AROC - BACSU - GREMLIN Contacts

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AROC - Chorismate synthase

UniProt:	P31104	Sequences: MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHGRGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMKRQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVAGHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGGIVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHDEIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFSASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	390 (344)
Sequences:	3242 (1567)
Seq/√Len:	84.5

ECOLI - AROC
BACSU - AROC
HALSA - AROC
SULSO - AROC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
57_K	77_E	4.853	1.00
241_L	301_T	3.644	1.00
326_D	330_K	3.495	1.00
224_V	356_V	3.237	1.00
257_G	264_F	3.229	1.00
31_D	150_K	3.192	1.00
35_E	149_K	3.172	1.00
76_V	139_T	3.161	1.00
262_I	292_R	3.011	1.00
214_D	272_S	2.963	1.00
227_M	306_I	2.904	1.00
151_I	361_A	2.717	1.00
244_K	363_A	2.611	1.00
212_N	270_N	2.360	1.00
245_L	356_V	2.308	1.00
264_F	311_V	2.305	1.00
193_C	202_M	2.297	1.00
21_V	72_I	2.292	1.00
63_R	126_M	2.292	1.00
108_P	118_A	2.270	1.00
225_E	305_P	2.268	1.00
249_V	308_V	2.245	1.00
3_Y	16_T	2.208	1.00
257_G	311_V	2.191	1.00
18_I	147_V	2.159	1.00
224_V	360_I	2.131	1.00
165_Q	268_G	2.119	1.00
259_E	309_R	2.043	1.00
56_A	74_L	2.043	1.00
249_V	356_V	2.040	1.00
321_P	333_F	2.039	1.00
28_T	31_D	2.009	1.00
6_A	73_A	2.006	1.00
159_V	357_A	1.984	1.00
208_E	212_N	1.977	1.00
238_D	247_A	1.975	1.00
162_H	194_Y	1.949	1.00
26_Y	66_R	1.925	1.00
53_K	79_N	1.904	1.00
189_S	199_G	1.896	1.00
289_A	323_K	1.874	1.00
168_A	205_A	1.854	1.00
308_V	356_V	1.839	1.00
165_Q	168_A	1.835	1.00
198_A	201_K	1.825	1.00
277_E	323_K	1.818	1.00
16_T	74_L	1.815	1.00
113_A	298_G	1.797	1.00
137_E	141_R	1.769	1.00
205_A	209_A	1.757	1.00
279_I	289_A	1.757	1.00
165_Q	170_K	1.753	1.00
244_K	247_A	1.751	1.00
221_E	309_R	1.716	1.00
13_Q	75_V	1.709	1.00
209_A	216_I	1.671	1.00
321_P	335_A	1.668	1.00
252_I	352_A	1.667	1.00
266_A	274_V	1.664	1.00
33_N	37_A	1.636	1.00
13_Q	59_M	1.634	1.00
27_I	147_V	1.628	1.00
190_P	203_M	1.620	1.00
155_L	364_V	1.611	1.00
223_I	305_P	1.599	1.00
200_K	203_M	1.570	1.00
244_K	366_E	1.563	1.00
6_A	15_T	1.523	1.00
21_V	147_V	1.515	1.00
32_I	146_A	1.492	0.99
296_L	306_I	1.486	0.99
312_M	352_A	1.479	0.99
74_L	143_A	1.476	0.99
265_E	268_G	1.455	0.99
218_G	345_V	1.454	0.99
164_L	221_E	1.450	0.99
153_S	158_K	1.445	0.99
269_R	274_V	1.444	0.99
219_I	309_R	1.440	0.99
310_G	352_A	1.429	0.99
249_V	310_G	1.424	0.99
185_V	188_E	1.412	0.99
275_H	322_L	1.400	0.99
