CHER - BACSU - GREMLIN Contacts

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CHER - Chemotaxis protein methyltransferase

UniProt:	P31105	Sequences: MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFKDFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAACSTGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRYFTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLKMAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	256 (248)
Sequences:	4570 (3514)
Seq/√Len:	223.1

ECOLI - CHER
BACSU - CHER
HALSA - Q9HQX0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
104_T	135_A	3.260	1.00
196_D	224_K	2.885	1.00
153_P	156_V	2.812	1.00
42_S	45_D	2.704	1.00
198_I	219_M	2.641	1.00
244_G	254_Q	2.528	1.00
162_T	172_K	2.481	1.00
164_N	170_E	2.460	1.00
34_L	56_L	2.434	1.00
98_W	129_T	2.378	1.00
77_R	230_F	2.328	1.00
223_L	227_G	2.272	1.00
143_V	170_E	2.215	1.00
106_E	148_S	2.189	1.00
46_F	56_L	2.180	1.00
108_P	128_A	2.170	1.00
220_A	243_F	2.150	1.00
143_V	168_S	2.143	1.00
129_T	184_H	2.110	1.00
173_T	177_K	2.109	1.00
49_A	53_D	2.086	1.00
79_E	83_T	2.071	1.00
117_Q	156_V	2.053	1.00
81_L	197_L	2.033	1.00
9_T	13_Q	2.021	1.00
40_F	49_A	2.014	1.00
97_I	111_L	1.993	1.00
125_Q	180_T	1.981	1.00
116_D	175_I	1.952	1.00
116_D	174_E	1.911	1.00
111_L	199_V	1.911	1.00
133_E	183_K	1.903	1.00
110_T	114_L	1.890	1.00
128_A	179_I	1.885	1.00
67_N	135_A	1.866	1.00
41_Q	45_D	1.806	1.00
154_L	158_D	1.805	1.00
34_L	46_F	1.801	1.00
117_Q	159_R	1.797	1.00
116_D	178_N	1.789	1.00
136_L	183_K	1.783	1.00
69_S	104_T	1.775	1.00
35_Y	40_F	1.769	1.00
124_Y	178_N	1.741	1.00
186_L	203_V	1.702	1.00
217_L	242_K	1.690	1.00
173_T	176_K	1.682	1.00
75_Y	79_E	1.675	1.00
67_N	103_S	1.666	1.00
156_V	160_Y	1.596	1.00
198_I	223_L	1.590	1.00
246_V	254_Q	1.560	1.00
165_A	168_S	1.560	1.00
115_L	124_Y	1.558	1.00
113_M	117_Q	1.493	1.00
82_E	117_Q	1.476	1.00
214_E	218_K	1.473	1.00
200_C	219_M	1.470	1.00
127_L	182_K	1.469	1.00
79_E	82_E	1.450	1.00
204_F	215_L	1.438	1.00
142_G	171_V	1.407	1.00
127_L	195_F	1.402	1.00
137_E	141_K	1.399	1.00
204_F	216_Y	1.391	1.00
108_P	126_I	1.384	1.00
187_L	211_A	1.384	1.00
14_L	57_L	1.378	1.00
149_L	157_K	1.366	1.00
161_F	171_V	1.365	1.00
112_A	126_I	1.364	1.00
97_I	115_L	1.355	1.00
72_Y	110_T	1.345	1.00
6_V	51_E	1.341	1.00
99_S	199_V	1.339	1.00
100_A	186_L	1.332	1.00
112_A	178_N	1.328	1.00
175_I	178_N	1.320	1.00
