GREMLIN Database
PURA - Adenylosuccinate synthetase
UniProt: P29726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (421)
Sequences: 3002 (1509)
Seq/√Len: 73.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
339_T372_E6.2221.00
347_R367_E5.9211.00
53_H299_T5.4501.00
338_E377_T4.3381.00
84_A195_Q3.7221.00
391_E395_H3.7201.00
385_S388_E3.6231.00
51_K298_T3.3961.00
349_K365_E3.3521.00
371_E399_R3.3491.00
48_I89_R3.1801.00
386_L394_R3.1311.00
328_L397_L3.0861.00
399_R403_L3.0221.00
290_R303_P2.9621.00
287_D291_E2.9231.00
84_A88_E2.8281.00
339_T374_P2.7281.00
288_Q337_I2.7091.00
77_K188_E2.6991.00
309_F314_V2.6901.00
392_N395_H2.6611.00
342_I399_R2.5811.00
311_S403_L2.5681.00
342_I373_M2.5161.00
341_K372_E2.4991.00
260_H325_D2.4511.00
288_Q292_V2.4401.00
114_E129_K2.4311.00
28_E215_R2.4031.00
181_K184_D2.3991.00
75_D110_L2.3471.00
336_G378_E2.3441.00
157_A161_E2.3311.00
29_V210_A2.2541.00
386_L398_E2.2461.00
347_R352_I2.2191.00
335_A380_I2.2061.00
104_V147_I2.2061.00
108_Y163_N2.1741.00
183_E187_D2.1421.00
151_L200_V2.1261.00
124_K274_D2.1221.00
291_E296_Y2.1191.00
348_Y366_C2.0911.00
326_L404_T2.0781.00
226_M313_V2.0781.00
31_A251_L2.0241.00
68_I72_M2.0161.00
74_V102_A2.0101.00
209_D213_E2.0081.00
348_Y353_I1.9761.00
325_D409_S1.9461.00
374_P392_N1.9421.00
399_R402_Q1.9281.00
172_E179_G1.8981.00
97_R201_C1.8741.00
391_E394_R1.8561.00
97_R206_V1.8521.00
348_Y365_E1.8291.00
342_I403_L1.8231.00
394_R398_E1.8201.00
373_M399_R1.8061.00
80_V195_Q1.7691.00
212_D405_G1.7211.00
9_T323_I1.7031.00
336_G377_T1.6851.00
395_H398_E1.6731.00
383_A388_E1.6531.00
74_V79_L1.6511.00
182_L186_L1.6511.00
309_F400_V1.6501.00
194_Q197_K1.6321.00
398_E423_L1.6311.00
147_I200_V1.6271.00
345_R352_I1.6220.99
184_D188_E1.6200.99
292_V336_G1.6190.99
374_P395_H1.6080.99
84_A87_H1.6080.99
378_E392_N1.6070.99
401_S423_L1.5770.99
74_V147_I1.5730.99
160_L182_L1.5700.99
37_N75_D1.5660.99
290_R296_Y1.5640.99
68_I74_V1.5560.99
47_G416_D1.5390.99
156_F160_L1.5310.99
45_F60_F1.5230.99
65_T97_R1.5190.99
384_K388_E1.5140.99
161_E182_L1.5060.99
77_K192_Y1.5020.99
157_A186_L1.5010.99
37_N105_I1.5000.99
153_R190_Y1.4810.99
37_N78_A1.4690.99
208_N212_D1.4550.99
103_H144_G1.4550.99
343_C368_P1.4450.99
398_E401_S1.4420.99
151_L197_K1.4420.99
397_L408_L1.4400.99
211_L217_V1.4390.99
386_L423_L1.4350.99
79_L83_L1.4300.99
335_A379_D1.4290.99
5_V247_S1.4290.99
283_D286_G1.4240.99
318_R323_I1.4170.99
286_G306_V1.3950.98
79_L96_L1.3940.98
344_V352_I1.3890.98
3_S219_F1.3880.98
398_E402_Q1.3850.98
102_A147_I1.3820.98
156_F189_Y1.3700.98
201_C206_V1.3670.98
348_Y362_A1.3620.98
67_V203_T1.3610.98
225_V321_S1.3420.98
