GREMLIN Database
AROB - 3-dehydroquinate synthase
UniProt: P31102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (341)
Sequences: 4477 (3149)
Seq/√Len: 170.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_L290_R4.4671.00
334_N338_K3.1411.00
124_D161_K3.1261.00
86_Q118_T2.9811.00
80_D83_T2.9251.00
231_Q238_I2.8401.00
176_K265_D2.8301.00
100_I112_A2.8071.00
117_A156_A2.7971.00
244_F271_M2.6871.00
281_T348_E2.4221.00
255_E316_R2.4111.00
82_Y115_V2.3651.00
174_P177_E2.2551.00
345_S348_E2.2521.00
334_N340_A2.2501.00
89_A100_I2.2031.00
279_E288_R2.2031.00
188_H221_G2.1941.00
44_D72_S2.1601.00
278_S333_L2.1581.00
311_S350_E2.1541.00
193_D220_K2.1471.00
280_K351_S2.1441.00
114_F118_T2.0941.00
89_A94_M2.0911.00
238_I241_Y2.0801.00
48_D52_G2.0591.00
109_G137_S2.0471.00
220_K223_S2.0401.00
223_S227_S2.0211.00
219_F223_S2.0181.00
66_K92_F1.9611.00
46_E72_S1.9551.00
186_I298_L1.9431.00
79_M145_V1.9291.00
52_G67_K1.9131.00
175_E179_R1.8921.00
94_M98_S1.8851.00
68_V88_E1.8711.00
40_M89_A1.8581.00
227_S231_Q1.8551.00
192_Y224_I1.8441.00
150_G153_L1.8341.00
190_F291_L1.8191.00
87_S149_L1.8061.00
190_F333_L1.7941.00
42_V112_A1.7931.00
147_H154_I1.7801.00
284_C287_D1.7731.00
275_L291_L1.7691.00
88_E92_F1.7671.00
23_K54_E1.7511.00
48_D69_T1.7481.00
241_Y339_V1.7381.00
82_Y86_Q1.7151.00
15_V222_I1.7041.00
261_I269_L1.6931.00
276_Y292_V1.6571.00
194_R198_E1.6521.00
192_Y227_S1.6481.00
82_Y118_T1.6471.00
335_E338_K1.6281.00
175_E209_I1.6281.00
202_N205_S1.6261.00
40_M94_M1.6211.00
97_S324_R1.6161.00
228_V241_Y1.6081.00
309_E312_V1.5731.00
102_A112_A1.5691.00
70_V108_V1.5601.00
279_E285_E1.5561.00
159_Q233_E1.5511.00
38_R64_P1.5481.00
271_M295_L1.5231.00
333_L339_V1.5221.00
197_L336_L1.5211.00
248_L273_F1.5001.00
318_M346_R1.4921.00
204_H297_S1.4801.00
82_Y144_A1.4701.00
79_M83_T1.4651.00
53_D57_H1.4641.00
195_A198_E1.4491.00
285_E289_K1.4451.00
139_V222_I1.4441.00
272_Q292_V1.4131.00
45_E71_P1.4121.00
199_E217_M1.4111.00
43_T48_D1.4111.00
268_A295_L1.4071.00
24_K27_E1.4021.00
87_S91_R1.4011.00
88_E91_R1.3751.00
81_M84_K1.3691.00
85_L111_L1.3681.00
56_L67_K1.3641.00
277_I330_F1.3521.00
180_S262_T1.3471.00
70_V76_A1.3441.00
312_V315_N1.3191.00
20_G168_D1.3191.00
40_M88_E1.3141.00
188_H224_I1.3081.00
85_L115_V1.3071.00
109_G127_Q1.2991.00
82_Y145_V1.2951.00
327_K343_T1.2851.00
19_Q168_D1.2841.00
254_A316_R1.2831.00
191_I244_F1.2831.00
287_D335_E1.2801.00
167_T218_I1.2781.00
216_D220_K1.2751.00
346_R350_E1.2721.00
40_M68_V1.2631.00
53_D56_L1.2631.00
314_L350_E1.2451.00
190_F197_L1.2341.00
39_I99_C1.2341.00
199_E202_N1.2271.00
98_S123_I1.2221.00
45_E72_S1.2121.00
82_Y111_L1.2101.00
87_S147_H1.2041.00
314_L318_M1.2001.00
135_H170_L1.1961.00
