GREMLIN Database
GSA - Glutamate-1-semialdehyde 2,1-aminomutase
UniProt: P30949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (379)
Sequences: 20907 (12629)
Seq/√Len: 648.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_K83_E4.3811.00
227_R231_E4.0601.00
390_E422_K3.9851.00
46_K54_E3.5731.00
187_L225_G3.3611.00
332_R414_E3.3441.00
101_L316_K3.1571.00
41_R48_F3.1121.00
250_Y256_Y2.9151.00
332_R410_D2.8441.00
73_R320_P2.7151.00
343_A421_E2.6431.00
76_E80_K2.6411.00
325_N329_K2.6321.00
409_T412_D2.5621.00
58_Y416_T2.4091.00
101_L319_T2.4001.00
225_G228_D2.3481.00
313_E316_K2.3271.00
336_G417_I2.3021.00
73_R313_E2.2441.00
228_D232_Q2.2241.00
40_E50_I2.2181.00
73_R317_Q2.2161.00
386_G389_N2.2151.00
46_K412_D2.2141.00
328_K410_D2.2031.00
71_N317_Q2.1871.00
390_E426_E2.1511.00
386_G426_E2.1171.00
191_K232_Q2.1021.00
48_F54_E2.0301.00
101_L312_L1.9801.00
137_K200_D1.9791.00
336_G414_E1.9781.00
344_H421_E1.9641.00
392_V419_A1.9471.00
98_L311_G1.9311.00
205_I238_I1.8701.00
75_V79_K1.8531.00
334_E338_S1.8531.00
331_D335_E1.8441.00
386_G390_E1.8401.00
111_I283_A1.8271.00
415_N419_A1.8171.00
49_D53_N1.8121.00
317_Q321_E1.7951.00
53_N391_G1.7891.00
283_A287_E1.7871.00
93_E97_E1.7811.00
40_E84_Y1.7791.00
190_V226_L1.7411.00
110_E283_A1.7291.00
78_L310_A1.7231.00
204_V230_T1.7051.00
100_K104_D1.6971.00
115_V277_G1.6951.00
191_K195_Q1.6751.00
206_V226_L1.6731.00
78_L82_A1.6731.00
344_H425_A1.6711.00
46_K415_N1.6571.00
336_G339_K1.6481.00
334_E352_R1.6431.00
43_K72_D1.6261.00
122_T265_C1.6251.00
348_H362_T1.5911.00
266_L278_A1.5911.00
105_R319_T1.5821.00
188_E192_L1.5661.00
271_G276_V1.5611.00
194_F235_S1.5591.00
274_L307_A1.5331.00
329_K332_R1.5311.00
250_Y327_I1.5261.00
54_E415_N1.5101.00
80_K84_Y1.5031.00
141_F222_F1.5001.00
132_Y285_I1.5001.00
45_S412_D1.4931.00
329_K413_I1.4891.00
99_A114_M1.4691.00
101_L104_D1.4661.00
239_F254_Q1.4581.00
334_E357_I1.4561.00
336_G418_Q1.4511.00
221_G224_Q1.4451.00
266_L280_G1.4411.00
106_V280_G1.4401.00
45_S407_A1.4391.00
386_G423_V1.4281.00
139_L201_I1.4231.00
250_Y255_G1.4191.00
97_E312_L1.4131.00
387_M394_L1.4051.00
325_N328_K1.3991.00
138_I203_G1.3911.00
227_R230_T1.3841.00
313_E317_Q1.3801.00
112_V280_G1.3771.00
227_R237_L1.3771.00
49_D55_Y1.3761.00
390_E423_V1.3721.00
124_S279_Y1.3691.00
338_S341_A1.3601.00
72_D76_E1.3571.00
276_V308_M1.3551.00
191_K225_G1.3551.00
192_L196_Q1.3531.00
126_L138_I1.3491.00