187_E	192_R	1.393	0.99
12_P	57_K	1.388	0.99
248_A	359_E	1.387	0.99
246_A	250_L	1.382	0.99
166_I	343_C	1.371	0.99
222_V	352_A	1.365	0.99
296_L	301_T	1.361	0.99
280_W	331_E	1.356	0.99
16_T	144_A	1.347	0.99
129_V	234_Y	1.346	0.99
115_L	278_I	1.346	0.99
191_V	206_I	1.337	0.99
103_R	337_I	1.335	0.99
45_R	207_D	1.334	0.99
278_I	288_R	1.332	0.99
26_Y	154_E	1.329	0.99
279_I	287_T	1.324	0.99
249_V	258_V	1.322	0.99
149_K	353_E	1.319	0.99
62_V	72_I	1.316	0.99
323_K	333_F	1.315	0.99
108_P	327_I	1.312	0.99
106_S	328_E	1.303	0.98
25_L	151_I	1.289	0.98
158_K	225_E	1.288	0.98
207_D	210_K	1.286	0.98
27_I	67_T	1.284	0.98
258_V	308_V	1.272	0.98
107_R	332_P	1.262	0.98
255_F	312_M	1.258	0.98
160_A	186_T	1.255	0.98
16_T	140_V	1.243	0.98
234_Y	300_M	1.241	0.98
35_E	146_A	1.238	0.98
38_R	353_E	1.236	0.98
66_R	123_H	1.235	0.98
287_T	304_M	1.231	0.98
214_D	270_N	1.227	0.98
204_A	208_E	1.212	0.98
12_P	77_E	1.209	0.98
254_A	344_A	1.207	0.97
243_S	247_A	1.206	0.97
118_A	327_I	1.206	0.97
250_L	260_F	1.202	0.97
149_K	357_A	1.187	0.97
169_V	198_A	1.185	0.97
161_G	349_S	1.184	0.97
326_D	332_P	1.181	0.97
363_A	366_E	1.177	0.97
224_V	306_I	1.176	0.97
165_Q	219_I	1.173	0.97
28_T	150_K	1.170	0.97
267_A	311_V	1.165	0.97
111_G	297_E	1.163	0.97
135_A	344_A	1.156	0.97
213_G	319_Y	1.154	0.97
157_I	364_V	1.144	0.97
205_A	270_N	1.142	0.96
262_I	266_A	1.142	0.96
231_V	364_V	1.137	0.96
312_M	348_A	1.129	0.96
27_I	31_D	1.119	0.96
224_V	227_M	1.117	0.96
18_I	74_L	1.116	0.96
233_S	363_A	1.110	0.96
277_E	289_A	1.100	0.96
312_M	344_A	1.090	0.95
31_D	34_F	1.086	0.95
272_S	318_L	1.084	0.95
49_M	80_D	1.082	0.95
172_E	198_A	1.078	0.95
262_I	269_R	1.074	0.95
227_M	231_V	1.073	0.95
106_S	326_D	1.068	0.95
205_A	208_E	1.068	0.95
212_N	320_K	1.062	0.95
255_F	310_G	1.061	0.95
203_M	207_D	1.057	0.95
195_D	198_A	1.057	0.95
297_E	302_T	1.055	0.95
288_R	304_M	1.050	0.94
215_S	315_I	1.048	0.94
148_A	358_W	1.044	0.94
40_Q	53_K	1.042	0.94
219_I	264_F	1.032	0.94
165_Q	267_A	1.030	0.94
281_D	287_T	1.029	0.94
220_V	352_A	1.028	0.94
324_S	332_P	1.026	0.94
356_V	360_I	1.025	0.94
324_S	334_S	1.019	0.93
141_R	355_A	1.017	0.93
31_D	153_S	1.011	0.93
119_I	229_V	1.001	0.93
170_K	268_G	0.997	0.93
248_A	355_A	0.990	0.92
252_I	355_A	0.990	0.92
169_V	201_K	0.988	0.92
8_E	68_L	0.983	0.92
116_N	278_I	0.971	0.92
49_M	210_K	0.969	0.92
21_V	25_L	0.969	0.92
102_K	126_M	0.967	0.92
317_T	336_S	0.967	0.92
33_N	36_L	0.963	0.91
201_K	204_A	0.958	0.91
24_G	66_R	0.955	0.91
115_L	119_I	0.948	0.91
199_G	203_M	0.943	0.91
245_L	308_V	0.938	0.90
111_G	293_L	0.936	0.90
116_N	300_M	0.936	0.90
193_C	199_G	0.935	0.90
