GREMLIN Database
PABC - Aminodeoxychorismate lyase
UniProt: P28821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (269)
Sequences: 8894 (5875)
Seq/√Len: 358.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_C223_K4.4931.00
192_C221_E3.2401.00
193_I215_A3.1741.00
48_E65_K3.1261.00
51_E65_K3.0591.00
225_G231_A3.0421.00
8_Y78_L2.5911.00
204_D209_R2.5661.00
126_Q129_G2.5641.00
271_L275_K2.4331.00
194_Y225_G2.4161.00
176_A226_R2.4141.00
64_S67_E2.3931.00
74_K78_L2.3921.00
218_I272_L2.3551.00
45_W209_R2.2371.00
58_Q162_N2.2101.00
189_K236_D2.1651.00
70_E74_K2.1581.00
129_G132_L2.1351.00
28_G147_S2.1111.00
212_I222_L2.0911.00
238_A250_F2.0041.00
29_V53_A1.9961.00
180_G183_S1.9831.00
218_I268_A1.9331.00
55_K62_T1.9151.00
184_N205_G1.8951.00
74_K77_K1.8881.00
50_L92_I1.8271.00
131_V252_K1.7951.00
44_D69_L1.7901.00
209_R213_E1.7811.00
267_S271_L1.7701.00
42_L210_F1.7691.00
27_I94_A1.7611.00
133_S159_E1.6881.00
159_E163_D1.6771.00
187_W227_Y1.6701.00
268_A272_L1.6681.00
36_Y246_E1.6621.00
11_E17_S1.6461.00
188_R265_A1.6231.00
128_E252_K1.6021.00
54_L92_I1.5741.00
5_N110_T1.5671.00
211_I241_T1.5671.00
10_E13_D1.5601.00
71_M111_V1.5571.00
238_A253_I1.5541.00
29_V54_L1.5451.00
185_V238_A1.5401.00
48_E52_R1.5301.00
252_K255_E1.5111.00
197_S226_R1.5101.00
43_L47_I1.5091.00
272_L275_K1.5031.00
59_I92_I1.5021.00
44_D48_E1.4981.00
186_F241_T1.4971.00
180_G240_M1.4781.00
176_A228_E1.4491.00
193_I220_L1.4421.00
172_T176_A1.4381.00
43_L69_L1.4161.00
33_F40_P1.4111.00
213_E217_D1.4111.00
69_L73_D1.4091.00
81_I86_A1.4041.00
187_W235_A1.3951.00
52_R55_K1.3951.00
268_A271_L1.3571.00
187_W194_Y1.3521.00
215_A220_L1.3521.00
186_F239_W1.3441.00
35_L76_L1.3421.00
208_R224_T1.3261.00
52_R204_D1.3241.00
200_T226_R1.3201.00
59_I109_P1.3001.00
188_R193_I1.2931.00
70_E73_D1.2901.00
187_W238_A1.2791.00
40_P43_L1.2751.00
42_L45_W1.2741.00
22_G28_G1.2671.00
45_W213_E1.2661.00
24_L89_R1.2501.00
237_E263_G1.2471.00
158_R162_N1.2461.00
169_I185_V1.2431.00
189_K234_T1.2431.00
195_T208_R1.2381.00
233_L256_V1.2331.00
3_Y71_M1.2191.00
75_L113_C1.2111.00
45_W48_E1.2101.00
125_L129_G1.2071.00
262_S267_S1.2061.00
35_L86_A1.2021.00
242_N245_L1.1991.00
53_A145_L1.1951.00
72_L88_V1.1891.00
73_D77_K1.1851.00
67_E70_E1.1731.00
194_Y223_K1.1721.00
20_D93_S1.1641.00
66_H70_E1.1591.00
252_K257_N1.1531.00
40_P72_L1.1531.00
220_L265_A1.1481.00
22_G93_S1.1461.00
56_D145_L1.1431.00
228_E231_A1.1331.00
189_K194_Y1.1301.00
28_G148_H1.1281.00
237_E266_T1.1261.00
71_M113_C1.1111.00
230_E234_T1.1021.00
3_Y8_Y1.1021.00
189_K231_A1.0981.00
8_Y75_L1.0931.00
215_A269_L1.0931.00
227_Y231_A1.0761.00
156_A170_F1.0691.00
208_R212_I1.0621.00
186_F208_R1.0601.00
29_V50_L1.0551.00
72_L113_C1.0481.00
198_L208_R1.0461.00
194_Y227_Y1.0421.00
92_I111_V1.0391.00
197_S225_G1.0381.00
91_N112_L1.0381.00
157_K161_G1.0341.00
23_F93_S1.0291.00
