GREMLIN Database
YOXB - Uncharacterized protein YoxB
UniProt: P28671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (235)
Sequences: 133 (113)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_T100_S5.4571.00
32_F73_Y4.2860.98
112_D124_S4.0030.97
202_I212_C3.8580.96
153_Y158_P3.3000.90
47_H98_G2.9980.85
110_M224_G2.7690.80
60_A107_L2.5590.74
51_I54_D2.5540.74
93_T143_K2.5250.73
15_V127_K2.4310.70
141_V174_F2.3820.68
57_L188_I2.3810.68
145_P177_E2.3360.67
39_E149_Q2.3170.66
137_H177_E2.2590.64
11_F34_L2.1840.61
217_P223_N2.1230.59
103_M140_S2.1190.59
57_L116_L1.9710.53
143_K174_F1.9290.52
96_A188_I1.9170.51
50_F108_I1.7890.46
234_K242_R1.7870.46
217_P230_F1.7790.46
152_N223_N1.7780.46
45_S144_Y1.7720.45
113_L229_Q1.7410.44
45_S145_P1.7290.44
229_Q239_R1.7170.43
107_L187_L1.6820.42
46_P72_A1.6640.41
117_P125_A1.6620.41
136_L192_K1.6560.41
43_Y207_L1.6270.40
69_M138_T1.6260.40
112_D152_N1.6080.39
34_L122_I1.5830.38
123_Q127_K1.5760.38
42_I97_A1.5630.37
60_A150_Q1.5350.36
240_Q243_S1.5180.36
72_A97_A1.5020.35
142_I155_G1.4900.35
30_D112_D1.4820.34
189_P223_N1.4800.34
58_V93_T1.4800.34
49_E137_H1.4670.34
240_Q244_F1.4520.33
127_K132_L1.4370.33
12_A86_L1.4110.32
11_F132_L1.4030.32
68_Q218_H1.4020.32
60_A187_L1.3930.31
97_A103_M1.3850.31
129_F226_R1.3790.31
11_F17_F1.3740.31
108_I122_I1.3410.30
221_G226_R1.3320.29
216_F229_Q1.3310.29
217_P222_A1.3300.29
8_L49_E1.3260.29
146_V226_R1.3100.29
142_I160_I1.3000.28
42_I142_I1.2980.28
224_G228_K1.2960.28
79_S92_D1.2830.28
61_G68_Q1.2790.28
61_G218_H1.2790.28
152_N158_P1.2720.27
120_F194_A1.2670.27
47_H195_E1.2620.27
40_L112_D1.2490.27
152_N217_P1.2430.26
225_H231_S1.2310.26
169_Y174_F1.2240.26
70_K74_E1.1830.25
60_A198_C1.1830.25
107_L193_A1.1780.25
129_F201_L1.1650.24
76_A98_G1.1640.24
42_I93_T1.1550.24
68_Q220_S1.1500.24
116_L241_I1.1410.23
19_P22_L1.1380.23
152_N230_F1.1260.23
57_L127_K1.1260.23
75_T85_T1.1200.23
38_N76_A1.1140.23
200_T204_Q1.1020.22
56_S135_M1.1010.22
134_H181_V1.0990.22
121_G150_Q1.0980.22
122_I176_A1.0950.22
107_L190_L1.0910.22
51_I118_Q1.0880.22
94_K190_L1.0840.22
7_C13_E1.0780.22
60_A212_C1.0740.22
73_Y103_M1.0730.22
189_P217_P1.0660.21
43_Y112_D1.0660.21
103_M170_A1.0630.21
14_K38_N1.0630.21
46_P177_E1.0550.21
72_A135_M1.0550.21
140_S190_L1.0510.21
69_M98_G1.0500.21
26_D51_I1.0420.21
76_A196_T1.0410.21
60_A141_V1.0370.21
108_I197_V1.0370.21
124_S161_T1.0360.21
61_G220_S1.0340.21
144_Y177_E1.0330.21
36_Q142_I1.0320.21
120_F201_L1.0310.20
181_V201_L1.0220.20
72_A96_A1.0210.20
