GREMLIN Database
CHER - Chemotaxis protein methyltransferase
UniProt: P31105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (248)
Sequences: 4570 (3514)
Seq/√Len: 223.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_T135_A3.2601.00
196_D224_K2.8851.00
153_P156_V2.8121.00
42_S45_D2.7041.00
198_I219_M2.6411.00
244_G254_Q2.5281.00
162_T172_K2.4811.00
164_N170_E2.4601.00
34_L56_L2.4341.00
98_W129_T2.3781.00
77_R230_F2.3281.00
223_L227_G2.2721.00
143_V170_E2.2151.00
106_E148_S2.1891.00
46_F56_L2.1801.00
108_P128_A2.1701.00
220_A243_F2.1501.00
143_V168_S2.1431.00
129_T184_H2.1101.00
173_T177_K2.1091.00
49_A53_D2.0861.00
79_E83_T2.0711.00
117_Q156_V2.0531.00
81_L197_L2.0331.00
9_T13_Q2.0211.00
40_F49_A2.0141.00
97_I111_L1.9931.00
125_Q180_T1.9811.00
116_D175_I1.9521.00
116_D174_E1.9111.00
111_L199_V1.9111.00
133_E183_K1.9031.00
110_T114_L1.8901.00
128_A179_I1.8851.00
67_N135_A1.8661.00
41_Q45_D1.8061.00
154_L158_D1.8051.00
34_L46_F1.8011.00
117_Q159_R1.7971.00
116_D178_N1.7891.00
136_L183_K1.7831.00
69_S104_T1.7751.00
35_Y40_F1.7691.00
124_Y178_N1.7411.00
186_L203_V1.7021.00
217_L242_K1.6901.00
173_T176_K1.6821.00
75_Y79_E1.6751.00
67_N103_S1.6661.00
156_V160_Y1.5961.00
198_I223_L1.5901.00
246_V254_Q1.5601.00
165_A168_S1.5601.00
115_L124_Y1.5581.00
113_M117_Q1.4931.00
82_E117_Q1.4761.00
214_E218_K1.4731.00
200_C219_M1.4701.00
127_L182_K1.4691.00
79_E82_E1.4501.00
204_F215_L1.4381.00
142_G171_V1.4071.00
127_L195_F1.4021.00
137_E141_K1.3991.00
204_F216_Y1.3911.00
108_P126_I1.3841.00
187_L211_A1.3841.00
14_L57_L1.3781.00
149_L157_K1.3661.00
161_F171_V1.3651.00
112_A126_I1.3641.00
97_I115_L1.3551.00
72_Y110_T1.3451.00
6_V51_E1.3411.00
99_S199_V1.3391.00
100_A186_L1.3321.00
112_A178_N1.3281.00
175_I178_N1.3201.00
67_N132_D1.3121.00
108_P179_I1.3071.00
116_D160_Y1.2601.00
49_A56_L1.2591.00
50_L60_T1.2441.00
137_E140_K1.2431.00
62_D134_K1.2411.00
194_D224_K1.2361.00
12_K208_T1.2281.00
102_C108_P1.2251.00
146_E163_Q1.2201.00
209_E212_K1.2161.00
171_V175_I1.2141.00
62_D132_D1.2121.00
101_A203_V1.2011.00
191_Y215_L1.1991.00
96_K125_Q1.1871.00
213_E217_L1.1871.00
113_M160_Y1.1851.00
162_T170_E1.1831.00
70_E151_E1.1761.00
154_L157_K1.1621.00
133_E137_E1.1571.00
45_D48_A1.1511.00
99_S111_L1.1421.00
228_V246_V1.1371.00
48_A52_K1.1321.00
145_Q148_S1.1311.00
65_T131_I1.1271.00
10_K57_L1.1261.00
103_S135_A1.1121.00
146_E169_Y1.1111.00
84_A87_P1.1091.00
85_I228_V1.1021.00
175_I179_I1.0961.00
113_M161_F1.0911.00
74_N77_R1.0871.00
208_T211_A1.0861.00
27_M64_M1.0831.00
82_E118_Q1.0831.00
170_E176_K1.0801.00
204_F231_V1.0751.00
94_P123_G1.0721.00
89_I95_L1.0691.00
116_D124_Y1.0621.00
99_S102_C1.0611.00