99_K	102_K	0.935	0.90
40_Q	51_I	0.927	0.90
221_E	307_V	0.924	0.90
185_V	196_E	0.913	0.89
277_E	290_T	0.913	0.89
14_L	140_V	0.911	0.89
160_A	225_E	0.910	0.89
2_R	19_E	0.910	0.89
163_V	345_V	0.909	0.89
200_K	204_A	0.908	0.89
222_V	308_V	0.907	0.89
104_Q	126_M	0.906	0.89
280_W	330_K	0.906	0.89
262_I	265_E	0.902	0.88
220_V	312_M	0.900	0.88
16_T	73_A	0.898	0.88
269_R	273_E	0.897	0.88
281_D	285_G	0.897	0.88
169_V	205_A	0.895	0.88
14_L	139_T	0.891	0.88
219_I	257_G	0.891	0.88
191_V	199_G	0.888	0.88
167_G	216_I	0.883	0.87
247_A	251_S	0.879	0.87
21_V	148_A	0.878	0.87
205_A	216_I	0.877	0.87
163_V	166_I	0.871	0.87
169_V	202_M	0.870	0.87
197_E	201_K	0.870	0.87
315_I	342_S	0.866	0.86
209_A	270_N	0.865	0.86
156_G	226_G	0.864	0.86
57_K	75_V	0.863	0.86
198_A	202_M	0.863	0.86
23_A	370_L	0.863	0.86
172_E	195_D	0.862	0.86
44_G	47_R	0.859	0.86
189_S	196_E	0.856	0.86
82_K	100_E	0.856	0.86
280_W	286_Y	0.853	0.86
150_K	153_S	0.852	0.85
162_H	221_E	0.852	0.85
137_E	235_V	0.849	0.85
8_E	11_G	0.849	0.85
43_H	47_R	0.847	0.85
172_E	175_E	0.846	0.85
241_L	363_A	0.843	0.85
214_D	320_K	0.843	0.85
193_C	198_A	0.842	0.85
107_R	324_S	0.839	0.85
116_N	297_E	0.836	0.84
240_K	253_N	0.832	0.84
141_R	251_S	0.830	0.84
32_I	58_I	0.829	0.84
245_L	359_E	0.827	0.84
160_A	223_I	0.826	0.84
63_R	127_R	0.825	0.84
216_I	270_N	0.824	0.83
167_G	205_A	0.822	0.83
242_D	256_K	0.822	0.83
161_G	222_V	0.821	0.83
315_I	344_A	0.818	0.83
233_S	238_D	0.818	0.83
58_I	62_V	0.817	0.83
262_I	274_V	0.815	0.83
102_K	105_I	0.813	0.83
59_M	75_V	0.811	0.83
76_V	140_V	0.811	0.83
58_I	143_A	0.808	0.82
222_V	310_G	0.807	0.82
199_G	202_M	0.807	0.82
224_V	308_V	0.805	0.82
319_Y	337_I	0.804	0.82
293_L	297_E	0.802	0.82
288_R	302_T	0.797	0.81
163_V	346_P	0.789	0.81
345_V	348_A	0.787	0.81
72_I	147_V	0.786	0.80
25_L	361_A	0.785	0.80
316_P	351_V	0.784	0.80
62_V	150_K	0.782	0.80
5_T	141_R	0.779	0.80
242_D	246_A	0.774	0.79
367_Q	370_L	0.772	0.79
286_Y	325_V	0.768	0.79
82_K	99_K	0.761	0.78
5_T	137_E	0.759	0.78
231_V	360_I	0.759	0.78
213_G	320_K	0.758	0.78
33_N	55_Q	0.758	0.78
3_Y	358_W	0.753	0.78
207_D	211_A	0.752	0.77
46_G	206_I	0.751	0.77
219_I	267_A	0.750	0.77
238_D	244_K	0.750	0.77
55_Q	79_N	0.748	0.77
242_D	260_F	0.747	0.77
116_N	302_T	0.745	0.77
17_I	73_A	0.742	0.77
38_R	350_V	0.740	0.76
168_A	268_G	0.739	0.76
29_E	33_N	0.738	0.76
249_V	352_A	0.738	0.76
348_A	352_A	0.737	0.76
359_E	362_N	0.736	0.76
171_A	198_A	0.735	0.76
18_I	148_A	0.735	0.76
4_L	17_I	0.735	0.76
159_V	360_I	0.732	0.76
272_S	320_K	0.731	0.75
175_E	178_S	0.730	0.75
244_K	359_E	0.729	0.75
326_D	329_T	0.728	0.75
