GUAA - BACSU - GREMLIN Contacts

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GUAA - GMP synthase [glutamine-hydrolyzing]

UniProt:	P29727	Sequences: MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAASQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMSKADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	513 (508)
Sequences:	2681 (1072)
Seq/√Len:	47.6

ECOLI - GUAA
BACSU - GUAA
HALSA - GUAAB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_M	166_W	4.817	1.00
258_K	414_E	4.737	1.00
52_G	193_C	4.583	1.00
284_R	312_D	4.463	1.00
161_K	164_K	4.255	1.00
409_L	413_R	3.663	1.00
313_E	316_K	3.521	1.00
377_T	383_D	3.393	1.00
212_I	216_V	3.255	1.00
219_K	321_D	3.172	1.00
377_T	387_W	3.144	1.00
125_P	180_Y	2.851	1.00
282_K	406_E	2.800	1.00
210_Q	214_E	2.770	1.00
433_W	468_G	2.757	1.00
234_V	324_A	2.740	1.00
304_N	308_Y	2.723	1.00
433_W	465_S	2.689	1.00
283_D	287_N	2.675	1.00
464_T	474_A	2.654	1.00
458_I	495_I	2.650	1.00
465_S	468_G	2.639	1.00
222_L	320_I	2.629	1.00
9_I	52_G	2.613	1.00
238_I	324_A	2.596	1.00
250_F	256_L	2.595	1.00
419_L	460_I	2.578	1.00
503_T	508_A	2.578	1.00
98_K	140_E	2.568	1.00
387_W	430_R	2.567	1.00
261_A	278_K	2.517	1.00
122_R	191_G	2.490	1.00
26_I	54_I	2.453	1.00
476_I	480_V	2.432	1.00
389_Q	435_Y	2.412	1.00
236_V	381_I	2.387	1.00
161_K	165_K	2.365	1.00
317_L	320_I	2.333	1.00
187_N	191_G	2.326	1.00
208_E	211_K	2.250	1.00
487_R	491_E	2.250	1.00
292_V	301_I	2.158	1.00
7_E	197_G	2.152	1.00
453_T	496_N	2.143	1.00
7_E	51_K	2.132	1.00
288_K	305_E	2.121	1.00
410_E	413_R	2.116	1.00
115_E	150_T	2.113	1.00
332_I	365_N	2.110	1.00
250_F	261_A	2.107	1.00
406_E	410_E	2.096	1.00
124_L	128_Q	2.078	1.00
480_V	484_I	2.074	1.00
148_D	160_S	2.063	1.00
265_M	276_V	2.052	1.00
259_G	262_E	2.040	1.00
190_F	197_G	2.033	1.00
219_K	322_Y	2.007	0.99
205_I	375_L	1.985	0.99
428_L	480_V	1.971	0.99
100_E	139_V	1.937	0.99
262_E	278_K	1.915	0.99
73_K	76_E	1.894	0.99
118_P	148_D	1.869	0.99
256_L	261_A	1.868	0.99
265_M	278_K	1.839	0.99
111_N	127_E	1.833	0.99
234_V	238_I	1.833	0.99
482_E	486_T	1.829	0.99
421_E	425_N	1.826	0.99
26_I	189_V	1.823	0.99
223_C	324_A	1.821	0.99
9_I	189_V	1.805	0.99
36_H	40_L	1.793	0.99
473_W	478_W	1.774	0.99
55_L	81_V	1.772	0.99
432_I	474_A	1.771	0.99
266_K	270_E	1.770	0.99
183_D	186_K	1.747	0.98
9_I	193_C	1.746	0.98
