GREMLIN Database
PABB - Aminodeoxychorismate synthase component 1
UniProt: P28820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 470 (445)
Sequences: 5470 (3720)
Seq/√Len: 176.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_S355_G4.4471.00
81_H362_D4.2291.00
328_R356_E4.1851.00
376_I400_T4.1751.00
328_R359_D3.5621.00
199_E203_S3.5051.00
286_R301_E3.3611.00
276_L354_Q3.2181.00
335_N354_Q3.0051.00
212_Y217_D2.9721.00
441_V444_H2.9671.00
285_T346_V2.9631.00
212_Y390_E2.8341.00
336_E339_A2.7171.00
203_S443_K2.7111.00
33_V47_G2.6971.00
162_A165_K2.6261.00
199_E443_K2.6161.00
202_F434_A2.6081.00
228_S427_Q2.5751.00
198_T201_G2.5561.00
75_D368_H2.5301.00
404_G414_F2.5151.00
75_D78_R2.5041.00
383_R386_E2.4971.00
211_Q215_S2.4041.00
300_N304_H2.4011.00
299_A342_K2.3801.00
296_E300_N2.3371.00
333_R354_Q2.3341.00
288_R295_D2.3221.00
197_F205_A2.3181.00
228_S429_F2.3021.00
358_Q361_Y2.2831.00
218_V221_V2.2371.00
204_Q207_E2.2311.00
361_Y365_D2.2281.00
235_P260_Q2.1931.00
108_Y385_M2.1911.00
373_G416_I2.1381.00
230_S427_Q2.0991.00
275_K356_E2.0841.00
261_I398_L2.0741.00
296_E299_A2.0001.00
209_I221_V1.9941.00
276_L356_E1.9661.00
289_G294_E1.9641.00
42_R142_D1.9471.00
22_F32_H1.9301.00
387_I391_L1.9101.00
342_K347_M1.8901.00
220_Q435_G1.8851.00
45_I140_V1.8611.00
262_I423_A1.8521.00
323_L327_S1.8491.00
303_I349_I1.8451.00
340_I349_I1.8261.00
252_A403_I1.8201.00
290_K294_E1.8131.00
234_H237_Q1.8071.00
268_L413_Q1.7931.00
292_N296_E1.7931.00
252_A263_C1.7911.00
326_V369_A1.7791.00
21_Q141_Y1.7781.00
33_V103_I1.7761.00
443_K447_K1.7591.00
207_E210_K1.7491.00
423_A428_A1.7191.00
211_Q214_A1.7151.00
279_T319_E1.7081.00
294_E297_A1.6931.00
305_N308_E1.6921.00
196_P394_T1.6741.00
199_E446_Y1.6711.00
282_I350_V1.6401.00
341_E350_V1.6371.00
280_R341_E1.6351.00
289_G298_L1.6341.00
161_T165_K1.6081.00
255_E260_Q1.6071.00
23_E240_K1.5831.00
298_L301_E1.5781.00
328_R358_Q1.5771.00
102_A134_V1.5621.00
447_K451_K1.5601.00
207_E442_P1.5591.00
297_A301_E1.5441.00
367_I406_F1.5321.00
223_L434_A1.5291.00
209_I223_L1.4951.00
165_K168_E1.4831.00
291_T294_E1.4801.00
212_Y383_R1.4661.00
168_E172_M1.4571.00
225_I449_S1.4571.00
106_L110_Y1.4541.00
231_L423_A1.4521.00
398_L417_V1.4511.00
421_I428_A1.4211.00
277_L327_S1.4191.00
162_A173_W1.4091.00
212_Y387_I1.4051.00
162_A166_L1.4041.00
193_F229_Q1.3961.00
299_A340_I1.3901.00
208_K390_E1.3881.00
324_G330_G1.3731.00
263_C415_N1.3631.00
323_L355_G1.3571.00
109_D389_E1.3541.00
201_G204_Q1.3511.00
367_I414_F1.3361.00
444_H447_K1.3351.00
280_R336_E1.3351.00
120_L389_E1.3321.00
203_S207_E1.3251.00
206_V442_P1.3241.00
44_S143_H1.3231.00
169_L173_W1.3191.00
123_D126_E1.3081.00
238_I423_A1.2931.00
447_K450_F1.2911.00
226_R429_F1.2911.00
201_G393_P1.2891.00
18_F141_Y1.2861.00
31_H53_T1.2841.00
76_P130_I1.2821.00
