GREMLIN Database
HEM2 - Delta-aminolevulinic acid dehydratase
UniProt: P30950 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (318)
Sequences: 2874 (1470)
Seq/√Len: 82.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_R259_D3.4981.00
258_R262_N3.4831.00
234_A260_V3.4761.00
91_Q94_H3.4341.00
87_D126_D3.0871.00
64_E316_K3.0421.00
30_D303_K3.0071.00
292_K321_W2.9091.00
117_A154_Q2.8031.00
166_N171_F2.6231.00
250_S302_M2.5941.00
238_V266_L2.5811.00
299_L318_A2.5011.00
100_Q153_S2.4791.00
234_A245_L2.4731.00
103_I115_V2.4241.00
156_K184_F2.3251.00
152_V178_A2.2971.00
107_K160_D2.2911.00
137_V186_N2.2161.00
22_K223_D2.2121.00
281_K291_E2.1881.00
227_R256_I2.1681.00
44_K54_H2.1401.00
139_L142_E2.1161.00
93_Y146_L2.0441.00
261_K308_D2.0421.00
290_K293_E2.0351.00
46_A54_H2.0341.00
66_A70_K2.0311.00
67_E320_K2.0201.00
295_V321_W2.0141.00
194_V234_A1.9981.00
257_M270_A1.9981.00
95_D156_K1.9521.00
282_A288_W1.9481.00
269_V309_L1.9221.00
8_H236_S1.9191.00
15_K19_E1.9081.00
45_K55_H1.8731.00
244_F269_V1.8621.00
148_A178_A1.8291.00
69_V110_F1.8201.00
86_D90_T1.8111.00
103_I117_A1.8001.00
62_K110_F1.7591.00
32_I309_L1.7561.00
235_Q239_E1.7321.00
60_L63_D1.7321.00
228_M261_K1.7291.00
259_D262_N1.6861.00
44_K60_L1.6861.00
93_Y149_Q1.6741.00
19_E74_Q1.6451.00
296_L318_A1.6411.00
48_P206_D1.6391.00
6_N232_R1.6221.00
62_K109_H1.5961.00
58_L105_E1.5951.00
47_V53_V1.5891.00
235_Q264_F1.5881.00
132_L146_L1.5861.00
251_L272_N1.5691.00
63_D66_A1.5671.00
75_S116_V1.5541.00
200_F298_I1.5521.00
61_L106_I1.5381.00
295_V314_H1.5120.99
44_K56_V1.4950.99
66_A110_F1.4860.99
43_G57_S1.4750.99
19_E29_S1.4750.99
228_M259_D1.4720.99
252_S301_S1.4650.99
25_R29_S1.4620.99
161_I244_F1.4590.99
76_V115_V1.4380.99
42_E60_L1.4370.99
39_E101_K1.4330.99
317_D320_K1.4310.99
254_M302_M1.4310.99
76_V113_M1.4310.99
156_K182_E1.4240.99
67_E316_K1.4070.99
33_Y68_L1.3990.99
121_L150_T1.3920.99
250_S270_A1.3910.99
49_S206_D1.3900.99
291_E295_V1.3790.99
190_M244_F1.3760.99
260_V268_L1.3720.99
272_N314_H1.3610.99
77_I311_I1.3560.99
77_I163_A1.3490.99
38_V45_K1.3480.99
117_A159_A1.3300.99
291_E317_D1.3270.99
280_V298_I1.3270.99
134_K142_E1.3250.99
11_L21_V1.3180.98
238_V245_L1.3170.98
31_F318_A1.3140.98
119_T162_I1.3120.98
65_V110_F1.2960.98
62_K105_E1.2840.98
289_I294_I1.2650.98
193_A234_A1.2650.98
238_V264_F1.2640.98
65_V106_I1.2610.98
24_T302_M1.2560.98
161_I188_P1.2560.98
65_V113_M1.2520.98
152_V182_E1.2460.98
200_F252_S1.2450.98
272_N298_I1.2350.98
148_A174_V1.2300.98
32_I116_V1.2200.97
