GREMLIN Database
DHPS - Dihydropteroate synthase
UniProt: P28822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (255)
Sequences: 4512 (3155)
Seq/√Len: 197.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E60_D2.9611.00
117_V145_V2.9201.00
207_K210_I2.8611.00
267_A271_K2.8551.00
81_E111_S2.7811.00
69_G88_V2.7291.00
222_T246_T2.7151.00
228_I242_G2.6581.00
96_T122_S2.5791.00
58_I101_V2.5481.00
209_E253_K2.5381.00
114_D142_E2.4251.00
177_V183_E2.3991.00
117_V143_H2.3581.00
82_D86_S2.2111.00
234_L268_R2.1991.00
241_E268_R2.1701.00
172_S175_I2.1671.00
124_I140_A2.0851.00
229_G239_R2.0701.00
105_V116_A2.0121.00
135_K138_S1.9881.00
27_V267_A1.9681.00
220_L250_G1.9671.00
55_K98_E1.9661.00
85_M89_I1.9481.00
173_V216_Y1.9341.00
53_H56_E1.8761.00
226_R230_R1.8731.00
240_A265_Q1.8451.00
29_G57_M1.8371.00
139_V143_H1.8041.00
247_V266_I1.7921.00
244_G269_M1.7571.00
110_A133_D1.7331.00
248_C273_M1.7301.00
240_A262_D1.7211.00
83_E86_S1.7121.00
60_D264_K1.7061.00
54_A95_I1.6991.00
44_Y53_H1.6941.00
249_L252_Q1.6911.00
123_I148_V1.6621.00
114_D118_K1.6541.00
174_K178_E1.6461.00
26_L63_H1.6231.00
243_T247_V1.6151.00
70_E109_K1.6151.00
115_E118_K1.6081.00
212_S256_D1.5971.00
251_I270_A1.5941.00
72_T127_I1.5931.00
130_A147_I1.5861.00
165_M204_V1.5861.00
85_M115_E1.5811.00
31_L57_M1.5771.00
113_A136_M1.5301.00
24_K63_H1.5271.00
80_S83_E1.5271.00
156_R200_D1.5221.00
203_A207_K1.5211.00
43_K237_E1.5131.00
240_A244_G1.5011.00
187_I257_I1.4771.00
85_M112_V1.4481.00
235_P238_E1.4331.00
107_T113_A1.4251.00
55_K99_L1.4131.00
46_S49_K1.4011.00
50_A91_V1.4011.00
118_K143_H1.3811.00
111_S115_E1.3751.00
192_I222_T1.3751.00
28_M219_L1.3651.00
117_V139_V1.3581.00
55_K59_D1.3531.00
153_R195_A1.3351.00
176_A181_V1.3221.00
94_R98_E1.3131.00
198_Y227_F1.2991.00
160_D163_P1.2981.00
138_S179_A1.2951.00
52_L55_K1.2811.00
231_V272_M1.2741.00
208_L220_L1.2631.00
88_V105_V1.2621.00
243_T266_I1.2571.00
48_D52_L1.2491.00
92_I116_A1.2221.00
198_Y231_V1.2191.00
247_V258_V1.2071.00
51_L55_K1.2031.00
166_L210_I1.2021.00
197_T200_D1.1981.00
183_E216_Y1.1971.00
174_K177_V1.1881.00
114_D143_H1.1871.00
67_I95_I1.1831.00
25_T274_D1.1771.00
249_L276_M1.1701.00
212_S218_V1.1661.00
63_H267_A1.1661.00
182_D185_N1.1641.00
128_W132_H1.1501.00
202_L231_V1.1411.00
138_S142_E1.1321.00
54_A65_I1.1281.00
241_E244_G1.1181.00
244_G266_I1.1171.00
165_M169_L1.1171.00
129_G149_L1.1131.00
153_R156_R1.1011.00
248_C269_M1.0951.00
51_L94_R1.0831.00
173_V188_L1.0791.00
40_D44_Y1.0771.00
31_L65_I1.0761.00
144_N185_N1.0691.00
109_K112_V1.0651.00
158_Y164_D1.0621.00
146_P187_I1.0611.00
251_I258_V1.0611.00
166_L211_F1.0551.00
166_L213_G1.0501.00
130_A137_A1.0491.00
92_I119_A1.0401.00
188_L216_Y1.0381.00
49_K52_L1.0351.00
93_E119_A1.0311.00
