GREMLIN Database
MOTA - Motility protein A
UniProt: P28611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (249)
Sequences: 2347 (1546)
Seq/√Len: 98.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_V223_I3.7791.00
151_G202_H3.7701.00
88_L100_S3.4191.00
88_L96_A3.2851.00
19_G38_I3.1041.00
64_R68_K3.0051.00
43_T150_A2.9311.00
147_F204_F2.8081.00
11_L45_S2.7831.00
167_I188_V2.7661.00
106_D219_R2.5811.00
112_G226_V2.5471.00
140_H215_E2.4181.00
133_V216_V2.3441.00
48_V56_I2.3231.00
148_T205_A2.2971.00
74_T77_E2.2961.00
175_N178_E2.2611.00
59_V147_F2.1941.00
196_T201_W2.1871.00
12_A199_V2.1851.00
136_M216_V2.1831.00
111_N132_E2.1791.00
26_S168_A2.1791.00
40_I196_T2.1681.00
82_F238_I2.0981.00
43_T154_A2.0701.00
66_L204_F2.0101.00
32_N35_A1.9471.00
50_A206_N1.9421.00
5_S207_K1.9321.00
154_A196_T1.9271.00
29_A171_S1.9271.00
140_H212_S1.8821.00
225_G242_L1.8671.00
52_P55_E1.8641.00
137_E216_V1.8621.00
57_K61_T1.8551.00
53_T57_K1.8141.00
109_L222_M1.7731.00
228_S233_Q1.7571.00
62_L143_G1.7441.00
136_M140_H1.6951.00
13_F17_S1.6901.00
10_I14_V1.6331.00
132_E251_R1.6321.00
20_M30_L1.6271.00
36_I40_I1.6161.00
126_R130_T1.5831.00
16_L42_G1.5401.00
27_F31_A1.5311.00
156_T187_F1.5231.00
80_P239_E1.5151.00
169_A187_F1.5141.00
6_L10_I1.5061.00
126_R224_E1.5061.00
224_E245_Y1.4871.00
61_T64_R1.4701.00
5_S66_L1.4621.00
154_A201_W1.4481.00
148_T209_K1.4271.00
5_S49_I1.4241.00
56_I59_V1.4041.00
236_K239_E1.4000.99
239_E243_L1.4000.99
12_A45_S1.3960.99
55_E210_R1.3910.99
84_E87_Q1.3910.99
47_V150_A1.3780.99
14_V18_V1.3460.99
82_F225_G1.3300.99
129_M226_V1.2990.99
7_I14_V1.2790.99
100_S103_D1.2740.99
16_L195_F1.2600.99
163_V183_I1.2480.99
159_V183_I1.2440.99
18_V22_L1.2440.99
47_V56_I1.2350.99
35_A189_A1.2300.99
159_V189_A1.2260.99
150_A201_W1.2210.99
178_E181_H1.2200.99
116_A125_I1.2170.99
59_V63_F1.2010.98
124_F233_Q1.2010.98
81_M104_V1.1990.98
88_L92_E1.1960.98
78_L222_M1.1890.98
22_L37_L1.1800.98
144_A212_S1.1640.98
89_A97_L1.1560.98
111_N240_Q1.1540.98
140_H208_L1.1460.98
59_V146_I1.1450.98
168_A182_A1.1430.98
30_L168_A1.1200.98
183_I194_I1.1110.97
66_L207_K1.1090.97
131_E135_A1.1030.97
101_I114_S1.1020.97
162_A191_L1.1000.97
183_I187_F1.0850.97
7_I11_L1.0850.97
15_A45_S1.0760.97
183_I189_A1.0720.97
136_M212_S1.0660.97
178_E182_A1.0630.97
14_V17_S1.0630.97
156_T183_I1.0590.97
218_L222_M1.0530.96
16_L199_V1.0490.96
112_G129_M1.0400.96
32_N185_A1.0360.96
21_V27_F1.0360.96
46_A153_Y1.0310.96
102_E114_S1.0300.96
195_F199_V1.0280.96
63_F147_F1.0210.96
121_S124_F1.0200.96
55_E146_I1.0130.96
13_F200_L0.9970.95
179_L183_I0.9940.95
162_A169_A0.9890.95
51_F145_A0.9870.95
77_E81_M0.9720.94
160_L195_F0.9520.94