182_M185_V1.1881.00
68_V85_L1.1801.00
42_V115_V1.1771.00
131_T134_A1.1731.00
117_A158_Y1.1701.00
39_I101_I1.1701.00
18_G167_T1.1691.00
255_E312_V1.1671.00
213_Q216_D1.1621.00
287_D336_L1.1521.00
42_V100_I1.1491.00
199_E216_D1.1471.00
93_H319_N1.1461.00
203_I298_L1.1401.00
226_A230_Q1.1351.00
95_D98_S1.1221.00
177_E262_T1.1211.00
171_R211_N1.1191.00
76_A81_M1.1171.00
26_C58_L1.1151.00
56_L60_Q1.1121.00
196_F199_E1.1011.00
289_K293_S1.0981.00
118_T156_A1.0951.00
43_T108_V1.0931.00
310_T350_E1.0901.00
277_I352_W1.0871.00
244_F291_L1.0831.00
165_Y222_I1.0821.00
292_V296_K1.0731.00
167_T215_N1.0711.00
196_F217_M1.0691.00
206_L217_M1.0631.00
48_D67_K1.0621.00
16_F162_A1.0570.99
262_T265_D1.0560.99
178_L209_I1.0550.99
197_L290_R1.0540.99
276_Y279_E1.0520.99
45_E49_R1.0510.99
248_L274_A1.0460.99
177_E180_S1.0410.99
244_F275_L1.0360.99
274_A331_I1.0350.99
272_Q295_L1.0310.99
249_G266_A1.0240.99
14_P162_A1.0200.99
125_F158_Y1.0180.99
70_V111_L1.0170.99
41_F56_L1.0120.99
240_A329_Q1.0010.99
55_M103_F0.9980.99
18_G24_K0.9970.99
100_I123_I0.9960.99
350_E354_N0.9910.99
185_V200_L0.9900.99
269_L272_Q0.9880.99
304_I313_L0.9850.99
279_E286_M0.9840.99
43_T47_V0.9710.99
205_S213_Q0.9680.99
91_R149_L0.9620.99
76_A107_V0.9610.99
84_K88_E0.9610.99
99_C124_D0.9600.99
314_L346_R0.9590.99
268_A300_Y0.9560.99
79_M82_Y0.9560.99
44_D76_A0.9560.99
76_A108_V0.9540.99
227_S230_Q0.9530.99
101_I128_M0.9530.99
310_T354_N0.9530.99
87_S148_P0.9490.99
70_V81_M0.9470.99
25_A55_M0.9450.99
66_K94_M0.9390.99
38_R98_S0.9390.99
36_L124_D0.9380.99
168_D171_R0.9370.99
275_L284_C0.9330.99
276_Y352_W0.9280.99
79_M86_Q0.9280.99
278_S284_C0.9280.99
179_R299_G0.9270.99
25_A164_L0.9240.99
18_G21_I0.9240.99
276_Y280_K0.9200.99
43_T69_T0.9120.99
332_V341_D0.9120.99
27_E31_S0.9100.98
188_H196_F0.9080.98
90_I147_H0.9010.98
20_G23_K0.9010.98
71_P81_M0.8980.98
158_Y234_K0.8970.98
296_K302_S0.8950.98
55_M59_L0.8940.98
330_F344_F0.8900.98
249_G267_V0.8870.98
40_M66_K0.8850.98
283_G340_A0.8830.98
235_E240_A0.8830.98
210_T213_Q0.8820.98
348_E351_S0.8820.98
28_L164_L0.8820.98
281_T345_S0.8790.98
103_F169_F0.8760.98
194_R335_E0.8750.98
41_F52_G0.8740.98
347_N351_S0.8710.98
194_R336_L0.8690.98
102_A127_Q0.8620.98
256_Y261_I0.8610.98
223_S226_A0.8600.98
47_V51_Y0.8600.98
165_Y218_I0.8580.98
278_S332_V0.8550.98
201_L293_S0.8500.98
19_Q171_R0.8500.98
327_K342_H0.8470.98
192_Y238_I0.8450.98
51_Y103_F0.8450.98
143_V156_A0.8430.98
57_H60_Q0.8420.97
42_V85_L0.8410.97
186_I295_L0.8360.97
278_S283_G0.8340.97
189_A196_F0.8330.97
16_F28_L0.8240.97
132_L178_L0.8240.97
95_D323_T0.8210.97
52_G56_L0.8160.97
22_R169_F0.8110.97
216_D223_S0.8050.97
205_S210_T0.8040.97
146_N177_E0.8030.97
