CHEA - BACSU - GREMLIN Contacts

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CHEA - Chemotaxis protein CheA

UniProt:	P29072	Sequences: MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEEQGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	672 (649)
Sequences:	2443 (1856)
Seq/√Len:	72.9

ECOLI - CHEA
BACSU - CHEA
HALSA - Q9HQW7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
453_L	458_I	8.041	1.00
525_A	528_Q	7.930	1.00
421_L	427_E	7.845	1.00
378_K	427_E	7.674	1.00
419_T	451_A	6.809	1.00
423_K	527_G	6.510	1.00
380_E	428_S	6.281	1.00
31_D	34_D	5.390	1.00
91_E	119_K	4.922	1.00
447_E	531_L	4.471	1.00
378_K	428_S	4.389	1.00
384_I	432_V	4.359	1.00
225_A	229_E	4.282	1.00
459_L	468_I	4.273	1.00
455_R	478_D	4.184	1.00
382_S	430_K	4.154	1.00
461_K	464_E	4.112	1.00
371_L	499_I	3.953	1.00
454_N	526_E	3.866	1.00
416_A	419_T	3.725	1.00
580_E	593_Y	3.703	1.00
455_R	481_I	3.696	1.00
564_E	585_R	3.569	1.00
224_S	227_D	3.513	1.00
419_T	422_Q	3.438	1.00
460_E	464_E	3.344	1.00
459_L	481_I	3.337	1.00
549_K	628_S	3.314	1.00
591_V	612_I	3.276	1.00
410_I	431_V	3.180	1.00
457_K	494_D	3.121	1.00
419_T	423_K	3.077	1.00
453_L	482_Y	3.029	1.00
379_I	410_I	2.894	1.00
486_F	520_V	2.874	1.00
38_V	74_I	2.872	1.00
477_E	480_Q	2.860	1.00
587_H	621_P	2.808	1.00
545_V	556_A	2.715	1.00
73_A	78_D	2.698	1.00
456_K	460_E	2.556	1.00
455_R	459_L	2.510	1.00
459_L	463_L	2.434	1.00
478_D	481_I	2.428	1.00
612_I	623_A	2.422	1.00
455_R	526_E	2.405	1.00
66_L	121_D	2.344	1.00
380_E	430_K	2.330	1.00
482_Y	524_S	2.281	1.00
374_E	498_D	2.219	1.00
467_V	487_A	2.198	1.00
379_I	414_I	2.136	1.00
70_V	120_L	2.128	1.00
432_V	447_E	2.118	1.00
598_F	665_I	2.102	1.00
436_Y	445_E	2.078	1.00
455_R	482_Y	2.060	1.00
467_V	484_L	2.053	1.00
470_E	474_E	2.051	1.00
485_I	506_L	2.044	1.00
67_L	92_A	2.002	1.00
29_E	369_R	2.000	1.00
45_A	64_T	1.994	1.00
406_I	431_V	1.993	1.00
414_I	429_G	1.953	1.00
17_H	44_A	1.917	1.00
468_I	476_L	1.902	1.00
361_F	433_L	1.887	1.00
223_Q	227_D	1.884	1.00
219_F	228_I	1.880	1.00
555_F	600_I	1.875	1.00
486_F	522_V	1.864	1.00
42_F	75_R	1.861	1.00
15_K	104_I	1.854	1.00
479_N	523_K	1.845	1.00
589_V	614_V	1.814	1.00
35_L	77_G	1.812	1.00
583_D	586_G	1.807	1.00
451_A	457_K	1.769	1.00
118_A	122_V	1.743	1.00
368_I	410_I	1.735	1.00
593_Y	625_V	1.734	1.00
441_H	535_Q	1.733	1.00
114_S	118_A	1.688	1.00
417_P	427_E	1.673	1.00
168_I	243_V	1.659	1.00
557_I	613_I	1.655	1.00
416_A	451_A	1.651	1.00
476_L	484_L	1.646	1.00
456_K	459_L	1.645	1.00
610_L	625_V	1.645	1.00
584_F	614_V	1.637	1.00
73_A	79_M	1.628	0.99
358_E	386_A	1.605	0.99
363_R	399_G	1.599	0.99
409_S	532_F	1.591	0.99
453_L	485_I	1.574	0.99
260_Q	264_P	1.563	0.99
368_I	406_I	1.551	0.99
506_L	532_F	1.548	0.99
479_N	521_S	1.541	0.99
165_R	220_L	1.540	0.99
85_W	123_N	1.530	0.99
82_T	85_W	1.528	0.99
295_I	302_L	1.526	0.99
461_K	465_R	1.524	0.99
53_A	61_A	1.517	0.99
190_L	194_G	1.517	0.99
171_S	214_D	1.503	0.99