312_L316_K1.3361.00
39_M47_I1.3351.00
270_I276_V1.3261.00
332_R336_G1.3201.00
421_E425_A1.3181.00
408_H413_I1.3121.00
125_A265_C1.3121.00
324_K328_K1.3091.00
129_A238_I1.3051.00
195_Q233_Y1.3041.00
97_E316_K1.3021.00
336_G421_E1.2921.00
206_V223_L1.2871.00
251_N255_G1.2841.00
104_D319_T1.2821.00
103_I112_V1.2801.00
43_K70_T1.2791.00
340_T417_I1.2751.00
183_P189_S1.2751.00
71_N321_E1.2681.00
329_K410_D1.2671.00
254_Q264_T1.2641.00
340_T421_E1.2631.00
132_Y288_Q1.2621.00
41_R84_Y1.2611.00
221_G257_F1.2561.00
204_V226_L1.2501.00
188_E191_K1.2491.00
122_T205_I1.2471.00
263_L281_G1.2381.00
276_V311_G1.2231.00
257_F353_A1.2231.00
179_T182_V1.2181.00
76_E79_K1.2171.00
75_V83_E1.2141.00
115_V279_Y1.2091.00
70_T75_V1.2071.00
239_F259_V1.2031.00
78_L306_L1.2001.00
270_I278_A1.1951.00
77_S313_E1.1911.00
183_P186_D1.1851.00
67_L317_Q1.1831.00
256_Y353_A1.1821.00
111_I287_E1.1751.00
260_T282_K1.1721.00
224_Q228_D1.1681.00
187_L229_I1.1681.00
137_K172_P1.1671.00
387_M419_A1.1601.00
412_D415_N1.1601.00
316_K320_P1.1571.00
75_V82_A1.1541.00
79_K82_A1.1481.00
418_Q422_K1.1381.00
185_N219_Q1.1381.00
155_K205_I1.1321.00
114_M308_M1.1271.00
263_L279_Y1.1071.00
236_L285_I1.1061.00
327_I331_D1.1041.00
135_R234_G1.1031.00
387_M423_V1.0961.00
43_K54_E1.0941.00
191_K229_I1.0921.00
46_K56_I1.0911.00
119_T152_L1.0811.00
392_V416_T1.0751.00
155_K171_V1.0751.00
224_Q258_G1.0731.00
410_D414_E1.0631.00
252_C266_L1.0621.00
390_E419_A1.0601.00
40_E93_E1.0551.00
45_S56_I1.0541.00
335_E339_K1.0521.00
387_M392_V1.0491.00
415_N418_Q1.0441.00
317_Q320_P1.0391.00
174_G177_K1.0361.00
230_T235_S1.0351.00
126_L155_K1.0311.00
272_G314_T1.0231.00
191_K233_Y1.0221.00
414_E418_Q1.0171.00
128_L279_Y1.0081.00
98_L312_L1.0061.00
40_E52_G0.9801.00
121_A265_C0.9791.00
249_D255_G0.9781.00
191_K228_D0.9771.00
140_K205_I0.9681.00
109_V280_G0.9671.00
67_L314_T0.9601.00
74_V310_A0.9571.00
66_I269_V0.9561.00
43_K48_F0.9541.00
175_I189_S0.9521.00
411_E414_E0.9501.00
226_L237_L0.9461.00
101_L105_R0.9451.00
246_F318_L0.9431.00
325_N410_D0.9421.00
141_F218_P0.9421.00
40_E48_F0.9411.00
194_F201_I0.9371.00
223_L257_F0.9351.00
105_R251_N0.9291.00
56_I412_D0.9241.00
154_I168_S0.9231.00
385_K389_N0.9221.00
382_S386_G0.9221.00
208_P239_F0.9211.00
348_H360_F0.9191.00
174_G178_N0.9191.00
341_A347_P0.9181.00
189_S192_L0.9171.00
228_D231_E0.9151.00
309_T313_E0.9131.00
198_G233_Y0.9121.00
324_K327_I0.9101.00