67_N	132_D	1.312	1.00
108_P	179_I	1.307	1.00
116_D	160_Y	1.260	1.00
49_A	56_L	1.259	1.00
50_L	60_T	1.244	1.00
137_E	140_K	1.243	1.00
62_D	134_K	1.241	1.00
194_D	224_K	1.236	1.00
12_K	208_T	1.228	1.00
102_C	108_P	1.225	1.00
146_E	163_Q	1.220	1.00
209_E	212_K	1.216	1.00
171_V	175_I	1.214	1.00
62_D	132_D	1.212	1.00
101_A	203_V	1.201	1.00
191_Y	215_L	1.199	1.00
96_K	125_Q	1.187	1.00
213_E	217_L	1.187	1.00
113_M	160_Y	1.185	1.00
162_T	170_E	1.183	1.00
70_E	151_E	1.176	1.00
154_L	157_K	1.162	1.00
133_E	137_E	1.157	1.00
45_D	48_A	1.151	1.00
99_S	111_L	1.142	1.00
228_V	246_V	1.137	1.00
48_A	52_K	1.132	1.00
145_Q	148_S	1.131	1.00
65_T	131_I	1.127	1.00
10_K	57_L	1.126	1.00
103_S	135_A	1.112	1.00
146_E	169_Y	1.111	1.00
84_A	87_P	1.109	1.00
85_I	228_V	1.102	1.00
175_I	179_I	1.096	1.00
113_M	161_F	1.091	1.00
74_N	77_R	1.087	1.00
208_T	211_A	1.086	1.00
27_M	64_M	1.083	1.00
82_E	118_Q	1.083	1.00
170_E	176_K	1.080	1.00
204_F	231_V	1.075	1.00
94_P	123_G	1.072	1.00
89_I	95_L	1.069	1.00
116_D	124_Y	1.062	1.00
99_S	102_C	1.061	1.00
109_Y	176_K	1.054	1.00
129_T	182_K	1.051	1.00
34_L	37_K	1.044	1.00
7_F	47_A	1.039	1.00
72_Y	156_V	1.036	1.00
80_V	230_F	1.034	1.00
164_N	167_R	1.033	1.00
101_A	219_M	1.015	1.00
76_K	79_E	1.007	1.00
109_Y	181_F	1.004	1.00
88_L	228_V	1.001	1.00
81_L	111_L	0.998	1.00
217_L	221_H	0.987	1.00
34_L	38_K	0.986	1.00
58_N	133_E	0.986	1.00
23_K	30_R	0.985	1.00
113_M	156_V	0.984	1.00
6_V	47_A	0.982	1.00
29_R	66_I	0.981	1.00
82_E	114_L	0.966	1.00
164_N	168_S	0.961	1.00
199_V	230_F	0.957	1.00
203_V	207_F	0.952	1.00
74_N	233_S	0.951	1.00
38_K	59_E	0.949	1.00
174_E	177_K	0.946	1.00
38_K	49_A	0.942	1.00
47_A	51_E	0.938	1.00
5_S	8_T	0.937	1.00
80_V	84_A	0.933	1.00
219_M	243_F	0.926	1.00
62_D	133_E	0.916	0.99
146_E	157_K	0.915	0.99
138_K	141_K	0.912	0.99
34_L	63_R	0.912	0.99
5_S	9_T	0.907	0.99
143_V	164_N	0.902	0.99
38_K	56_L	0.891	0.99
94_P	125_Q	0.886	0.99
86_L	115_L	0.882	0.99
163_Q	169_Y	0.881	0.99
155_S	159_R	0.880	0.99
65_T	132_D	0.879	0.99
100_A	203_V	0.877	0.99
55_A	59_E	0.877	0.99
26_Q	66_I	0.873	0.99
170_E	173_T	0.867	0.99
220_A	242_K	0.867	0.99
185_N	188_A	0.859	0.99
46_F	49_A	0.859	0.99
34_L	60_T	0.852	0.99
132_D	135_A	0.852	0.99
161_F	169_Y	0.850	0.99
10_K	47_A	0.847	0.99
195_F	198_I	0.846	0.99
230_F	252_F	0.846	0.99
35_Y	43_F	0.837	0.99
117_Q	160_Y	0.835	0.99
80_V	252_F	0.833	0.99
84_A	88_L	0.829	0.99
