GREMLIN Database
AROC - Chorismate synthase
UniProt: P31104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (344)
Sequences: 3242 (1567)
Seq/√Len: 84.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_K77_E4.8531.00
241_L301_T3.6441.00
326_D330_K3.4951.00
224_V356_V3.2371.00
257_G264_F3.2291.00
31_D150_K3.1921.00
35_E149_K3.1721.00
76_V139_T3.1611.00
262_I292_R3.0111.00
214_D272_S2.9631.00
227_M306_I2.9041.00
151_I361_A2.7171.00
244_K363_A2.6111.00
212_N270_N2.3601.00
245_L356_V2.3081.00
264_F311_V2.3051.00
193_C202_M2.2971.00
21_V72_I2.2921.00
63_R126_M2.2921.00
108_P118_A2.2701.00
225_E305_P2.2681.00
249_V308_V2.2451.00
3_Y16_T2.2081.00
257_G311_V2.1911.00
18_I147_V2.1591.00
224_V360_I2.1311.00
165_Q268_G2.1191.00
259_E309_R2.0431.00
56_A74_L2.0431.00
249_V356_V2.0401.00
321_P333_F2.0391.00
28_T31_D2.0091.00
6_A73_A2.0061.00
159_V357_A1.9841.00
208_E212_N1.9771.00
238_D247_A1.9751.00
162_H194_Y1.9491.00
26_Y66_R1.9251.00
53_K79_N1.9041.00
189_S199_G1.8961.00
289_A323_K1.8741.00
168_A205_A1.8541.00
308_V356_V1.8391.00
165_Q168_A1.8351.00
198_A201_K1.8251.00
277_E323_K1.8181.00
16_T74_L1.8151.00
113_A298_G1.7971.00
137_E141_R1.7691.00
205_A209_A1.7571.00
279_I289_A1.7571.00
165_Q170_K1.7531.00
244_K247_A1.7511.00
221_E309_R1.7161.00
13_Q75_V1.7091.00
209_A216_I1.6711.00
321_P335_A1.6681.00
252_I352_A1.6671.00
266_A274_V1.6641.00
33_N37_A1.6361.00
13_Q59_M1.6341.00
27_I147_V1.6281.00
190_P203_M1.6201.00
155_L364_V1.6111.00
223_I305_P1.5991.00
200_K203_M1.5701.00
244_K366_E1.5631.00
6_A15_T1.5231.00
21_V147_V1.5151.00
32_I146_A1.4920.99
296_L306_I1.4860.99
312_M352_A1.4790.99
74_L143_A1.4760.99
265_E268_G1.4550.99
218_G345_V1.4540.99
164_L221_E1.4500.99
153_S158_K1.4450.99
269_R274_V1.4440.99
219_I309_R1.4400.99
310_G352_A1.4290.99
249_V310_G1.4240.99
185_V188_E1.4120.99
275_H322_L1.4000.99
187_E192_R1.3930.99
12_P57_K1.3880.99
248_A359_E1.3870.99
246_A250_L1.3820.99
166_I343_C1.3710.99
222_V352_A1.3650.99
296_L301_T1.3610.99
280_W331_E1.3560.99
16_T144_A1.3470.99
129_V234_Y1.3460.99
115_L278_I1.3460.99
191_V206_I1.3370.99
103_R337_I1.3350.99
45_R207_D1.3340.99
278_I288_R1.3320.99
26_Y154_E1.3290.99
279_I287_T1.3240.99
249_V258_V1.3220.99
149_K353_E1.3190.99
62_V72_I1.3160.99
323_K333_F1.3150.99
108_P327_I1.3120.99
106_S328_E1.3030.98
25_L151_I1.2890.98
158_K225_E1.2880.98
207_D210_K1.2860.98
27_I67_T1.2840.98
258_V308_V1.2720.98
107_R332_P1.2620.98
255_F312_M1.2580.98
160_A186_T1.2550.98
16_T140_V1.2430.98
234_Y300_M1.2410.98
35_E146_A1.2380.98
38_R353_E1.2360.98
66_R123_H1.2350.98
287_T304_M1.2310.98
214_D270_N1.2270.98
204_A208_E1.2120.98
12_P77_E1.2090.98
254_A344_A1.2070.97
243_S247_A1.2060.97
118_A327_I1.2060.97
250_L260_F1.2020.97