67_L	96_L	1.495	0.99
400_D	508_V	1.486	0.99
451_A	454_N	1.480	0.99
523_K	533_S	1.474	0.99
464_E	494_D	1.473	0.99
569_D	572_D	1.472	0.99
87_D	373_K	1.470	0.99
549_K	552_E	1.467	0.99
316_R	556_A	1.466	0.99
232_I	235_V	1.465	0.99
19_Q	97_E	1.463	0.99
458_I	481_I	1.463	0.99
414_I	451_A	1.453	0.99
35_L	39_H	1.439	0.99
206_L	212_G	1.437	0.99
164_K	245_Q	1.431	0.99
169_K	216_Q	1.429	0.99
74_I	85_W	1.425	0.99
434_K	445_E	1.417	0.99
226_E	229_E	1.410	0.99
122_V	126_H	1.406	0.98
29_E	32_P	1.390	0.98
375_L	410_I	1.389	0.98
384_I	434_K	1.388	0.98
350_L	541_S	1.385	0.98
418_E	427_E	1.380	0.98
445_E	533_S	1.376	0.98
269_P	273_E	1.374	0.98
459_L	476_L	1.371	0.98
360_V	365_P	1.367	0.98
556_A	634_E	1.367	0.98
457_K	460_E	1.362	0.98
22_N	90_F	1.359	0.98
262_D	265_A	1.357	0.98
423_K	451_A	1.353	0.98
74_I	81_V	1.352	0.98
468_I	481_I	1.349	0.98
562_I	613_I	1.342	0.98
522_V	532_F	1.341	0.98
468_I	484_L	1.327	0.98
15_K	101_Q	1.317	0.98
544_S	634_E	1.306	0.98
547_L	656_L	1.305	0.98
227_D	231_L	1.304	0.98
582_I	612_I	1.302	0.97
455_R	524_S	1.295	0.97
257_E	260_Q	1.287	0.97
226_E	230_Q	1.284	0.97
482_Y	526_E	1.281	0.97
556_A	662_A	1.271	0.97
167_E	216_Q	1.270	0.97
59_D	109_G	1.267	0.97
113_I	116_V	1.264	0.97
149_E	155_I	1.259	0.97
178_L	182_R	1.253	0.97
307_N	638_K	1.253	0.97
565_T	629_F	1.250	0.97
263_S	278_P	1.247	0.97
378_K	421_L	1.241	0.97
379_I	431_V	1.239	0.97
615_V	667_C	1.238	0.97
227_D	230_Q	1.238	0.97
72_D	76_N	1.236	0.97
166_Y	221_T	1.234	0.97
262_D	267_A	1.229	0.96
202_S	205_V	1.225	0.96
418_E	421_L	1.224	0.96
155_I	158_A	1.214	0.96
434_K	447_E	1.211	0.96
46_H	49_K	1.211	0.96
232_I	241_V	1.207	0.96
349_I	352_M	1.206	0.96
364_F	433_L	1.205	0.96
43_R	46_H	1.201	0.96
482_Y	522_V	1.200	0.96
262_D	266_A	1.195	0.96
148_D	152_R	1.194	0.96
398_I	512_K	1.193	0.96
461_K	494_D	1.191	0.96
563_I	616_K	1.183	0.96
355_V	395_I	1.183	0.96
417_P	421_L	1.178	0.95
318_R	334_T	1.171	0.95
364_F	371_L	1.168	0.95
595_K	602_D	1.167	0.95
493_A	496_I	1.166	0.95
182_R	185_M	1.165	0.95
520_V	532_F	1.163	0.95
58_T	62_H	1.148	0.95
381_L	406_I	1.144	0.95
257_E	262_D	1.141	0.95
148_D	151_E	1.139	0.95
556_A	635_V	1.139	0.95
551_E	600_I	1.136	0.94
463_L	468_I	1.136	0.94
457_K	464_E	1.133	0.94
263_S	267_A	1.129	0.94
258_S	263_S	1.128	0.94
17_H	20_T	1.120	0.94
394_V	398_I	1.117	0.94
367_M	371_L	1.113	0.94
411_D	500_S	1.109	0.94
258_S	262_D	1.108	0.94
545_V	635_V	1.107	0.94
516_L	536_L	1.103	0.94
10_F	52_S	1.101	0.94
33_T	80_E	1.100	0.93
182_R	186_V	1.097	0.93
52_S	61_A	1.095	0.93
18_L	96_L	1.091	0.93
239_E	243_V	1.091	0.93
262_D	273_E	1.089	0.93
270_A	275_Q	1.086	0.93
447_E	528_Q	1.086	0.93
147_Y	150_F	1.080	0.93
460_E	463_L	1.077	0.93
557_I	624_F	1.070	0.93
463_L	476_L	1.069	0.92
26_L	29_E	1.068	0.92
319_L	334_T	1.067	0.92
382_S	432_V	1.066	0.92
261_E	265_A	1.064	0.92
154_V	160_E	1.061	0.92
179_K	182_R	1.055	0.92
168_I	172_L	1.054	0.92
237_E	241_V	1.050	0.92
463_L	470_E	1.048	0.92