85_I	197_L	0.827	0.99
149_L	169_Y	0.826	0.99
37_K	59_E	0.824	0.99
112_A	175_I	0.824	0.99
147_R	150_Q	0.818	0.99
15_T	131_I	0.812	0.99
24_E	28_K	0.811	0.99
8_T	18_D	0.810	0.99
56_L	59_E	0.805	0.99
214_E	217_L	0.805	0.99
19_L	27_M	0.798	0.99
46_F	60_T	0.792	0.98
31_L	43_F	0.791	0.98
72_Y	152_V	0.788	0.98
93_R	122_P	0.786	0.98
231_V	237_I	0.781	0.98
157_K	161_F	0.767	0.98
207_F	211_A	0.764	0.98
78_W	110_T	0.763	0.98
211_A	215_L	0.763	0.98
35_Y	42_S	0.759	0.98
69_S	103_S	0.754	0.98
155_S	158_D	0.754	0.98
226_N	254_Q	0.746	0.98
139_A	181_F	0.746	0.98
114_L	118_Q	0.744	0.98
149_L	152_V	0.743	0.98
86_L	118_Q	0.738	0.98
4_Y	27_M	0.736	0.98
85_I	230_F	0.723	0.97
76_K	249_D	0.720	0.97
118_Q	122_P	0.718	0.97
77_R	233_S	0.718	0.97
92_S	196_D	0.718	0.97
210_S	213_E	0.718	0.97
135_A	139_A	0.718	0.97
184_H	190_R	0.717	0.97
65_T	135_A	0.717	0.97
77_R	250_T	0.716	0.97
81_L	199_V	0.714	0.97
138_K	144_Y	0.713	0.97
22_Y	29_R	0.712	0.97
104_T	138_K	0.712	0.97
33_S	63_R	0.712	0.97
73_R	206_Y	0.711	0.97
6_V	44_K	0.711	0.97
119_K	122_P	0.710	0.97
218_K	221_H	0.709	0.97
43_F	47_A	0.709	0.97
202_N	206_Y	0.708	0.97
96_K	195_F	0.708	0.97
85_I	89_I	0.708	0.97
120_G	159_R	0.707	0.97
141_K	170_E	0.706	0.97
28_K	32_T	0.705	0.97
245_L	253_Y	0.701	0.97
223_L	243_F	0.699	0.97
49_A	52_K	0.698	0.97
81_L	114_L	0.695	0.97
21_L	208_T	0.693	0.96
8_T	12_K	0.692	0.96
152_V	161_F	0.690	0.96
156_V	159_R	0.686	0.96
134_K	137_E	0.685	0.96
8_T	20_T	0.684	0.96
5_S	21_L	0.683	0.96
87_P	228_V	0.679	0.96
145_Q	149_L	0.678	0.96
8_T	27_M	0.677	0.96
119_K	124_Y	0.676	0.96
228_V	252_F	0.676	0.96
46_F	50_L	0.670	0.96
146_E	167_R	0.670	0.96
138_K	148_S	0.669	0.96
192_E	195_F	0.662	0.95
194_D	222_S	0.659	0.95
146_E	150_Q	0.656	0.95
116_D	120_G	0.655	0.95
6_V	9_T	0.652	0.95
86_L	228_V	0.645	0.95
58_N	62_D	0.643	0.95
99_S	108_P	0.643	0.95
100_A	219_M	0.642	0.95
68_V	212_K	0.642	0.95
144_Y	171_V	0.640	0.95
97_I	197_L	0.634	0.94
117_Q	155_S	0.633	0.94
163_Q	168_S	0.632	0.94
19_L	66_I	0.631	0.94
17_V	61_L	0.626	0.94
145_Q	168_S	0.626	0.94
93_R	224_K	0.620	0.94
100_A	199_V	0.619	0.94
134_K	138_K	0.619	0.94
133_E	140_K	0.615	0.93
213_E	241_E	0.614	0.93
25_A	28_K	0.610	0.93
164_N	169_Y	0.606	0.93
80_V	250_T	0.606	0.93
34_L	49_A	0.603	0.93
126_I	178_N	0.595	0.92
59_E	62_D	0.595	0.92
12_K	18_D	0.594	0.92
44_K	47_A	0.594	0.92
8_T	47_A	0.592	0.92
38_K	46_F	0.589	0.92