194_A230_S1.2731.00
434_A449_S1.2731.00
55_K62_T1.2681.00
36_E243_R1.2651.00
278_E354_Q1.2601.00
446_Y450_F1.2601.00
235_P423_A1.2581.00
313_V337_F1.2561.00
199_E447_K1.2561.00
238_I421_I1.2531.00
165_K173_W1.2521.00
313_V338_M1.2521.00
218_V384_T1.2511.00
208_K211_Q1.2471.00
432_S453_A1.2391.00
335_N352_N1.2371.00
253_Y260_Q1.2351.00
224_S431_Q1.2331.00
252_A261_I1.2321.00
206_V436_V1.2321.00
421_I456_M1.2201.00
250_Y268_L1.2171.00
109_D395_R1.2121.00
203_S442_P1.2111.00
162_A172_M1.2071.00
222_N433_G1.2011.00
140_V151_I1.2011.00
357_L366_I1.1911.00
81_H365_D1.1901.00
134_V408_Y1.1831.00
81_H85_K1.1801.00
405_W413_Q1.1781.00
16_D24_K1.1771.00
383_R390_E1.1701.00
272_K277_L1.1641.00
293_E297_A1.1611.00
208_K212_Y1.1581.00
200_D204_Q1.1571.00
106_L406_F1.1481.00
407_G411_D1.1461.00
221_V388_I1.1441.00
207_E211_Q1.1431.00
272_K366_I1.1421.00
195_A225_I1.1341.00
225_I446_Y1.1301.00
165_K169_L1.1291.00
277_L323_L1.1291.00
204_Q208_K1.1241.00
167_S171_Q1.1221.00
26_A255_E1.1071.00
278_E352_N1.1051.00
316_V337_F1.1031.00
309_R338_M1.1021.00
299_A347_M1.1021.00
132_F414_F1.0991.00
123_D395_R1.0981.00
98_F101_G1.0971.00
398_L422_Y1.0971.00
214_A438_I1.0921.00
273_K411_D1.0891.00
225_I450_F1.0871.00
241_T462_L1.0841.00
118_K386_E1.0791.00
98_F103_I1.0791.00
76_P113_Y1.0781.00
201_G205_A1.0761.00
238_I262_I1.0751.00
230_S426_G1.0741.00
141_Y148_L1.0741.00
283_A375_T1.0731.00
275_K359_D1.0691.00
223_L436_V1.0691.00
229_Q428_A1.0681.00
364_V406_F1.0671.00
235_P253_Y1.0661.00
297_A300_N1.0641.00
75_D113_Y1.0631.00
403_I417_V1.0601.00
217_D383_R1.0571.00
197_F393_P1.0551.00
246_N264_G1.0551.00
127_T422_Y1.0521.00
79_A82_S1.0461.00
51_I136_D1.0431.00
236_Y253_Y1.0390.99
14_Q240_K1.0380.99
78_R82_S1.0360.99
286_R308_E1.0300.99
14_Q17_S1.0290.99
280_R352_N1.0270.99
231_L238_I1.0250.99
294_E298_L1.0240.99
272_K357_L1.0230.99
263_C403_I1.0210.99
17_S20_Q1.0180.99
252_A415_N1.0100.99
139_A148_L1.0090.99
402_S414_F1.0000.99
269_L370_V0.9940.99
137_D152_T0.9930.99
131_Y256_T0.9920.99
231_L428_A0.9890.99
246_N345_H0.9880.99
85_K362_D0.9880.99
446_Y449_S0.9880.99
430_M453_A0.9860.99
430_M457_Q0.9810.99
286_R298_L0.9790.99
221_V387_I0.9780.99
283_A312_H0.9760.99
78_R81_H0.9750.99
315_L375_T0.9740.99
303_I340_I0.9730.99
389_E395_R0.9700.99
97_D273_K0.9700.99
248_S251_M0.9660.99
163_D167_S0.9640.99
50_P135_F0.9610.99
80_F132_F0.9600.99
127_T259_F0.9580.99
269_L279_T0.9560.99
81_H368_H0.9530.99
161_T164_V0.9510.99
115_E382_V0.9500.99
64_K67_D0.9490.99
328_R331_S0.9480.99
239_Y243_R0.9470.99
261_I403_I0.9430.99
283_A315_L0.9410.99
125_L429_F0.9400.99
210_K438_I0.9390.99
112_R389_E0.9360.99
458_R461_E0.9340.99
323_L370_V0.9310.99
166_L169_L0.9300.99
162_A169_L0.9270.99
222_N377_T0.9220.99
209_I436_V0.9200.99
106_L132_F0.9190.99
209_I218_V0.9190.99