134_E	137_E	1.046	0.92
361_F	564_E	1.045	0.92
43_R	49_K	1.042	0.91
195_E	220_L	1.040	0.91
113_I	117_S	1.036	0.91
278_P	281_N	1.036	0.91
438_S	535_Q	1.033	0.91
45_A	71_L	1.033	0.91
280_K	283_E	1.031	0.91
118_A	121_D	1.028	0.91
232_I	238_I	1.028	0.91
257_E	265_A	1.028	0.91
230_Q	234_G	1.027	0.91
431_V	530_S	1.027	0.91
178_L	181_V	1.026	0.91
47_T	51_M	1.023	0.91
546_L	613_I	1.023	0.91
49_K	68_E	1.022	0.91
6_Y	54_T	1.022	0.91
17_H	51_M	1.022	0.91
93_L	97_E	1.021	0.91
364_F	367_M	1.020	0.91
277_Q	280_K	1.019	0.91
119_K	122_V	1.018	0.91
54_T	71_L	1.017	0.90
511_N	520_V	1.017	0.90
67_L	89_L	1.016	0.90
177_M	183_V	1.015	0.90
213_T	228_I	1.015	0.90
259_K	263_S	1.015	0.90
177_M	180_A	1.013	0.90
612_I	625_V	1.009	0.90
166_Y	225_A	1.005	0.90
40_D	52_S	1.002	0.90
46_H	65_H	1.002	0.90
22_N	97_E	1.001	0.90
316_R	634_E	0.997	0.90
465_R	481_I	0.995	0.89
549_K	630_I	0.994	0.89
521_S	535_Q	0.993	0.89
315_D	338_M	0.993	0.89
180_A	183_V	0.993	0.89
152_R	155_I	0.988	0.89
457_K	465_R	0.987	0.89
418_E	422_Q	0.986	0.89
308_L	348_I	0.982	0.89
90_F	406_I	0.981	0.89
316_R	545_V	0.981	0.89
517_G	637_L	0.980	0.89
46_H	50_G	0.979	0.89
458_I	485_I	0.976	0.89
43_R	65_H	0.973	0.88
256_E	262_D	0.971	0.88
95_H	116_V	0.964	0.88
135_P	268_V	0.961	0.88
207_E	211_F	0.959	0.88
106_G	110_K	0.954	0.87
79_M	85_W	0.954	0.87
231_L	234_G	0.950	0.87
302_L	641_G	0.949	0.87
611_H	629_F	0.947	0.87
638_K	657_G	0.946	0.87
346_Q	635_V	0.943	0.87
168_I	217_V	0.942	0.87
580_E	596_E	0.939	0.87
264_P	270_A	0.938	0.87
264_P	269_P	0.938	0.87
485_I	661_V	0.937	0.86
550_L	600_I	0.934	0.86
258_S	266_A	0.934	0.86
21_C	349_I	0.932	0.86
165_R	245_Q	0.932	0.86
260_Q	266_A	0.929	0.86
125_A	128_E	0.929	0.86
228_I	237_E	0.926	0.86
260_Q	268_V	0.925	0.86
426_P	430_K	0.924	0.86
454_N	482_Y	0.923	0.86
555_F	598_F	0.922	0.86
322_I	331_L	0.921	0.86
498_D	536_L	0.921	0.86
60_L	100_V	0.919	0.85
545_V	634_E	0.918	0.85
261_E	266_A	0.917	0.85
266_A	269_P	0.915	0.85
94_D	366_R	0.914	0.85
595_K	605_K	0.912	0.85
135_P	140_S	0.911	0.85
147_Y	151_E	0.909	0.85
57_Y	61_A	0.909	0.85
61_A	64_T	0.908	0.85
366_R	370_Q	0.907	0.85
255_P	267_A	0.907	0.85
352_M	355_V	0.902	0.84
156_Q	159_E	0.901	0.84
523_K	531_L	0.901	0.84
179_K	183_V	0.899	0.84
554_T	630_I	0.899	0.84
221_T	243_V	0.899	0.84
20_T	44_A	0.897	0.84
378_K	417_P	0.894	0.84
39_H	508_V	0.892	0.84
24_K	37_L	0.892	0.84
555_F	592_V	0.891	0.84
205_V	210_D	0.890	0.84
268_V	273_E	0.887	0.83
130_A	269_P	0.885	0.83
203_A	206_L	0.885	0.83
59_D	103_I	0.884	0.83
266_A	271_K	0.883	0.83
57_Y	64_T	0.883	0.83
269_P	275_Q	0.882	0.83
485_I	522_V	0.882	0.83
272_Q	283_E	0.881	0.83
45_A	54_T	0.880	0.83
201_P	206_L	0.880	0.83
480_Q	483_E	0.880	0.83
47_T	643_Y	0.880	0.83
598_F	649_A	0.879	0.83
6_Y	51_M	0.878	0.83
189_K	192_E	0.877	0.83
71_L	445_E	0.875	0.82
51_M	55_M	0.875	0.82
24_K	40_D	0.874	0.82
465_R	490_F	0.874	0.82
71_L	661_V	0.872	0.82
547_L	556_A	0.871	0.82