40_G59_D1.2160.97
97_G100_Q1.2120.97
114_V161_I1.2100.97
281_K317_D1.2050.97
65_V76_V1.2050.97
64_E68_L1.2050.97
235_Q263_E1.2030.97
22_K225_A1.1930.97
56_V60_L1.1870.97
199_E293_E1.1860.97
66_A109_H1.1810.97
270_A302_M1.1760.97
228_M308_D1.1690.97
69_V113_M1.1490.96
252_S298_I1.1380.96
245_L266_L1.1170.96
33_Y53_V1.1160.96
251_L298_I1.1130.96
284_A289_I1.1090.96
178_A182_E1.1090.96
105_E108_E1.0990.95
134_K139_L1.0980.95
312_T315_A1.0960.95
251_L301_S1.0900.95
199_E294_I1.0900.95
89_G125_T1.0880.95
299_L302_M1.0870.95
318_A321_W1.0740.95
96_H101_K1.0720.95
16_A114_V1.0680.95
68_L316_K1.0670.95
284_A295_V1.0630.94
127_H133_V1.0610.94
85_K211_T1.0610.94
200_F280_V1.0590.94
13_T186_N1.0460.94
245_L260_V1.0440.94
38_V43_G1.0400.94
227_R258_R1.0320.93
196_Y222_M1.0310.93
292_K295_V1.0230.93
120_C130_C1.0170.93
13_T137_V1.0160.93
62_K66_A0.9970.92
17_M114_V0.9930.92
31_F312_T0.9920.92
107_K115_V0.9910.92
14_S188_P0.9900.92
225_A300_T0.9830.92
116_V163_A0.9810.92
55_H209_N0.9730.91
106_I110_F0.9640.91
303_K310_I0.9630.91
73_I319_A0.9610.91
147_L166_N0.9610.91
261_K265_T0.9600.91
37_V61_L0.9550.91
38_V55_H0.9540.90
119_T154_Q0.9520.90
280_V314_H0.9510.90
254_M257_M0.9480.90
69_V112_E0.9470.90
245_L268_L0.9440.90
33_Y316_K0.9440.90
151_A162_I0.9410.90
50_M278_S0.9400.90
28_P319_A0.9400.90
298_I314_H0.9390.90
231_L234_A0.9390.90
71_L320_K0.9360.90
298_I301_S0.9340.90
38_V57_S0.9340.90
172_V189_I0.9320.89
13_T17_M0.9310.89
296_L321_W0.9300.89
86_D89_G0.9290.89
281_K285_Q0.9280.89
71_L316_K0.9220.89
58_L102_A0.9210.89
116_V161_I0.9140.88
173_T177_E0.9110.88
103_I159_A0.9090.88
235_Q265_T0.9050.88
244_F309_L0.9050.88
93_Y153_S0.9000.88
68_L76_V0.8990.88
64_E67_E0.8970.88
120_C217_R0.8960.87
49_S288_W0.8960.87
257_M302_M0.8940.87
230_A256_I0.8920.87
123_E209_N0.8910.87
280_V289_I0.8890.87
105_E109_H0.8890.87
17_M188_P0.8870.87
130_C217_R0.8840.87
42_E59_D0.8820.87
5_F8_H0.8730.86
280_V294_I0.8720.86
292_K296_L0.8690.86
99_V124_Y0.8680.86
164_P175_I0.8670.86
121_L146_L0.8650.86
88_C93_Y0.8620.85
200_F294_I0.8600.85
146_L150_T0.8570.85
41_L57_S0.8540.85
6_N239_E0.8530.85
254_M301_S0.8500.85
291_E321_W0.8460.84
35_I61_L0.8440.84
190_M309_L0.8420.84
106_I113_M0.8410.84
194_V245_L0.8410.84
28_P31_F0.8320.83
296_L300_T0.8320.83
284_A291_E0.8290.83
257_M307_A0.8290.83
32_I311_I0.8230.83
281_K295_V0.8220.83
145_E149_Q0.8200.82
231_L260_V0.8200.82
245_L264_F0.8170.82
146_L149_Q0.8120.82
154_Q162_I0.8100.82
281_K314_H0.8060.81
144_L174_V0.8030.81
318_A322_L0.8030.81
