GREMLIN Database
HPPK - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UniProt: P29252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 167 (148)
Sequences: 4434 (3452)
Seq/√Len: 283.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_S131_E3.9751.00
118_R121_E2.8341.00
39_S58_M2.6871.00
7_I97_L2.5851.00
73_E111_Q2.5241.00
82_L95_A2.5091.00
69_F109_T2.3151.00
26_L81_E2.1661.00
4_I61_E2.1531.00
143_A151_R2.1511.00
45_D54_Q2.1121.00
75_T97_L2.0891.00
16_R43_E2.0151.00
43_E54_Q1.9981.00
100_L119_M1.9931.00
24_V60_V1.9751.00
69_F111_Q1.9311.00
42_Y131_E1.9161.00
107_I114_V1.8781.00
47_V118_R1.8041.00
6_Y61_E1.7951.00
4_I63_K1.7821.00
11_S16_R1.7691.00
30_H74_L1.7121.00
76_Q86_R1.6941.00
108_E113_I1.6611.00
67_N70_E1.6531.00
11_S19_Y1.6421.00
9_L20_L1.6241.00
30_H33_V1.6201.00
49_Y88_V1.6151.00
15_D18_T1.6141.00
123_L127_A1.5531.00
24_V38_V1.5491.00
16_R19_Y1.5101.00
41_I56_L1.5031.00
5_A62_I1.4771.00
26_L82_L1.4331.00
37_K61_E1.4101.00
101_L136_V1.4061.00
77_Q81_E1.3551.00
49_Y55_F1.3511.00
74_L77_Q1.3191.00
41_I58_M1.3191.00
52_Q92_P1.3101.00
17_E21_R1.3061.00
18_T22_Q1.2721.00
8_A100_L1.2631.00
36_T61_E1.2491.00
21_R41_I1.2461.00
19_Y82_L1.2381.00
138_K141_T1.2371.00
48_G90_W1.2111.00
36_T63_K1.2051.00
7_I75_T1.1951.00
64_T102_F1.1921.00
22_Q82_L1.1751.00
34_T63_K1.1751.00
120_Y141_T1.1621.00
88_V91_G1.1541.00
6_Y133_C1.1441.00
5_A71_L1.1411.00
99_I114_V1.1391.00
101_L119_M1.1201.00
101_L104_R1.1101.00
13_I53_A1.0961.00
37_K132_I1.0911.00
28_H35_V1.0901.00
20_L41_I1.0691.00
89_R118_R1.0601.00
144_E147_Q1.0591.00
86_R94_T1.0581.00
52_Q91_G1.0471.00
49_Y90_W1.0421.00
16_R56_L1.0231.00
22_Q26_L1.0191.00
6_Y101_L1.0101.00
8_A58_M1.0091.00
27_L60_V1.0091.00
35_V62_I0.9891.00
146_D150_V0.9681.00
7_I62_I0.9651.00
82_L94_T0.9621.00
38_V60_V0.9581.00
8_A125_V0.9571.00
119_M125_V0.9561.00
133_C136_V0.9511.00
6_Y129_L0.9401.00
42_Y127_A0.9371.00
5_A102_F0.9301.00
6_Y136_V0.9231.00
101_L145_T0.9181.00
50_E55_F0.9141.00
105_E114_V0.9131.00
127_A149_G0.9111.00
9_L60_V0.9081.00
9_L58_M0.9021.00
88_V92_P0.9011.00
120_Y148_E0.8921.00
72_L76_Q0.8901.00
51_D55_F0.8781.00
22_Q25_A0.8721.00
141_T148_E0.8681.00
68_P105_E0.8671.00
101_L114_V0.8641.00
33_V62_I0.8631.00
26_L29_Q0.8541.00
130_A149_G0.8341.00
5_A64_T0.8291.00
16_R53_A0.8140.99
32_A65_S0.8120.99
11_S20_L0.8060.99
69_F107_I0.8060.99
38_V58_M0.8050.99
33_V74_L0.8000.99
27_L75_T0.7980.99
14_G19_Y0.7910.99
20_L58_M0.7860.99
6_Y100_L0.7840.99
