GREMLIN Database
GLPP - Glycerol uptake operon antiterminator regulatory protein
UniProt: P30300 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (178)
Sequences: 642 (519)
Seq/√Len: 38.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A54_M4.0661.00
141_E157_R3.9951.00
159_E163_E3.1901.00
18_Q178_T3.0141.00
22_F30_G3.0061.00
64_I70_G2.8781.00
11_P27_F2.7771.00
95_K126_D2.6911.00
48_Q81_A2.6821.00
30_G47_A2.6641.00
45_K49_K2.5541.00
20_D46_E2.5331.00
44_I78_I2.5221.00
91_I101_A2.4471.00
85_S91_I2.4231.00
137_S161_D2.2681.00
41_K77_D2.2090.99
74_I80_P1.9900.99
21_E178_T1.9720.99
105_L116_S1.9400.98
93_K96_Q1.9170.98
86_T153_G1.8920.98
15_N18_Q1.8920.98
57_H153_G1.8610.98
142_I150_I1.8070.98
119_F131_L1.8050.98
44_I54_M1.7880.97
19_F47_A1.7630.97
72_E93_K1.7550.97
73_F77_D1.7260.97
13_I47_A1.7150.97
28_S53_N1.6760.96
143_K150_I1.6410.96
16_M34_D1.6240.95
75_C99_I1.6200.95
40_L78_I1.6060.95
40_L73_F1.5860.95
60_L176_S1.5850.95
175_T180_L1.5470.94
104_R129_E1.4920.93
151_F174_T1.4400.91
85_S90_V1.4080.91
61_I95_K1.3840.90
130_V142_I1.3760.89
117_M142_I1.3720.89
71_A97_K1.3640.89
86_T106_F1.3530.89
162_V180_L1.3530.89
40_L48_Q1.3430.88
102_I127_F1.3250.88
61_I64_I1.3200.87
32_I47_A1.2960.86
29_Y53_N1.2960.86
165_A170_A1.2670.85
103_Q156_I1.2610.85
57_H86_T1.2570.85
76_Q128_I1.2490.84
14_R60_L1.2370.84
44_I81_A1.2330.84
32_I54_M1.2240.83
12_A33_L1.2160.83
135_V138_L1.2140.83
160_E164_Q1.2140.83
104_R153_G1.2110.82
114_E145_K1.2100.82
88_S167_K1.2000.82
118_E171_V1.1900.81
68_E131_L1.1520.79
108_L164_Q1.1360.78
140_Q144_E1.1330.78
36_H72_E1.1290.78
33_L104_R1.1240.77
43_V55_M1.0910.75
55_M82_G1.0690.74
94_A101_A1.0690.74
108_L131_L1.0650.73
128_I146_T1.0540.73
85_S101_A1.0520.72
143_K171_V1.0500.72
128_I148_I1.0500.72
107_L137_S1.0260.71
72_E97_K1.0240.70
34_D110_T1.0170.70
120_I125_P1.0080.69
58_V71_A1.0060.69
141_E145_K1.0050.69
51_G144_E0.9990.69
103_Q149_P0.9780.67
11_P131_L0.9770.67
121_G173_V0.9760.67
57_H125_P0.9600.65
19_F23_L0.9570.65
29_Y84_I0.9520.65
83_I159_E0.9490.64
121_G145_K0.9410.64
65_K115_K0.9390.64
13_I30_G0.9280.63
24_N179_K0.9220.62
33_L84_I0.9060.61
32_I176_S0.9020.60
16_M176_S0.8880.59
32_I43_V0.8840.59
82_G104_R0.8800.59
24_N50_H0.8790.58
139_I152_A0.8740.58
71_A99_I0.8730.58
84_I131_L0.8690.58
13_I43_V0.8660.57
46_E50_H0.8630.57
58_V74_I0.8590.57
91_I123_H0.8510.56
81_A105_L0.8480.56
8_P159_E0.8470.56
44_I105_L0.8410.55
8_P43_V0.8400.55
33_L59_D0.8300.54
17_K179_K0.8260.54
162_V165_A0.8260.54
32_I107_L0.8200.53
115_K118_E0.8190.53
139_I165_A0.8120.53
43_V176_S0.8100.52
36_H69_Y0.8090.52
29_Y56_V0.8070.52
114_E117_M0.8040.52
15_N22_F0.7940.51
65_K90_V0.7930.51
149_P166_L0.7880.50
144_E178_T0.7850.50
127_F130_V0.7850.50
93_K115_K0.7840.50
141_E144_E0.7810.50
88_S103_Q0.7810.50
71_A83_I0.7780.49
12_A174_T0.7780.49
32_I66_H0.7720.49
55_M180_L0.7700.49
137_S162_V0.7650.48
112_A153_G0.7630.48
124_K148_I0.7620.48