228_V	254_Q	0.588	0.92
115_L	126_I	0.588	0.92
152_V	156_V	0.588	0.92
101_A	200_C	0.587	0.92
60_T	132_D	0.584	0.91
185_N	189_D	0.579	0.91
198_I	222_S	0.579	0.91
184_H	188_A	0.579	0.91
135_A	138_K	0.579	0.91
98_W	101_A	0.577	0.91
73_R	202_N	0.574	0.91
118_Q	121_L	0.573	0.91
113_M	116_D	0.571	0.91
87_P	118_Q	0.570	0.90
113_M	152_V	0.568	0.90
123_G	178_N	0.566	0.90
71_F	144_Y	0.566	0.90
205_I	234_T	0.565	0.90
44_K	48_A	0.564	0.90
10_K	51_E	0.564	0.90
32_T	36_E	0.564	0.90
55_A	58_N	0.563	0.90
157_K	169_Y	0.563	0.90
128_A	200_C	0.563	0.90
198_I	215_L	0.562	0.90
113_M	171_V	0.560	0.90
27_M	251_F	0.560	0.90
162_T	165_A	0.557	0.89
95_L	115_L	0.557	0.89
191_Y	218_K	0.557	0.89
90_K	93_R	0.556	0.89
113_M	175_I	0.556	0.89
30_R	66_I	0.556	0.89
209_E	213_E	0.555	0.89
10_K	14_L	0.555	0.89
109_Y	179_I	0.554	0.89
103_S	205_I	0.554	0.89
38_K	43_F	0.553	0.89
85_I	115_L	0.553	0.89
54_Q	58_N	0.552	0.89
23_K	234_T	0.552	0.89
18_D	21_L	0.551	0.89
101_A	129_T	0.550	0.89
146_E	149_L	0.550	0.89
19_L	23_K	0.549	0.89
28_K	43_F	0.549	0.89
7_F	31_L	0.546	0.88
183_K	188_A	0.545	0.88
40_F	45_D	0.545	0.88
212_K	216_Y	0.542	0.88
82_E	156_V	0.541	0.88
187_L	215_L	0.540	0.88
66_I	206_Y	0.539	0.88
157_K	160_Y	0.539	0.88
97_I	126_I	0.538	0.88
240_P	243_F	0.536	0.88
70_E	212_K	0.536	0.88
162_T	173_T	0.535	0.87
133_E	136_L	0.533	0.87
205_I	232_G	0.533	0.87
81_L	86_L	0.531	0.87
128_A	139_A	0.522	0.86
23_K	66_I	0.521	0.86
184_H	222_S	0.520	0.86
4_Y	24_E	0.518	0.86
215_L	218_K	0.517	0.86
102_C	139_A	0.517	0.86
184_H	191_Y	0.515	0.85
48_A	51_E	0.515	0.85
64_M	185_N	0.510	0.85
109_Y	144_Y	0.508	0.85
4_Y	43_F	0.507	0.85
11_W	64_M	0.507	0.85
17_V	185_N	0.506	0.84
23_K	26_Q	0.506	0.84
72_Y	114_L	0.506	0.84
140_K	182_K	0.505	0.84
185_N	208_T	0.505	0.84
35_Y	46_F	0.502	0.84
211_A	214_E	0.501	0.84
96_K	182_K	0.501	0.84
101_A	215_L	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1af7A	1	0.9805	100	0.299	Contact Map
4qnuA	2	0.8555	99.9	0.715	Contact Map
3i53A	2	0.8516	99.9	0.74	Contact Map
3gwzA	3	0.8594	99.8	0.751	Contact Map
4gqbA	4	0.832	99.8	0.751	Contact Map
4z2yA	2	0.7891	99.8	0.765	Contact Map
2ip2A	2	0.8516	99.7	0.776	Contact Map
1qzzA	2	0.8359	99.7	0.781	Contact Map
4ineA	2	0.8477	99.7	0.788	Contact Map
2r3sA	4	0.8633	99.7	0.79	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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