58_V185_A1.0120.20
47_H136_L1.0080.20
23_T30_D1.0060.20
15_V97_A1.0040.20
170_A195_E0.9990.20
16_H242_R0.9930.20
69_M97_A0.9910.19
60_A78_E0.9910.19
15_V166_L0.9890.19
188_I236_Q0.9880.19
36_Q91_V0.9870.19
76_A83_G0.9820.19
156_Y231_S0.9810.19
24_K136_L0.9800.19
229_Q237_L0.9740.19
187_L216_F0.9740.19
111_L217_P0.9740.19
129_F146_V0.9680.19
178_L187_L0.9660.19
49_E205_H0.9650.19
122_I135_M0.9490.18
131_E160_I0.9450.18
108_I141_V0.9380.18
15_V60_A0.9360.18
110_M216_F0.9210.18
27_L225_H0.9180.18
73_Y98_G0.9170.18
227_L231_S0.9150.18
9_K12_A0.9150.18
78_E127_K0.9150.18
83_G145_P0.9090.18
59_I117_P0.9070.17
105_H168_T0.9040.17
98_G138_T0.8940.17
152_N189_P0.8930.17
11_F184_P0.8850.17
47_H156_Y0.8810.17
75_T169_Y0.8780.17
24_K192_K0.8710.17
14_K32_F0.8710.17
51_I84_G0.8670.17
38_N56_S0.8660.17
74_E118_Q0.8640.17
213_L217_P0.8590.16
176_A204_Q0.8580.16
83_G243_S0.8500.16
224_G227_L0.8500.16
110_M155_G0.8490.16
180_H187_L0.8480.16
119_A211_I0.8480.16
55_A191_G0.8480.16
225_H229_Q0.8470.16
83_G92_D0.8460.16
46_P71_T0.8450.16
45_S127_K0.8420.16
116_L224_G0.8370.16
76_A148_I0.8350.16
115_G238_E0.8290.16
157_K170_A0.8290.16
18_L69_M0.8240.16
58_V133_R0.8190.16
66_F73_Y0.8120.15
69_M187_L0.8100.15
51_I228_K0.8090.15
120_F234_K0.8060.15
73_Y225_H0.7970.15
59_I190_L0.7940.15
164_P179_N0.7920.15
51_I239_R0.7900.15
9_K230_F0.7860.15
72_A80_L0.7850.15
12_A16_H0.7810.15
65_G220_S0.7810.15
62_I147_F0.7790.15
131_E241_I0.7750.15
215_G221_G0.7750.15
58_V70_K0.7720.15
65_G94_K0.7710.15
71_T149_Q0.7700.15
89_M212_C0.7660.15
89_M211_I0.7650.14
174_F200_T0.7640.14
88_Q209_N0.7620.14
68_Q147_F0.7590.14
147_F218_H0.7590.14
34_L93_T0.7530.14
16_H116_L0.7520.14
38_N243_S0.7520.14
87_E116_L0.7510.14
147_F152_N0.7510.14
107_L139_T0.7440.14
225_H244_F0.7410.14
137_H195_E0.7390.14
118_Q123_Q0.7390.14
229_Q240_Q0.7380.14
102_S125_A0.7370.14
111_L201_L0.7310.14
137_H140_S0.7300.14
45_S177_E0.7290.14
116_L170_A0.7210.14
31_P88_Q0.7190.14
32_F69_M0.7180.14
45_S69_M0.7100.13
225_H240_Q0.7090.13
93_T142_I0.7080.13
94_K140_S0.7070.13
94_K107_L0.7060.13
177_E220_S0.7020.13
140_S218_H0.7020.13
68_Q140_S0.7020.13
60_A90_A0.7010.13
8_L90_A0.7000.13
115_G145_P0.6950.13
42_I169_Y0.6950.13
177_E226_R0.6890.13
114_C244_F0.6860.13
132_L137_H0.6850.13
165_I178_L0.6820.13
69_M73_Y0.6800.13
111_L146_V0.6800.13
47_H66_F0.6760.13
82_Q194_A0.6760.13
75_T154_T0.6720.13
216_F225_H0.6640.13
213_L234_K0.6630.13
98_G144_Y0.6600.13
220_S226_R0.6580.13
136_L193_A0.6580.13
208_Q235_E0.6580.13