419_L	484_I	1.746	0.98
252_D	278_K	1.730	0.98
51_K	195_C	1.728	0.98
288_K	304_N	1.727	0.98
52_G	195_C	1.726	0.98
222_L	249_I	1.717	0.98
44_E	47_K	1.710	0.98
201_M	375_L	1.703	0.98
489_V	503_T	1.700	0.98
118_P	160_S	1.700	0.98
180_Y	183_D	1.691	0.98
383_D	430_R	1.689	0.98
432_I	476_I	1.686	0.98
10_L	36_H	1.681	0.98
259_G	263_G	1.662	0.98
438_V	512_W	1.651	0.98
284_R	305_E	1.649	0.98
258_K	417_A	1.647	0.98
128_Q	180_Y	1.646	0.98
129_V	179_E	1.639	0.98
146_T	162_A	1.638	0.98
377_T	430_R	1.625	0.98
457_T	499_V	1.621	0.98
215_T	359_E	1.618	0.97
286_L	409_L	1.611	0.97
75_F	91_M	1.605	0.97
308_Y	311_D	1.599	0.97
218_D	245_Q	1.590	0.97
417_A	421_E	1.586	0.97
448_M	453_T	1.584	0.97
92_T	142_P	1.577	0.97
121_F	158_A	1.539	0.97
10_L	45_I	1.538	0.97
112_I	149_A	1.518	0.96
88_M	138_V	1.508	0.96
374_A	377_T	1.504	0.96
221_V	324_A	1.495	0.96
46_K	77_L	1.492	0.96
70_C	90_L	1.482	0.96
159_M	168_G	1.478	0.96
420_R	429_E	1.476	0.96
428_L	431_D	1.467	0.95
472_D	504_S	1.464	0.95
205_I	209_M	1.441	0.95
92_T	159_M	1.428	0.95
337_T	340_A	1.419	0.95
284_R	288_K	1.413	0.94
422_E	425_N	1.404	0.94
215_T	361_I	1.399	0.94
426_H	483_V	1.396	0.94
355_D	358_F	1.394	0.94
400_V	409_L	1.392	0.94
475_R	482_E	1.392	0.94
462_A	474_A	1.372	0.94
290_K	403_E	1.368	0.93
8_M	48_M	1.362	0.93
113_R	150_T	1.360	0.93
238_I	361_I	1.355	0.93
448_M	489_V	1.352	0.93
321_D	359_E	1.345	0.93
70_C	75_F	1.331	0.92
220_Q	319_G	1.330	0.92
297_Q	301_I	1.328	0.92
12_L	36_H	1.326	0.92
429_E	435_Y	1.323	0.92
408_K	456_Y	1.323	0.92
144_G	161_K	1.322	0.92
405_T	408_K	1.320	0.92
463_V	510_I	1.320	0.92
223_C	238_I	1.318	0.92
336_G	340_A	1.312	0.92
262_E	266_K	1.309	0.92
211_K	215_T	1.305	0.92
384_E	424_A	1.301	0.92
39_T	338_A	1.300	0.92
440_P	459_G	1.297	0.91
420_R	435_Y	1.294	0.91
261_A	280_D	1.293	0.91
448_M	496_N	1.291	0.91
247_T	277_I	1.288	0.91
220_Q	245_Q	1.287	0.91
459_G	499_V	1.279	0.91
113_R	127_E	1.279	0.91
311_D	356_M	1.278	0.91
105_R	135_G	1.276	0.91
41_T	44_E	1.262	0.90
422_E	487_R	1.258	0.90
283_D	406_E	1.253	0.90
69_R	94_Y	1.253	0.90
415_S	437_T	1.244	0.90
202_E	378_E	1.239	0.89
406_E	409_L	1.233	0.89
223_C	235_A	1.232	0.89
261_A	265_M	1.229	0.89
141_V	156_N	1.222	0.89
460_I	484_I	1.219	0.89
426_H	480_V	1.216	0.89
40_L	44_E	1.207	0.88
232_S	381_I	1.199	0.88
42_A	71_D	1.199	0.88