234_L238_E1.0311.00
81_E85_M1.0261.00
81_E109_K1.0131.00
51_L54_A1.0091.00
110_A139_V1.0091.00
24_K274_D1.0061.00
220_L255_C1.0021.00
222_T247_V0.9991.00
36_D73_R0.9971.00
96_T103_I0.9971.00
252_Q273_M0.9871.00
137_A175_I0.9861.00
146_P185_N0.9841.00
70_E108_Y0.9780.99
166_L214_L0.9770.99
114_D139_V0.9710.99
54_A99_L0.9710.99
156_R195_A0.9650.99
153_R168_D0.9590.99
93_E97_K0.9560.99
173_V186_I0.9550.99
166_L170_M0.9530.99
108_Y128_W0.9490.99
25_T258_V0.9490.99
249_L253_K0.9480.99
210_I213_G0.9470.99
221_A257_I0.9460.99
163_P167_S0.9440.99
64_I257_I0.9420.99
198_Y230_R0.9400.99
27_V270_A0.9400.99
64_I123_I0.9370.99
94_R97_K0.9300.99
248_C252_Q0.9200.99
128_W133_D0.9180.99
93_E118_K0.9150.99
53_H57_M0.8960.99
41_G44_Y0.8890.99
132_H168_D0.8890.99
58_I99_L0.8860.99
51_L91_V0.8820.99
102_P122_S0.8800.99
67_I103_I0.8750.99
202_L275_A0.8630.99
192_I220_L0.8620.99
186_I216_Y0.8570.99
244_G248_C0.8550.99
250_G255_C0.8520.99
133_D136_M0.8510.99
173_V177_V0.8460.99
153_R200_D0.8440.98
192_I227_F0.8430.98
62_A263_V0.8420.98
60_D265_Q0.8370.98
103_I121_A0.8370.98
203_A206_N0.8360.98
105_V121_A0.8350.98
192_I208_L0.8310.98
162_L204_V0.8300.98
188_L218_V0.8270.98
241_E245_A0.8260.98
252_Q277_L0.8250.98
39_S240_A0.8230.98
56_E59_D0.8230.98
161_L165_M0.8200.98
224_R262_D0.8190.98
111_S114_D0.8150.98
266_I269_M0.8120.98
162_L165_M0.8080.98
245_A248_C0.8070.98
269_M273_M0.8020.98
132_H152_N0.8010.98
162_L207_K0.8000.98
79_V109_K0.8000.98
173_V214_L0.7990.98
202_L227_F0.7970.98
262_D265_Q0.7940.98
140_A147_I0.7920.98
33_V69_G0.7910.98
248_C270_A0.7900.98
169_L188_L0.7880.98
149_L176_A0.7860.98
89_I115_E0.7830.98
200_D203_A0.7770.97
188_L214_L0.7770.97
114_D135_K0.7660.97
141_A179_A0.7530.97
52_L56_E0.7530.97
47_L94_R0.7520.97
89_I119_A0.7500.97
156_R197_T0.7480.97
70_E78_C0.7460.97
31_L53_H0.7450.97
151_H196_K0.7430.97
170_M214_L0.7390.97
29_G263_V0.7380.96
198_Y201_N0.7370.96
144_N182_D0.7360.96
163_P210_I0.7350.96
202_L272_M0.7340.96
159_N164_D0.7320.96
95_I103_I0.7300.96
206_N277_L0.7300.96
241_E265_Q0.7300.96
251_I273_M0.7250.96
208_L250_G0.7240.96
176_A179_A0.7230.96
25_T251_I0.7230.96
110_A135_K0.7220.96
57_M62_A0.7170.96
273_M277_L0.7160.96
177_V216_Y0.7160.96
205_M227_F0.7140.96
181_V185_N0.7140.96
28_M257_I0.7120.96
85_M116_A0.7080.96
141_A181_V0.7050.95
115_E119_A0.7040.95
33_V91_V0.7030.95
175_I179_A0.7020.95
40_D43_K0.7020.95
111_S135_K0.7010.95
55_K58_I0.6990.95
129_G172_S0.6960.95
95_I99_L0.6910.95
137_A176_A0.6850.95
147_I186_I0.6830.95
205_M222_T0.6820.95
243_T260_V0.6800.94
229_G232_L0.6790.94
231_V275_A0.6760.94
192_I205_M0.6760.94
80_S86_S0.6750.94
127_I152_N0.6740.94
89_I93_E0.6700.94
85_M111_S0.6670.94
198_Y202_L0.6630.94
247_V270_A0.6620.94
62_A65_I0.6600.94