368_I	372_Q	0.870	0.82
494_D	531_L	0.870	0.82
162_G	165_R	0.869	0.82
6_Y	55_M	0.868	0.82
261_E	275_Q	0.867	0.82
155_I	159_E	0.867	0.82
121_D	125_A	0.863	0.82
460_E	470_E	0.863	0.82
354_M	538_L	0.862	0.82
258_S	264_P	0.862	0.82
11_I	103_I	0.861	0.81
394_V	399_G	0.860	0.81
14_S	48_L	0.859	0.81
39_H	615_V	0.858	0.81
493_A	497_S	0.858	0.81
592_V	670_L	0.858	0.81
653_A	663_L	0.857	0.81
439_G	490_F	0.856	0.81
478_D	525_A	0.856	0.81
131_A	264_P	0.856	0.81
71_L	85_W	0.855	0.81
88_I	123_N	0.854	0.81
346_Q	506_L	0.854	0.81
540_L	636_V	0.854	0.81
63_L	67_L	0.853	0.81
38_V	651_S	0.848	0.80
106_G	109_G	0.847	0.80
73_A	124_G	0.845	0.80
47_T	318_R	0.843	0.80
267_A	270_A	0.839	0.80
101_Q	105_D	0.837	0.80
43_R	50_G	0.836	0.79
167_E	244_I	0.834	0.79
314_I	633_Q	0.833	0.79
543_I	641_G	0.832	0.79
172_L	176_C	0.831	0.79
168_I	219_F	0.831	0.79
281_N	284_Q	0.830	0.79
163_F	222_H	0.830	0.79
208_T	213_T	0.830	0.79
159_E	162_G	0.829	0.79
315_D	318_R	0.828	0.79
115_E	119_K	0.828	0.79
263_S	275_Q	0.827	0.79
118_A	133_A	0.827	0.79
313_V	346_Q	0.827	0.79
224_S	256_E	0.826	0.79
272_Q	276_K	0.825	0.79
181_V	185_M	0.825	0.79
28_L	32_P	0.824	0.79
166_Y	172_L	0.823	0.78
318_R	403_V	0.822	0.78
228_I	243_V	0.822	0.78
51_M	632_Q	0.821	0.78
150_F	154_V	0.820	0.78
258_S	265_A	0.818	0.78
165_R	170_I	0.817	0.78
236_S	239_E	0.817	0.78
264_P	268_V	0.816	0.78
172_L	177_M	0.815	0.78
51_M	54_T	0.814	0.78
169_K	214_D	0.814	0.78
168_I	190_L	0.813	0.78
228_I	233_N	0.813	0.78
390_L	542_I	0.812	0.77
185_M	189_K	0.808	0.77
229_E	236_S	0.807	0.77
46_H	68_E	0.806	0.77
219_F	234_G	0.805	0.77
132_S	136_A	0.805	0.77
55_M	183_V	0.804	0.77
476_L	481_I	0.803	0.77
361_F	585_R	0.802	0.77
49_K	65_H	0.802	0.77
354_M	375_L	0.802	0.77
215_F	221_T	0.801	0.77
301_R	651_S	0.800	0.76
276_K	283_E	0.800	0.76
317_G	392_R	0.798	0.76
262_D	278_P	0.796	0.76
276_K	281_N	0.796	0.76
221_T	228_I	0.796	0.76
261_E	267_A	0.795	0.76
542_I	636_V	0.795	0.76
299_I	517_G	0.794	0.76
277_Q	281_N	0.794	0.76
5_Q	12_D	0.794	0.76
318_R	634_E	0.793	0.76
219_F	242_E	0.792	0.76
262_D	272_Q	0.792	0.76
158_A	162_G	0.792	0.76
256_E	276_K	0.791	0.76
263_S	268_V	0.790	0.76
193_V	219_F	0.789	0.75
63_L	95_H	0.788	0.75
235_V	238_I	0.788	0.75
444_I	573_I	0.787	0.75
135_P	138_A	0.785	0.75
266_A	283_E	0.784	0.75
94_D	370_Q	0.783	0.75
525_A	531_L	0.782	0.75
17_H	47_T	0.782	0.75
388_T	439_G	0.780	0.75
493_A	499_I	0.780	0.75
178_L	183_V	0.769	0.74
170_I	176_C	0.769	0.74
75_R	508_V	0.769	0.74
295_I	392_R	0.768	0.73
459_L	623_A	0.766	0.73
259_K	278_P	0.765	0.73
321_Q	658_D	0.764	0.73
520_V	639_S	0.763	0.73
263_S	270_A	0.763	0.73
29_E	387_E	0.762	0.73
471_K	474_E	0.762	0.73
221_T	395_I	0.762	0.73
26_L	90_F	0.761	0.73
565_T	634_E	0.761	0.73
169_K	242_E	0.760	0.73
261_E	270_A	0.760	0.73
437_H	540_L	0.760	0.73
199_T	204_E	0.759	0.73
168_I	232_I	0.759	0.73
354_M	388_T	0.756	0.72
613_I	626_V	0.755	0.72
512_K	520_V	0.755	0.72
64_T	96_L	0.751	0.72
