GREMLIN Database
LEPS - Signal peptidase I S
UniProt: P28628 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (161)
Sequences: 6789 (4625)
Seq/√Len: 364.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_Q106_K3.5811.00
141_Y163_K3.1621.00
92_T133_P3.0341.00
91_D103_N2.8901.00
42_D45_Y2.7971.00
94_E133_P2.7291.00
140_K162_T2.6541.00
141_Y166_I2.5561.00
140_K160_L2.5091.00
68_R88_L2.4161.00
72_V143_V2.3631.00
66_F85_I2.3381.00
92_T135_K2.2461.00
57_N60_V2.1641.00
68_R91_D2.0421.00
61_K66_F2.0241.00
45_Y49_H1.9731.00
41_G50_N1.9251.00
43_S83_K1.8411.00
85_I143_V1.8031.00
68_R102_I1.7901.00
30_R35_A1.7741.00
56_V168_G1.7691.00
35_A58_M1.7541.00
57_N171_K1.7221.00
162_T165_Q1.7191.00
22_A26_A1.6931.00
82_V170_S1.6881.00
80_H167_A1.6741.00
136_V160_L1.6691.00
101_Y106_K1.6581.00
83_K151_S1.6511.00
72_V166_I1.6151.00
145_G151_S1.6141.00
48_L82_V1.5771.00
100_L107_V1.5671.00
56_V73_V1.5251.00
13_L17_K1.5241.00
38_V53_R1.5041.00
89_P141_Y1.5041.00
137_P160_L1.4931.00
18_A22_A1.4871.00
158_L161_F1.4121.00
95_M100_L1.3921.00
139_N163_K1.3871.00
136_V140_K1.3861.00
96_K101_Y1.3721.00
36_P174_F1.3531.00
74_L81_Y1.3511.00
70_D169_T1.3511.00
88_L91_D1.3491.00
137_P140_K1.2651.00
152_M156_N1.2651.00
61_K169_T1.2431.00
92_T104_G1.2231.00
42_D50_N1.2171.00
94_E101_Y1.2141.00
52_E179_E1.2031.00
89_P163_K1.1891.00
39_V48_L1.1831.00
93_V102_I1.1721.00
75_N167_A1.1681.00
60_V64_G1.1661.00
52_E173_V1.1641.00
11_S15_W1.1621.00
34_F171_K1.1511.00
75_N80_H1.1411.00
74_L143_V1.1331.00
134_V160_L1.0961.00
83_K145_G1.0891.00
45_Y50_N1.0871.00
39_V54_V1.0741.00
103_N107_V1.0701.00
40_D50_N1.0631.00
91_D102_I1.0411.00
64_G70_D1.0391.00
44_M71_I1.0361.00
65_E163_K1.0121.00
103_N106_K1.0101.00
11_S14_E1.0011.00
43_S151_S0.9971.00
163_K166_I0.9841.00
29_I33_I0.9801.00
54_V170_S0.9801.00
96_K99_Q0.9781.00
113_A116_K0.9691.00
72_V85_I0.9691.00
87_G93_V0.9601.00
53_R175_Y0.9531.00
29_I34_F0.9441.00
109_E148_R0.9411.00
12_I16_A0.9391.00
109_E112_L0.9311.00
100_L144_M0.9291.00
81_Y158_L0.9071.00
30_R36_P0.8991.00
34_F55_F0.8961.00
53_R174_F0.8951.00
43_S145_G0.8891.00
10_K13_L0.8871.00
13_L16_A0.8711.00
54_V173_V0.8691.00
170_S173_V0.8681.00
14_E18_A0.8631.00
129_D155_R0.8621.00
142_F154_S0.8621.00
41_G158_L0.8611.00
15_W18_A0.8491.00
37_Y56_V0.8481.00
46_P49_H0.8441.00
131_F134_V0.8411.00
85_I88_L0.8401.00
89_P138_D0.8361.00
15_W19_I0.8301.00
173_V179_E0.8111.00
37_Y80_H0.8111.00
17_K21_I0.7941.00
41_G48_L0.7931.00
59_T62_Y0.7891.00
42_D150_N0.7891.00
98_D149_R0.7881.00
57_N62_Y0.7841.00
86_I100_L0.7831.00
73_V80_H0.7781.00
33_I59_T0.7781.00
16_A20_V0.7751.00
27_L31_N0.7711.00
69_G111_Y0.7621.00
81_Y161_F0.7601.00