443_R	455_D	1.198	0.88
419_L	437_T	1.192	0.88
244_D	273_N	1.190	0.87
455_D	494_H	1.183	0.87
305_E	308_Y	1.182	0.87
225_L	248_C	1.182	0.87
186_K	191_G	1.180	0.87
389_Q	420_R	1.179	0.87
19_N	35_L	1.172	0.87
249_I	279_V	1.168	0.86
7_E	196_E	1.157	0.86
116_G	146_T	1.156	0.86
431_D	464_T	1.155	0.86
14_F	55_L	1.153	0.86
411_I	494_H	1.152	0.86
40_L	45_I	1.145	0.85
411_I	495_I	1.140	0.85
6_N	198_E	1.137	0.85
125_P	128_Q	1.137	0.85
140_E	143_E	1.136	0.85
30_G	200_S	1.125	0.84
69_R	93_H	1.124	0.84
423_I	435_Y	1.121	0.84
268_F	276_V	1.117	0.84
98_K	139_V	1.110	0.83
305_E	309_V	1.109	0.83
208_E	212_I	1.101	0.83
473_W	485_S	1.100	0.83
499_V	512_W	1.096	0.83
411_I	456_Y	1.092	0.82
9_I	195_C	1.091	0.82
311_D	357_Q	1.089	0.82
277_I	316_K	1.086	0.82
124_L	180_Y	1.085	0.82
210_Q	213_R	1.085	0.82
216_V	245_Q	1.084	0.82
293_S	403_E	1.084	0.82
297_Q	304_N	1.080	0.82
291_G	403_E	1.079	0.82
156_N	159_M	1.077	0.82
252_D	282_K	1.076	0.82
423_I	426_H	1.074	0.81
389_Q	423_I	1.073	0.81
282_K	410_E	1.073	0.81
131_W	177_H	1.072	0.81
424_A	429_E	1.070	0.81
425_N	483_V	1.070	0.81
119_D	160_S	1.064	0.81
146_T	160_S	1.062	0.81
481_L	502_I	1.060	0.81
292_V	297_Q	1.059	0.80
475_R	479_D	1.055	0.80
265_M	269_S	1.054	0.80
212_I	238_I	1.047	0.80
125_P	179_E	1.040	0.79
437_T	458_I	1.039	0.79
151_S	154_C	1.037	0.79
255_L	397_G	1.036	0.79
422_E	491_E	1.032	0.79
35_L	333_I	1.028	0.78
216_V	361_I	1.026	0.78
223_C	248_C	1.022	0.78
437_T	495_I	1.021	0.78
212_I	361_I	1.015	0.78
112_I	151_S	1.013	0.77
419_L	462_A	1.013	0.77
432_I	462_A	1.009	0.77
149_A	158_A	1.005	0.77
422_E	483_V	1.005	0.77
236_V	272_F	0.998	0.76
377_T	386_V	0.996	0.76
6_N	207_I	0.993	0.76
201_M	204_F	0.992	0.76
389_Q	429_E	0.989	0.76
263_G	384_E	0.986	0.75
42_A	73_K	0.983	0.75
256_L	264_V	0.981	0.75
336_G	339_T	0.980	0.75
41_T	45_I	0.975	0.75
412_V	438_V	0.969	0.74
253_H	286_L	0.967	0.74
72_E	76_E	0.966	0.74
294_D	297_Q	0.963	0.74
23_T	35_L	0.961	0.74
43_E	47_K	0.957	0.73
206_E	210_Q	0.956	0.73
78_D	81_V	0.955	0.73
221_V	242_I	0.954	0.73
315_D	357_Q	0.952	0.73
115_E	146_T	0.952	0.73
204_F	375_L	0.946	0.72
288_K	301_I	0.945	0.72
220_Q	247_T	0.943	0.72
102_A	137_L	0.941	0.72
414_E	417_A	0.941	0.72
109_K	131_W	0.940	0.72
88_M	159_M	0.936	0.72
29_F	185_L	0.932	0.71
52_G	189_V	0.930	0.71
142_P	159_M	0.930	0.71
318_K	321_D	0.928	0.71
