GREMLIN Database
LEXA - LexA repressor
UniProt: P31080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (186)
Sequences: 4901 (3467)
Seq/√Len: 254.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V47_L4.0391.00
166_R179_E3.8391.00
89_V154_V3.0001.00
126_D183_M2.7781.00
139_V164_V2.6771.00
18_E22_K2.6491.00
91_A123_I2.5831.00
134_L137_D2.4661.00
130_D181_P2.3701.00
173_H187_I2.3551.00
151_E196_K2.2951.00
120_M138_Y2.2351.00
168_Y177_Q2.1831.00
120_M140_I2.1371.00
14_F72_E2.1091.00
29_R33_E2.0901.00
147_A153_V2.0671.00
117_H143_Q2.0511.00
11_I15_I2.0381.00
29_R40_S2.0321.00
170_E175_R2.0231.00
82_N106_P1.9911.00
83_V120_M1.9611.00
88_K124_M1.9501.00
131_A179_E1.8831.00
46_H53_K1.8791.00
156_M192_S1.8441.00
168_Y175_R1.7791.00
141_V197_V1.7641.00
17_A21_S1.7621.00
163_T178_P1.7041.00
44_H48_A1.6311.00
133_I152_I1.6091.00
122_E138_Y1.6031.00
177_Q185_P1.6021.00
18_E21_S1.5801.00
164_V197_V1.5611.00
188_L191_V1.5531.00
35_V65_A1.4871.00
69_L72_E1.4631.00
126_D182_T1.4401.00
38_A41_S1.4111.00
132_G179_E1.3901.00
31_I43_V1.3691.00
141_V154_V1.3661.00
155_A167_F1.3601.00
123_I164_V1.3511.00
51_E58_R1.3501.00
28_V47_L1.3291.00
123_I139_V1.3241.00
14_F18_E1.3121.00
40_S44_H1.3101.00
156_M194_L1.3101.00
85_V103_E1.2891.00
45_G50_L1.2771.00
12_L47_L1.2501.00
131_A152_I1.2461.00
153_V167_F1.2341.00
139_V197_V1.2261.00
92_G165_K1.2261.00
30_E34_A1.2231.00
53_K58_R1.2211.00
37_L43_V1.2081.00
105_F120_M1.2041.00
42_T46_H1.1911.00
34_A65_A1.1811.00
28_V40_S1.1711.00
27_S30_E1.1541.00
116_E142_K1.1491.00
18_E66_I1.1441.00
127_S165_K1.1381.00
37_L42_T1.1351.00
119_F143_Q1.1241.00
32_G40_S1.1241.00
28_V44_H1.1201.00
32_G35_V1.1141.00
51_E57_R1.1141.00
152_I166_R1.1111.00
30_E33_E1.1071.00
175_R185_P1.1041.00
43_V46_H1.0981.00
57_R67_E1.0951.00
118_V198_I1.0871.00
41_S44_H1.0841.00
37_L46_H1.0741.00
130_D179_E1.0711.00
118_V140_I1.0581.00
166_R177_Q1.0571.00
178_P185_P1.0411.00
12_L19_V1.0411.00
154_V164_V1.0371.00
42_T45_G1.0331.00
12_L49_R1.0261.00
133_I164_V1.0101.00
45_G51_E1.0031.00
121_L154_V1.0021.00
123_I133_I1.0001.00
90_T94_P1.0001.00
94_P163_T0.9921.00
16_K47_L0.9901.00
83_V118_V0.9851.00
22_K66_I0.9821.00
22_K67_E0.9701.00
89_V121_L0.9691.00
130_D134_L0.9581.00
169_K174_I0.9431.00
10_D13_R0.9431.00
28_V43_V0.9431.00
149_N169_K0.9321.00
175_R187_I0.9301.00
68_I72_E0.9281.00
131_A166_R0.9241.00
125_G135_D0.9231.00
89_V164_V0.9221.00
154_V197_V0.9221.00
92_G125_G0.9191.00
63_P68_I0.9161.00
148_N151_E0.9041.00
45_G49_R0.8881.00
125_G165_K0.8881.00
29_R32_G0.8831.00
90_T95_I0.8811.00
31_I62_K0.8811.00
13_R17_A0.8771.00
55_L59_D0.8681.00
118_V143_Q0.8681.00
147_A196_K0.8631.00
31_I34_A0.8610.99
85_V120_M0.8610.99
54_G58_R0.8530.99
153_V196_K0.8520.99
170_E173_H0.8520.99
54_G57_R0.8490.99
88_K122_E0.8480.99
85_V138_Y0.8370.99
102_E122_E0.8340.99
152_I164_V0.8340.99
157_T161_E0.8310.99
156_M160_D0.8270.99
32_G43_V0.8210.99
28_V45_G0.8160.99
155_A176_L0.8130.99
157_T188_L0.8110.99
51_E56_I0.8100.99
51_E54_G0.8060.99
117_H144_Q0.8030.99
41_S45_G0.7950.99