287_S298_L0.9170.99
287_S451_K0.9160.99
106_L367_I0.9150.99
57_K60_I0.9130.99
312_H315_L0.9130.99
168_E173_W0.9110.99
165_K172_M0.9110.99
305_N444_H0.9110.99
300_N303_I0.9090.99
166_L170_E0.9060.99
454_F458_R0.9050.99
114_I371_F0.9050.99
194_A228_S0.9030.99
36_E239_Y0.8980.99
110_Y130_I0.8960.99
47_G103_I0.8910.98
49_D137_D0.8910.98
259_F424_T0.8890.98
210_K214_A0.8870.98
308_E444_H0.8870.98
251_M264_G0.8860.98
272_K363_A0.8860.98
117_F386_E0.8830.98
29_R49_D0.8810.98
227_Q457_Q0.8810.98
376_I418_I0.8800.98
227_Q450_F0.8800.98
209_I391_L0.8780.98
109_D112_R0.8750.98
51_I134_V0.8720.98
33_V135_F0.8710.98
111_A385_M0.8700.98
193_F457_Q0.8680.98
53_T131_Y0.8660.98
277_L366_I0.8610.98
286_R451_K0.8610.98
110_Y113_Y0.8580.98
222_N400_T0.8580.98
167_S170_E0.8550.98
200_D203_S0.8540.98
303_I309_R0.8530.98
77_L110_Y0.8520.98
105_F398_L0.8520.98
274_G411_D0.8510.98
65_H68_E0.8510.98
124_D394_T0.8410.98
138_I151_I0.8400.98
258_D424_T0.8390.98
218_V387_I0.8360.98
106_L130_I0.8360.98
268_L278_E0.8350.98
137_D168_E0.8350.98
336_E352_N0.8340.98
260_Q423_A0.8300.98
55_K131_Y0.8290.98
421_I430_M0.8270.97
52_A83_W0.8260.97
170_E174_L0.8240.97
275_K328_R0.8200.97
222_N376_I0.8190.97
191_G230_S0.8140.97
312_H400_T0.8110.97
22_F253_Y0.8100.97
434_A444_H0.8090.97
42_R144_Q0.8080.97
107_S129_D0.8070.97
57_K129_D0.8050.97
344_S455_A0.8020.97
333_R356_E0.8000.97
324_G329_Y0.7990.97
207_E214_A0.7980.97
224_S449_S0.7920.97
302_L340_I0.7910.97
121_S389_E0.7890.97
248_S345_H0.7890.97
206_V210_K0.7880.97
43_Y140_V0.7850.97
195_A449_S0.7820.96
319_E373_G0.7790.96
363_A412_L0.7780.96
287_S290_K0.7770.96
209_I388_I0.7730.96
301_E304_H0.7720.96
150_L173_W0.7700.96
54_V79_A0.7590.96
161_T166_L0.7580.96
269_L283_A0.7570.96
239_Y262_I0.7570.96
256_T259_F0.7570.96
119_M389_E0.7560.96
312_H375_T0.7560.96
457_Q461_E0.7550.96
203_S441_V0.7550.96
221_V384_T0.7540.96
382_V385_M0.7530.96
272_K275_K0.7520.96
45_I138_I0.7520.96
383_R387_I0.7510.96
362_D365_D0.7500.96
106_L414_F0.7470.95
52_A63_I0.7470.95
232_S426_G0.7460.95
165_K170_E0.7420.95
205_A223_L0.7420.95
309_R337_F0.7410.95
203_S206_V0.7400.95
269_L319_E0.7380.95
57_K62_T0.7370.95
373_G415_N0.7370.95
287_S444_H0.7350.95
26_A234_H0.7350.95
111_A114_I0.7340.95
406_F412_L0.7330.95
114_I368_H0.7330.95
161_T172_M0.7310.95
56_G61_T0.7310.95
317_D320_R0.7300.95
106_L404_G0.7290.95
254_L403_I0.7270.95
48_L137_D0.7270.95
279_T323_L0.7250.95
339_A352_N0.7240.95
161_T173_W0.7230.95
343_Y350_V0.7220.95
164_V167_S0.7220.95
312_H319_E0.7170.94
279_T370_V0.7170.94
126_E424_T0.7170.94
150_L169_L0.7170.94
269_L312_H0.7170.94
387_I390_E0.7150.94
205_A209_I0.7140.94
376_I416_I0.7130.94
287_S447_K0.7120.94
271_S278_E0.7120.94
60_I71_F0.7120.94
112_R118_K0.7100.94
21_Q139_A0.7060.94
196_P228_S0.7050.94
56_G130_I0.7040.94
14_Q19_L0.7010.94