149_K357_A1.1870.97
169_V198_A1.1850.97
161_G349_S1.1840.97
326_D332_P1.1810.97
363_A366_E1.1770.97
224_V306_I1.1760.97
165_Q219_I1.1730.97
28_T150_K1.1700.97
267_A311_V1.1650.97
111_G297_E1.1630.97
135_A344_A1.1560.97
213_G319_Y1.1540.97
157_I364_V1.1440.97
205_A270_N1.1420.96
262_I266_A1.1420.96
231_V364_V1.1370.96
312_M348_A1.1290.96
27_I31_D1.1190.96
224_V227_M1.1170.96
18_I74_L1.1160.96
233_S363_A1.1100.96
277_E289_A1.1000.96
312_M344_A1.0900.95
31_D34_F1.0860.95
272_S318_L1.0840.95
49_M80_D1.0820.95
172_E198_A1.0780.95
262_I269_R1.0740.95
227_M231_V1.0730.95
106_S326_D1.0680.95
205_A208_E1.0680.95
212_N320_K1.0620.95
255_F310_G1.0610.95
203_M207_D1.0570.95
195_D198_A1.0570.95
297_E302_T1.0550.95
288_R304_M1.0500.94
215_S315_I1.0480.94
148_A358_W1.0440.94
40_Q53_K1.0420.94
219_I264_F1.0320.94
165_Q267_A1.0300.94
281_D287_T1.0290.94
220_V352_A1.0280.94
324_S332_P1.0260.94
356_V360_I1.0250.94
324_S334_S1.0190.93
141_R355_A1.0170.93
31_D153_S1.0110.93
119_I229_V1.0010.93
170_K268_G0.9970.93
248_A355_A0.9900.92
252_I355_A0.9900.92
169_V201_K0.9880.92
8_E68_L0.9830.92
116_N278_I0.9710.92
49_M210_K0.9690.92
21_V25_L0.9690.92
102_K126_M0.9670.92
317_T336_S0.9670.92
33_N36_L0.9630.91
201_K204_A0.9580.91
24_G66_R0.9550.91
115_L119_I0.9480.91
199_G203_M0.9430.91
245_L308_V0.9380.90
111_G293_L0.9360.90
116_N300_M0.9360.90
193_C199_G0.9350.90
99_K102_K0.9350.90
40_Q51_I0.9270.90
221_E307_V0.9240.90
185_V196_E0.9130.89
277_E290_T0.9130.89
14_L140_V0.9110.89
160_A225_E0.9100.89
2_R19_E0.9100.89
163_V345_V0.9090.89
200_K204_A0.9080.89
222_V308_V0.9070.89
104_Q126_M0.9060.89
280_W330_K0.9060.89
262_I265_E0.9020.88
220_V312_M0.9000.88
16_T73_A0.8980.88
269_R273_E0.8970.88
281_D285_G0.8970.88
169_V205_A0.8950.88
14_L139_T0.8910.88
219_I257_G0.8910.88
191_V199_G0.8880.88
167_G216_I0.8830.87
247_A251_S0.8790.87
21_V148_A0.8780.87
205_A216_I0.8770.87
163_V166_I0.8710.87
169_V202_M0.8700.87
197_E201_K0.8700.87
315_I342_S0.8660.86
209_A270_N0.8650.86
156_G226_G0.8640.86
57_K75_V0.8630.86
198_A202_M0.8630.86
23_A370_L0.8630.86
172_E195_D0.8620.86
44_G47_R0.8590.86
189_S196_E0.8560.86
82_K100_E0.8560.86
280_W286_Y0.8530.86
150_K153_S0.8520.85
162_H221_E0.8520.85
137_E235_V0.8490.85
8_E11_G0.8490.85
43_H47_R0.8470.85
172_E175_E0.8460.85
241_L363_A0.8430.85
214_D320_K0.8430.85
193_C198_A0.8420.85
107_R324_S0.8390.85
116_N297_E0.8360.84
240_K253_N0.8320.84
141_R251_S0.8300.84
32_I58_I0.8290.84
245_L359_E0.8270.84
160_A223_I0.8260.84
63_R127_R0.8250.84
216_I270_N0.8240.83
167_G205_A0.8220.83
242_D256_K0.8220.83
161_G222_V0.8210.83
315_I344_A0.8180.83
233_S238_D0.8180.83
58_I62_V0.8170.83
262_I274_V0.8150.83
102_K105_I0.8130.83
59_M75_V0.8110.83
76_V140_V0.8110.83
