GREMLIN Database
CH10 - 10 kDa chaperonin
UniProt: P28599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 94 (92)
Sequences: 2697 (1173)
Seq/√Len: 122.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E79_T4.2911.00
12_E38_K3.8401.00
9_V89_I2.8441.00
47_V53_R2.6261.00
75_K80_E2.4341.00
48_L52_E2.3311.00
13_L66_F2.2031.00
36_E63_R2.1351.00
41_A60_E1.9691.00
48_L54_V1.9681.00
59_K62_D1.9531.00
58_V89_I1.8961.00
40_V81_Y1.8391.00
37_G66_F1.8111.00
18_E31_K1.7191.00
67_S70_A1.7171.00
2_L91_A1.6561.00
2_L10_V1.6051.00
38_K63_R1.5861.00
10_V83_I1.5371.00
14_V63_R1.4951.00
3_K92_V1.4931.00
14_V38_K1.4891.00
19_K25_V1.4861.00
56_L86_E1.4691.00
44_S57_E1.4291.00
73_E80_E1.4221.00
57_E86_E1.4181.00
42_A56_L1.3931.00
69_Y85_R1.3551.00
66_F82_L1.3471.00
11_I84_L1.3261.00
11_I37_G1.3101.00
46_R87_S1.2641.00
37_G84_L1.2571.00
35_Q68_K1.2060.99
38_K60_E1.1840.99
38_K61_G1.1750.99
8_R85_R1.1510.99
12_E81_Y1.1460.99
35_Q72_T1.1370.99
28_D31_K1.1110.99
64_I89_I1.1030.99
68_K73_E1.0740.98
44_S56_L1.0720.98
34_P68_K1.0510.98
14_V36_E1.0380.98
7_D85_R1.0270.98
20_T23_G0.9580.97
83_I90_L0.9400.96
46_R86_E0.9130.96
53_R57_E0.8950.95
10_V81_Y0.8860.95
76_Y81_Y0.8640.94
6_G57_E0.8630.94
72_T88_D0.8500.94
62_D92_V0.8410.93
58_V92_V0.8370.93
14_V37_G0.7980.91
2_L83_I0.7830.91
46_R69_Y0.7810.91
69_Y81_Y0.7720.90
67_S90_L0.7680.90
7_D45_G0.7670.90
47_V54_V0.7640.90
71_G74_V0.7630.90
14_V27_P0.7560.89
6_G26_L0.7550.89
67_S73_E0.7550.89
12_E15_E0.7260.87
47_V51_G0.7180.87
34_P72_T0.7150.86
76_Y91_A0.7060.86
45_G51_G0.7050.86
27_P67_S0.7040.85
42_A60_E0.7030.85
13_L87_S0.6970.85
32_E68_K0.6950.85
68_K71_G0.6850.84
67_S88_D0.6800.83
13_L33_K0.6800.83
65_I74_V0.6740.83
59_K92_V0.6700.83
6_G53_R0.6690.82
31_K73_E0.6670.82
37_G82_L0.6640.82
11_I64_I0.6600.82
46_R85_R0.6510.81
45_G56_L0.6510.81
44_S53_R0.6500.81
58_V86_E0.6470.80
68_K88_D0.6410.80
16_S22_S0.6390.80
8_R67_S0.6370.79
2_L65_I0.6230.78
47_V57_E0.6210.78
25_V37_G0.6130.77
18_E26_L0.6080.76
68_K72_T0.6070.76
8_R71_G0.6070.76
66_F84_L0.6060.76
23_G64_I0.6050.76
17_E20_T0.6020.75
27_P30_A0.5930.74
73_E77_E0.5910.74
47_V55_A0.5800.73
46_R53_R0.5780.72
17_E21_A0.5750.72
21_A77_E0.5730.72
33_K68_K0.5720.72
44_S48_L0.5710.72
85_R88_D0.5600.70
25_V48_L0.5580.70
75_K78_G0.5510.69
21_A29_S0.5490.69
47_V50_S0.5480.68
6_G44_S0.5460.68
38_K79_T0.5410.67
35_Q73_E0.5390.67
70_A84_L0.5370.67
7_D86_E0.5340.66
44_S47_V0.5330.66
65_I90_L0.5310.66
44_S92_V0.5280.66
32_E78_G0.5270.65
16_S44_S0.5270.65
11_I65_I0.5180.64
48_L53_R0.5170.64
15_E18_E0.5170.64
19_K23_G0.5170.64
8_R83_I0.5170.64
26_L65_I0.5160.64
4_P7_D0.5120.63
13_L36_E0.5100.63
16_S21_A0.5070.62
2_L74_V0.5060.62
39_I55_A0.5020.62
18_E28_D0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pj1O 3 1 100 0.056 Contact Map
3nx6A 1 0.7979 100 0.057 Contact Map
1we3O 3 1 100 0.059 Contact Map
1pcqO 3 1 100 0.064 Contact Map
1p3hA 5 1 100 0.073 Contact Map
1g31A 4 0.883 99.9 0.258 Contact Map
3ukoA 4 0.8936 50.5 0.893 Contact Map
4c4oA 4 0.8936 48.9 0.894 Contact Map
1e3iA 2 0.8936 47.4 0.895 Contact Map
2jhfA 2 0.8936 47.3 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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