180_I348_H0.9091.00
73_R316_K0.9081.00
318_L323_Y0.9081.00
65_L272_G0.9051.00
137_K201_I0.9051.00
76_E83_E0.9001.00
137_K195_Q0.8991.00
136_N200_D0.8981.00
338_S342_G0.8931.00
203_G238_I0.8931.00
73_R76_E0.8901.00
323_Y326_F0.8841.00
217_P353_A0.8811.00
142_E183_P0.8761.00
209_V353_A0.8741.00
182_V193_A0.8731.00
45_S409_T0.8721.00
193_A196_Q0.8681.00
178_N181_T0.8681.00
229_I233_Y0.8641.00
58_Y408_H0.8611.00
119_T149_G0.8581.00
128_L281_G0.8581.00
38_F96_N0.8571.00
80_K83_E0.8561.00
220_E224_Q0.8551.00
56_I415_N0.8501.00
38_F50_I0.8501.00
67_L74_V0.8461.00
125_A238_I0.8441.00
221_G225_G0.8431.00
105_R315_L0.8401.00
132_Y236_L0.8391.00
256_Y327_I0.8391.00
339_K343_A0.8381.00
274_L306_L0.8341.00
349_T360_F0.8341.00
356_M403_F0.8291.00
129_A236_L0.8291.00
231_E260_T0.8271.00
80_K309_T0.8251.00
408_H416_T0.8221.00
103_I109_V0.8221.00
234_G284_E0.8211.00
129_A203_G0.8211.00
336_G413_I0.8211.00
108_S264_T0.8211.00
330_G334_E0.8191.00
116_S120_E0.8181.00
355_S408_H0.8131.00
50_I93_E0.8121.00
246_F315_L0.8111.00
107_P254_Q0.8081.00
335_E338_S0.8071.00
244_T356_M0.8051.00
58_Y392_V0.8001.00
182_V186_D0.7991.00
402_L420_A0.7971.00
97_E101_L0.7941.00
175_I178_N0.7891.00
137_K197_F0.7891.00
102_V280_G0.7881.00
343_A425_A0.7831.00
211_G243_M0.7811.00
63_G403_F0.7801.00
56_I416_T0.7801.00
73_R77_S0.7781.00
108_S260_T0.7771.00
44_G407_A0.7751.00
254_Q259_V0.7731.00
45_S405_S0.7731.00
227_R259_V0.7711.00
299_G302_S0.7701.00
204_V235_S0.7691.00
340_T344_H0.7681.00
131_G296_Y0.7671.00
361_F383_Y0.7651.00
351_N360_F0.7611.00
98_L308_M0.7611.00
339_K421_E0.7611.00
252_C264_T0.7561.00
422_K426_E0.7531.00
112_V278_A0.7511.00
251_N319_T0.7501.00
332_R335_E0.7481.00
339_K342_G0.7481.00
231_E237_L0.7471.00
94_V309_T0.7411.00
328_K332_R0.7401.00
246_F270_I0.7401.00
230_T237_L0.7401.00
95_E99_A0.7391.00
77_S310_A0.7381.00
129_A263_L0.7371.00
383_Y420_A0.7371.00
225_G229_I0.7361.00
246_F266_L0.7341.00
217_P352_R0.7301.00
115_V121_A0.7291.00
127_R297_Q0.7271.00
194_F229_I0.7261.00
39_M42_G0.7231.00
74_V272_G0.7231.00
246_F251_N0.7231.00
208_P223_L0.7221.00
248_V256_Y0.7211.00
266_L270_I0.7211.00
117_S120_E0.7201.00
350_F357_I0.7191.00
193_A197_F0.7181.00
92_T95_E0.7161.00
94_V312_L0.7161.00
126_L205_I0.7151.00
197_F200_D0.7121.00
201_I235_S0.7121.00
284_E287_E0.7121.00
60_L403_F0.7111.00
82_A306_L0.7081.00
326_F330_G0.7071.00
328_K331_D0.7061.00
134_G200_D0.7051.00