159_V169_A0.9410.93
162_A170_L0.9400.93
107_A110_K0.9370.93
173_M180_G0.9350.93
23_K168_A0.9320.93
55_E142_A0.9300.93
20_M25_V0.9270.93
169_A183_I0.9270.93
31_A36_I0.9260.93
181_H184_S0.9260.93
78_L218_L0.9240.93
247_P250_D0.9230.93
125_I230_L0.9210.93
62_L66_L0.9200.93
157_L182_A0.9200.93
73_L77_E0.9110.92
180_G184_S0.9090.92
207_K211_K0.9070.92
147_F208_L0.9060.92
130_T223_I0.9000.92
38_I164_I0.8970.92
69_E211_K0.8940.91
144_A209_K0.8860.91
50_A149_Q0.8840.91
212_S216_V0.8790.91
63_F204_F0.8780.91
51_F149_Q0.8750.91
120_Q128_I0.8720.90
81_M109_L0.8710.90
159_V194_I0.8700.90
181_H185_A0.8670.90
88_L97_L0.8650.90
163_V194_I0.8640.90
85_W97_L0.8600.90
170_L191_L0.8600.90
57_K60_P0.8570.90
85_W113_L0.8540.90
87_Q91_R0.8500.89
115_M128_I0.8470.89
228_S241_K0.8450.89
224_E241_K0.8430.89
40_I44_I0.8430.89
179_L182_A0.8420.89
175_N184_S0.8400.89
26_S29_A0.8390.89
248_A251_R0.8380.89
20_M191_L0.8320.88
23_K189_A0.8270.88
153_Y198_Y0.8260.88
114_S240_Q0.8250.88
58_K142_A0.8240.88
22_L34_A0.8240.88
147_F201_W0.8220.88
39_I195_F0.8150.87
149_Q153_Y0.8130.87
9_I13_F0.8090.87
75_I218_L0.8060.87
196_T200_L0.8060.87
228_S238_I0.8010.86
127_D131_E0.7950.86
86_A225_G0.7900.86
156_T169_A0.7890.85
24_G182_A0.7880.85
33_P36_I0.7870.85
84_E100_S0.7850.85
144_A148_T0.7830.85
23_K187_F0.7800.85
176_T181_H0.7790.85
156_T189_A0.7750.84
37_L151_G0.7730.84
46_A199_V0.7720.84
156_T163_V0.7720.84
91_R120_Q0.7710.84
20_M159_V0.7710.84
83_S239_E0.7710.84
53_T56_I0.7680.84
159_V163_V0.7670.84
122_A231_E0.7640.84
30_L169_A0.7640.84
116_A226_V0.7630.83
4_T50_A0.7600.83
51_F146_I0.7600.83
162_A188_V0.7590.83
116_A230_L0.7490.82
133_V219_R0.7460.82
90_R234_A0.7440.82
233_Q241_K0.7440.82
139_R215_E0.7420.82
47_V59_V0.7410.82
137_E212_S0.7390.81
11_L48_V0.7320.81
163_V187_F0.7320.81
133_V220_E0.7310.81
124_F127_D0.7280.81
15_A41_A0.7250.80
149_Q152_T0.7230.80
178_E184_S0.7220.80
157_L160_L0.7200.80
35_A162_A0.7190.80
151_G187_F0.7190.80
159_V187_F0.7180.80
175_N179_L0.7170.80
9_I49_I0.7120.79
83_S235_P0.7050.78
168_A171_S0.7010.78
60_P63_F0.7010.78
47_V146_I0.7000.78
208_L215_E0.7000.78
4_T11_L0.6970.78
61_T145_A0.6930.77
55_E214_Q0.6910.77
113_L117_V0.6890.77
32_N38_I0.6870.77
119_G232_G0.6870.77
63_F67_F0.6860.76
85_W226_V0.6840.76
66_L147_F0.6780.76
221_V245_Y0.6770.76
24_G168_A0.6760.75
157_L181_H0.6730.75
48_V53_T0.6690.75
62_L208_L0.6680.75
156_T159_V0.6670.74
169_A198_Y0.6650.74
81_M100_S0.6630.74
162_A183_I0.6630.74
134_E137_E0.6600.74
139_R208_L0.6580.73
69_E72_Q0.6580.73
26_S171_S0.6540.73
73_L106_D0.6530.73
142_A145_A0.6510.73
229_V238_I0.6500.73
46_A157_L0.6480.72
135_A138_D0.6450.72
61_T249_K0.6440.72