58_I143_A0.8080.82
222_V310_G0.8070.82
199_G202_M0.8070.82
224_V308_V0.8050.82
319_Y337_I0.8040.82
293_L297_E0.8020.82
288_R302_T0.7970.81
163_V346_P0.7890.81
345_V348_A0.7870.81
72_I147_V0.7860.80
25_L361_A0.7850.80
316_P351_V0.7840.80
62_V150_K0.7820.80
5_T141_R0.7790.80
242_D246_A0.7740.79
367_Q370_L0.7720.79
286_Y325_V0.7680.79
82_K99_K0.7610.78
5_T137_E0.7590.78
231_V360_I0.7590.78
213_G320_K0.7580.78
33_N55_Q0.7580.78
3_Y358_W0.7530.78
207_D211_A0.7520.77
46_G206_I0.7510.77
219_I267_A0.7500.77
238_D244_K0.7500.77
55_Q79_N0.7480.77
242_D260_F0.7470.77
116_N302_T0.7450.77
17_I73_A0.7420.77
38_R350_V0.7400.76
168_A268_G0.7390.76
29_E33_N0.7380.76
249_V352_A0.7380.76
348_A352_A0.7370.76
359_E362_N0.7360.76
171_A198_A0.7350.76
18_I148_A0.7350.76
4_L17_I0.7350.76
159_V360_I0.7320.76
272_S320_K0.7310.75
175_E178_S0.7300.75
244_K359_E0.7290.75
326_D329_T0.7280.75
46_G203_M0.7280.75
208_E211_A0.7270.75
266_A293_L0.7270.75
238_D366_E0.7260.75
104_Q334_S0.7250.75
137_E140_V0.7230.75
123_H129_V0.7230.75
141_R235_V0.7210.74
14_L76_V0.7170.74
171_A174_T0.7160.74
173_K195_D0.7130.74
58_I74_L0.7130.74
265_E269_R0.7110.73
219_I311_V0.7110.73
166_I206_I0.7100.73
29_E57_K0.7090.73
36_L139_T0.7080.73
33_N40_Q0.7080.73
301_T306_I0.7060.73
279_I331_E0.7030.73
6_A17_I0.7000.72
250_L258_V0.6980.72
279_I323_K0.6980.72
202_M206_I0.6940.72
250_L308_V0.6940.72
67_T150_K0.6910.71
220_V348_A0.6910.71
37_A40_Q0.6890.71
15_T59_M0.6890.71
74_L147_V0.6880.71
209_A212_N0.6870.71
150_K154_E0.6860.71
135_A253_N0.6860.71
206_I343_C0.6850.71
278_I297_E0.6840.71
46_G191_V0.6830.70
111_G316_P0.6800.70
233_S366_E0.6790.70
103_R107_R0.6760.70
117_G133_S0.6720.69
227_M300_M0.6720.69
312_M351_V0.6700.69
204_A207_D0.6680.69
242_D258_V0.6670.69
23_A367_Q0.6630.68
323_K331_E0.6630.68
270_N273_E0.6620.68
296_L302_T0.6600.68
3_Y18_I0.6590.68
59_M73_A0.6590.68
33_N56_A0.6590.68
227_M364_V0.6580.68
3_Y144_A0.6540.67
11_G127_R0.6490.67
201_K205_A0.6490.67
280_W284_K0.6480.66
18_I21_V0.6470.66
278_I286_Y0.6450.66
280_W325_V0.6450.66
316_P336_S0.6450.66
206_I209_A0.6410.66
5_T240_K0.6360.65
132_R137_E0.6350.65
293_L306_I0.6350.65
118_A126_M0.6350.65
164_L219_I0.6350.65
164_L170_K0.6340.65
105_I126_M0.6300.64
282_E285_G0.6290.64
149_K159_V0.6280.64
63_R125_D0.6270.64
213_G335_A0.6250.64
222_V356_V0.6240.64
135_A351_V0.6240.64
365_V368_F0.6240.64
24_G123_H0.6240.64
5_T132_R0.6230.63
83_H127_R0.6230.63
29_E55_Q0.6220.63
3_Y355_A0.6210.63
59_M77_E0.6210.63
240_K243_S0.6190.63
35_E38_R0.6170.63
245_L258_V0.6100.62
361_A365_V0.6090.62
355_A359_E0.6080.62
44_G189_S0.6070.61
43_H48_R0.6070.61
266_A269_R0.6050.61
344_A351_V0.6030.61
67_T147_V0.6010.61
32_I74_L0.6010.61
254_A348_A0.6010.61
27_I150_K0.5990.60