19_L240_K0.7000.94
197_F201_G0.6970.93
131_Y259_F0.6970.93
317_D322_D0.6930.93
299_A303_I0.6920.93
112_R119_M0.6900.93
170_E173_W0.6880.93
226_R394_T0.6840.93
171_Q175_T0.6830.93
197_F225_I0.6830.93
127_T398_L0.6820.93
51_I102_A0.6820.93
20_Q24_K0.6820.93
196_P225_I0.6790.93
83_W86_T0.6790.93
81_H364_V0.6790.93
236_Y240_K0.6780.92
268_L280_R0.6770.92
123_D226_R0.6750.92
334_V337_F0.6740.92
227_Q432_S0.6730.92
238_I428_A0.6710.92
16_D20_Q0.6710.92
112_R129_D0.6700.92
252_A420_T0.6690.92
22_F26_A0.6670.92
166_L172_M0.6670.92
128_P259_F0.6650.92
373_G384_T0.6640.92
125_L395_R0.6640.92
111_A389_E0.6630.92
113_Y129_D0.6610.92
74_G78_R0.6610.92
318_L374_G0.6600.91
85_K88_E0.6570.91
119_M395_R0.6560.91
212_Y386_E0.6540.91
36_E251_M0.6530.91
43_Y97_D0.6530.91
293_E296_E0.6530.91
261_I420_T0.6520.91
309_R313_V0.6510.91
224_S433_G0.6510.91
423_A426_G0.6500.91
367_I412_L0.6500.91
345_H455_A0.6490.91
269_L315_L0.6480.91
394_T431_Q0.6480.91
222_N415_N0.6470.91
270_V366_I0.6470.91
312_H347_M0.6460.91
312_H316_V0.6460.91
115_E325_R0.6460.91
116_N386_E0.6450.91
205_A393_P0.6440.90
326_V366_I0.6440.90
226_R431_Q0.6440.90
103_I254_L0.6430.90
60_I73_E0.6420.90
286_R347_M0.6410.90
121_S124_D0.6410.90
82_S85_K0.6400.90
233_V238_I0.6400.90
247_P344_S0.6390.90
261_I417_V0.6390.90
45_I103_I0.6380.90
61_T79_A0.6380.90
22_F46_A0.6370.90
162_A170_E0.6350.90
340_I347_M0.6340.90
153_H408_Y0.6320.90
321_N325_R0.6320.90
319_E400_T0.6300.89
291_T297_A0.6300.89
213_I438_I0.6290.89
272_K412_L0.6280.89
161_T169_L0.6280.89
356_E359_D0.6280.89
222_N373_G0.6270.89
172_M175_T0.6270.89
101_G408_Y0.6270.89
275_K357_L0.6260.89
246_N455_A0.6250.89
287_S294_E0.6240.89
280_R343_Y0.6220.89
280_R339_A0.6220.89
310_A439_D0.6200.89
373_G400_T0.6180.89
277_L357_L0.6170.89
171_Q174_L0.6160.88
277_L355_G0.6160.88
192_S461_E0.6150.88
373_G376_I0.6120.88
150_L166_L0.6120.88
65_H70_L0.6110.88
245_V458_R0.6110.88
164_V168_E0.6110.88
257_P260_Q0.6110.88
458_R462_L0.6090.88
206_V434_A0.6080.88
308_E375_T0.6070.88
162_A168_E0.6060.88
320_R379_A0.6060.88
22_F236_Y0.6050.88
400_T415_N0.6040.87
336_E341_E0.6040.87
32_H255_E0.6030.87
450_F454_F0.6030.87
263_C373_G0.6020.87
312_H351_S0.6010.87
382_V386_E0.6000.87
276_L335_N0.5990.87
314_M322_D0.5980.87
150_L172_M0.5980.87
222_N384_T0.5970.87
202_F449_S0.5950.87
219_F321_N0.5950.87
222_N263_C0.5940.87
16_D21_Q0.5930.86
29_R48_L0.5930.86
37_S41_G0.5900.86
365_D369_A0.5890.86
295_D347_M0.5880.86
139_A150_L0.5880.86
252_A373_G0.5860.86
220_Q437_V0.5840.86
25_L46_A0.5840.86
210_K442_P0.5830.86
29_R255_E0.5830.86
245_V345_H0.5830.86
393_P431_Q0.5830.86
15_K23_E0.5820.85
56_G76_P0.5820.85
117_F389_E0.5810.85
142_D147_S0.5790.85
301_E305_N0.5790.85
384_T435_G0.5790.85
386_E390_E0.5780.85
132_F404_G0.5770.85
205_A391_L0.5770.85
108_Y377_T0.5760.85
