GREMLIN Database
PCP - Pyrrolidone-carboxylate peptidase
UniProt: P28618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (192)
Sequences: 1457 (1099)
Seq/√Len: 79.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_A148_F3.9001.00
148_F152_M3.3701.00
77_Q134_A3.2751.00
88_A146_Y3.1571.00
51_L150_G3.1391.00
47_F90_A3.0851.00
46_V96_E2.9801.00
22_W42_Q2.7761.00
49_S96_E2.5841.00
23_E26_K2.5611.00
24_A69_V2.5111.00
11_D45_T2.5021.00
109_G149_Y2.4551.00
4_K37_I2.4091.00
80_P123_T2.3961.00
75_R79_T2.3441.00
25_A69_V2.3081.00
46_V49_S2.2751.00
68_C151_L2.1281.00
41_E57_A2.1201.00
87_L137_Y2.0651.00
7_I28_L2.0651.00
106_S153_D2.0401.00
39_T61_H1.9811.00
67_I167_I1.9461.00
73_G171_Y1.8281.00
82_R137_Y1.8091.00
167_I196_A1.7921.00
16_E71_Q1.7891.00
43_I147_L1.7581.00
72_A75_R1.7541.00
54_L151_L1.7431.00
71_Q175_Q1.7001.00
155_I164_G1.6961.00
113_Y153_D1.6471.00
152_M164_G1.6311.00
65_I163_R1.5861.00
69_V193_L1.5350.99
24_A193_L1.5270.99
55_R154_H1.4990.99
122_M126_M1.4770.99
31_F194_R1.4640.99
47_F143_V1.4590.99
151_L164_G1.4490.99
155_I162_I1.4460.99
102_D120_K1.4300.99
148_F165_G1.4120.99
24_A169_I1.3830.99
5_V36_A1.3790.99
131_I188_T1.3770.99
30_G40_A1.3230.98
78_I192_A1.3210.98
110_P153_D1.3160.98
41_E60_K1.3080.98
119_V135_V1.3000.98
68_C164_G1.2970.98
52_D56_Q1.2970.98
41_E61_H1.2950.98
125_K195_I1.2890.98
50_A146_Y1.2690.98
126_M195_I1.2630.98
56_Q60_K1.2590.98
27_R190_V1.2550.98
50_A147_L1.2320.97
126_M196_A1.2130.97
169_I189_I1.1760.96
29_N40_A1.1650.96
50_A143_V1.1630.96
78_I167_I1.1590.96
173_P183_S1.1560.96
105_I146_Y1.1470.96
191_R194_R1.1470.96
44_P53_T1.1390.96
58_I162_I1.1310.96
58_I154_H1.1230.95
122_M196_A1.1050.95
58_I63_P1.0930.95
55_R158_T1.0910.95
86_N145_N1.0880.94
5_V65_I1.0840.94
85_I141_T1.0760.94
18_V23_E1.0740.94
124_A128_E1.0680.94
188_T191_R1.0670.94
119_V137_Y1.0580.94
105_I108_D1.0560.94
9_G25_A1.0520.93
43_I54_L1.0440.93
70_G144_C1.0380.93
11_D95_N1.0340.93
11_D43_I1.0100.92
89_D102_D1.0100.92
186_L189_I1.0010.92
68_C147_L1.0000.92
25_A40_A0.9990.92
39_T57_A0.9920.91
21_S43_I0.9840.91
155_I160_P0.9780.91
111_A114_W0.9780.91
7_I29_N0.9780.91
137_Y141_T0.9730.90
58_I66_V0.9720.90
115_T148_F0.9670.90
146_Y150_G0.9640.90
57_A61_H0.9370.89
51_L146_Y0.9360.89
20_P71_Q0.9260.88
139_A145_N0.9170.88
151_L155_I0.9130.87
120_K135_V0.9120.87
80_P119_V0.9050.87
22_W26_K0.8980.87
88_A105_I0.8950.86
4_K39_T0.8920.86
108_D153_D0.8890.86
154_H159_S0.8860.86
192_A196_A0.8860.86
129_H195_I0.8800.85
51_L147_L0.8790.85
115_T165_G0.8780.85
186_L190_V0.8640.84
59_Q154_H0.8610.84
49_S52_D0.8570.84
83_V112_A0.8550.84
117_L165_G0.8420.83
126_M131_I0.8310.82
36_A65_I0.8300.82
70_G166_F0.8240.81
47_F100_P0.8210.81
54_L68_C0.8190.81
92_I99_Q0.8170.81
10_F143_V0.8090.80
85_I145_N0.8080.80
16_E179_K0.7990.79
125_K128_E0.7980.79
80_P115_T0.7900.79
119_V123_T0.7880.78
82_R87_L0.7870.78
77_Q80_P0.7830.78
8_T68_C0.7780.78
11_D142_F0.7760.77
138_T141_T0.7750.77
185_S188_T0.7730.77
180_T184_L0.7730.77
104_E107_P0.7720.77
141_T145_N0.7720.77
187_D190_V0.7680.77
90_A100_P0.7680.77
80_P133_A0.7680.77
79_T134_A0.7630.76
53_T56_Q0.7540.75
131_I195_I0.7520.75