87_Q238_I0.6430.72
162_A198_Y0.6430.72
157_L171_S0.6430.72
18_V27_F0.6410.72
43_T201_W0.6330.71
39_I199_V0.6320.70
117_V234_A0.6290.70
157_L168_A0.6270.70
73_L218_L0.6240.69
120_Q125_I0.6230.69
157_L183_I0.6210.69
32_N159_V0.6190.69
225_G241_K0.6180.69
189_A195_F0.6170.69
15_A30_L0.6160.68
115_M233_Q0.6120.68
20_M164_I0.6100.68
17_S27_F0.6090.68
177_D181_H0.6080.67
162_A189_A0.6080.67
131_E244_M0.6060.67
148_T152_T0.6050.67
135_A150_A0.6050.67
169_A189_A0.6040.67
162_A178_E0.6010.67
153_Y202_H0.6000.66
15_A19_G0.6000.66
54_K58_K0.5990.66
23_K169_A0.5990.66
126_R231_E0.5960.66
28_S31_A0.5940.66
227_L241_K0.5940.66
52_P58_K0.5930.66
163_V169_A0.5890.65
161_G189_A0.5860.65
187_F195_F0.5860.65
67_F227_L0.5860.65
104_V112_G0.5860.65
227_L231_E0.5860.65
30_L183_I0.5860.65
82_F229_V0.5850.65
185_A192_L0.5840.64
87_Q236_K0.5830.64
86_A95_L0.5810.64
127_D130_T0.5800.64
233_Q238_I0.5780.64
192_L198_Y0.5760.63
79_I221_V0.5750.63
25_V164_I0.5750.63
95_L117_V0.5730.63
206_N209_K0.5730.63
9_I17_S0.5720.63
147_F150_A0.5710.63
49_I66_L0.5710.63
229_V241_K0.5710.63
132_E244_M0.5710.63
237_V240_Q0.5700.63
39_I43_T0.5690.62
8_G48_V0.5680.62
201_W204_F0.5670.62
33_P37_L0.5660.62
152_T168_A0.5650.62
4_T57_K0.5650.62
35_A159_V0.5630.62
141_Q144_A0.5580.61
156_T195_F0.5580.61
70_N211_K0.5570.61
66_L208_L0.5570.61
107_A248_A0.5570.61
175_N183_I0.5540.60
20_M32_N0.5540.60
157_L163_V0.5480.60
49_I52_P0.5450.59
11_L14_V0.5430.59
86_A229_V0.5390.58
111_N115_M0.5380.58
215_E219_R0.5370.58
72_Q77_E0.5360.58
140_H143_G0.5350.58
116_A240_Q0.5350.58
82_F242_L0.5310.57
11_L15_A0.5310.57
67_F207_K0.5300.57
222_M226_V0.5280.57
164_I169_A0.5260.56
59_V62_L0.5250.56
113_L163_V0.5250.56
54_K214_Q0.5230.56
101_I117_V0.5170.55
98_E179_L0.5170.55
125_I242_L0.5160.55
81_M105_D0.5160.55
76_E246_L0.5150.55
39_I150_A0.5150.55
162_A192_L0.5140.55
94_L232_G0.5130.55
56_I60_P0.5130.55
15_A37_L0.5100.54
172_H175_N0.5080.54
197_G202_H0.5070.54
88_L121_S0.5070.54
89_A95_L0.5060.54
109_L227_L0.5060.54
114_S221_V0.5050.53
20_M34_A0.5050.53
152_T156_T0.5040.53
12_A46_A0.5040.53
39_I194_I0.5030.53
94_L114_S0.5020.53
89_A96_A0.5010.53
88_L129_M0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.9185 79.9 0.944 Contact Map
1i5pA 1 0.5481 70 0.948 Contact Map
4aw6A 2 0.9148 69.3 0.949 Contact Map
4ev6A 3 0.2222 29.8 0.96 Contact Map
2qk1A 1 0.8074 22.2 0.962 Contact Map
4i0uA 4 0.2148 21.4 0.963 Contact Map
2c9kA 1 0.4074 13.2 0.966 Contact Map
2gyqA 2 0.5407 9.5 0.968 Contact Map
3dl8G 1 0.2333 9 0.968 Contact Map
1mhsA 2 0.3259 7.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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