109_Y176_K1.0541.00
129_T182_K1.0511.00
34_L37_K1.0441.00
7_F47_A1.0391.00
72_Y156_V1.0361.00
80_V230_F1.0341.00
164_N167_R1.0331.00
101_A219_M1.0151.00
76_K79_E1.0071.00
109_Y181_F1.0041.00
88_L228_V1.0011.00
81_L111_L0.9981.00
217_L221_H0.9871.00
34_L38_K0.9861.00
58_N133_E0.9861.00
23_K30_R0.9851.00
113_M156_V0.9841.00
6_V47_A0.9821.00
29_R66_I0.9811.00
82_E114_L0.9661.00
164_N168_S0.9611.00
199_V230_F0.9571.00
203_V207_F0.9521.00
74_N233_S0.9511.00
38_K59_E0.9491.00
174_E177_K0.9461.00
38_K49_A0.9421.00
47_A51_E0.9381.00
5_S8_T0.9371.00
80_V84_A0.9331.00
219_M243_F0.9261.00
62_D133_E0.9160.99
146_E157_K0.9150.99
138_K141_K0.9120.99
34_L63_R0.9120.99
5_S9_T0.9070.99
143_V164_N0.9020.99
38_K56_L0.8910.99
94_P125_Q0.8860.99
86_L115_L0.8820.99
163_Q169_Y0.8810.99
155_S159_R0.8800.99
65_T132_D0.8790.99
100_A203_V0.8770.99
55_A59_E0.8770.99
26_Q66_I0.8730.99
170_E173_T0.8670.99
220_A242_K0.8670.99
185_N188_A0.8590.99
46_F49_A0.8590.99
34_L60_T0.8520.99
132_D135_A0.8520.99
161_F169_Y0.8500.99
10_K47_A0.8470.99
195_F198_I0.8460.99
230_F252_F0.8460.99
35_Y43_F0.8370.99
117_Q160_Y0.8350.99
80_V252_F0.8330.99
84_A88_L0.8290.99
85_I197_L0.8270.99
149_L169_Y0.8260.99
37_K59_E0.8240.99
112_A175_I0.8240.99
147_R150_Q0.8180.99
15_T131_I0.8120.99
24_E28_K0.8110.99
8_T18_D0.8100.99
56_L59_E0.8050.99
214_E217_L0.8050.99
19_L27_M0.7980.99
46_F60_T0.7920.98
31_L43_F0.7910.98
72_Y152_V0.7880.98
93_R122_P0.7860.98
231_V237_I0.7810.98
157_K161_F0.7670.98
207_F211_A0.7640.98
78_W110_T0.7630.98
211_A215_L0.7630.98
35_Y42_S0.7590.98
69_S103_S0.7540.98
155_S158_D0.7540.98
226_N254_Q0.7460.98
139_A181_F0.7460.98
114_L118_Q0.7440.98
149_L152_V0.7430.98
86_L118_Q0.7380.98
4_Y27_M0.7360.98
85_I230_F0.7230.97
76_K249_D0.7200.97
118_Q122_P0.7180.97
77_R233_S0.7180.97
92_S196_D0.7180.97
210_S213_E0.7180.97
135_A139_A0.7180.97
184_H190_R0.7170.97
65_T135_A0.7170.97
77_R250_T0.7160.97
81_L199_V0.7140.97
138_K144_Y0.7130.97
22_Y29_R0.7120.97
104_T138_K0.7120.97
33_S63_R0.7120.97
73_R206_Y0.7110.97
6_V44_K0.7110.97
119_K122_P0.7100.97
218_K221_H0.7090.97
43_F47_A0.7090.97
202_N206_Y0.7080.97
96_K195_F0.7080.97
85_I89_I0.7080.97
120_G159_R0.7070.97
141_K170_E0.7060.97
28_K32_T0.7050.97
245_L253_Y0.7010.97
223_L243_F0.6990.97
49_A52_K0.6980.97
81_L114_L0.6950.97
21_L208_T0.6930.96
8_T12_K0.6920.96
152_V161_F0.6900.96
156_V159_R0.6860.96
134_K137_E0.6850.96
8_T20_T0.6840.96
5_S21_L0.6830.96
87_P228_V0.6790.96
145_Q149_L0.6780.96
8_T27_M0.6770.96
119_K124_Y0.6760.96
228_V252_F0.6760.96
46_F50_L0.6700.96
146_E167_R0.6700.96
138_K148_S0.6690.96
192_E195_F0.6620.95
194_D222_S0.6590.95
146_E150_Q0.6560.95
116_D120_G0.6550.95
