GREMLIN Database
PABA - Aminodeoxychorismate/anthranilate synthase component 2
UniProt: P28819 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (176)
Sequences: 12374 (6925)
Seq/√Len: 522.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_A132_V2.9851.00
94_V133_K2.9751.00
85_I162_I2.5551.00
119_K176_F2.5261.00
92_D133_K2.3431.00
144_T156_R2.2631.00
19_L48_M2.2531.00
157_H160_L2.2221.00
142_T156_R2.2051.00
57_D87_Q2.2031.00
86_A155_I2.1951.00
3_L29_K2.1801.00
21_E178_K2.1711.00
142_T158_N2.1611.00
143_V152_I2.1291.00
35_T38_E2.1231.00
22_L182_R2.1231.00
63_L88_V2.0261.00
92_D136_T1.9731.00
66_I84_S1.9701.00
63_L87_Q1.9101.00
176_F179_E1.8991.00
4_M16_V1.8781.00
145_A154_A1.8541.00
18_Y178_K1.8501.00
82_H164_G1.7791.00
46_F188_Y1.7261.00
112_K156_R1.7181.00
133_K136_T1.7171.00
7_N49_I1.6651.00
157_H161_P1.6421.00
27_V42_L1.6261.00
29_K34_I1.5961.00
182_R186_E1.5721.00
179_E182_R1.5591.00
140_C159_D1.5171.00
94_V131_I1.5141.00
143_V146_Q1.4961.00
155_I164_G1.4771.00
38_E41_E1.4481.00
97_E151_E1.4131.00
132_V155_I1.4031.00
101_H129_S1.3761.00
30_R33_S1.3751.00
40_E68_H1.3721.00
15_L78_V1.3681.00
4_M48_M1.3571.00
116_E187_T1.3271.00
156_R163_E1.3251.00
49_I62_S1.3171.00
85_I164_G1.3151.00
67_K70_A1.3071.00
40_E72_K1.3071.00
89_F162_I1.2831.00
140_C158_N1.2701.00
46_F184_F1.2601.00
64_E67_K1.2591.00
86_A91_G1.2581.00
24_E185_I1.2451.00
34_I38_E1.2441.00
48_M76_F1.2301.00
82_H132_V1.2201.00
131_I151_E1.2201.00
141_F155_I1.2121.00
57_D92_D1.1921.00
27_V44_P1.1871.00
112_K144_T1.1831.00
7_N62_S1.1771.00
64_E68_H1.1571.00
141_F157_H1.1531.00
59_A84_S1.1441.00
115_F154_A1.1431.00
146_Q150_G1.1261.00
2_I46_F1.1211.00
70_A160_L1.1071.00
110_D142_T1.0721.00
163_E187_T1.0651.00
137_L143_V1.0651.00
36_I40_E1.0621.00
86_A138_P1.0621.00
2_I188_Y1.0511.00
18_Y21_E1.0471.00
110_D146_Q1.0401.00
183_N187_T1.0381.00
108_E146_Q1.0361.00
140_C157_H1.0281.00
47_L65_A1.0231.00
82_H155_I1.0221.00
96_A131_I1.0221.00
15_L181_L1.0191.00
93_V132_V1.0181.00
113_T156_R0.9981.00
5_I65_A0.9751.00
16_V20_G0.9731.00
72_K160_L0.9731.00
34_I42_L0.9721.00
76_F165_V0.9691.00
47_L73_I0.9671.00
158_N161_P0.9651.00
3_L42_L0.9621.00
37_D41_E0.9601.00
3_L39_I0.9561.00
67_K88_V0.9531.00
49_I75_I0.9461.00
65_A69_F0.9431.00
79_C168_H0.9411.00
109_H146_Q0.9401.00
89_F141_F0.9381.00
14_N17_Q0.9341.00
34_I39_I0.9301.00
118_L176_F0.9221.00
37_D40_E0.9211.00
2_I24_E0.9141.00
22_L181_L0.9131.00
70_A162_I0.9081.00
55_S58_E0.9031.00
119_K175_S0.8941.00
4_M11_F0.8871.00
54_C58_E0.8841.00
91_G136_T0.8821.00
37_D68_H0.8811.00
20_G26_L0.8801.00
167_F180_M0.8781.00
91_G138_P0.8761.00
78_V165_V0.8741.00
98_R149_E0.8731.00
137_L152_I0.8721.00
8_Y30_R0.8631.00
40_E71_G0.8631.00
65_A68_H0.8611.00
147_T151_E0.8511.00
66_I75_I0.8461.00
17_Q20_G0.8431.00
29_K38_E0.8421.00
95_R99_L0.8411.00
105_S148_K0.8401.00
113_T163_E0.8381.00
59_A62_S0.8361.00