67_S70_K0.6570.13
120_F158_P0.6550.12
131_E149_Q0.6520.12
32_F103_M0.6500.12
204_Q207_L0.6480.12
213_L222_A0.6460.12
97_A174_F0.6450.12
139_T230_F0.6430.12
85_T186_L0.6420.12
187_L232_K0.6410.12
93_T114_C0.6410.12
58_V139_T0.6410.12
57_L173_H0.6390.12
106_N144_Y0.6370.12
40_L224_G0.6350.12
122_I131_E0.6340.12
62_I162_H0.6340.12
69_M144_Y0.6310.12
98_G141_V0.6310.12
92_D160_I0.6300.12
55_A104_R0.6280.12
18_L194_A0.6260.12
112_D118_Q0.6230.12
164_P203_R0.6230.12
98_G133_R0.6200.12
177_E189_P0.6200.12
61_G147_F0.6190.12
49_E235_E0.6180.12
99_F218_H0.6160.12
68_Q99_F0.6160.12
110_M225_H0.6160.12
61_G140_S0.6140.12
93_T174_F0.6020.12
62_I68_Q0.6010.12
62_I218_H0.6010.12
29_T233_N0.6010.12
171_F200_T0.5980.12
121_G203_R0.5980.12
50_F69_M0.5960.11
158_P226_R0.5940.11
11_F15_V0.5930.11
236_Q243_S0.5920.11
146_V177_E0.5910.11
147_F158_P0.5820.11
60_A174_F0.5810.11
80_L244_F0.5800.11
58_V142_I0.5790.11
19_P41_G0.5760.11
166_L190_L0.5760.11
73_Y142_I0.5740.11
19_P25_S0.5730.11
8_L233_N0.5700.11
54_D172_G0.5680.11
20_S71_T0.5680.11
92_D121_G0.5660.11
47_H192_K0.5650.11
11_F159_A0.5640.11
148_I165_I0.5610.11
49_E89_M0.5580.11
31_P91_V0.5560.11
34_L56_S0.5560.11
89_M141_V0.5510.11
239_R243_S0.5460.11
176_A200_T0.5460.11
52_N55_A0.5450.11
63_T87_E0.5450.11
98_G102_S0.5440.11
82_Q184_P0.5430.11
173_H205_H0.5430.11
62_I106_N0.5430.11
189_P218_H0.5430.11
68_Q189_P0.5430.11
149_Q162_H0.5420.11
7_C211_I0.5420.11
160_I224_G0.5420.11
239_R244_F0.5420.11
38_N193_A0.5390.11
85_T145_P0.5380.11
130_G175_P0.5330.11
16_H235_E0.5330.11
86_L90_A0.5320.10
15_V84_G0.5260.10
148_I170_A0.5250.10
185_A211_I0.5250.10
25_S53_R0.5240.10
228_K236_Q0.5230.10
61_G99_F0.5220.10
53_R204_Q0.5210.10
92_D114_C0.5190.10
8_L156_Y0.5180.10
99_F194_A0.5160.10
117_P172_G0.5100.10
94_K138_T0.5100.10
44_Y215_G0.5090.10
129_F138_T0.5090.10
122_I127_K0.5090.10
73_Y76_A0.5080.10
45_S98_G0.5080.10
121_G171_F0.5070.10
115_G118_Q0.5060.10
115_G176_A0.5050.10
88_Q242_R0.5020.10
22_L91_V0.5010.10
59_I152_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wywA 1 0.6797 97.8 0.922 Contact Map
1mugA 1 0.625 97.6 0.925 Contact Map
1ui0A 1 0.7227 97.6 0.925 Contact Map
2c2qA 1 0.6758 97.6 0.925 Contact Map
1oe4A 2 0.8516 97.6 0.925 Contact Map
1vk2A 1 0.6992 97.4 0.928 Contact Map
2d3yA 1 0.7422 97.3 0.929 Contact Map
2l3fA 1 0.6016 95.1 0.943 Contact Map
3ikbA 1 0.7344 94.4 0.945 Contact Map
1xmkA 1 0.293 41 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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