400_V	413_R	0.927	0.71
137_L	154_C	0.927	0.71
70_C	94_Y	0.927	0.71
141_V	147_V	0.924	0.71
169_V	173_P	0.922	0.70
341_Q	451_A	0.921	0.70
109_K	129_V	0.919	0.70
286_L	413_R	0.918	0.70
282_K	286_L	0.917	0.70
224_A	307_I	0.915	0.70
410_E	414_E	0.913	0.70
250_F	264_V	0.913	0.70
349_V	352_L	0.911	0.70
485_S	503_T	0.910	0.69
30_G	374_A	0.910	0.69
186_K	197_G	0.907	0.69
147_V	156_N	0.901	0.69
444_S	457_T	0.895	0.68
169_V	184_L	0.894	0.68
233_V	376_G	0.892	0.68
356_M	360_L	0.890	0.68
281_A	309_V	0.885	0.67
119_D	148_D	0.885	0.67
165_K	194_E	0.884	0.67
354_E	357_Q	0.883	0.67
7_E	195_C	0.882	0.67
175_V	470_T	0.881	0.67
406_E	413_R	0.878	0.67
302_I	397_G	0.876	0.66
10_L	48_M	0.873	0.66
171_F	184_L	0.873	0.66
111_N	152_H	0.873	0.66
322_Y	359_E	0.872	0.66
284_R	309_V	0.871	0.66
124_L	183_D	0.868	0.66
251_V	309_V	0.868	0.66
423_I	432_I	0.866	0.66
128_Q	179_E	0.864	0.65
279_V	313_E	0.864	0.65
236_V	274_M	0.862	0.65
39_T	339_T	0.861	0.65
455_D	489_V	0.858	0.65
267_T	385_I	0.854	0.64
229_V	376_G	0.854	0.64
43_E	46_K	0.853	0.64
28_E	470_T	0.851	0.64
383_D	387_W	0.850	0.64
420_R	424_A	0.848	0.64
268_F	273_N	0.848	0.64
268_F	274_M	0.846	0.64
408_K	439_L	0.844	0.64
251_V	279_V	0.844	0.64
178_S	184_L	0.843	0.63
61_S	136_D	0.842	0.63
91_M	95_L	0.841	0.63
269_S	276_V	0.841	0.63
252_D	265_M	0.839	0.63
286_L	406_E	0.838	0.63
311_D	355_D	0.838	0.63
324_A	361_I	0.834	0.63
421_E	487_R	0.834	0.63
90_L	94_Y	0.832	0.62
12_L	41_T	0.832	0.62
253_H	305_E	0.832	0.62
93_H	98_K	0.828	0.62
204_F	208_E	0.827	0.62
150_T	154_C	0.824	0.62
312_D	316_K	0.824	0.62
137_L	155_P	0.823	0.62
207_I	211_K	0.823	0.62
74_I	81_V	0.823	0.62
162_A	165_K	0.821	0.61
75_F	94_Y	0.821	0.61
111_N	129_V	0.820	0.61
287_N	290_K	0.818	0.61
144_G	165_K	0.817	0.61
457_T	512_W	0.816	0.61
200_S	203_N	0.816	0.61
11_V	19_N	0.815	0.61
88_M	168_G	0.813	0.61
209_M	241_A	0.810	0.60
374_A	378_E	0.810	0.60
428_L	432_I	0.809	0.60
263_G	417_A	0.804	0.60
24_R	28_E	0.800	0.59
311_D	315_D	0.798	0.59
30_G	197_G	0.798	0.59
186_K	190_F	0.798	0.59
248_C	268_F	0.797	0.59
249_I	320_I	0.797	0.59
189_V	195_C	0.786	0.58
60_N	341_Q	0.785	0.58
46_K	73_K	0.784	0.58
42_A	46_K	0.784	0.58
232_S	268_F	0.782	0.58
117_T	126_N	0.780	0.57
483_V	486_T	0.780	0.57
213_R	245_Q	0.779	0.57
427_G	432_I	0.776	0.57
81_V	166_W	0.776	0.57