178_L	191_N	0.751	0.72
323_A	331_L	0.750	0.72
256_E	263_S	0.748	0.71
388_T	540_L	0.748	0.71
171_S	240_H	0.746	0.71
553_E	664_I	0.745	0.71
64_T	405_L	0.744	0.71
193_V	231_L	0.741	0.71
133_A	137_E	0.741	0.71
593_Y	596_E	0.739	0.71
546_L	562_I	0.739	0.71
266_A	272_Q	0.738	0.70
464_E	495_Q	0.737	0.70
269_P	272_Q	0.736	0.70
52_S	57_Y	0.736	0.70
133_A	573_I	0.735	0.70
21_C	71_L	0.735	0.70
136_A	139_Q	0.734	0.70
257_E	269_P	0.734	0.70
440_N	512_K	0.734	0.70
301_R	512_K	0.733	0.70
546_L	616_K	0.732	0.70
81_V	85_W	0.731	0.70
266_A	422_Q	0.730	0.70
266_A	277_Q	0.730	0.70
478_D	482_Y	0.730	0.70
354_M	437_H	0.729	0.70
256_E	271_K	0.729	0.70
463_L	471_K	0.727	0.69
259_K	264_P	0.726	0.69
541_S	637_L	0.723	0.69
553_E	600_I	0.722	0.69
581_V	657_G	0.722	0.69
69_N	72_D	0.720	0.69
284_Q	287_H	0.720	0.69
322_I	557_I	0.720	0.69
259_K	265_A	0.720	0.69
42_F	65_H	0.719	0.68
256_E	282_D	0.717	0.68
54_T	61_A	0.716	0.68
456_K	478_D	0.715	0.68
257_E	271_K	0.715	0.68
147_Y	157_E	0.714	0.68
234_G	243_V	0.714	0.68
255_P	266_A	0.714	0.68
636_V	664_I	0.713	0.68
7_L	57_Y	0.712	0.68
276_K	280_K	0.712	0.68
43_R	47_T	0.712	0.68
510_K	514_E	0.712	0.68
234_G	241_V	0.711	0.68
221_T	224_S	0.711	0.68
128_E	284_Q	0.709	0.67
294_T	345_L	0.708	0.67
346_Q	350_L	0.707	0.67
258_S	271_K	0.707	0.67
279_A	601_E	0.707	0.67
559_I	634_E	0.707	0.67
45_A	67_L	0.706	0.67
376_N	418_E	0.705	0.67
559_I	632_Q	0.703	0.67
175_N	178_L	0.702	0.67
154_V	158_A	0.702	0.67
445_E	531_L	0.702	0.67
132_S	257_E	0.701	0.67
261_E	264_P	0.700	0.66
208_T	211_F	0.700	0.66
208_T	232_I	0.699	0.66
70_V	479_N	0.699	0.66
134_E	272_Q	0.698	0.66
228_I	234_G	0.697	0.66
154_V	159_E	0.697	0.66
257_E	261_E	0.696	0.66
267_A	272_Q	0.695	0.66
437_H	651_S	0.694	0.66
90_F	661_V	0.694	0.66
168_I	228_I	0.691	0.65
405_L	653_A	0.689	0.65
322_I	334_T	0.688	0.65
440_N	540_L	0.687	0.65
43_R	68_E	0.686	0.65
368_I	431_V	0.685	0.65
270_A	274_K	0.685	0.65
271_K	276_K	0.682	0.64
232_I	237_E	0.682	0.64
162_G	166_Y	0.681	0.64
97_E	101_Q	0.680	0.64
437_H	538_L	0.679	0.64
50_G	65_H	0.679	0.64
346_Q	565_T	0.677	0.64
458_I	468_I	0.677	0.64
26_L	38_V	0.677	0.64
22_N	512_K	0.677	0.64
228_I	231_L	0.676	0.64
265_A	268_V	0.674	0.63
126_H	129_S	0.674	0.63
454_N	460_E	0.674	0.63
130_A	270_A	0.673	0.63
272_Q	279_A	0.673	0.63
344_D	405_L	0.672	0.63
395_I	540_L	0.672	0.63
338_M	342_S	0.668	0.63
162_G	168_I	0.668	0.63
14_S	17_H	0.667	0.63
148_D	157_E	0.667	0.63
433_L	564_E	0.667	0.63
26_L	370_Q	0.666	0.63
259_K	270_A	0.665	0.62
595_K	604_R	0.665	0.62
205_V	255_P	0.665	0.62
137_E	140_S	0.665	0.62
152_R	156_Q	0.663	0.62
64_T	390_L	0.662	0.62
321_Q	325_E	0.662	0.62
258_S	272_Q	0.661	0.62
44_A	665_I	0.661	0.62
454_N	478_D	0.660	0.62
51_M	355_V	0.659	0.62
29_E	370_Q	0.659	0.62
136_A	140_S	0.659	0.62
559_I	637_L	0.658	0.62
346_Q	365_P	0.658	0.62
467_V	566_A	0.658	0.62
180_A	215_F	0.657	0.61
316_R	339_T	0.657	0.61
229_E	240_H	0.657	0.61
133_A	264_P	0.655	0.61