65_K69_L1.0231.00
47_I69_L1.0191.00
240_M250_F1.0081.00
197_S224_T1.0081.00
30_F150_Y0.9951.00
51_E62_T0.9891.00
186_F212_I0.9871.00
172_T201_G0.9771.00
167_E181_I0.9771.00
270_Q274_K0.9771.00
3_Y63_V0.9761.00
175_G230_E0.9761.00
75_L115_V0.9741.00
198_L204_D0.9691.00
51_E55_K0.9691.00
191_R236_D0.9641.00
44_D65_K0.9621.00
128_E131_V0.9611.00
29_V92_I0.9601.00
127_K132_L0.9581.00
52_R144_R0.9571.00
159_E162_N0.9561.00
56_D144_R0.9511.00
169_I232_L0.9491.00
4_V14_A0.9441.00
216_K221_E0.9361.00
128_E251_T0.9351.00
215_A222_L0.9351.00
76_L86_A0.9251.00
177_V185_V0.9251.00
126_Q131_V0.9191.00
95_G110_T0.9181.00
216_K224_T0.9161.00
48_E51_E0.9121.00
52_R56_D0.9091.00
196_P227_Y0.9091.00
129_G180_G0.9061.00
45_W210_F0.9051.00
263_G266_T0.9031.00
77_K80_D0.8981.00
167_E180_G0.8961.00
129_G250_F0.8951.00
184_N241_T0.8941.00
24_L91_N0.8901.00
18_P112_L0.8751.00
205_G241_T0.8751.00
190_G236_D0.8731.00
188_R237_E0.8691.00
213_E216_K0.8671.00
16_L23_F0.8611.00
24_L114_F0.8501.00
45_W206_V0.8461.00
47_I72_L0.8451.00
124_P128_E0.8361.00
51_E68_I0.8361.00
75_L79_N0.8341.00
138_T173_E0.8331.00
47_I51_E0.8331.00
58_Q158_R0.8331.00
171_L229_L0.8321.00
254_E257_N0.8311.00
264_E268_A0.8301.00
156_A181_I0.8221.00
7_R15_V0.8221.00
54_L59_I0.8211.00
217_D272_L0.8201.00
191_R221_E0.8201.00
177_V187_W0.8171.00
168_G181_I0.8161.00
47_I65_K0.8141.00
67_E71_M0.8111.00
265_A268_A0.8091.00
20_D95_G0.8081.00
264_E267_S0.8041.00
267_S270_Q0.8031.00
13_D17_S0.7981.00
167_E183_S0.7981.00
86_A115_V0.7951.00
37_E82_K0.7931.00
212_I224_T0.7881.00
124_P127_K0.7861.00
15_V18_P0.7811.00
57_L151_L0.7811.00
33_F72_L0.7771.00
35_L40_P0.7761.00
214_N218_I0.7741.00
102_V161_G0.7691.00
8_Y71_M0.7691.00
263_G267_S0.7671.00
135_R140_E0.7641.00
194_Y231_A0.7621.00
43_L72_L0.7621.00
4_V112_L0.7611.00
174_D226_R0.7591.00
235_A238_A0.7581.00
71_M74_K0.7561.00
20_D97_S0.7551.00
35_L88_V0.7531.00
66_H69_L0.7501.00
63_V67_E0.7491.00
179_E203_L0.7481.00
91_N148_H0.7431.00
128_E166_V0.7411.00
188_R239_W0.7391.00
230_E233_L0.7381.00
212_I216_K0.7351.00
215_A218_I0.7351.00
185_V196_P0.7341.00
36_Y41_F0.7311.00
191_R220_L0.7311.00
34_R243_S0.7311.00
23_F112_L0.7251.00
251_T262_S0.7240.99
231_A234_T0.7230.99
127_K131_V0.7230.99
68_I111_V0.7230.99
210_F213_E0.7220.99
47_I68_I0.7220.99
217_D276_E0.7180.99
87_R244_V0.7160.99
137_N141_G0.7160.99
156_A168_G0.7120.99
41_F210_F0.7120.99
96_I110_T0.7110.99
199_D226_R0.7110.99
259_G263_G0.7110.99
104_Q107_D0.7100.99
93_S112_L0.7090.99
63_V71_M0.7080.99
173_E176_A0.7030.99
245_L248_I0.7030.99
14_A112_L0.7010.99
26_G149_H0.6990.99
32_T87_R0.6970.99
197_S200_T0.6960.99
31_E53_A0.6930.99
163_D254_E0.6890.99
127_K130_K0.6850.99
11_E19_F0.6790.99
157_K167_E0.6780.99
158_R161_G0.6760.99
232_L253_I0.6750.99
27_I154_M0.6750.99
137_N140_E0.6740.99
34_R246_E0.6740.99
4_V9_M0.6720.99
103_A158_R0.6670.99