48_L71_I0.7561.00
36_P53_R0.7501.00
127_L130_D0.7501.00
152_M158_L0.7491.00
75_N165_Q0.7381.00
144_M148_R0.7381.00
94_E104_G0.7361.00
139_N162_T0.7311.00
77_D165_Q0.7271.00
45_Y147_N0.7271.00
49_H176_P0.7211.00
71_I170_S0.7211.00
104_G107_V0.7191.00
128_T156_N0.7181.00
39_V50_N0.7130.99
46_P113_A0.7110.99
49_H52_E0.7090.99
49_H179_E0.7060.99
85_I141_Y0.7050.99
40_D48_L0.6950.99
86_I144_M0.6940.99
114_A117_K0.6890.99
107_V111_Y0.6880.99
28_L32_F0.6850.99
154_S159_G0.6850.99
142_F160_L0.6830.99
136_V139_N0.6800.99
87_G91_D0.6760.99
12_I15_W0.6760.99
143_V161_F0.6710.99
57_N169_T0.6650.99
37_Y173_V0.6650.99
19_I23_V0.6610.99
81_Y152_M0.6610.99
37_Y73_V0.6610.99
26_A30_R0.6590.99
93_V136_V0.6570.99
68_R87_G0.6550.99
23_V27_L0.6530.99
176_P179_E0.6480.99
60_V63_I0.6450.99
47_T71_I0.6380.99
73_V167_A0.6350.99
42_D49_H0.6320.99
10_K14_E0.6320.99
40_D52_E0.6310.99
37_Y54_V0.6290.99
147_N150_N0.6290.99
48_L170_S0.6250.99
39_V82_V0.6250.99
103_N110_P0.6220.99
173_V176_P0.6210.99
17_K20_V0.6210.99
25_L29_I0.6150.98
25_L28_L0.6070.98
42_D147_N0.6060.98
128_T131_F0.6060.98
73_V170_S0.6050.98
54_V82_V0.6040.98
126_H129_D0.5990.98
66_F166_I0.5960.98
93_V142_F0.5930.98
74_L83_K0.5930.98
60_V169_T0.5880.98
94_E132_G0.5880.98
10_K17_K0.5870.98
11_S16_A0.5860.98
29_I32_F0.5850.98
113_A117_K0.5850.98
102_I148_R0.5770.98
20_V24_V0.5750.98
19_I22_A0.5740.98
95_M98_D0.5700.97
102_I107_V0.5690.97
64_G67_D0.5680.97
66_F88_L0.5650.97
22_A25_L0.5650.97
74_L161_F0.5610.97
155_R159_G0.5600.97
42_D51_R0.5600.97
67_D138_D0.5600.97
134_V142_F0.5580.97
93_V144_M0.5580.97
21_I25_L0.5470.97
33_I36_P0.5460.97
105_K138_D0.5430.97
71_I83_K0.5430.97
55_F171_K0.5410.97
59_T63_I0.5390.96
163_K167_A0.5350.96
30_R37_Y0.5300.96
114_A149_R0.5300.96
126_H130_D0.5290.96
87_G102_I0.5280.96
67_D169_T0.5270.96
14_E17_K0.5260.96
74_L158_L0.5260.96
112_L116_K0.5250.96
76_G79_V0.5160.96
116_K149_R0.5150.95
41_G145_G0.5120.95
73_V168_G0.5110.95
64_G169_T0.5090.95
130_D133_P0.5090.95
63_I66_F0.5080.95
94_E131_F0.5080.95
18_A21_I0.5080.95
24_V27_L0.5060.95
155_R161_F0.5060.95
37_Y167_A0.5060.95
111_Y114_A0.5030.95
35_A80_H0.5000.95
127_L131_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b12A 1 0.837 100 0.22 Contact Map
4nv4A 2 0.6033 100 0.222 Contact Map
4me8A 1 0.5924 100 0.279 Contact Map
4n31A 5 0.7663 100 0.301 Contact Map
4k8wA 2 0.6359 100 0.356 Contact Map
1kcaA 6 0.5109 98.9 0.781 Contact Map
1umuA 2 0.5707 98.6 0.806 Contact Map
3bdnA 2 0.6576 98.4 0.814 Contact Map
2hnfA 1 0.587 97.8 0.842 Contact Map
3k2zA 2 0.6522 97.6 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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