G213_A0.9460.24
14_K145_F0.9440.24
24_L95_A0.9380.24
182_M219_S0.9360.24
28_I159_V0.9350.24
11_L64_L0.9310.24
12_N185_N0.9310.24
72_H107_L0.9300.24
94_L107_L0.9300.24
96_G107_L0.9300.24
237_T240_Q0.9240.24
162_H239_S0.9220.23
34_D179_K0.9190.23
24_L30_A0.9170.23
36_D176_F0.9160.23
60_V120_A0.9150.23
73_D177_V0.9030.23
18_K119_L0.8960.23
55_R59_I0.8920.22
13_T113_I0.8900.22
13_T71_T0.8840.22
11_L99_F0.8800.22
48_A62_A0.8790.22
200_K205_I0.8790.22
148_V203_E0.8790.22
10_N15_L0.8770.22
28_I63_M0.8760.22
69_L90_Q0.8710.22
89_R127_N0.8690.22
15_L21_H0.8670.22
23_Y127_N0.8570.21
22_P126_I0.8530.21
137_S156_F0.8510.21
128_E180_R0.8500.21
98_Y106_L0.8450.21
144_F180_R0.8380.21
159_V168_W0.8380.21
127_N130_K0.8290.20
26_K217_I0.8290.20
66_Q98_Y0.8180.20
60_V65_V0.8180.20
148_V180_R0.8150.20
91_L94_L0.8100.20
91_L96_G0.8100.20
72_H91_L0.8100.20
63_M102_L0.8090.20
201_T228_Q0.8030.20
63_M71_T0.8020.20
68_A102_L0.7970.19
201_T204_E0.7930.19
125_E195_F0.7870.19
89_R115_M0.7870.19
129_H136_R0.7830.19
18_K156_F0.7830.19
21_H83_R0.7820.19
108_S178_F0.7800.19
94_L104_Y0.7780.19
72_H104_Y0.7780.19
96_G104_Y0.7780.19
152_E180_R0.7750.19
121_T210_F0.7730.19
92_T103_Y0.7640.18
45_F142_N0.7620.18
117_R135_D0.7610.18
85_E186_D0.7600.18
133_L235_L0.7580.18
155_L168_W0.7560.18
124_K152_E0.7510.18
125_E134_Y0.7500.18
123_I127_N0.7440.18
15_L119_L0.7420.18
59_I200_K0.7410.18
20_S25_A0.7360.18
68_A135_D0.7360.18
193_G199_G0.7350.18
99_F172_S0.7340.18
41_F137_S0.7330.18
126_I131_I0.7320.18
148_V156_F0.7260.17
61_T137_S0.7250.17
16_K47_E0.7250.17
66_Q90_Q0.7220.17
31_P41_F0.7210.17
142_N184_G0.7190.17
153_S170_K0.7180.17
64_L69_L0.7130.17
35_E190_D0.7120.17
11_L42_H0.7120.17
19_L120_A0.7100.17
177_V180_R0.7080.17
52_N189_L0.7030.17
228_Q231_L0.6990.17
8_L61_T0.6950.17
31_P62_A0.6940.17
221_L235_L0.6920.16
24_L128_E0.6870.16
36_D102_L0.6850.16
25_A175_F0.6790.16
223_L227_I0.6760.16
102_L124_K0.6750.16
183_N199_G0.6730.16
69_L155_L0.6710.16
145_F187_A0.6700.16
73_D184_G0.6690.16
71_T124_K0.6650.16
108_S205_I0.6630.16
180_R184_G0.6620.16
61_T147_S0.6620.16
75_V166_P0.6610.16
86_N178_F0.6600.16
137_S187_A0.6590.16
68_A176_F0.6580.16
140_D174_D0.6580.16
132_R145_F0.6570.16
23_Y124_K0.6540.16
48_A182_M0.6480.15
77_T131_I0.6480.15
55_R230_I0.6470.15
8_L76_T0.6450.15
22_P159_V0.6430.15
144_F225_S0.6420.15
63_M66_Q0.6380.15
11_L45_F0.6370.15
34_D37_K0.6350.15
35_E38_L0.6350.15
120_A123_I0.6310.15
61_T67_S0.6290.15
183_N193_G0.6280.15
124_K128_E0.6250.15
94_L97_D0.6220.15
72_H97_D0.6220.15
38_L115_M0.6190.15
47_E59_I0.6180.15
60_V106_L0.6170.15
72_H90_Q0.6160.15
90_Q96_G0.6160.15
90_Q94_L0.6160.15
67_S124_K0.6140.15
100_S107_L0.6120.14
69_L151_V0.6100.14
122_A163_F0.6100.14
18_K98_Y0.6080.14
36_D185_N0.6070.14
52_N148_V0.6060.14
189_L201_T0.6050.14
67_S176_F0.6020.14
82_K123_I0.6010.14
127_N168_W0.5980.14
90_Q120_A0.5940.14
44_L159_V0.5920.14
98_Y207_E0.5900.14
92_T221_L0.5870.14
11_L175_F0.5870.14
49_D171_L0.5860.14
102_L181_L0.5860.14
60_V123_I0.5830.14
146_E207_E0.5830.14
20_S153_S0.5830.14
204_E213_A0.5820.14
23_Y64_L0.5810.14
8_L30_A0.5800.14
113_I158_R0.5800.14
28_I35_E0.5790.14
13_T142_N0.5790.14
26_K69_L0.5780.14
105_S142_N0.5750.14
220_L237_T0.5730.14
127_N133_L0.5720.14
36_D234_R0.5700.14
54_D78_A0.5700.14
109_E170_K0.5690.14
142_N229_N0.5630.13
83_R151_V0.5620.13
37_K63_M0.5600.13
29_S175_F0.5590.13
35_E180_R0.5550.13
22_P127_N0.5520.13
40_L75_V0.5460.13
218_E221_L0.5450.13
140_D143_D0.5440.13
64_L75_V0.5440.13
57_N101_G0.5420.13
33_I159_V0.5360.13
143_D223_L0.5340.13
204_E210_F0.5330.13
131_I211_K0.5320.13
153_S218_E0.5300.13
105_S126_I0.5300.13
42_H45_F0.5290.13
43_A105_S0.5240.13
52_N193_G0.5220.12
92_T152_E0.5220.12
133_L151_V0.5190.12
38_L219_S0.5180.12
56_E73_D0.5160.12
96_G130_K0.5140.12
72_H130_K0.5140.12
94_L130_K0.5140.12
215_N218_E0.5100.12
221_L230_I0.5090.12
133_L146_E0.5020.12
27_H231_L0.5020.12
99_F103_Y0.5010.12
38_L77_T0.5010.12
187_A219_S0.5010.12
68_A101_G0.5000.12
211_K240_Q0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqbB 1 0.988 95.3 0.917 Contact Map
3pkoA 2 0.9801 94.8 0.92 Contact Map
3aqbA 1 0.5299 94.6 0.921 Contact Map
4jxyA 5 0.9283 94.5 0.921 Contact Map
3wjkA 2 0.9801 94.5 0.921 Contact Map
4lobA 2 0.9602 94.3 0.922 Contact Map
3mzvA 2 0.9841 94.1 0.922 Contact Map
3qkcB 2 0.8486 94 0.923 Contact Map
4fp4A 2 0.8446 94 0.923 Contact Map
1v4eA 3 0.9402 93.1 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.