31_V	190_F	0.774	0.57
203_N	378_E	0.774	0.57
50_P	79_I	0.772	0.57
161_K	166_W	0.771	0.57
440_P	457_T	0.769	0.56
412_V	512_W	0.765	0.56
330_T	365_N	0.764	0.56
441_D	455_D	0.763	0.56
455_D	493_K	0.762	0.56
354_E	359_E	0.759	0.55
350_G	353_P	0.754	0.55
234_V	364_L	0.754	0.55
422_E	426_H	0.753	0.55
59_P	68_F	0.752	0.55
225_L	268_F	0.749	0.54
220_Q	320_I	0.749	0.54
29_F	189_V	0.748	0.54
135_G	451_A	0.748	0.54
113_R	126_N	0.747	0.54
225_L	276_V	0.747	0.54
262_E	282_K	0.744	0.54
63_Y	451_A	0.743	0.54
255_L	286_L	0.741	0.54
464_T	472_D	0.739	0.53
223_C	328_L	0.737	0.53
457_T	508_A	0.735	0.53
482_E	485_S	0.734	0.53
69_R	90_L	0.734	0.53
8_M	50_P	0.733	0.53
119_D	191_G	0.733	0.53
443_R	456_Y	0.732	0.53
20_Q	368_F	0.732	0.53
29_F	182_N	0.731	0.53
28_E	182_N	0.729	0.52
412_V	415_S	0.727	0.52
130_V	178_S	0.726	0.52
314_A	320_I	0.725	0.52
222_L	321_D	0.722	0.52
95_L	166_W	0.721	0.52
160_S	165_K	0.719	0.51
208_E	375_L	0.719	0.51
16_S	56_S	0.718	0.51
441_D	457_T	0.716	0.51
73_K	77_L	0.716	0.51
92_T	168_G	0.715	0.51
176_R	468_G	0.715	0.51
480_V	483_V	0.714	0.51
432_I	464_T	0.714	0.51
63_Y	67_S	0.713	0.51
31_V	195_C	0.712	0.51
29_F	186_K	0.712	0.51
502_I	512_W	0.708	0.50
21_L	132_M	0.708	0.50
45_I	50_P	0.707	0.50
501_D	513_E	0.707	0.50
144_G	162_A	0.707	0.50
81_V	94_Y	0.707	0.50
448_M	455_D	0.705	0.50
389_Q	474_A	0.705	0.50
119_D	165_K	0.702	0.50
183_D	187_N	0.701	0.50
350_G	365_N	0.697	0.49
109_K	472_D	0.697	0.49
120_L	184_L	0.696	0.49
82_L	120_L	0.695	0.49
104_Q	153_H	0.693	0.49
212_I	360_L	0.693	0.49
176_R	466_I	0.691	0.49
11_V	23_T	0.690	0.49
113_R	152_H	0.690	0.49
176_R	465_S	0.687	0.48
131_W	472_D	0.686	0.48
437_T	459_G	0.684	0.48
438_V	499_V	0.683	0.48
82_L	167_Y	0.682	0.48
36_H	45_I	0.682	0.48
63_Y	136_D	0.680	0.48
121_F	171_F	0.679	0.47
401_L	444_S	0.678	0.47
220_Q	275_N	0.677	0.47
259_G	417_A	0.675	0.47
307_I	350_G	0.675	0.47
416_D	501_D	0.675	0.47
290_K	406_E	0.674	0.47
31_V	189_V	0.673	0.47
101_A	451_A	0.673	0.47
333_I	339_T	0.673	0.47
12_L	40_L	0.673	0.47
203_N	206_E	0.672	0.47
121_F	178_S	0.672	0.47
448_M	492_V	0.671	0.47
121_F	187_N	0.671	0.47
419_L	423_I	0.668	0.46
110_A	131_W	0.667	0.46
84_I	169_V	0.666	0.46
128_Q	178_S	0.666	0.46
415_S	419_L	0.666	0.46
211_K	214_E	0.662	0.46
473_W	502_I	0.661	0.46
462_A	476_I	0.660	0.46
222_L	358_F	0.660	0.46