314_H321_W0.8010.81
104_T156_K0.7950.80
14_S17_M0.7930.80
280_V284_A0.7880.80
282_A286_N0.7850.80
5_F177_E0.7840.79
103_I154_Q0.7840.79
171_F191_S0.7820.79
66_A69_V0.7810.79
39_E83_E0.7800.79
200_F251_L0.7770.79
119_T166_N0.7760.79
265_T268_L0.7740.79
151_A175_I0.7720.78
26_L31_F0.7680.78
65_V105_E0.7640.78
35_I78_V0.7630.78
58_L98_I0.7620.78
106_I115_V0.7560.77
35_I64_E0.7560.77
272_N280_V0.7540.77
125_T133_V0.7540.77
38_V41_L0.7460.76
133_V138_I0.7460.76
104_T108_E0.7380.75
80_G130_C0.7380.75
230_A234_A0.7370.75
231_L235_Q0.7360.75
87_D127_H0.7350.75
20_M74_Q0.7340.75
246_I311_I0.7310.75
53_V277_Y0.7310.75
296_L322_L0.7290.74
315_A319_A0.7290.74
26_L299_L0.7270.74
80_G120_C0.7260.74
56_V64_E0.7250.74
26_L318_A0.7210.74
194_V260_V0.7200.73
226_N229_E0.7180.73
200_F314_H0.7160.73
26_L296_L0.7150.73
120_C123_E0.7150.73
80_G217_R0.7140.73
47_V206_D0.7140.73
14_S114_V0.7140.73
58_L62_K0.7120.73
45_K209_N0.7070.72
6_N236_S0.7070.72
61_L65_V0.7060.72
81_I123_E0.7050.72
43_G60_L0.7020.72
81_I209_N0.7010.71
76_V106_I0.7010.71
191_S194_V0.7010.71
122_C130_C0.6990.71
147_L171_F0.6970.71
123_E130_C0.6970.71
82_P98_I0.6960.71
119_T171_F0.6940.71
252_S302_M0.6940.71
208_A212_P0.6880.70
40_G43_G0.6870.70
231_L263_E0.6870.70
152_V155_A0.6800.69
279_M283_A0.6780.69
37_V102_A0.6730.68
5_F236_S0.6720.68
291_E314_H0.6710.68
138_I168_M0.6690.68
78_V103_I0.6650.67
155_A187_I0.6580.67
269_V311_I0.6560.66
294_I298_I0.6550.66
123_E217_R0.6530.66
246_I269_V0.6530.66
71_L319_A0.6510.66
55_H123_E0.6500.66
252_S272_N0.6460.65
57_S60_L0.6430.65
58_L101_K0.6420.65
8_H11_L0.6390.64
19_E225_A0.6380.64
224_P300_T0.6380.64
21_V223_D0.6340.64
295_V317_D0.6330.64
251_L302_M0.6320.64
228_M258_R0.6310.63
82_P100_Q0.6310.63
65_V68_L0.6300.63
44_K64_E0.6300.63
122_C208_A0.6260.63
178_A181_K0.6250.63
62_K65_V0.6250.63
51_P288_W0.6250.63
281_K284_A0.6240.63
143_S147_L0.6240.63
36_F204_F0.6230.62
272_N299_L0.6220.62
218_K293_E0.6210.62
41_L59_D0.6210.62
133_V139_L0.6200.62
73_I316_K0.6180.62
122_C217_R0.6160.62
23_E226_N0.6150.61
77_I116_V0.6120.61
155_A188_P0.6110.61
197_S218_K0.6100.61
137_V185_V0.6080.61
261_K266_L0.6060.60
49_S278_S0.6050.60
100_Q154_Q0.6050.60
11_L188_P0.6050.60
121_L132_L0.6040.60
284_A290_K0.6010.60
15_K22_K0.6010.60
137_V219_T0.6000.60
234_A238_V0.5990.59
130_C208_A0.5990.59
35_I76_V0.5970.59
295_V298_I0.5940.59
71_L74_Q0.5930.59
172_V175_I0.5920.59
100_Q150_T0.5920.59
16_A19_E0.5910.58
40_G57_S0.5900.58
180_D185_V0.5900.58
142_E145_E0.5870.58
43_G59_D0.5860.58