184_Y218_P0.7041.00
190_V204_V0.7041.00
381_A385_K0.7011.00
189_S193_A0.7001.00
209_V248_V0.6981.00
352_R357_I0.6971.00
267_G277_G0.6971.00
107_P255_G0.6951.00
91_P96_N0.6911.00
145_Y148_H0.6911.00
329_K355_S0.6901.00
101_L315_L0.6901.00
70_T82_A0.6891.00
218_P221_G0.6871.00
96_N100_K0.6801.00
53_N389_N0.6801.00
128_L289_I0.6791.00
122_T152_L0.6781.00
211_G356_M0.6771.00
47_I393_F0.6771.00
416_T419_A0.6761.00
94_V98_L0.6761.00
206_V237_L0.6741.00
94_V308_M0.6741.00
224_Q257_F0.6731.00
290_A296_Y0.6721.00
361_F424_F0.6721.00
59_V395_P0.6711.00
124_S297_Q0.6681.00
383_Y423_V0.6671.00
237_L259_V0.6671.00
151_S168_S0.6671.00
84_Y93_E0.6641.00
411_E415_N0.6641.00
383_Y387_M0.6621.00
106_V264_T0.6621.00
56_I392_V0.6611.00
330_G352_R0.6611.00
81_V84_Y0.6611.00
350_F359_F0.6581.00
329_K408_H0.6531.00
109_V264_T0.6531.00
282_K285_I0.6511.00
281_G286_M0.6511.00
132_Y284_E0.6501.00
220_E353_A0.6481.00
332_R413_I0.6471.00
105_R252_C0.6461.00
333_L417_I0.6451.00
210_A213_M0.6451.00
319_T322_S0.6441.00
344_H424_F0.6441.00
125_A263_L0.6421.00
242_V265_C0.6421.00
186_D189_S0.6391.00
325_N409_T0.6361.00
238_I263_L0.6341.00
402_L416_T0.6341.00
285_I288_Q0.6331.00
220_E257_F0.6311.00
362_T365_P0.6291.00
382_S385_K0.6291.00
384_Y396_P0.6281.00
387_M420_A0.6281.00
94_V97_E0.6281.00
359_F420_A0.6281.00
128_L263_L0.6281.00
341_A350_F0.6271.00
254_Q261_P0.6251.00
182_V189_S0.6231.00
135_R235_S0.6221.00
223_L239_F0.6181.00
210_A216_V0.6161.00
392_V415_N0.6151.00
417_I421_E0.6151.00
346_I362_T0.6141.00
136_N170_G0.6131.00
98_L276_V0.6111.00
85_G88_F0.6111.00
139_L193_A0.6091.00
423_V426_E0.6091.00
106_V252_C0.6081.00
190_V225_G0.6061.00
38_F91_P0.6061.00
333_L357_I0.6061.00
108_S254_Q0.6061.00
325_N413_I0.6061.00
118_G242_V0.6051.00
192_L195_Q0.6041.00
331_D334_E0.6031.00
187_L190_V0.6031.00
141_F226_L0.6021.00
66_I406_T0.6011.00
45_S408_H0.6011.00
42_G47_I0.6011.00
60_L405_S0.5991.00
82_A310_A0.5981.00
103_I110_E0.5971.00
54_E419_A0.5961.00
81_V94_V0.5951.00
74_V314_T0.5941.00
77_S80_K0.5921.00
194_F233_Y0.5861.00
333_L413_I0.5851.00
209_V356_M0.5851.00
419_A423_V0.5851.00
329_K409_T0.5841.00
246_F252_C0.5821.00
168_S171_V0.5791.00
133_T202_A0.5791.00
115_V120_E0.5781.00
267_G301_L0.5781.00
130_R150_D0.5761.00
179_T186_D0.5751.00
172_P193_A0.5751.00
347_P424_F0.5731.00
310_A313_E0.5731.00
231_E284_E0.5721.00
420_A424_F0.5711.00
326_F406_T0.5701.00