100_I116_A0.8010.97
191_I241_Y0.7990.97
192_Y228_V0.7910.96
135_H165_Y0.7870.96
44_D47_V0.7870.96
46_E76_A0.7850.96
200_L294_W0.7790.96
51_Y172_S0.7790.96
284_C291_L0.7790.96
17_I219_F0.7790.96
280_K348_E0.7750.96
46_E131_T0.7740.96
37_T95_D0.7740.96
103_F128_M0.7740.96
83_T87_S0.7730.96
95_D326_G0.7720.96
203_I297_S0.7690.96
190_F244_F0.7640.96
176_K262_T0.7630.96
341_D344_F0.7600.95
286_M289_K0.7600.95
139_V226_A0.7570.95
72_S76_A0.7560.95
272_Q302_S0.7520.95
41_F55_M0.7500.95
78_S81_M0.7490.95
186_I294_W0.7470.95
216_D219_F0.7460.95
24_K28_L0.7450.95
215_N219_F0.7440.95
56_L65_V0.7410.95
68_V84_K0.7400.95
120_M153_L0.7390.95
288_R292_V0.7390.95
120_M144_A0.7380.95
292_V303_Q0.7370.95
332_V340_A0.7370.95
182_M298_L0.7350.95
277_I348_E0.7330.94
183_A268_A0.7310.94
276_Y288_R0.7290.94
129_P134_A0.7270.94
158_Y161_K0.7240.94
198_E201_L0.7210.94
107_V146_N0.7210.94
198_E290_R0.7190.94
28_L162_A0.7180.94
90_I153_L0.7170.94
274_A332_V0.7170.94
178_L214_L0.7120.94
274_A278_S0.7120.94
179_R207_R0.7120.94
94_M119_F0.7120.94
43_T52_G0.7120.94
41_F65_V0.7090.93
185_V188_H0.7070.93
28_L31_S0.7060.93
150_G258_Y0.7040.93
275_L333_L0.7030.93
43_T67_K0.7010.93
289_K292_V0.7010.93
239_R243_N0.6990.93
284_C333_L0.6990.93
243_N321_K0.6980.93
90_I119_F0.6970.93
280_K352_W0.6960.93
274_A330_F0.6950.93
11_S161_K0.6920.93
127_Q137_S0.6890.92
197_L294_W0.6870.92
269_L273_F0.6860.92
109_G134_A0.6860.92
43_T73_G0.6840.92
180_S265_D0.6830.92
78_S146_N0.6820.92
19_Q167_T0.6810.92
199_E213_Q0.6800.92
217_M221_G0.6780.92
19_Q215_N0.6770.92
279_E284_C0.6740.92
329_Q342_H0.6720.91
45_E69_T0.6710.91
255_E313_L0.6680.91
275_L288_R0.6680.91
221_G224_I0.6670.91
29_L99_C0.6650.91
273_F352_W0.6650.91
283_G334_N0.6630.91
197_L291_L0.6620.91
54_E57_H0.6610.91
101_I126_I0.6600.91
203_I206_L0.6590.91
272_Q276_Y0.6570.91
344_F349_L0.6540.90
55_M128_M0.6500.90
256_Y260_Q0.6470.90
281_T343_T0.6460.90
80_D84_K0.6440.90
46_E49_R0.6440.90
25_A128_M0.6430.90
54_E58_L0.6400.89
147_H150_G0.6360.89
305_R308_T0.6350.89
76_A111_L0.6330.89
93_H315_N0.6330.89
191_I224_I0.6320.89
191_I271_M0.6300.89
102_A109_G0.6300.89
38_R94_M0.6270.88
86_Q154_I0.6270.88
124_D158_Y0.6270.88
78_S82_Y0.6260.88
60_Q64_P0.6250.88
283_G332_V0.6250.88
55_M101_I0.6240.88
37_T99_C0.6240.88
60_Q65_V0.6240.88
40_M98_S0.6230.88
351_S354_N0.6230.88
240_A324_R0.6230.88
18_G166_D0.6210.88
46_E50_L0.6190.88
227_S238_I0.6190.88
201_L294_W0.6190.88
331_I341_D0.6190.88
38_R95_D0.6170.88
43_T103_F0.6170.88
293_S297_S0.6160.88
269_L301_P0.6150.87
120_M323_T0.6150.87
244_F333_L0.6130.87
38_R66_K0.6110.87
120_M319_N0.6100.87
199_E220_K0.6090.87
111_L115_V0.6090.87
296_K303_Q0.6080.87
252_V261_I0.6070.87