112_I	128_Q	0.660	0.46
222_L	234_V	0.657	0.45
415_S	458_I	0.656	0.45
485_S	502_I	0.655	0.45
465_S	472_D	0.655	0.45
253_H	503_T	0.654	0.45
474_A	477_P	0.653	0.45
34_E	48_M	0.652	0.45
205_I	240_K	0.652	0.45
119_D	192_V	0.650	0.45
242_I	246_L	0.650	0.45
10_L	40_L	0.649	0.44
123_D	191_G	0.648	0.44
107_Y	135_G	0.646	0.44
116_G	119_D	0.645	0.44
46_K	49_N	0.645	0.44
419_L	435_Y	0.645	0.44
19_N	56_S	0.645	0.44
110_A	132_M	0.645	0.44
112_I	130_V	0.644	0.44
11_V	35_L	0.643	0.44
123_D	183_D	0.640	0.44
29_F	190_F	0.640	0.44
339_T	342_T	0.640	0.44
76_E	164_K	0.639	0.43
304_N	354_E	0.639	0.43
252_D	261_A	0.639	0.43
293_S	404_V	0.638	0.43
351_G	365_N	0.638	0.43
460_I	480_V	0.637	0.43
16_S	19_N	0.636	0.43
221_V	238_I	0.636	0.43
322_Y	358_F	0.633	0.43
345_S	361_I	0.633	0.43
307_I	311_D	0.632	0.43
221_V	245_Q	0.632	0.43
105_R	451_A	0.631	0.43
123_D	187_N	0.631	0.43
224_A	324_A	0.629	0.42
40_L	48_M	0.628	0.42
424_A	435_Y	0.626	0.42
176_R	433_W	0.626	0.42
307_I	361_I	0.624	0.42
497_R	501_D	0.624	0.42
485_S	489_V	0.622	0.42
81_V	91_M	0.617	0.41
68_F	381_I	0.617	0.41
375_L	486_T	0.617	0.41
55_L	75_F	0.617	0.41
485_S	508_A	0.617	0.41
72_E	94_Y	0.614	0.41
74_I	77_L	0.614	0.41
40_L	47_K	0.613	0.41
82_L	169_V	0.612	0.41
63_Y	69_R	0.612	0.41
239_H	274_M	0.611	0.41
389_Q	412_V	0.611	0.41
119_D	122_R	0.610	0.41
53_I	79_I	0.610	0.41
244_D	275_N	0.609	0.41
62_V	93_H	0.608	0.40
475_R	478_W	0.607	0.40
58_G	68_F	0.607	0.40
63_Y	93_H	0.607	0.40
307_I	320_I	0.607	0.40
489_V	494_H	0.606	0.40
95_L	164_K	0.606	0.40
236_V	386_V	0.606	0.40
419_L	480_V	0.605	0.40
412_V	478_W	0.605	0.40
85_C	89_Q	0.604	0.40
328_L	468_G	0.603	0.40
121_F	148_D	0.602	0.40
85_C	134_H	0.602	0.40
266_K	271_G	0.601	0.40
36_H	44_E	0.601	0.40
440_P	455_D	0.600	0.40
255_L	289_L	0.599	0.40
120_L	192_V	0.599	0.40
223_C	268_F	0.598	0.39
454_Y	497_R	0.597	0.39
297_Q	300_K	0.596	0.39
458_I	498_V	0.596	0.39
107_Y	451_A	0.595	0.39
90_L	107_Y	0.595	0.39
223_C	246_L	0.593	0.39
260_E	388_R	0.593	0.39
439_L	501_D	0.592	0.39
336_G	342_T	0.591	0.39
229_V	232_S	0.590	0.39
155_P	268_F	0.589	0.39
472_D	475_R	0.588	0.39
401_L	442_I	0.588	0.39
219_K	245_Q	0.586	0.38
240_K	244_D	0.585	0.38
438_V	442_I	0.584	0.38
58_G	62_V	0.584	0.38
114_I	127_E	0.584	0.38
259_G	414_E	0.583	0.38
42_A	77_L	0.583	0.38
418_I	421_E	0.583	0.38