163_D166_L0.5750.85
63_I72_K0.5750.85
74_G82_S0.5750.85
173_W177_L0.5750.85
269_L375_T0.5740.85
137_D150_L0.5730.85
56_G113_Y0.5730.85
123_D424_T0.5730.85
64_K69_M0.5720.84
222_N319_E0.5720.84
264_G405_W0.5660.84
77_L114_I0.5660.84
223_L391_L0.5660.84
31_H131_Y0.5640.84
229_Q460_L0.5630.84
106_L371_F0.5620.83
217_D321_N0.5610.83
304_H309_R0.5610.83
293_E359_D0.5580.83
282_I418_I0.5570.83
371_F400_T0.5560.83
283_A434_A0.5560.83
19_L34_L0.5560.83
98_F413_Q0.5560.83
222_N252_A0.5550.83
198_T225_I0.5550.83
87_L408_Y0.5540.83
203_S446_Y0.5540.83
317_D321_N0.5530.82
99_Q407_G0.5530.82
306_E309_R0.5500.82
71_F74_G0.5490.82
220_Q315_L0.5490.82
100_G138_I0.5480.82
105_F371_F0.5480.82
280_R335_N0.5470.82
270_V412_L0.5470.82
99_Q409_N0.5470.82
68_E71_F0.5470.82
52_A134_V0.5470.82
51_I408_Y0.5470.82
175_T179_A0.5460.82
375_T434_A0.5460.82
457_Q460_L0.5450.82
263_C400_T0.5440.81
23_E236_Y0.5440.81
204_Q211_Q0.5430.81
331_S356_E0.5430.81
20_Q23_E0.5420.81
53_T133_L0.5420.81
288_R342_K0.5410.81
453_A457_Q0.5410.81
312_H338_M0.5410.81
451_K454_F0.5410.81
135_F138_I0.5410.81
62_T69_M0.5380.81
59_G113_Y0.5380.81
238_I460_L0.5380.81
376_I456_M0.5380.81
23_E27_Q0.5370.81
31_H49_D0.5370.81
370_V414_F0.5370.81
270_V370_V0.5370.81
219_F320_R0.5350.80
242_L264_G0.5350.80
219_F377_T0.5340.80
317_D379_A0.5330.80
363_A410_H0.5330.80
309_R349_I0.5320.80
325_R382_V0.5310.80
121_S393_P0.5310.80
262_I421_I0.5310.80
195_A227_Q0.5310.80
200_D207_E0.5300.80
19_L236_Y0.5300.80
319_E415_N0.5290.80
121_S395_R0.5290.80
314_M317_D0.5280.79
345_H458_R0.5280.79
264_G456_M0.5270.79
247_P264_G0.5270.79
125_L226_R0.5270.79
283_A437_V0.5260.79
436_V444_H0.5230.79
35_L254_L0.5230.79
129_D395_R0.5220.79
168_E171_Q0.5210.79
21_Q418_I0.5200.78
279_T353_V0.5200.78
77_L368_H0.5180.78
348_H435_G0.5170.78
26_A32_H0.5170.78
107_S110_Y0.5160.78
111_A375_T0.5150.78
54_V61_T0.5140.78
195_A446_Y0.5130.78
161_T168_E0.5110.77
450_F457_Q0.5110.77
373_G402_S0.5110.77
314_M320_R0.5100.77
248_S455_A0.5080.77
289_G292_N0.5080.77
198_T203_S0.5080.77
37_S44_S0.5070.77
63_I69_M0.5070.77
210_K437_V0.5070.77
105_F127_T0.5060.77
319_E375_T0.5060.77
116_N119_M0.5050.76
348_H376_I0.5040.76
216_G320_R0.5040.76
199_E225_I0.5040.76
195_A432_S0.5020.76
305_N376_I0.5020.76
315_L379_A0.5010.76
210_K441_V0.5010.76
315_L434_A0.5000.76
162_A177_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k0eA 1 0.9234 100 0.16 Contact Map
1i1qA 2 0.9766 100 0.16 Contact Map
1qdlA 1 0.8809 100 0.182 Contact Map
4grhA 1 0.9043 100 0.183 Contact Map
3logA 1 0.9191 100 0.225 Contact Map
3h9mA 1 0.8277 100 0.239 Contact Map
2fn0A 2 0.866 100 0.272 Contact Map
3gseA 1 0.8447 100 0.321 Contact Map
3bzmA 1 0.8617 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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