137_M141_A1.3360.98
359_S362_A1.3340.98
70_N231_Q1.3280.98
186_L190_Y1.3250.98
265_S314_V1.3240.98
219_F253_S1.3220.98
371_E403_L1.3080.98
384_K418_S1.2950.97
77_K81_T1.2920.97
282_K285_I1.2880.97
76_P196_I1.2820.97
187_D191_E1.2690.97
281_L286_G1.2660.97
318_R406_I1.2560.97
29_V207_L1.2480.97
335_A378_E1.2390.97
256_P324_T1.2340.97
208_N257_K1.2220.96
311_S399_R1.2210.96
3_S211_L1.2170.96
210_A215_R1.2150.96
118_E177_T1.2090.96
157_A182_L1.2060.96
341_K370_Y1.2060.96
256_P322_G1.2050.96
413_V419_Q1.2000.96
352_I367_E1.1630.95
29_V206_V1.1630.95
356_F363_L1.1590.95
30_I64_K1.1530.95
384_K419_Q1.1500.95
157_A183_E1.1490.95
21_D417_R1.1420.95
33_Y242_P1.1390.95
311_S342_I1.1340.95
344_V371_E1.1230.94
208_N319_R1.1220.94
153_R157_A1.1210.94
335_A377_T1.1140.94
160_L186_L1.1130.94
85_Y88_E1.1110.94
161_E165_E1.1100.94
212_D257_K1.1080.94
65_T206_V1.1060.94
400_V408_L1.1010.94
155_A159_K1.0990.94
204_S319_R1.0950.93
381_T419_Q1.0940.93
312_V345_R1.0900.93
118_E129_K1.0850.93
348_Y351_E1.0850.93
287_D303_P1.0830.93
145_I156_F1.0810.93
205_V319_R1.0790.93
80_V196_I1.0730.93
207_L217_V1.0730.93
152_D361_K1.0690.93
111_K114_E1.0670.93
8_G14_E1.0570.92
347_R350_G1.0570.92
100_N358_A1.0500.92
106_L189_Y1.0460.92
187_D190_Y1.0380.92
352_I369_V1.0290.91
225_V317_A1.0280.91
254_A322_G1.0270.91
25_E61_Y1.0240.91
241_N249_S1.0200.91
101_R358_A1.0120.90
98_I147_I1.0100.90
74_V98_I1.0060.90
383_A386_L0.9970.90
284_E287_D0.9910.90
373_M395_H0.9820.89
288_Q291_E0.9820.89
211_L253_S0.9820.89
311_S400_V0.9780.89
287_D290_R0.9780.89
401_S408_L0.9750.89
205_V209_D0.9710.89
311_S314_V0.9680.88
411_F421_N0.9610.88
269_T313_V0.9610.88
291_E294_R0.9590.88
260_H409_S0.9570.88
309_F404_T0.9550.88
285_I337_I0.9500.87
207_L251_L0.9470.87
157_A190_Y0.9440.87
210_A213_E0.9390.87
164_L168_N0.9380.87
105_I135_A0.9360.87
317_A321_S0.9340.87
280_E305_R0.9320.86
189_Y192_Y0.9290.86
248_Q255_R0.9220.86
139_K230_D0.9220.86
289_I329_N0.9190.86
223_Q227_L0.9190.86
115_V177_T0.9190.86
285_I288_Q0.9180.86
193_G197_K0.9170.86
115_V171_L0.9050.85
158_E162_R0.9040.85
62_K95_N0.9000.84
226_M316_H0.8990.84
270_T330_S0.8980.84
362_A365_E0.8970.84
263_G323_I0.8960.84
331_I393_A0.8940.84
203_T206_V0.8940.84
245_A249_S0.8930.84
382_G413_V0.8880.84
197_K200_V0.8860.84
137_M143_I0.8830.83
123_N158_E0.8810.83
111_K180_F0.8800.83
79_L199_Y0.8800.83
180_F185_I0.8780.83
381_T413_V0.8740.83
205_V355_E0.8720.83
5_V258_I0.8710.82
123_N236_F0.8710.82
227_L271_R0.8690.82
85_Y89_R0.8680.82
384_K413_V0.8650.82
410_I420_T0.8640.82
191_E194_Q0.8620.82
189_Y193_G0.8580.82
169_R174_M0.8570.81
209_D354_E0.8540.81
87_H195_Q0.8540.81
42_T49_T0.8440.80