21_H27_I0.6630.99
132_L169_I0.6630.99
186_F195_T0.6620.99
33_F90_L0.6620.99
195_T224_T0.6590.99
14_A18_P0.6550.99
157_K182_I0.6520.99
37_E83_D0.6500.99
101_F153_N0.6500.99
32_T244_V0.6500.99
129_G169_I0.6490.99
210_F214_N0.6470.99
160_I164_P0.6470.99
169_I238_A0.6440.99
247_I269_L0.6440.99
48_E209_R0.6430.99
175_G229_L0.6430.99
23_F91_N0.6420.99
131_V254_E0.6420.99
63_V111_V0.6420.99
171_L177_V0.6360.99
102_V107_D0.6340.99
183_S240_M0.6330.99
246_E274_K0.6320.99
125_L128_E0.6320.99
8_Y74_K0.6280.99
22_G147_S0.6250.99
130_K163_D0.6230.98
232_L238_A0.6220.98
177_V227_Y0.6220.98
32_T242_N0.6190.98
260_S263_G0.6180.98
93_S110_T0.6160.98
87_R116_N0.6160.98
79_N115_V0.6130.98
126_Q132_L0.6130.98
130_K165_R0.6130.98
193_I239_W0.6120.98
214_N272_L0.6120.98
138_T141_G0.6120.98
40_P73_D0.6110.98
51_E64_S0.6100.98
211_I269_L0.6080.98
190_G221_E0.6070.98
29_V57_L0.6060.98
125_L132_L0.6060.98
146_K203_L0.6050.98
227_Y235_A0.6030.98
259_G262_S0.6020.98
187_W232_L0.6010.98
9_M12_K0.6010.98
189_K235_A0.5970.98
156_A159_E0.5950.98
21_H94_A0.5920.98
246_E273_Y0.5920.98
193_I265_A0.5880.98
178_A202_I0.5860.98
16_L20_D0.5850.98
189_K192_C0.5820.98
136_R140_E0.5820.98
238_A258_Y0.5810.98
72_L90_L0.5800.98
130_K252_K0.5790.98
229_L233_L0.5770.98
186_F193_I0.5760.98
188_R191_R0.5750.97
55_K60_E0.5730.97
130_K166_V0.5700.97
133_S163_D0.5680.97
50_L90_L0.5670.97
43_L73_D0.5650.97
19_F96_I0.5640.97
133_S136_R0.5640.97
233_L254_E0.5630.97
150_Y153_N0.5630.97
216_K222_L0.5620.97
206_V209_R0.5590.97
137_N152_N0.5540.97
207_T273_Y0.5540.97
89_R148_H0.5530.97
160_I168_G0.5530.97
33_F43_L0.5510.97
140_E143_F0.5480.97
134_I137_N0.5460.97
207_T243_S0.5430.96
42_L206_V0.5420.96
184_N204_D0.5410.96
195_T198_L0.5400.96
126_Q248_I0.5390.96
251_T258_Y0.5370.96
137_N143_F0.5360.96
135_R139_P0.5330.96
31_E50_L0.5300.96
206_V210_F0.5300.96
134_I159_E0.5270.96
41_F243_S0.5260.96
165_R252_K0.5260.96
150_Y203_L0.5240.96
146_K179_E0.5220.96
33_F47_I0.5180.95
22_G148_H0.5160.95
17_S96_I0.5130.95
88_V115_V0.5120.95
27_I59_I0.5110.95
25_Y149_H0.5110.95
19_F24_L0.5110.95
210_F273_Y0.5100.95
11_E79_N0.5090.95
135_R138_T0.5090.95
81_I115_V0.5080.95
272_L276_E0.5070.95
249_P263_G0.5060.95
59_I94_A0.5040.95
187_W225_G0.5040.95
87_R99_K0.5040.95
7_R13_D0.5020.95
44_D66_H0.5020.95
90_L113_C0.5020.95
34_R118_L0.5010.95
29_V145_L0.5000.94
82_K86_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iyeA 5 0.9898 100 0.097 Contact Map
2eiyA 5 0.9863 100 0.11 Contact Map
3u0gA 5 0.9795 100 0.114 Contact Map
4chiA 2 0.9693 100 0.142 Contact Map
4tm5A 2 0.9488 100 0.151 Contact Map
3dtgA 2 0.9863 100 0.155 Contact Map
4cmfA 4 0.9761 100 0.156 Contact Map
3daaA 2 0.9283 100 0.157 Contact Map
3uzoA 2 0.9795 100 0.16 Contact Map
4dqnA 2 0.9863 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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