145_A167_F0.8361.00
5_I29_K0.8321.00
59_A63_L0.8301.00
115_F167_F0.8201.00
71_G160_L0.8161.00
22_L185_I0.8131.00
22_L178_K0.8091.00
46_F185_I0.8071.00
3_L44_P0.8071.00
69_F75_I0.8021.00
19_L24_E0.7991.00
112_K142_T0.7961.00
165_V169_P0.7881.00
63_L84_S0.7881.00
36_I68_H0.7851.00
63_L67_K0.7821.00
40_E73_I0.7791.00
7_N31_N0.7781.00
144_T154_A0.7711.00
29_K42_L0.7661.00
57_D93_V0.7631.00
79_C83_Q0.7581.00
69_F73_I0.7581.00
39_I44_P0.7521.00
4_M19_L0.7461.00
11_F16_V0.7361.00
107_I146_Q0.7361.00
23_G26_L0.7361.00
36_I65_A0.7231.00
89_F157_H0.7201.00
5_I39_I0.7181.00
126_R153_M0.7181.00
114_I163_E0.7181.00
31_N60_G0.7171.00
118_L179_E0.7151.00
116_E177_G0.7131.00
6_D12_T0.7121.00
110_D144_T0.7071.00
68_H71_G0.7071.00
19_L181_L0.7061.00
91_G132_V0.7041.00
89_F160_L0.7021.00
19_L185_I0.7011.00
24_E46_F0.7001.00
13_Y16_V0.7001.00
144_T163_E0.6991.00
163_E184_F0.6971.00
66_I88_V0.6921.00
156_R183_N0.6911.00
66_I70_A0.6891.00
57_D63_L0.6891.00
116_E179_E0.6821.00
55_S95_R0.6811.00
55_S130_L0.6751.00
61_I64_E0.6701.00
118_L180_M0.6701.00
47_L75_I0.6671.00
48_M184_F0.6661.00
178_K182_R0.6651.00
99_L129_S0.6621.00
38_E42_L0.6621.00
112_K163_E0.6591.00
44_P73_I0.6501.00
117_G183_N0.6491.00
12_T28_V0.6491.00
12_T50_S0.6481.00
43_S73_I0.6431.00
14_N18_Y0.6281.00
108_E148_K0.6211.00
55_S87_Q0.6201.00
157_H162_I0.6191.00
62_S84_S0.6191.00
52_G80_L0.6181.00
87_Q92_D0.6081.00
16_V28_V0.6071.00
4_M26_L0.6061.00
117_G179_E0.5970.99
54_C57_D0.5970.99
165_V180_M0.5960.99
93_V130_L0.5960.99
64_E69_F0.5940.99
17_Q21_E0.5920.99
61_I65_A0.5900.99
3_L27_V0.5900.99
101_H127_Y0.5870.99
5_I34_I0.5840.99
167_F177_G0.5820.99
76_F180_M0.5810.99
18_Y181_L0.5800.99
100_M147_T0.5720.99
4_M12_T0.5710.99
2_I19_L0.5640.99
31_N62_S0.5630.99
136_T139_S0.5620.99
4_M50_S0.5580.99
182_R185_I0.5540.99
127_Y130_L0.5530.99
70_A89_F0.5530.99
175_S178_K0.5510.99
110_D156_R0.5500.99
75_I85_I0.5450.99
115_F145_A0.5380.99
96_A151_E0.5370.99
111_G156_R0.5330.99
7_N84_S0.5310.99
76_F163_E0.5300.99
185_I188_Y0.5280.99
83_Q166_Q0.5240.99
111_G183_N0.5230.99
131_I150_G0.5220.99
51_P79_C0.5210.99
79_C128_H0.5210.99
109_H113_T0.5200.99
2_I45_D0.5200.99
76_F184_F0.5190.99
96_A99_L0.5180.99
116_E186_E0.5130.98
49_I66_I0.5110.98
40_E43_S0.5090.98
183_N186_E0.5080.98
39_I65_A0.5080.98
100_M103_K0.5040.98
46_F76_F0.5040.98
109_H112_K0.5020.98
106_D145_A0.5010.98
24_E188_Y0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqiA 3 0.9124 100 0.191 Contact Map
1gpmA 3 0.9845 100 0.201 Contact Map
2ywbA 4 0.9588 100 0.201 Contact Map
2vxoA 2 0.9639 100 0.215 Contact Map
3uowA 2 0.9742 100 0.242 Contact Map
1a9xB 1 0.9536 100 0.268 Contact Map
1qdlB 2 0.9588 100 0.281 Contact Map
1i1qB 1 0.9381 100 0.288 Contact Map
3r75A 2 0.9485 100 0.29 Contact Map
2vpiA 1 0.933 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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