416_D419_Q0.8380.80
67_V206_V0.8360.80
285_I289_I0.8340.80
379_D413_V0.8260.79
353_I366_C0.8240.79
397_L411_F0.8230.79
99_S203_T0.8210.79
204_S231_Q0.8180.78
49_T294_R0.8170.78
120_K162_R0.8130.78
219_F251_L0.8120.78
29_V65_T0.8110.78
260_H324_T0.8090.78
127_T133_G0.8090.78
379_D382_G0.8090.78
147_I196_I0.8070.77
44_K49_T0.8050.77
46_D418_S0.8040.77
107_P188_E0.8020.77
245_A254_A0.8010.77
169_R173_K0.8000.77
148_A358_A0.7970.77
314_V404_T0.7940.76
111_K177_T0.7920.76
347_R369_V0.7920.76
86_L91_V0.7920.76
243_V246_V0.7910.76
363_L366_C0.7910.76
289_I330_S0.7900.76
54_L72_M0.7860.76
153_R186_L0.7860.76
284_E288_Q0.7860.76
386_L397_L0.7850.75
19_I410_I0.7850.75
111_K115_V0.7850.75
164_L180_F0.7800.75
76_P80_V0.7800.75
173_K176_E0.7790.75
325_D407_P0.7790.75
243_V249_S0.7780.75
67_V201_C0.7770.75
140_A229_I0.7770.75
397_L423_L0.7720.74
414_G419_Q0.7710.74
337_I340_L0.7700.74
395_H402_Q0.7700.74
75_D78_A0.7700.74
397_L401_S0.7700.74
103_H135_A0.7690.74
55_I224_G0.7690.74
296_Y303_P0.7640.73
33_Y246_V0.7640.73
34_Q224_G0.7630.73
279_T370_Y0.7630.73
340_L377_T0.7600.73
139_K146_R0.7590.73
316_H319_R0.7590.73
6_V27_A0.7560.73
55_I86_L0.7550.73
315_R403_L0.7530.72
222_A227_L0.7530.72
115_V129_K0.7510.72
70_N250_V0.7500.72
70_N241_N0.7490.72
387_S394_R0.7490.72
49_T298_T0.7480.72
265_S326_L0.7480.72
217_V253_S0.7460.72
29_V67_V0.7440.71
81_T85_Y0.7420.71
53_H85_Y0.7410.71
100_N200_V0.7410.71
32_R222_A0.7400.71
383_A394_R0.7380.71
203_T207_L0.7370.71
63_D92_S0.7360.71
244_A248_Q0.7310.70
3_S253_S0.7300.70
223_Q271_R0.7280.70
291_E303_P0.7260.70
145_I163_N0.7250.69
281_L285_I0.7250.69
233_T271_R0.7250.69
73_V136_Y0.7230.69
80_V192_Y0.7220.69
28_E216_R0.7220.69
323_I406_I0.7220.69
188_E191_E0.7210.69
87_H92_S0.7200.69
268_Y333_V0.7190.69
87_H93_T0.7190.69
353_I362_A0.7180.69
59_I66_C0.7180.69
330_S333_V0.7160.69
83_L93_T0.7100.68
80_V84_A0.7100.68
327_S410_I0.7100.68
108_Y167_K0.7080.68
373_M403_L0.7070.68
345_R369_V0.7060.67
191_E195_Q0.7040.67
78_A105_I0.7040.67
265_S328_L0.7030.67
373_M392_N0.7030.67
352_I371_E0.7020.67
138_D167_K0.7000.67
270_T306_V0.6990.67
292_V337_I0.6990.67
53_H78_A0.6990.67
47_G418_S0.6980.67
50_Y89_R0.6970.66
293_G333_V0.6950.66
340_L396_Y0.6940.66
68_I79_L0.6930.66
110_L114_E0.6930.66
190_Y193_G0.6920.66
100_N148_A0.6910.66
154_D158_E0.6910.66
66_C298_T0.6910.66
7_V247_S0.6880.65
61_Y64_K0.6870.65
111_K129_K0.6860.65
159_K162_R0.6850.65
336_G340_L0.6840.65
347_R351_E0.6810.65
116_E137_M0.6810.65
62_K92_S0.6800.65
315_R354_E0.6790.64
222_A271_R0.6790.64
4_V262_V0.6780.64
219_F247_S0.6780.64
9_T265_S0.6770.64
4_V27_A0.6760.64
281_L306_V0.6760.64