161_L204_V0.6590.94
153_R164_D0.6540.93
268_R272_M0.6530.93
130_A176_A0.6510.93
63_H102_P0.6480.93
51_L98_E0.6450.93
92_I96_T0.6440.93
264_K268_R0.6440.93
39_S42_G0.6420.93
89_I116_A0.6390.92
228_I272_M0.6380.92
90_P93_E0.6370.92
246_T272_M0.6350.92
226_R240_A0.6340.92
69_G92_I0.6310.92
88_V92_I0.6300.92
110_A128_W0.6280.92
82_D111_S0.6270.92
146_P217_P0.6260.92
89_I92_I0.6250.92
242_G268_R0.6250.92
208_L255_C0.6240.92
171_E175_I0.6210.91
205_M220_L0.6210.91
45_D49_K0.6210.91
169_L173_V0.6190.91
234_L264_K0.6190.91
66_D104_S0.6160.91
202_L276_M0.6160.91
170_M213_G0.6140.91
141_A176_A0.6120.91
249_L273_M0.6090.91
57_M65_I0.6050.90
27_V263_V0.6050.90
270_A274_D0.6000.90
166_L188_L0.5970.90
39_S224_R0.5970.90
51_L99_L0.5970.90
244_G247_V0.5960.90
130_A140_A0.5940.89
78_C132_H0.5910.89
158_Y200_D0.5870.89
21_Y26_L0.5860.89
123_I146_P0.5820.89
229_G236_P0.5820.89
171_E174_K0.5790.88
205_M246_T0.5780.88
164_D167_S0.5780.88
57_M263_V0.5770.88
117_V124_I0.5760.88
136_M147_I0.5750.88
31_L44_Y0.5740.88
271_K274_D0.5690.87
247_V260_V0.5670.87
35_P87_R0.5660.87
137_A141_A0.5660.87
167_S170_M0.5590.86
137_A179_A0.5580.86
232_L268_R0.5560.86
151_H158_Y0.5550.86
130_A149_L0.5540.86
123_I187_I0.5520.86
76_A154_P0.5510.86
266_I270_A0.5500.86
108_Y127_I0.5490.85
160_D207_K0.5480.85
137_A172_S0.5480.85
137_A147_I0.5450.85
153_R158_Y0.5450.85
209_E212_S0.5440.85
67_I92_I0.5430.85
72_T152_N0.5430.85
167_S171_E0.5420.85
150_M191_G0.5400.85
160_D164_D0.5380.84
128_W152_N0.5360.84
109_K133_D0.5350.84
162_L203_A0.5340.84
51_L95_I0.5340.84
47_L91_V0.5330.84
176_A186_I0.5320.84
140_A181_V0.5290.83
47_L51_L0.5290.83
39_S44_Y0.5280.83
228_I246_T0.5280.83
76_A79_V0.5280.83
163_P166_L0.5270.83
58_I102_P0.5260.83
136_M139_V0.5260.83
33_V88_V0.5240.83
28_M64_I0.5240.83
170_M173_V0.5230.83
92_I103_I0.5180.82
168_D172_S0.5150.82
248_C277_L0.5150.82
161_L200_D0.5130.81
208_L212_S0.5130.81
44_Y50_A0.5100.81
128_W154_P0.5100.81
47_L50_A0.5090.81
130_A136_M0.5070.81
152_N172_S0.5060.81
113_A124_I0.5050.80
84_E109_K0.5050.80
73_R76_A0.5040.80
162_L210_I0.5040.80
54_A58_I0.5040.80
157_N200_D0.5040.80
42_G53_H0.5030.80
35_P83_E0.5020.80
170_M174_K0.5010.80
110_A136_M0.5010.80
70_E79_V0.5000.80
129_G168_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bmbA 1 0.9789 100 0.165 Contact Map
2vefA 1 0.8632 100 0.183 Contact Map
2vp8A 2 0.8105 100 0.187 Contact Map
4nirA 3 0.9614 100 0.203 Contact Map
2dqwA 2 0.8632 100 0.214 Contact Map
3tr9A 3 0.9333 100 0.223 Contact Map
1eyeA 2 0.8491 100 0.225 Contact Map
2y5sA 2 0.9333 100 0.226 Contact Map
4pzvA 1 0.8702 100 0.235 Contact Map
1aj0A 1 0.9579 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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