354_M	623_A	0.654	0.61
184_Y	187_F	0.654	0.61
4_N	347_S	0.654	0.61
546_L	653_A	0.653	0.61
302_L	318_R	0.653	0.61
188_E	191_N	0.652	0.61
400_D	541_S	0.651	0.61
354_M	370_Q	0.651	0.61
222_H	274_K	0.651	0.61
308_L	414_I	0.650	0.61
309_F	347_S	0.650	0.61
13_E	42_F	0.649	0.61
308_L	543_I	0.649	0.61
653_A	661_V	0.649	0.61
263_S	271_K	0.648	0.60
62_H	414_I	0.648	0.60
147_Y	155_I	0.648	0.60
183_V	239_E	0.647	0.60
215_F	234_G	0.646	0.60
265_A	273_E	0.646	0.60
183_V	238_I	0.646	0.60
309_F	541_S	0.645	0.60
554_T	660_E	0.644	0.60
267_A	275_Q	0.643	0.60
268_V	271_K	0.643	0.60
219_F	243_V	0.643	0.60
14_S	100_V	0.642	0.60
274_K	278_P	0.641	0.60
34_D	39_H	0.641	0.60
335_V	632_Q	0.641	0.60
498_D	513_L	0.640	0.59
160_E	163_F	0.639	0.59
375_L	499_I	0.639	0.59
215_F	219_F	0.639	0.59
207_E	210_D	0.638	0.59
234_G	238_I	0.638	0.59
343_G	634_E	0.637	0.59
411_D	507_D	0.636	0.59
595_K	610_L	0.635	0.59
405_L	532_F	0.635	0.59
444_I	661_V	0.634	0.59
432_V	446_V	0.634	0.59
267_A	277_Q	0.633	0.59
409_S	619_D	0.633	0.59
172_L	180_A	0.632	0.59
436_Y	443_F	0.632	0.59
65_H	68_E	0.632	0.59
138_A	245_Q	0.631	0.58
455_R	458_I	0.629	0.58
269_P	276_K	0.629	0.58
275_Q	278_P	0.627	0.58
221_T	231_L	0.627	0.58
440_N	565_T	0.625	0.58
440_N	545_V	0.625	0.58
221_T	234_G	0.623	0.57
316_R	544_S	0.623	0.57
57_Y	103_I	0.622	0.57
131_A	134_E	0.621	0.57
262_D	284_Q	0.621	0.57
82_T	242_E	0.621	0.57
99_M	103_I	0.620	0.57
186_V	190_L	0.619	0.57
140_S	258_S	0.619	0.57
138_A	274_K	0.619	0.57
312_L	345_L	0.619	0.57
261_E	272_Q	0.618	0.57
22_N	51_M	0.617	0.57
55_M	182_R	0.617	0.57
278_P	283_E	0.616	0.57
225_A	245_Q	0.616	0.57
544_S	556_A	0.616	0.57
268_V	427_E	0.615	0.56
190_L	219_F	0.614	0.56
320_E	339_T	0.613	0.56
332_T	592_V	0.613	0.56
256_E	280_K	0.612	0.56
255_P	272_Q	0.612	0.56
534_I	540_L	0.612	0.56
314_I	654_T	0.612	0.56
273_E	276_K	0.611	0.56
346_Q	638_K	0.611	0.56
129_S	275_Q	0.610	0.56
400_D	512_K	0.610	0.56
641_G	661_V	0.609	0.56
262_D	271_K	0.609	0.56
53_A	508_V	0.608	0.56
92_A	589_V	0.608	0.56
431_V	589_V	0.607	0.55
372_Q	566_A	0.607	0.55
390_L	562_I	0.606	0.55
157_E	162_G	0.605	0.55
201_P	207_E	0.605	0.55
157_E	273_E	0.605	0.55
115_E	271_K	0.603	0.55
259_K	273_E	0.603	0.55
80_E	125_A	0.601	0.55
396_D	512_K	0.601	0.55
179_K	237_E	0.601	0.55
172_L	232_I	0.600	0.55
150_F	153_T	0.599	0.55
355_V	651_S	0.599	0.55
131_A	156_Q	0.597	0.54
481_I	576_T	0.597	0.54
582_I	623_A	0.597	0.54
189_K	194_G	0.596	0.54
318_R	344_D	0.595	0.54
261_E	281_N	0.594	0.54
228_I	241_V	0.594	0.54
54_T	346_Q	0.593	0.54
130_A	136_A	0.593	0.54
355_V	633_Q	0.592	0.54
398_I	548_I	0.592	0.54
423_K	426_P	0.592	0.54
427_E	430_K	0.591	0.54
265_A	269_P	0.591	0.54
52_S	629_F	0.591	0.54
409_S	530_S	0.590	0.53
9_V	17_H	0.590	0.53
233_N	236_S	0.590	0.53
483_E	510_K	0.590	0.53
166_Y	228_I	0.590	0.53
48_L	512_K	0.589	0.53
570_R	608_E	0.589	0.53
301_R	351_N	0.588	0.53
208_T	215_F	0.588	0.53
666_D	669_A	0.587	0.53