46_G	203_M	0.728	0.75
208_E	211_A	0.727	0.75
266_A	293_L	0.727	0.75
238_D	366_E	0.726	0.75
104_Q	334_S	0.725	0.75
137_E	140_V	0.723	0.75
123_H	129_V	0.723	0.75
141_R	235_V	0.721	0.74
14_L	76_V	0.717	0.74
171_A	174_T	0.716	0.74
173_K	195_D	0.713	0.74
58_I	74_L	0.713	0.74
265_E	269_R	0.711	0.73
219_I	311_V	0.711	0.73
166_I	206_I	0.710	0.73
29_E	57_K	0.709	0.73
36_L	139_T	0.708	0.73
33_N	40_Q	0.708	0.73
301_T	306_I	0.706	0.73
279_I	331_E	0.703	0.73
6_A	17_I	0.700	0.72
250_L	258_V	0.698	0.72
279_I	323_K	0.698	0.72
202_M	206_I	0.694	0.72
250_L	308_V	0.694	0.72
67_T	150_K	0.691	0.71
220_V	348_A	0.691	0.71
37_A	40_Q	0.689	0.71
15_T	59_M	0.689	0.71
74_L	147_V	0.688	0.71
209_A	212_N	0.687	0.71
150_K	154_E	0.686	0.71
135_A	253_N	0.686	0.71
206_I	343_C	0.685	0.71
278_I	297_E	0.684	0.71
46_G	191_V	0.683	0.70
111_G	316_P	0.680	0.70
233_S	366_E	0.679	0.70
103_R	107_R	0.676	0.70
117_G	133_S	0.672	0.69
227_M	300_M	0.672	0.69
312_M	351_V	0.670	0.69
204_A	207_D	0.668	0.69
242_D	258_V	0.667	0.69
23_A	367_Q	0.663	0.68
323_K	331_E	0.663	0.68
270_N	273_E	0.662	0.68
296_L	302_T	0.660	0.68
3_Y	18_I	0.659	0.68
59_M	73_A	0.659	0.68
33_N	56_A	0.659	0.68
227_M	364_V	0.658	0.68
3_Y	144_A	0.654	0.67
11_G	127_R	0.649	0.67
201_K	205_A	0.649	0.67
280_W	284_K	0.648	0.66
18_I	21_V	0.647	0.66
278_I	286_Y	0.645	0.66
280_W	325_V	0.645	0.66
316_P	336_S	0.645	0.66
206_I	209_A	0.641	0.66
5_T	240_K	0.636	0.65
132_R	137_E	0.635	0.65
293_L	306_I	0.635	0.65
118_A	126_M	0.635	0.65
164_L	219_I	0.635	0.65
164_L	170_K	0.634	0.65
105_I	126_M	0.630	0.64
282_E	285_G	0.629	0.64
149_K	159_V	0.628	0.64
63_R	125_D	0.627	0.64
213_G	335_A	0.625	0.64
222_V	356_V	0.624	0.64
135_A	351_V	0.624	0.64
365_V	368_F	0.624	0.64
24_G	123_H	0.624	0.64
5_T	132_R	0.623	0.63
83_H	127_R	0.623	0.63
29_E	55_Q	0.622	0.63
3_Y	355_A	0.621	0.63
59_M	77_E	0.621	0.63
240_K	243_S	0.619	0.63
35_E	38_R	0.617	0.63
245_L	258_V	0.610	0.62
361_A	365_V	0.609	0.62
355_A	359_E	0.608	0.62
44_G	189_S	0.607	0.61
43_H	48_R	0.607	0.61
266_A	269_R	0.605	0.61
344_A	351_V	0.603	0.61
67_T	147_V	0.601	0.61
32_I	74_L	0.601	0.61
254_A	348_A	0.601	0.61
27_I	150_K	0.599	0.60
162_H	223_I	0.597	0.60
5_T	140_V	0.597	0.60
161_G	353_E	0.597	0.60
306_I	360_I	0.596	0.60
158_K	226_G	0.594	0.60
51_I	80_D	0.592	0.59
223_I	307_V	0.592	0.59
30_E	34_F	0.591	0.59
81_W	100_E	0.590	0.59
171_A	194_Y	0.588	0.59
259_E	263_G	0.586	0.59
28_T	34_F	0.586	0.59
157_I	227_M	0.584	0.58
40_Q	43_H	0.583	0.58
25_L	150_K	0.581	0.58
252_I	351_V	0.581	0.58
243_S	251_S	0.580	0.58
238_D	363_A	0.579	0.58
15_T	73_A	0.579	0.58
169_V	209_A	0.578	0.58
279_I	286_Y	0.578	0.58