227_R262_N0.5850.58
17_M20_M0.5850.58
68_L113_M0.5830.57
121_L171_F0.5820.57
24_T300_T0.5800.57
224_P253_Y0.5800.57
52_D317_D0.5790.57
77_I80_G0.5790.57
81_I85_K0.5780.57
69_V111_P0.5780.57
93_Y150_T0.5780.57
120_C208_A0.5770.57
8_H232_R0.5770.57
25_R30_D0.5770.57
132_L150_T0.5760.56
228_M265_T0.5760.56
261_K264_F0.5750.56
121_L166_N0.5750.56
259_D263_E0.5740.56
61_L102_A0.5730.56
162_I189_I0.5730.56
196_Y227_R0.5710.56
56_V65_V0.5710.56
298_I302_M0.5700.56
84_E91_Q0.5690.56
24_T225_A0.5680.55
312_T318_A0.5670.55
250_S257_M0.5640.55
176_R180_D0.5640.55
162_I175_I0.5630.55
38_V59_D0.5630.55
45_K123_E0.5610.54
89_G121_L0.5610.54
107_K111_P0.5610.54
96_H104_T0.5590.54
174_V178_A0.5580.54
31_F116_V0.5570.54
80_G123_E0.5560.54
193_A260_V0.5540.54
65_V109_H0.5540.54
17_M161_I0.5530.53
261_K268_L0.5530.53
138_I220_Y0.5530.53
32_I75_S0.5520.53
24_T227_R0.5500.53
91_Q150_T0.5500.53
161_I190_M0.5490.53
110_F113_M0.5480.53
47_V55_H0.5450.52
36_F271_Y0.5450.52
92_A150_T0.5450.52
78_V99_V0.5440.52
81_I120_C0.5390.52
30_D310_I0.5370.51
154_Q159_A0.5320.51
216_D293_E0.5320.51
63_D109_H0.5300.50
81_I130_C0.5280.50
50_M288_W0.5280.50
208_A217_R0.5280.50
314_H317_D0.5280.50
260_V263_E0.5270.50
91_Q123_E0.5260.50
81_I217_R0.5260.50
143_S166_N0.5250.50
280_V291_E0.5240.50
42_E292_K0.5240.50
228_M232_R0.5220.49
302_M307_A0.5220.49
192_Y210_S0.5210.49
33_Y64_E0.5210.49
117_A151_A0.5200.49
41_L101_K0.5200.49
11_L17_M0.5200.49
63_D67_E0.5190.49
142_E146_L0.5190.49
66_A108_E0.5190.49
138_I219_T0.5180.49
278_S282_A0.5160.49
258_R261_K0.5140.48
7_R10_R0.5130.48
283_A288_W0.5120.48
35_I316_K0.5120.48
270_A307_A0.5110.48
67_E71_L0.5100.48
41_L44_K0.5090.48
77_I122_C0.5090.48
11_L14_S0.5080.48
38_V60_L0.5080.48
66_A112_E0.5080.48
133_V213_Q0.5070.47
46_A285_Q0.5070.47
66_A156_K0.5050.47
73_I113_M0.5050.47
26_L300_T0.5040.47
133_V137_V0.5030.47
78_V106_I0.5030.47
42_E57_S0.5030.47
134_K137_V0.5020.47
47_V207_A0.5020.47
35_I65_V0.5010.47
132_L142_E0.5000.46
235_Q238_V0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w1zA 5 0.9846 100 -0.011 Contact Map
1w5qA 5 0.9722 100 -0.002 Contact Map
3obkA 5 0.9969 100 0.005 Contact Map
1l6sA 5 0.9938 100 0.017 Contact Map
1h7nA 5 1 100 0.037 Contact Map
1pv8A 5 0.8642 100 0.044 Contact Map
3vcrA 3 0.5988 97.2 0.949 Contact Map
1wbhA 3 0.5833 97.2 0.949 Contact Map
3lg3A 4 0.8148 96.9 0.952 Contact Map
3i4eA 4 0.8302 96.7 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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