90_I149_L0.6070.87
239_R321_K0.6060.87
252_V269_L0.6060.87
293_S296_K0.6060.87
17_I222_I0.6060.87
271_M291_L0.6050.87
66_K88_E0.6030.86
97_S325_G0.6030.86
78_S111_L0.6010.86
45_E76_A0.5980.86
120_M123_I0.5960.86
140_G243_N0.5960.86
17_I215_N0.5960.86
193_D224_I0.5960.86
261_I265_D0.5940.86
329_Q343_T0.5930.86
109_G138_A0.5930.86
312_V316_R0.5920.85
96_R157_F0.5910.85
197_L201_L0.5870.85
204_H208_D0.5850.85
125_F159_Q0.5850.85
37_T325_G0.5850.85
233_E236_E0.5840.85
313_L317_M0.5840.85
194_R290_R0.5840.85
272_Q288_R0.5810.84
28_L32_L0.5790.84
29_L101_I0.5780.84
132_L218_I0.5780.84
231_Q237_G0.5770.84
141_G239_R0.5770.84
132_L185_V0.5760.84
294_W297_S0.5760.84
126_I162_A0.5740.84
141_G243_N0.5730.84
234_K238_I0.5710.83
347_N350_E0.5700.83
311_S346_R0.5700.83
99_C126_I0.5700.83
26_C63_W0.5690.83
29_L36_L0.5670.83
254_A258_Y0.5650.83
249_G271_M0.5640.83
316_R319_N0.5640.83
333_L340_A0.5610.82
18_G165_Y0.5590.82
179_R265_D0.5580.82
20_G166_D0.5570.82
194_R287_D0.5540.81
130_T169_F0.5500.81
49_R72_S0.5490.81
171_R209_I0.5480.81
185_V217_M0.5460.81
51_Y169_F0.5450.80
119_F150_G0.5410.80
137_S249_G0.5410.80
201_L297_S0.5410.80
147_H153_L0.5410.80
97_S236_E0.5410.80
41_F67_K0.5400.80
11_S234_K0.5400.80
89_A115_V0.5400.80
183_A271_M0.5390.80
254_A319_N0.5380.80
37_T98_S0.5370.79
98_S124_D0.5350.79
277_I344_F0.5340.79
37_T64_P0.5340.79
118_T144_A0.5330.79
119_F153_L0.5320.79
94_M120_M0.5320.79
207_R299_G0.5300.79
36_L99_C0.5280.78
52_G103_F0.5270.78
331_I339_V0.5270.78
99_C161_K0.5270.78
81_M111_L0.5260.78
179_R182_M0.5250.78
291_L295_L0.5240.78
70_V85_L0.5230.78
200_L298_L0.5230.78
192_Y241_Y0.5230.78
68_V92_F0.5230.78
175_E299_G0.5220.78
243_N322_K0.5220.78
22_R54_E0.5210.77
54_E168_D0.5210.77
290_R293_S0.5200.77
182_M186_I0.5200.77
219_F227_S0.5190.77
129_P133_L0.5180.77
323_T328_I0.5180.77
165_Y188_H0.5170.77
57_H61_E0.5150.77
79_M118_T0.5150.77
27_E30_T0.5140.76
349_L352_W0.5140.76
95_D120_M0.5140.76
135_H218_I0.5130.76
15_V165_Y0.5130.76
78_S145_V0.5120.76
11_S233_E0.5100.76
311_S315_N0.5090.76
252_V256_Y0.5080.76
229_V243_N0.5070.76
134_A137_S0.5050.75
39_I63_W0.5050.75
255_E309_E0.5040.75
47_V103_F0.5010.75
175_E178_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gruA 2 0.9751 100 0.292 Contact Map
3zokA 4 0.9862 100 0.297 Contact Map
3okfA 3 0.9834 100 0.31 Contact Map
1ujnA 2 0.9199 100 0.327 Contact Map
1xahA 1 0.9061 100 0.33 Contact Map
3qbeA 1 0.9558 100 0.333 Contact Map
4p53A 2 0.9641 100 0.343 Contact Map
1sg6A 1 0.9365 100 0.344 Contact Map
3clhA 2 0.8425 100 0.372 Contact Map
3ce9A 3 0.895 100 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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