245_L	249_V	0.577	0.58
278_I	325_V	0.576	0.57
254_A	312_M	0.573	0.57
68_L	127_R	0.571	0.57
171_A	195_D	0.570	0.57
35_E	142_V	0.568	0.56
214_D	273_E	0.566	0.56
73_A	140_V	0.566	0.56
259_E	264_F	0.565	0.56
237_Y	253_N	0.564	0.56
344_A	348_A	0.564	0.56
8_E	127_R	0.562	0.56
170_K	265_E	0.561	0.55
63_R	68_L	0.560	0.55
21_V	358_W	0.560	0.55
260_F	308_V	0.559	0.55
70_S	117_G	0.559	0.55
164_L	307_V	0.557	0.55
132_R	141_R	0.556	0.55
224_V	245_L	0.554	0.55
60_S	73_A	0.553	0.54
43_H	207_D	0.553	0.54
64_H	126_M	0.552	0.54
237_Y	247_A	0.552	0.54
164_L	309_R	0.551	0.54
36_L	143_A	0.551	0.54
210_K	213_G	0.549	0.54
319_Y	336_S	0.549	0.54
27_I	34_F	0.549	0.54
228_P	364_V	0.547	0.54
29_E	150_K	0.547	0.54
21_V	151_I	0.544	0.53
27_I	58_I	0.544	0.53
32_I	36_L	0.543	0.53
26_Y	150_K	0.543	0.53
253_N	348_A	0.541	0.53
235_V	251_S	0.540	0.53
133_S	137_E	0.540	0.53
161_G	352_A	0.540	0.53
38_R	187_E	0.539	0.53
137_E	251_S	0.539	0.53
297_E	317_T	0.538	0.52
56_A	62_V	0.538	0.52
162_H	171_A	0.536	0.52
206_I	210_K	0.536	0.52
280_W	285_G	0.535	0.52
32_I	150_K	0.534	0.52
34_F	37_A	0.533	0.52
16_T	253_N	0.532	0.52
274_V	293_L	0.532	0.52
3_Y	74_L	0.532	0.52
340_S	347_A	0.531	0.51
74_L	140_V	0.530	0.51
120_K	233_S	0.526	0.51
171_A	193_C	0.526	0.51
235_V	240_K	0.525	0.51
68_L	125_D	0.523	0.50
316_P	319_Y	0.523	0.50
36_L	228_P	0.523	0.50
224_V	231_V	0.523	0.50
122_N	129_V	0.520	0.50
21_V	27_I	0.520	0.50
51_I	79_N	0.520	0.50
243_S	296_L	0.519	0.50
293_L	302_T	0.518	0.50
201_K	208_E	0.518	0.50
188_E	196_E	0.516	0.49
23_A	70_S	0.515	0.49
11_G	68_L	0.514	0.49
18_I	146_A	0.512	0.49
29_E	58_I	0.512	0.49
222_V	249_V	0.512	0.49
144_A	358_W	0.511	0.49
162_H	186_T	0.510	0.49
149_K	153_S	0.510	0.49
196_E	199_G	0.510	0.49
161_G	220_V	0.509	0.49
14_L	51_I	0.509	0.49
317_T	351_V	0.508	0.48
293_L	301_T	0.507	0.48
22_P	365_V	0.506	0.48
82_K	102_K	0.506	0.48
44_G	346_P	0.506	0.48
80_D	99_K	0.504	0.48
305_P	308_V	0.504	0.48
27_I	62_V	0.504	0.48
160_A	176_Y	0.504	0.48
118_A	123_H	0.503	0.48
4_L	19_E	0.502	0.48
46_G	166_I	0.501	0.47
166_I	345_V	0.500	0.47
47_R	50_Q	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o11A	4	0.9564	100	0.025	Contact Map
1qxoA	4	0.9821	100	0.03	Contact Map
1q1lA	4	0.841	100	0.035	Contact Map
4ecdA	3	0.6949	100	0.039	Contact Map
1r53A	4	0.6974	100	0.079	Contact Map
1sq1A	4	0.7205	100	0.091	Contact Map
4ob9A	2	0.7769	100	0.095	Contact Map
1um0A	4	0.9026	100	0.095	Contact Map
4wdcA	1	0.4103	28.9	0.979	Contact Map
2dt8A	1	0.3846	21	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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