171_Y175_Q0.7480.75
82_R102_D0.7440.74
12_P22_W0.7420.74
91_R99_Q0.7410.74
9_G22_W0.7390.74
82_R120_K0.7340.73
141_T165_G0.7330.73
104_E111_A0.7310.73
13_F73_G0.7280.73
24_A189_I0.7130.71
59_Q62_Q0.7110.71
123_T135_V0.7100.71
106_S150_G0.7080.71
22_W169_I0.7060.70
131_I192_A0.7050.70
144_C166_F0.7050.70
72_A79_T0.7040.70
167_I193_L0.7030.70
45_T142_F0.7030.70
111_A156_S0.7030.70
176_T179_K0.7030.70
122_M195_I0.7020.70
57_A60_K0.7020.70
117_L122_M0.7000.70
5_V67_I0.6980.70
32_E37_I0.6870.68
4_K61_H0.6830.68
89_D105_I0.6820.68
33_T36_A0.6820.68
89_D120_K0.6800.68
89_D145_N0.6730.67
21_S69_V0.6720.67
69_V169_I0.6720.67
46_V98_H0.6670.66
113_Y156_S0.6670.66
114_W148_F0.6670.66
191_R195_I0.6660.66
9_G20_P0.6580.65
187_D191_R0.6550.65
182_P192_A0.6510.64
110_P156_S0.6510.64
83_V114_W0.6510.64
32_E35_E0.6500.64
70_G168_H0.6490.64
48_R98_H0.6490.64
68_C152_M0.6470.64
150_G155_I0.6450.64
101_I120_K0.6430.63
17_T174_Q0.6390.63
39_T63_P0.6370.63
21_S169_I0.6370.63
85_I139_A0.6330.62
24_A147_L0.6310.62
45_T143_V0.6300.62
71_Q171_Y0.6290.62
75_R138_T0.6290.62
10_F147_L0.6280.61
184_L188_T0.6260.61
158_T162_I0.6260.61
26_K42_Q0.6240.61
49_S53_T0.6230.61
50_A88_A0.6200.60
39_T194_R0.6190.60
82_R119_V0.6180.60
176_T183_S0.6180.60
144_C168_H0.6170.60
10_F142_F0.6160.60
5_V189_I0.6140.60
185_S192_A0.6130.60
90_A99_Q0.6130.60
88_A103_E0.6130.60
129_H191_R0.6110.59
36_A64_D0.6110.59
181_A193_L0.6100.59
21_S25_A0.6080.59
87_L119_V0.6060.59
54_L147_L0.6050.59
88_A142_F0.6020.58
59_Q158_T0.6010.58
67_I151_L0.6000.58
115_T152_M0.6000.58
6_L75_R0.5960.57
143_V147_L0.5920.57
142_F146_Y0.5890.57
119_V172_I0.5830.56
11_D42_Q0.5810.56
182_P185_S0.5800.55
186_L192_A0.5800.55
106_S110_P0.5790.55
85_I114_W0.5790.55
68_C155_I0.5770.55
84_A147_L0.5770.55
85_I138_T0.5770.55
56_Q59_Q0.5750.55
32_E36_A0.5750.55
154_H158_T0.5740.55
76_M80_P0.5700.54
125_K129_H0.5640.53
172_I175_Q0.5630.53
68_C90_A0.5620.53
23_E27_R0.5590.53
189_I193_L0.5580.53
41_E53_T0.5560.52
87_L138_T0.5520.52
13_F95_N0.5500.52
114_W141_T0.5470.51
26_K29_N0.5440.51
22_W25_A0.5390.50
16_E171_Y0.5380.50
152_M156_S0.5380.50
89_D101_I0.5330.49
30_G37_I0.5310.49
79_T123_T0.5310.49
55_R150_G0.5310.49
190_V194_R0.5300.49
47_F89_D0.5290.49
54_L154_H0.5280.49
74_G171_Y0.5240.48
18_V172_I0.5230.48
47_F146_Y0.5210.48
178_D181_A0.5190.48
27_R187_D0.5190.48
116_R155_I0.5190.48
105_I145_N0.5170.47
7_I194_R0.5160.47
79_T142_F0.5150.47
51_L55_R0.5120.47
48_R146_Y0.5110.47
153_D156_S0.5090.46
27_R156_S0.5090.46
62_Q161_H0.5080.46
52_D108_D0.5080.46
19_N70_G0.5070.46
124_A127_K0.5040.46
60_K124_A0.5010.45
118_P165_G0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ro0A 3 0.9721 100 0.129 Contact Map
3giuA 2 0.986 100 0.135 Contact Map
3lacA 3 0.9442 100 0.143 Contact Map
1a2zA 4 0.9767 100 0.15 Contact Map
1x10A 4 0.9442 100 0.16 Contact Map
1iu8A 3 0.9535 100 0.161 Contact Map
4hpsA 3 0.9535 100 0.162 Contact Map
2ebjA 3 0.893 100 0.188 Contact Map
3mnfA 4 0.9163 49.8 0.941 Contact Map
4ew1A 2 0.8465 40.7 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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