235_A	248_C	0.582	0.38
182_N	186_K	0.582	0.38
10_L	50_P	0.582	0.38
11_V	33_S	0.579	0.38
307_I	345_S	0.578	0.38
85_C	450_D	0.577	0.37
315_D	355_D	0.577	0.37
473_W	477_P	0.577	0.37
117_T	192_V	0.576	0.37
160_S	167_Y	0.575	0.37
270_E	384_E	0.575	0.37
99_V	136_D	0.575	0.37
26_I	330_T	0.573	0.37
12_L	45_I	0.572	0.37
36_H	41_T	0.572	0.37
36_H	48_M	0.571	0.37
202_E	486_T	0.570	0.37
9_I	110_A	0.570	0.37
307_I	352_L	0.569	0.37
100_E	137_L	0.568	0.37
247_T	275_N	0.568	0.37
124_L	178_S	0.568	0.37
89_Q	170_Q	0.568	0.37
444_S	508_A	0.564	0.36
248_C	273_N	0.564	0.36
144_G	164_K	0.564	0.36
437_T	500_Y	0.563	0.36
119_D	162_A	0.563	0.36
202_E	207_I	0.562	0.36
225_L	246_L	0.562	0.36
140_E	185_L	0.562	0.36
307_I	349_V	0.562	0.36
102_A	139_V	0.561	0.36
85_C	343_I	0.561	0.36
432_I	480_V	0.561	0.36
249_I	314_A	0.561	0.36
8_M	238_I	0.560	0.36
85_C	108_G	0.559	0.36
224_A	311_D	0.559	0.36
279_V	284_R	0.559	0.36
92_T	141_V	0.559	0.36
389_Q	419_L	0.558	0.36
483_V	487_R	0.557	0.36
163_D	167_Y	0.557	0.36
17_Q	85_C	0.557	0.36
18_Y	451_A	0.557	0.36
309_V	312_D	0.556	0.36
268_F	376_G	0.556	0.36
12_L	70_C	0.556	0.36
91_M	145_F	0.556	0.36
224_A	320_I	0.555	0.35
401_L	455_D	0.554	0.35
18_Y	175_V	0.554	0.35
473_W	482_E	0.554	0.35
423_I	427_G	0.553	0.35
11_V	345_S	0.552	0.35
185_L	189_V	0.552	0.35
435_Y	462_A	0.552	0.35
336_G	366_T	0.552	0.35
398_I	464_T	0.551	0.35
472_D	482_E	0.551	0.35
16_S	336_G	0.550	0.35
118_P	162_A	0.550	0.35
85_C	449_G	0.550	0.35
234_V	274_M	0.549	0.35
121_F	345_S	0.549	0.35
131_W	504_S	0.549	0.35
438_V	458_I	0.549	0.35
16_S	324_A	0.548	0.35
265_M	274_M	0.548	0.35
171_F	178_S	0.547	0.35
482_E	504_S	0.547	0.35
313_E	317_L	0.545	0.35
156_N	385_I	0.545	0.35
65_E	218_D	0.545	0.35
352_L	365_N	0.544	0.34
477_P	480_V	0.543	0.34
304_N	356_M	0.542	0.34
137_L	153_H	0.542	0.34
16_S	441_D	0.542	0.34
56_S	328_L	0.541	0.34
267_T	273_N	0.541	0.34
444_S	497_R	0.540	0.34
440_P	503_T	0.540	0.34
308_Y	355_D	0.540	0.34
114_I	124_L	0.539	0.34
224_A	238_I	0.539	0.34
478_W	485_S	0.539	0.34
499_V	502_I	0.539	0.34
162_A	167_Y	0.539	0.34
400_V	404_V	0.539	0.34
209_M	236_V	0.538	0.34
437_T	460_I	0.538	0.34
120_L	169_V	0.536	0.34
328_L	339_T	0.535	0.34
144_G	160_S	0.535	0.34
463_V	508_A	0.535	0.34
208_E	216_V	0.534	0.34
269_S	272_F	0.534	0.34
436_F	462_A	0.534	0.34