122_V	127_A	0.586	0.53
457_K	461_K	0.586	0.53
309_F	345_L	0.584	0.53
229_E	232_I	0.584	0.53
83_S	552_E	0.583	0.53
55_M	306_M	0.583	0.53
274_K	287_H	0.583	0.53
256_E	287_H	0.582	0.52
157_E	272_Q	0.581	0.52
262_D	270_A	0.581	0.52
593_Y	610_L	0.581	0.52
388_T	534_I	0.581	0.52
165_R	276_K	0.580	0.52
615_V	624_F	0.580	0.52
264_P	273_E	0.580	0.52
217_V	221_T	0.578	0.52
206_L	211_F	0.578	0.52
75_R	504_V	0.578	0.52
19_Q	23_E	0.577	0.52
545_V	636_V	0.576	0.52
301_R	343_G	0.576	0.52
649_A	666_D	0.575	0.52
50_G	68_E	0.575	0.52
274_K	277_Q	0.574	0.51
263_S	272_Q	0.574	0.51
262_D	277_Q	0.574	0.51
235_V	496_I	0.573	0.51
454_N	494_D	0.573	0.51
414_I	417_P	0.572	0.51
197_A	220_L	0.572	0.51
263_S	269_P	0.571	0.51
274_K	280_K	0.571	0.51
363_R	585_R	0.571	0.51
151_E	155_I	0.571	0.51
27_L	30_K	0.571	0.51
543_I	635_V	0.570	0.51
317_G	352_M	0.570	0.51
319_L	335_V	0.570	0.51
54_T	64_T	0.569	0.51
259_K	456_K	0.569	0.51
268_V	272_Q	0.569	0.51
361_F	364_F	0.569	0.51
259_K	262_D	0.568	0.51
410_I	417_P	0.568	0.51
270_A	273_E	0.568	0.51
17_H	93_L	0.568	0.51
150_F	159_E	0.568	0.51
36_Q	39_H	0.568	0.51
103_I	431_V	0.567	0.51
231_L	239_E	0.566	0.50
227_D	232_I	0.566	0.50
326_L	331_L	0.565	0.50
170_I	243_V	0.565	0.50
639_S	644_L	0.564	0.50
479_N	483_E	0.563	0.50
273_E	282_D	0.563	0.50
400_D	542_I	0.562	0.50
351_N	545_V	0.561	0.50
358_E	367_M	0.561	0.50
559_I	640_L	0.560	0.50
514_E	623_A	0.560	0.50
313_V	598_F	0.559	0.50
245_Q	274_K	0.558	0.49
70_V	431_V	0.558	0.49
65_H	94_D	0.558	0.49
131_A	160_E	0.557	0.49
430_K	457_K	0.557	0.49
259_K	272_Q	0.557	0.49
563_I	661_V	0.557	0.49
265_A	270_A	0.556	0.49
76_N	371_L	0.556	0.49
350_L	611_H	0.556	0.49
148_D	155_I	0.556	0.49
170_I	174_E	0.555	0.49
13_E	65_H	0.555	0.49
22_N	644_L	0.555	0.49
542_I	666_D	0.554	0.49
461_K	467_V	0.553	0.49
274_K	279_A	0.553	0.49
442_V	485_I	0.553	0.49
47_T	347_S	0.553	0.49
256_E	259_K	0.553	0.49
317_G	633_Q	0.552	0.49
178_L	184_Y	0.552	0.49
546_L	565_T	0.552	0.49
279_A	282_D	0.551	0.49
553_E	639_S	0.551	0.49
565_T	611_H	0.551	0.49
9_V	639_S	0.551	0.49
103_I	109_G	0.549	0.48
318_R	565_T	0.548	0.48
479_N	482_Y	0.548	0.48
233_N	239_E	0.547	0.48
393_T	497_S	0.547	0.48
228_I	235_V	0.547	0.48
379_I	409_S	0.547	0.48
6_Y	21_C	0.546	0.48
312_L	548_I	0.546	0.48
423_K	427_E	0.546	0.48
170_I	183_V	0.546	0.48
127_A	131_A	0.546	0.48
572_D	575_Q	0.546	0.48
314_I	661_V	0.546	0.48
177_M	182_R	0.546	0.48
463_L	474_E	0.545	0.48
267_A	273_E	0.545	0.48
397_E	644_L	0.545	0.48
130_A	601_E	0.545	0.48
66_L	69_N	0.545	0.48
20_T	23_E	0.544	0.48
208_T	271_K	0.544	0.48
150_F	155_I	0.544	0.48
568_I	610_L	0.544	0.48
431_V	603_T	0.543	0.48
231_L	237_E	0.543	0.48
244_I	278_P	0.542	0.47
316_R	390_L	0.542	0.47
201_P	212_G	0.542	0.47
454_N	497_S	0.542	0.47
256_E	265_A	0.540	0.47
212_G	215_F	0.540	0.47
91_E	596_E	0.539	0.47
361_F	388_T	0.539	0.47
517_G	654_T	0.539	0.47
47_T	343_G	0.539	0.47
183_V	234_G	0.538	0.47
255_P	273_E	0.538	0.47