162_H223_I0.5970.60
5_T140_V0.5970.60
161_G353_E0.5970.60
306_I360_I0.5960.60
158_K226_G0.5940.60
51_I80_D0.5920.59
223_I307_V0.5920.59
30_E34_F0.5910.59
81_W100_E0.5900.59
171_A194_Y0.5880.59
259_E263_G0.5860.59
28_T34_F0.5860.59
157_I227_M0.5840.58
40_Q43_H0.5830.58
25_L150_K0.5810.58
252_I351_V0.5810.58
243_S251_S0.5800.58
238_D363_A0.5790.58
15_T73_A0.5790.58
169_V209_A0.5780.58
279_I286_Y0.5780.58
245_L249_V0.5770.58
278_I325_V0.5760.57
254_A312_M0.5730.57
68_L127_R0.5710.57
171_A195_D0.5700.57
35_E142_V0.5680.56
214_D273_E0.5660.56
73_A140_V0.5660.56
259_E264_F0.5650.56
237_Y253_N0.5640.56
344_A348_A0.5640.56
8_E127_R0.5620.56
170_K265_E0.5610.55
63_R68_L0.5600.55
21_V358_W0.5600.55
260_F308_V0.5590.55
70_S117_G0.5590.55
164_L307_V0.5570.55
132_R141_R0.5560.55
224_V245_L0.5540.55
60_S73_A0.5530.54
43_H207_D0.5530.54
64_H126_M0.5520.54
237_Y247_A0.5520.54
164_L309_R0.5510.54
36_L143_A0.5510.54
210_K213_G0.5490.54
319_Y336_S0.5490.54
27_I34_F0.5490.54
228_P364_V0.5470.54
29_E150_K0.5470.54
21_V151_I0.5440.53
27_I58_I0.5440.53
32_I36_L0.5430.53
26_Y150_K0.5430.53
253_N348_A0.5410.53
235_V251_S0.5400.53
133_S137_E0.5400.53
161_G352_A0.5400.53
38_R187_E0.5390.53
137_E251_S0.5390.53
297_E317_T0.5380.52
56_A62_V0.5380.52
162_H171_A0.5360.52
206_I210_K0.5360.52
280_W285_G0.5350.52
32_I150_K0.5340.52
34_F37_A0.5330.52
16_T253_N0.5320.52
274_V293_L0.5320.52
3_Y74_L0.5320.52
340_S347_A0.5310.51
74_L140_V0.5300.51
120_K233_S0.5260.51
171_A193_C0.5260.51
235_V240_K0.5250.51
68_L125_D0.5230.50
316_P319_Y0.5230.50
36_L228_P0.5230.50
224_V231_V0.5230.50
122_N129_V0.5200.50
21_V27_I0.5200.50
51_I79_N0.5200.50
243_S296_L0.5190.50
293_L302_T0.5180.50
201_K208_E0.5180.50
188_E196_E0.5160.49
23_A70_S0.5150.49
11_G68_L0.5140.49
18_I146_A0.5120.49
29_E58_I0.5120.49
222_V249_V0.5120.49
144_A358_W0.5110.49
162_H186_T0.5100.49
149_K153_S0.5100.49
196_E199_G0.5100.49
161_G220_V0.5090.49
14_L51_I0.5090.49
317_T351_V0.5080.48
293_L301_T0.5070.48
22_P365_V0.5060.48
82_K102_K0.5060.48
44_G346_P0.5060.48
80_D99_K0.5040.48
305_P308_V0.5040.48
27_I62_V0.5040.48
160_A176_Y0.5040.48
118_A123_H0.5030.48
4_L19_E0.5020.48
46_G166_I0.5010.47
166_I345_V0.5000.47
47_R50_Q0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o11A 4 0.9564 100 0.025 Contact Map
1qxoA 4 0.9821 100 0.03 Contact Map
1q1lA 4 0.841 100 0.035 Contact Map
4ecdA 3 0.6949 100 0.039 Contact Map
1r53A 4 0.6974 100 0.079 Contact Map
1sq1A 4 0.7205 100 0.091 Contact Map
4ob9A 2 0.7769 100 0.095 Contact Map
1um0A 4 0.9026 100 0.095 Contact Map
4wdcA 1 0.4103 28.9 0.979 Contact Map
2dt8A 1 0.3846 21 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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