106_V266_L0.5701.00
74_V313_E0.5691.00
59_V393_F0.5691.00
408_H412_D0.5691.00
67_L323_Y0.5681.00
419_A422_K0.5671.00
66_I318_L0.5671.00
195_Q232_Q0.5661.00
347_P359_F0.5661.00
130_R166_P0.5651.00
187_L191_K0.5631.00
139_L190_V0.5631.00
385_K388_A0.5601.00
190_V229_I0.5601.00
107_P110_E0.5601.00
208_P244_T0.5591.00
229_I232_Q0.5591.00
126_L151_S0.5581.00
384_Y388_A0.5561.00
141_F206_V0.5561.00
105_R250_Y0.5561.00
140_K181_T0.5561.00
98_L114_M0.5551.00
326_F355_S0.5551.00
40_E43_K0.5551.00
208_P254_Q0.5541.00
359_F402_L0.5531.00
37_I40_E0.5531.00
77_S316_K0.5501.00
251_N318_L0.5491.00
336_G340_T0.5471.00
135_R200_D0.5471.00
332_R417_I0.5461.00
392_V423_V0.5451.00
182_V185_N0.5441.00
312_L319_T0.5431.00
86_T274_L0.5431.00
341_A349_T0.5421.00
363_N366_V0.5421.00
407_A412_D0.5421.00
251_N315_L0.5411.00
263_L285_I0.5401.00
416_T420_A0.5391.00
351_N358_G0.5371.00
188_E225_G0.5371.00
39_M90_A0.5361.00
75_V272_G0.5361.00
341_A424_F0.5351.00
41_R54_E0.5340.99
103_I280_G0.5320.99
43_K46_K0.5300.99
72_D83_E0.5300.99
84_Y94_V0.5280.99
212_N401_G0.5280.99
395_P398_Q0.5260.99
217_P257_F0.5240.99
315_L319_T0.5240.99
78_L274_L0.5240.99
56_I408_H0.5230.99
243_M401_G0.5220.99
103_I106_V0.5220.99
148_H298_A0.5210.99
67_L71_N0.5210.99
264_T280_G0.5200.99
321_E325_N0.5190.99
35_D388_A0.5190.99
141_F182_V0.5180.99
106_V112_V0.5170.99
42_G65_L0.5170.99
333_L336_G0.5170.99
243_M356_M0.5160.99
241_E253_A0.5160.99
159_G163_L0.5150.99
414_E417_I0.5140.99
90_A393_F0.5110.99
360_F400_E0.5110.99
413_I416_T0.5090.99
49_D391_G0.5090.99
97_E100_K0.5080.99
304_N307_A0.5080.99
190_V222_F0.5080.99
326_F329_K0.5070.99
405_S408_H0.5050.99
80_K313_E0.5040.99
177_K180_I0.5040.99
287_E291_P0.5030.99
162_T165_L0.5030.99
141_F204_V0.5030.99
74_V317_Q0.5020.99
269_V272_G0.5020.99
181_T186_D0.5020.99
133_T234_G0.5010.99
346_I424_F0.5010.99
391_G419_A0.5010.99
327_I330_G0.5010.99
226_L235_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2epjA 2 0.9698 100 0.368 Contact Map
4e77A 2 0.9395 100 0.391 Contact Map
4ao9A 2 0.9535 100 0.401 Contact Map
2ykyA 4 0.9535 100 0.404 Contact Map
4a0gA 2 0.9628 100 0.405 Contact Map
4atqA 7 0.9535 100 0.409 Contact Map
3k28A 2 0.986 100 0.411 Contact Map
4e3qA 3 0.9721 100 0.419 Contact Map
2cy8A 2 0.8814 100 0.421 Contact Map
4ffcA 4 0.9512 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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