6_V9_T0.6520.95
86_L228_V0.6450.95
58_N62_D0.6430.95
99_S108_P0.6430.95
100_A219_M0.6420.95
68_V212_K0.6420.95
144_Y171_V0.6400.95
97_I197_L0.6340.94
117_Q155_S0.6330.94
163_Q168_S0.6320.94
19_L66_I0.6310.94
17_V61_L0.6260.94
145_Q168_S0.6260.94
93_R224_K0.6200.94
100_A199_V0.6190.94
134_K138_K0.6190.94
133_E140_K0.6150.93
213_E241_E0.6140.93
25_A28_K0.6100.93
164_N169_Y0.6060.93
80_V250_T0.6060.93
34_L49_A0.6030.93
126_I178_N0.5950.92
59_E62_D0.5950.92
12_K18_D0.5940.92
44_K47_A0.5940.92
8_T47_A0.5920.92
38_K46_F0.5890.92
228_V254_Q0.5880.92
115_L126_I0.5880.92
152_V156_V0.5880.92
101_A200_C0.5870.92
60_T132_D0.5840.91
185_N189_D0.5790.91
198_I222_S0.5790.91
184_H188_A0.5790.91
135_A138_K0.5790.91
98_W101_A0.5770.91
73_R202_N0.5740.91
118_Q121_L0.5730.91
113_M116_D0.5710.91
87_P118_Q0.5700.90
113_M152_V0.5680.90
123_G178_N0.5660.90
71_F144_Y0.5660.90
205_I234_T0.5650.90
44_K48_A0.5640.90
10_K51_E0.5640.90
32_T36_E0.5640.90
55_A58_N0.5630.90
157_K169_Y0.5630.90
128_A200_C0.5630.90
198_I215_L0.5620.90
113_M171_V0.5600.90
27_M251_F0.5600.90
162_T165_A0.5570.89
95_L115_L0.5570.89
191_Y218_K0.5570.89
90_K93_R0.5560.89
113_M175_I0.5560.89
30_R66_I0.5560.89
209_E213_E0.5550.89
10_K14_L0.5550.89
109_Y179_I0.5540.89
103_S205_I0.5540.89
38_K43_F0.5530.89
85_I115_L0.5530.89
54_Q58_N0.5520.89
23_K234_T0.5520.89
18_D21_L0.5510.89
101_A129_T0.5500.89
146_E149_L0.5500.89
19_L23_K0.5490.89
28_K43_F0.5490.89
7_F31_L0.5460.88
183_K188_A0.5450.88
40_F45_D0.5450.88
212_K216_Y0.5420.88
82_E156_V0.5410.88
187_L215_L0.5400.88
66_I206_Y0.5390.88
157_K160_Y0.5390.88
97_I126_I0.5380.88
240_P243_F0.5360.88
70_E212_K0.5360.88
162_T173_T0.5350.87
133_E136_L0.5330.87
205_I232_G0.5330.87
81_L86_L0.5310.87
128_A139_A0.5220.86
23_K66_I0.5210.86
184_H222_S0.5200.86
4_Y24_E0.5180.86
215_L218_K0.5170.86
102_C139_A0.5170.86
184_H191_Y0.5150.85
48_A51_E0.5150.85
64_M185_N0.5100.85
109_Y144_Y0.5080.85
4_Y43_F0.5070.85
11_W64_M0.5070.85
17_V185_N0.5060.84
23_K26_Q0.5060.84
72_Y114_L0.5060.84
140_K182_K0.5050.84
185_N208_T0.5050.84
35_Y46_F0.5020.84
211_A214_E0.5010.84
96_K182_K0.5010.84
101_A215_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1af7A 1 0.9805 100 0.299 Contact Map
4qnuA 2 0.8555 99.9 0.715 Contact Map
3i53A 2 0.8516 99.9 0.74 Contact Map
3gwzA 3 0.8594 99.8 0.751 Contact Map
4gqbA 4 0.832 99.8 0.751 Contact Map
4z2yA 2 0.7891 99.8 0.765 Contact Map
2ip2A 2 0.8516 99.7 0.776 Contact Map
1qzzA 2 0.8359 99.7 0.781 Contact Map
4ineA 2 0.8477 99.7 0.788 Contact Map
2r3sA 4 0.8633 99.7 0.79 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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