87_R99_I0.7600.48
19_F111_S0.7550.47
7_Q75_C0.7550.47
139_I170_A0.7530.47
117_M120_I0.7520.47
34_D176_S0.7510.47
35_I108_L0.7490.47
55_M177_N0.7450.46
40_L55_M0.7420.46
116_S127_F0.7410.46
83_I164_Q0.7390.46
14_R67_D0.7330.45
64_I72_E0.7290.45
11_P53_N0.7260.45
65_K148_I0.7240.45
54_M81_A0.7230.44
75_C80_P0.7150.44
158_T163_E0.7120.44
33_L86_T0.7100.43
57_H104_R0.7060.43
41_K45_K0.7060.43
167_K171_V0.7020.43
157_R173_V0.6970.42
35_I116_S0.6960.42
7_Q112_A0.6910.42
71_A75_C0.6880.41
82_G129_E0.6810.41
85_S126_D0.6720.40
86_T103_Q0.6720.40
25_S168_A0.6700.40
21_E79_K0.6640.39
85_S142_I0.6630.39
113_M142_I0.6620.39
123_H156_I0.6610.39
6_N28_S0.6610.39
8_P56_V0.6560.39
30_G66_H0.6530.38
55_M151_F0.6500.38
104_R131_L0.6490.38
73_F87_R0.6490.38
60_L131_L0.6480.38
37_L151_F0.6450.38
33_L131_L0.6440.38
163_E167_K0.6410.37
133_G156_I0.6400.37
133_G170_A0.6390.37
129_E153_G0.6380.37
61_I107_L0.6330.37
31_V35_I0.6260.36
37_L90_V0.6220.36
85_S164_Q0.6200.36
159_E162_V0.6190.35
91_I125_P0.6180.35
55_M100_Y0.6170.35
27_F36_H0.6160.35
14_R161_D0.6120.35
12_A108_L0.6120.35
87_R170_A0.6110.35
138_L161_D0.6080.35
59_D133_G0.6070.34
99_I160_E0.6060.34
92_A155_F0.6050.34
19_F46_E0.6030.34
44_I48_Q0.6020.34
172_A180_L0.6020.34
12_A168_A0.5980.34
33_L60_L0.5960.34
133_G139_I0.5950.34
35_I155_F0.5940.33
134_I155_F0.5920.33
152_A161_D0.5890.33
143_K160_E0.5870.33
13_I16_M0.5810.32
14_R111_S0.5810.32
58_V100_Y0.5800.32
89_N103_Q0.5770.32
14_R110_T0.5750.32
75_C97_K0.5740.32
33_L110_T0.5720.32
56_V156_I0.5710.32
26_S123_H0.5700.32
164_Q167_K0.5700.32
130_V166_L0.5670.31
49_K139_I0.5660.31
75_C85_S0.5640.31
16_M43_V0.5640.31
9_I162_V0.5620.31
9_I59_D0.5610.31
67_D78_I0.5610.31
56_V74_I0.5610.31
115_K119_F0.5590.31
30_G118_E0.5570.31
8_P15_N0.5550.30
131_L153_G0.5530.30
32_I98_K0.5530.30
5_H26_S0.5520.30
24_N51_G0.5510.30
16_M167_K0.5500.30
17_K20_D0.5490.30
68_E85_S0.5490.30
14_R74_I0.5450.30
7_Q27_F0.5440.30
46_E98_K0.5430.29
110_T165_A0.5370.29
30_G60_L0.5330.29
49_K160_E0.5310.29
48_Q167_K0.5310.29
113_M146_T0.5300.29
72_E76_Q0.5290.28
61_I102_I0.5280.28
103_Q141_E0.5270.28
37_L70_G0.5260.28
32_I53_N0.5260.28
70_G127_F0.5250.28
10_L69_Y0.5230.28
51_G167_K0.5210.28
56_V143_K0.5170.28
36_H112_A0.5160.27
59_D162_V0.5120.27
85_S105_L0.5100.27
44_I69_Y0.5080.27
33_L175_T0.5060.27
113_M157_R0.5050.27
60_L152_A0.5050.27
23_L52_K0.5040.27
80_P174_T0.5020.26
131_L136_P0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vkfA 1 0.8906 100 0.218 Contact Map
3ktsA 1 0.9583 100 0.391 Contact Map
1wa3A 3 0.9271 98.7 0.846 Contact Map
4adtA 5 0.9375 98.5 0.857 Contact Map
4jejA 2 0.9479 98.5 0.857 Contact Map
3vcrA 3 0.9271 98.4 0.86 Contact Map
1vhcA 3 0.9271 98.4 0.861 Contact Map
4utuA 2 0.9219 98.4 0.862 Contact Map
3vndA 3 0.9427 98.4 0.863 Contact Map
1mxsA 3 0.9167 98.3 0.864 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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