550_L	595_K	0.538	0.47
512_K	545_V	0.538	0.47
379_I	613_I	0.537	0.47
463_L	522_V	0.536	0.47
559_I	565_T	0.536	0.47
266_A	275_Q	0.536	0.47
394_V	405_L	0.536	0.47
264_P	286_K	0.536	0.47
260_Q	271_K	0.536	0.47
276_K	282_D	0.535	0.47
398_I	589_V	0.535	0.47
403_V	508_V	0.535	0.47
133_A	166_Y	0.534	0.46
398_I	520_V	0.533	0.46
134_E	148_D	0.533	0.46
563_I	621_P	0.533	0.46
314_I	544_S	0.533	0.46
200_I	206_L	0.533	0.46
63_L	96_L	0.532	0.46
632_Q	635_V	0.532	0.46
90_F	366_R	0.532	0.46
228_I	232_I	0.532	0.46
357_V	399_G	0.532	0.46
133_A	152_R	0.531	0.46
89_L	533_S	0.531	0.46
173_N	239_E	0.530	0.46
71_L	644_L	0.530	0.46
438_S	443_F	0.530	0.46
299_I	302_L	0.530	0.46
27_L	128_E	0.528	0.46
75_R	400_D	0.528	0.46
159_E	164_K	0.528	0.46
313_V	649_A	0.527	0.46
193_V	228_I	0.527	0.46
272_Q	278_P	0.526	0.46
161_Q	280_K	0.526	0.46
42_F	94_D	0.526	0.46
244_I	264_P	0.525	0.45
101_Q	104_I	0.525	0.45
243_V	262_D	0.525	0.45
352_M	544_S	0.524	0.45
137_E	261_E	0.524	0.45
240_H	277_Q	0.523	0.45
220_L	274_K	0.523	0.45
58_T	410_I	0.523	0.45
258_S	261_E	0.523	0.45
173_N	240_H	0.522	0.45
559_I	666_D	0.521	0.45
92_A	560_S	0.521	0.45
70_V	79_M	0.520	0.45
351_N	544_S	0.520	0.45
140_S	151_E	0.520	0.45
561_S	615_V	0.519	0.45
397_E	512_K	0.519	0.45
207_E	213_T	0.518	0.45
95_H	113_I	0.518	0.45
345_L	433_L	0.517	0.44
409_S	493_A	0.517	0.44
281_N	287_H	0.516	0.44
223_Q	235_V	0.515	0.44
212_G	216_Q	0.514	0.44
21_C	41_I	0.514	0.44
267_A	271_K	0.513	0.44
228_I	236_S	0.512	0.44
155_I	160_E	0.512	0.44
47_T	403_V	0.512	0.44
346_Q	349_I	0.511	0.44
137_E	264_P	0.511	0.44
172_L	183_V	0.511	0.44
166_Y	232_I	0.511	0.44
84_D	128_E	0.510	0.44
261_E	269_P	0.510	0.44
216_Q	614_V	0.509	0.43
263_S	266_A	0.509	0.43
280_K	456_K	0.508	0.43
630_I	662_A	0.508	0.43
453_L	532_F	0.508	0.43
310_E	616_K	0.508	0.43
116_V	123_N	0.508	0.43
219_F	235_V	0.507	0.43
256_E	278_P	0.507	0.43
25_L	422_Q	0.506	0.43
316_R	644_L	0.506	0.43
180_A	232_I	0.505	0.43
72_D	75_R	0.505	0.43
216_Q	242_E	0.505	0.43
171_S	202_S	0.505	0.43
51_M	182_R	0.504	0.43
169_K	172_L	0.504	0.43
131_A	260_Q	0.503	0.43
383_I	406_I	0.503	0.43
521_S	524_S	0.503	0.43
23_E	592_V	0.503	0.43
301_R	318_R	0.503	0.43
281_N	477_E	0.502	0.43
548_I	557_I	0.502	0.43
53_A	547_L	0.502	0.43
298_N	349_I	0.502	0.43
568_I	608_E	0.502	0.43
135_P	279_A	0.501	0.42
354_M	542_I	0.501	0.42
613_I	631_G	0.501	0.42
139_Q	147_Y	0.500	0.42
79_M	454_N	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1b3qA	2	0.564	100	0.514	Contact Map
2lp4A	1	0.3304	100	0.831	Contact Map
1i58A	2	0.2812	100	0.837	Contact Map
1i5nA	1	0.192	100	0.859	Contact Map
3kyjA	1	0.1875	99.9	0.866	Contact Map
2ld6A	1	0.1949	99.9	0.869	Contact Map
2lchA	1	0.1667	99.9	0.878	Contact Map
4jpbW	1	0.1905	99.9	0.882	Contact Map
2qdlA	1	0.2039	99.9	0.887	Contact Map
2ho9A	1	0.2113	99.9	0.887	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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