112_L171_L0.6740.64
164_L182_L0.6730.64
133_G142_R0.6710.64
360_L364_A0.6710.64
246_V250_V0.6680.63
83_L199_Y0.6670.63
67_V207_L0.6640.63
371_E395_H0.6640.63
371_E374_P0.6630.63
29_V215_R0.6620.62
309_F403_L0.6610.62
92_S95_N0.6600.62
80_V83_L0.6590.62
168_N179_G0.6580.62
184_D187_D0.6540.62
51_K66_C0.6530.61
154_D157_A0.6510.61
295_E304_P0.6500.61
34_Q242_P0.6490.61
288_Q336_G0.6480.61
262_V325_D0.6470.61
37_N413_V0.6460.61
172_E175_Y0.6460.61
379_D419_Q0.6440.60
190_Y194_Q0.6430.60
227_L233_T0.6430.60
293_G306_V0.6420.60
20_T265_S0.6410.60
29_V217_V0.6410.60
326_L397_L0.6410.60
144_G234_Y0.6400.60
59_I96_L0.6390.60
55_I59_I0.6390.60
149_D159_K0.6380.60
127_T237_V0.6380.60
226_M356_F0.6370.60
101_R148_A0.6370.60
7_V244_A0.6360.59
80_V98_I0.6360.59
9_T263_G0.6340.59
340_L373_M0.6330.59
100_N202_D0.6330.59
103_H146_R0.6320.59
345_R354_E0.6280.58
188_E192_Y0.6270.58
284_E338_E0.6270.58
261_V323_I0.6260.58
31_A69_G0.6250.58
37_N290_R0.6250.58
211_L257_K0.6240.58
208_N254_A0.6240.58
155_A361_K0.6200.57
342_I400_V0.6180.57
168_N176_E0.6170.57
110_L188_E0.6170.57
380_I393_A0.6170.57
171_L177_T0.6170.57
127_T142_R0.6160.57
412_S420_T0.6160.57
205_V354_E0.6120.56
6_V120_K0.6100.56
5_V244_A0.6090.56
206_V210_A0.6090.56
410_I422_V0.6080.56
22_F412_S0.6070.56
33_Y412_S0.6030.55
19_I412_S0.6010.55
52_L59_I0.6000.55
81_T84_A0.5980.55
233_T269_T0.5970.55
148_A200_V0.5970.55
109_H138_D0.5970.55
70_N230_D0.5960.55
69_G250_V0.5950.54
119_R169_R0.5930.54
168_N175_Y0.5930.54
404_T408_L0.5920.54
50_Y298_T0.5910.54
236_F274_D0.5910.54
389_L393_A0.5900.54
342_I402_Q0.5870.53
361_K364_A0.5840.53
380_I413_V0.5840.53
100_N359_S0.5840.53
109_H221_G0.5820.53
408_L411_F0.5820.53
34_Q52_L0.5800.53
326_L400_V0.5800.53
344_V347_R0.5790.52
121_G274_D0.5790.52
361_K365_E0.5790.52
34_Q109_H0.5780.52
130_K299_T0.5780.52
53_H81_T0.5770.52
19_I327_S0.5770.52
312_V356_F0.5770.52
311_S404_T0.5760.52
125_I142_R0.5750.52
53_H298_T0.5750.52
205_V208_N0.5750.52
396_Y400_V0.5740.52
289_I340_L0.5730.52
351_E367_E0.5730.52
155_A158_E0.5720.52
181_K190_Y0.5720.52
307_G310_D0.5720.52
335_A413_V0.5720.52
115_V118_E0.5710.51
295_E302_R0.5710.51
168_N180_F0.5690.51
100_N151_L0.5690.51
162_R165_E0.5660.51
109_H135_A0.5660.51
391_E398_E0.5650.51
365_E381_T0.5650.51
309_F342_I0.5650.51
77_K189_Y0.5640.51
124_K129_K0.5640.51
24_S27_A0.5630.50
9_T224_G0.5630.50
413_V420_T0.5630.50
9_T314_V0.5630.50
294_R303_P0.5610.50
258_I261_V0.5610.50
342_I371_E0.5610.50
335_A381_T0.5600.50
37_N167_K0.5600.50
3_S217_V0.5590.50
55_I277_F0.5580.50
140_A143_I0.5580.50
10_Q142_R0.5580.50
24_S61_Y0.5580.50
45_F48_I0.5580.50
224_G412_S0.5560.50