87_E91_G0.7820.99
69_F73_E0.7820.99
16_R54_Q0.7800.99
66_L74_L0.7750.99
17_E56_L0.7720.99
61_E132_I0.7710.99
26_L78_I0.7630.99
76_Q80_N0.7590.99
120_Y138_K0.7580.99
106_N139_E0.7500.99
125_V128_P0.7480.99
19_Y94_T0.7430.99
30_H66_L0.7420.99
20_L56_L0.7420.99
61_E133_C0.7360.99
72_L112_L0.7340.99
143_A147_Q0.7260.99
59_A100_L0.7190.99
71_L102_F0.7110.99
17_E41_I0.7080.99
21_R25_A0.7040.99
59_A129_L0.7020.99
46_P54_Q0.6990.98
138_K142_S0.6930.98
49_Y52_Q0.6880.98
6_Y59_A0.6810.98
85_T88_V0.6780.98
25_A29_Q0.6690.98
4_I36_T0.6660.98
23_A78_I0.6660.98
64_T71_L0.6550.98
78_I82_L0.6550.98
53_A92_P0.6510.98
147_Q150_V0.6470.97
130_A145_T0.6470.97
130_A146_D0.6410.97
66_L70_E0.6360.97
113_I117_P0.6350.97
80_N86_R0.6340.97
43_E56_L0.6340.97
20_L24_V0.6290.97
127_A131_E0.6280.97
62_I71_L0.6260.97
42_Y128_P0.6230.97
129_L145_T0.6180.97
27_L62_I0.6150.97
126_L149_G0.6150.97
32_A74_L0.6100.96
78_I97_L0.6070.96
90_W118_R0.6050.96
100_L125_V0.6030.96
9_L23_A0.6000.96
24_V35_V0.5990.96
107_I112_L0.5950.96
46_P52_Q0.5910.96
70_E73_E0.5910.96
59_A125_V0.5910.96
21_R38_V0.5900.96
126_L148_E0.5900.96
116_H122_R0.5900.96
137_E144_E0.5890.96
7_I99_I0.5890.96
35_V38_V0.5880.96
47_V123_L0.5780.95
51_D92_P0.5760.95
48_G52_Q0.5750.95
140_A143_A0.5730.95
83_G94_T0.5720.95
44_T127_A0.5710.95
135_Q146_D0.5680.95
45_D123_L0.5620.94
130_A144_E0.5610.94
101_L129_L0.5590.94
87_E90_W0.5580.94
136_V145_T0.5580.94
74_L78_I0.5550.94
75_T99_I0.5550.94
77_Q80_N0.5550.94
119_M129_L0.5500.94
119_M126_L0.5470.94
101_L139_E0.5460.93
27_L33_V0.5450.93
123_L149_G0.5420.93
24_V58_M0.5390.93
47_V90_W0.5370.93
137_E143_A0.5330.93
9_L97_L0.5320.93
19_Y95_A0.5320.93
109_T113_I0.5290.92
28_H38_V0.5270.92
76_Q111_Q0.5270.92
33_V71_L0.5240.92
47_V121_E0.5210.92
66_L102_F0.5200.92
6_Y132_I0.5190.92
76_Q87_E0.5150.91
55_F92_P0.5120.91
35_V60_V0.5120.91
68_P102_F0.5120.91
76_Q99_I0.5110.91
72_L116_H0.5090.91
23_A95_A0.5070.91
19_Y53_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cg8A 4 0.8144 100 0.09 Contact Map
1cbkA 2 0.9581 100 0.095 Contact Map
4cwbA 1 0.9461 100 0.096 Contact Map
2qx0A 2 0.9461 100 0.098 Contact Map
2bmbA 1 0.9461 100 0.099 Contact Map
3ip0A 2 0.9401 100 0.105 Contact Map
4pzvA 1 0.9641 100 0.137 Contact Map
2rffA 1 0.6228 26.3 0.944 Contact Map
3v2iA 1 0.9162 17.4 0.949 Contact Map
1wlsA 2 0.5509 13.1 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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