84_P104_Y0.7940.99
176_L186_I0.7910.99
40_S46_H0.7900.99
18_E68_I0.7830.99
159_D190_N0.7810.99
46_H54_G0.7790.99
101_I104_Y0.7760.99
97_A162_A0.7730.99
14_F31_I0.7710.99
149_N168_Y0.7690.99
37_L41_S0.7670.99
57_R60_P0.7610.99
178_P183_M0.7570.99
118_V142_K0.7450.99
11_I46_H0.7380.98
140_I199_G0.7340.98
87_G121_L0.7330.98
56_I66_I0.7280.98
89_V92_G0.7260.98
82_N104_Y0.7250.98
126_D180_N0.7250.98
124_M135_D0.7220.98
53_K56_I0.7210.98
147_A167_F0.7190.98
147_A155_A0.7180.98
107_L111_M0.7170.98
48_A52_T0.7100.98
12_L55_L0.7080.98
133_I200_V0.7030.98
37_L57_R0.7020.98
178_P186_I0.7010.98
140_I201_F0.6990.98
38_A42_T0.6990.98
159_D189_Q0.6940.98
121_L162_A0.6930.98
126_D135_D0.6830.97
14_F17_A0.6810.97
145_N192_S0.6780.97
27_S31_I0.6760.97
81_V109_D0.6730.97
38_A45_G0.6720.97
46_H51_E0.6710.97
108_P111_M0.6680.97
24_Y31_I0.6650.97
37_L55_L0.6640.97
18_E72_E0.6600.97
81_V112_V0.6600.97
142_K145_N0.6570.97
16_K20_K0.6560.97
73_V77_Q0.6540.97
141_V164_V0.6530.97
59_D63_P0.6510.97
50_L54_G0.6500.97
83_V140_I0.6460.96
74_D77_Q0.6450.96
150_G168_Y0.6420.96
57_R61_T0.6300.96
42_T51_E0.6290.96
40_S45_G0.6250.96
132_G137_D0.6230.96
41_S48_A0.6230.96
19_V31_I0.6190.95
60_P64_R0.6170.95
16_K70_D0.6170.95
79_Q109_D0.6160.95
197_V200_V0.6140.95
174_I191_V0.6100.95
10_D49_R0.6080.95
14_F34_A0.6080.95
19_V24_Y0.6060.95
11_I31_I0.6040.95
54_G59_D0.6040.95
173_H189_Q0.6030.95
29_R50_L0.5980.95
119_F154_V0.5970.94
90_T135_D0.5970.94
51_E55_L0.5940.94
107_L112_V0.5930.94
46_H61_T0.5920.94
43_V47_L0.5850.94
116_E143_Q0.5830.94
46_H62_K0.5820.94
178_P184_E0.5800.94
139_V154_V0.5800.94
11_I53_K0.5780.93
131_A180_N0.5780.93
152_I183_M0.5770.93
80_V106_P0.5740.93
14_F68_I0.5740.93
41_S54_G0.5730.93
46_H49_R0.5690.93
46_H55_L0.5670.93
46_H52_T0.5660.93
156_M162_A0.5650.93
94_P178_P0.5650.93
12_L15_I0.5640.93
24_Y65_A0.5610.92
91_A165_K0.5600.92
19_V27_S0.5570.92
133_I137_D0.5570.92
152_I179_E0.5570.92
198_I201_F0.5560.92
167_F174_I0.5550.92
19_V28_V0.5530.92
10_D14_F0.5520.92
56_I59_D0.5510.92
92_G127_S0.5500.92
165_K178_P0.5480.92
37_L54_G0.5460.91
149_N167_F0.5410.91
137_D200_V0.5390.91
35_V41_S0.5380.91
22_K34_A0.5370.91
28_V53_K0.5340.91
60_P63_P0.5340.91
85_V105_F0.5320.90
53_K61_T0.5300.90
47_L51_E0.5270.90
18_E24_Y0.5250.90
45_G53_K0.5240.90
144_Q196_K0.5230.90
32_G37_L0.5180.89
170_E177_Q0.5180.89
13_R16_K0.5180.89
19_V22_K0.5160.89
28_V32_G0.5150.89
177_Q186_I0.5130.89
45_G52_T0.5060.88
139_V200_V0.5060.88
163_T186_I0.5040.88
51_E70_D0.5020.88
55_L58_R0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bdnA 2 0.9561 100 0.271 Contact Map
1jhfA 2 0.9463 100 0.287 Contact Map
3k2zA 2 0.9415 100 0.319 Contact Map
2fjrA 4 0.8634 100 0.399 Contact Map
2hnfA 1 0.5902 99.9 0.506 Contact Map
1umuA 2 0.4976 99.9 0.51 Contact Map
1kcaA 6 0.4439 99.9 0.584 Contact Map
2bnmA 3 0.8585 99.8 0.612 Contact Map
1dw9A 6 0.6976 99.6 0.669 Contact Map
4y42A 6 0.6927 99.5 0.703 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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