178_E181_K0.5560.50
343_C370_Y0.5550.49
349_K359_S0.5540.49
230_D241_N0.5530.49
339_T395_H0.5510.49
123_N162_R0.5500.49
268_Y293_G0.5500.49
367_E371_E0.5500.49
107_P185_I0.5500.49
61_Y137_M0.5490.49
64_K199_Y0.5490.49
12_G16_K0.5490.49
347_R371_E0.5480.49
161_E187_D0.5450.48
67_V97_R0.5440.48
116_E166_E0.5430.48
63_D95_N0.5430.48
43_I50_Y0.5410.48
386_L411_F0.5410.48
384_K421_N0.5410.48
70_N99_S0.5390.47
110_L130_K0.5390.47
211_L288_Q0.5380.47
54_L73_V0.5380.47
65_T215_R0.5380.47
12_G15_G0.5370.47
290_R313_V0.5370.47
272_V302_R0.5340.47
330_S334_L0.5340.47
81_T88_E0.5330.47
53_H130_K0.5330.47
318_R404_T0.5320.47
106_L163_N0.5320.47
383_A423_L0.5320.47
393_A413_V0.5310.46
148_A359_S0.5310.46
166_E170_L0.5300.46
165_E169_R0.5300.46
59_I91_V0.5290.46
383_A402_Q0.5280.46
44_K416_D0.5270.46
278_P366_C0.5260.46
209_D355_E0.5260.46
20_T43_I0.5260.46
25_E394_R0.5260.46
248_Q253_S0.5260.46
120_K364_A0.5250.46
395_H399_R0.5230.45
281_L308_W0.5230.45
67_V148_A0.5230.45
272_V300_T0.5230.45
43_I243_V0.5210.45
154_D352_I0.5200.45
264_V329_N0.5200.45
37_N110_L0.5190.45
6_V78_A0.5180.45
143_I166_E0.5180.45
32_R109_H0.5180.45
133_G271_R0.5170.45
8_G12_G0.5170.45
266_K295_E0.5170.45
192_Y196_I0.5170.45
152_D155_A0.5150.44
151_L193_G0.5150.44
19_I22_F0.5150.44
279_T343_C0.5150.44
195_Q198_K0.5150.44
206_V209_D0.5140.44
256_P261_V0.5140.44
243_V248_Q0.5140.44
248_Q258_I0.5140.44
77_K191_E0.5130.44
68_I96_L0.5130.44
37_N135_A0.5120.44
34_Q221_G0.5120.44
202_D316_H0.5120.44
37_N121_G0.5120.44
128_T134_P0.5100.44
114_E118_E0.5100.44
270_T329_N0.5090.44
167_K242_P0.5080.44
34_Q57_S0.5080.44
253_S257_K0.5080.44
401_S407_P0.5080.44
20_T30_I0.5070.43
6_V23_L0.5070.43
43_I49_T0.5070.43
75_D107_P0.5060.43
160_L185_I0.5060.43
172_E178_E0.5050.43
237_V271_R0.5050.43
152_D359_S0.5050.43
59_I93_T0.5040.43
286_G330_S0.5040.43
164_L181_K0.5040.43
104_V145_I0.5040.43
43_I51_K0.5040.43
222_A233_T0.5040.43
145_I149_D0.5030.43
243_V356_F0.5030.43
248_Q251_L0.5030.43
266_K272_V0.5020.43
380_I389_L0.5020.43
158_E161_E0.5020.43
88_E216_R0.5010.43
248_Q321_S0.5000.43
76_P104_V0.5000.43
326_L408_L0.5000.43
137_M166_E0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m9dA 2 0.9953 100 0.004 Contact Map
3hidA 2 0.9791 100 0.008 Contact Map
3ue9A 2 0.9721 100 0.009 Contact Map
1p9bA 2 0.9698 100 0.024 Contact Map
2v40A 2 0.9558 100 0.024 Contact Map
3r7tA 4 0.9465 100 0.028 Contact Map
1dj2A 2 0.9814 100 0.03 Contact Map
2d7uA 2 0.7419 100 0.203 Contact Map
1f8mA 4 0.6349 42.5 0.98 Contact Map
3dfzA 2 0.4116 26.6 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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