GREMLIN Database
FOLB - Dihydroneopterin aldolase
UniProt: P28823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (114)
Sequences: 2938 (2055)
Seq/√Len: 192.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_N55_E3.2941.00
22_N70_K2.8141.00
10_E27_R2.4571.00
44_T49_Q2.3631.00
34_A56_L2.3401.00
35_E92_Q2.3371.00
32_L60_C2.2781.00
59_V86_K2.1231.00
22_N68_P2.1161.00
33_T94_T2.1091.00
92_Q116_T2.0771.00
94_T116_T2.0441.00
69_V78_R2.0021.00
98_I110_S1.9491.00
40_K49_Q1.9151.00
77_E81_G1.8831.00
17_V47_L1.7911.00
8_G31_D1.7871.00
96_K114_E1.7751.00
64_V75_L1.7531.00
3_K33_T1.6961.00
5_Y112_A1.6881.00
12_Y27_R1.5751.00
83_V90_V1.5601.00
27_R101_D1.5601.00
63_I82_T1.5391.00
62_D66_G1.5351.00
61_K65_E1.5241.00
94_T114_E1.5241.00
32_L95_V1.4151.00
74_T78_R1.3771.00
96_K112_A1.3761.00
59_V82_T1.3371.00
42_G77_E1.3271.00
30_V64_V1.3071.00
36_L51_I1.2981.00
31_D98_I1.2701.00
20_E23_K1.2591.00
69_V75_L1.2581.00
59_V87_F1.2401.00
8_G29_K1.2401.00
10_E29_K1.2401.00
20_E24_L1.1951.00
11_F57_Y1.1901.00
18_F54_A1.1791.00
3_K114_E1.1701.00
80_A115_I1.1461.00
56_L83_V1.1431.00
3_K35_E1.1161.00
14_Y25_G1.1021.00
30_V79_I1.0871.00
46_D49_Q1.0831.00
69_V74_T1.0801.00
7_E96_K1.0611.00
9_M57_Y1.0571.00
31_D96_K1.0291.00
5_Y33_T1.0091.00
7_E110_S0.9961.00
6_V57_Y0.9951.00
11_F64_V0.9860.99
57_Y106_G0.9860.99
34_A90_V0.9840.99
51_I90_V0.9820.99
80_A93_C0.9750.99
47_L52_N0.9660.99
63_I78_R0.9490.99
21_E99_K0.9410.99
54_A58_H0.9270.99
60_C79_I0.9270.99
15_H28_F0.9180.99
61_K106_G0.9030.99
47_L50_T0.8970.99
40_K44_T0.8960.99
9_M60_C0.8940.99
12_Y25_G0.8820.99
112_A115_I0.8760.99
98_I108_Y0.8740.99
14_Y24_L0.8670.99
13_G28_F0.8600.99
58_H106_G0.8600.99
80_A95_V0.8530.98
76_A115_I0.8290.98
81_G85_G0.8240.98
19_T23_K0.8240.98
67_E78_R0.8160.98
7_E33_T0.8100.98
52_N58_H0.8100.98
5_Y114_E0.8070.98
38_L115_I0.7920.98
58_H62_D0.7900.97
42_G74_T0.7860.97
104_I111_V0.7820.97
58_H61_K0.7780.97
73_E99_K0.7780.97
77_E115_I0.7670.97
10_E107_H0.7670.97
5_Y96_K0.7650.97
84_L93_C0.7650.97
35_E94_T0.7470.96
38_L42_G0.7380.96
58_H105_P0.7240.96
30_V97_V0.7060.95
39_S43_Q0.7050.95
39_S42_G0.7040.95
98_I112_A0.7000.95
60_C95_V0.6920.95
11_F61_K0.6920.95
2_D42_G0.6880.94
21_E73_E0.6860.94
61_K105_P0.6850.94
63_I67_E0.6790.94
9_M106_G0.6780.94
34_A93_C0.6770.94
36_L50_T0.6700.94
38_L41_A0.6690.94
19_T22_N0.6610.93
76_A113_I0.6600.93
110_S115_I0.6520.93
54_A104_I0.6520.93
14_Y68_P0.6470.92
50_T71_L0.6410.92
79_I95_V0.6370.92
16_G99_K0.6360.92
98_I102_P0.6340.92
35_E91_Q0.6300.91
38_L50_T0.6290.91
2_D117_R0.6270.91
22_N67_E0.6210.91
2_D26_Q0.6210.91
24_L27_R0.6200.91
51_I89_P0.6140.90
43_Q85_G0.6130.90
37_D42_G0.6060.90
4_V50_T0.6040.90
32_L35_E0.6010.89
77_E117_R0.5990.89
21_E71_L0.5990.89
59_V85_G0.5950.89
63_I69_V0.5950.89
29_K98_I0.5940.89
39_S77_E0.5920.89
82_T86_K0.5920.89
102_P108_Y0.5910.89
63_I79_I0.5840.88
14_Y22_N0.5800.88
8_G98_I0.5790.88
59_V62_D0.5740.87
26_Q100_P0.5670.86
8_G110_S0.5620.86
76_A97_V0.5610.86
71_L99_K0.5560.85
86_K89_P0.5550.85
80_A84_L0.5540.85
43_Q46_D0.5510.85
28_F103_P0.5510.85
11_F65_E0.5410.84
75_L79_I0.5350.83
43_Q81_G0.5340.83
15_H103_P0.5320.83
75_L78_R0.5320.83
39_S116_T0.5310.83
40_K43_Q0.5270.82
71_L74_T0.5240.82
55_E59_V0.5200.81
11_F106_G0.5200.81
15_H108_Y0.5170.81
34_A60_C0.5130.81
16_G21_E0.5070.80
6_V11_F0.5050.80
35_E116_T0.5030.79
45_D53_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sqlA 5 1 100 0.086 Contact Map
1dhnA 4 1 100 0.086 Contact Map
3r2eA 4 0.9667 100 0.102 Contact Map
2o90A 4 0.9583 100 0.102 Contact Map
1z9wA 3 0.9 100 0.104 Contact Map
1nbuA 4 0.9833 100 0.105 Contact Map
3o1kA 4 0.9667 100 0.118 Contact Map
2cg8A 4 0.9667 100 0.126 Contact Map
1b9lA 4 0.9667 100 0.126 Contact Map
4aeyA 3 0.875 100 0.128 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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