328_L	337_T	0.534	0.34
445_V	452_R	0.533	0.33
161_K	167_Y	0.533	0.33
107_Y	192_V	0.533	0.33
405_T	439_L	0.533	0.33
368_F	439_L	0.533	0.33
415_S	495_I	0.532	0.33
483_V	491_E	0.532	0.33
398_I	439_L	0.532	0.33
102_A	105_R	0.531	0.33
320_I	361_I	0.531	0.33
453_T	492_V	0.531	0.33
426_H	432_I	0.531	0.33
198_E	398_I	0.530	0.33
89_Q	99_V	0.530	0.33
397_G	406_E	0.529	0.33
19_N	468_G	0.529	0.33
211_K	366_T	0.528	0.33
35_L	489_V	0.528	0.33
300_K	351_G	0.528	0.33
41_T	72_E	0.527	0.33
205_I	212_I	0.527	0.33
101_A	493_K	0.525	0.33
269_S	274_M	0.525	0.33
343_I	450_D	0.524	0.33
26_I	29_F	0.524	0.33
62_V	99_V	0.524	0.33
215_T	365_N	0.523	0.33
11_V	63_Y	0.522	0.32
106_E	134_H	0.522	0.32
234_V	361_I	0.522	0.32
51_K	58_G	0.520	0.32
205_I	378_E	0.520	0.32
26_I	31_V	0.519	0.32
277_I	317_L	0.518	0.32
410_E	495_I	0.517	0.32
104_Q	137_L	0.517	0.32
454_Y	496_N	0.517	0.32
328_L	433_W	0.517	0.32
105_R	448_M	0.517	0.32
205_I	379_L	0.516	0.32
349_V	353_P	0.516	0.32
185_L	443_R	0.515	0.32
290_K	404_V	0.515	0.32
74_I	166_W	0.515	0.32
8_M	49_N	0.515	0.32
485_S	499_V	0.515	0.32
328_L	472_D	0.515	0.32
16_S	440_P	0.514	0.32
44_E	48_M	0.514	0.32
457_T	495_I	0.514	0.32
398_I	490_N	0.514	0.32
435_Y	500_Y	0.513	0.32
401_L	441_D	0.513	0.32
284_R	308_Y	0.513	0.32
253_H	339_T	0.511	0.32
434_Q	461_R	0.511	0.32
328_L	465_S	0.510	0.31
307_I	360_L	0.510	0.31
140_E	165_K	0.510	0.31
138_V	147_V	0.510	0.31
12_L	19_N	0.508	0.31
425_N	491_E	0.508	0.31
59_P	62_V	0.508	0.31
38_H	68_F	0.508	0.31
248_C	272_F	0.507	0.31
60_N	339_T	0.507	0.31
442_I	457_T	0.506	0.31
311_D	358_F	0.505	0.31
486_T	490_N	0.504	0.31
256_L	272_F	0.504	0.31
461_R	501_D	0.503	0.31
60_N	268_F	0.503	0.31
232_S	376_G	0.502	0.31
411_I	415_S	0.502	0.31
267_T	274_M	0.501	0.31
404_V	409_L	0.501	0.31
412_V	501_D	0.500	0.31
261_A	282_K	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tqiA	3	0.8889	100	0.312	Contact Map
1gpmA	3	0.961	100	0.316	Contact Map
3uowA	2	0.9376	100	0.327	Contact Map
2ywbA	4	0.922	100	0.328	Contact Map
2vxoA	2	0.9825	100	0.34	Contact Map
2dplA	2	0.5595	100	0.609	Contact Map
2vpiA	1	0.3626	100	0.803	Contact Map
2lxnA	1	0.3645	100	0.827	Contact Map
3r75A	2	0.3684	100	0.839	Contact Map
1qdlB	2	0.3606	100	0.84	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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