GREMLIN Database
SECA - Protein translocase subunit SecA
UniProt: P28366 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 841 (787)
Sequences: 3354 (1611)
Seq/√Len: 57.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_R56_A5.8031.00
44_K47_E5.6491.00
114_V126_V5.1721.00
423_A452_K5.0881.00
175_S180_L4.7751.00
26_I86_L4.7071.00
34_E74_R4.6901.00
506_A534_I4.6361.00
249_D268_K4.1301.00
50_E54_K4.0771.00
202_H365_E3.8771.00
413_G566_S3.6621.00
36_L44_K3.6361.00
422_V434_V3.6141.00
27_D83_K3.5761.00
329_Y337_I3.4771.00
196_M615_F3.4201.00
33_Y68_V3.2291.00
31_G34_E3.2021.00
477_K498_G3.1881.00
120_T202_H3.1281.00
700_E709_R3.0891.00
37_S40_A3.0801.00
423_A427_M3.0461.00
81_P112_L3.0111.00
454_I480_V3.0071.00
311_G344_E2.9481.00
446_S456_H2.9251.00
457_Q466_R2.9241.00
636_E685_L2.9071.00
421_D538_Y2.8921.00
52_L57_T2.8841.00
314_V323_L2.8821.00
52_L119_L2.8441.00
498_G501_E2.7671.00
89_G113_P2.7511.00
178_N357_F2.7281.00
114_V145_F2.7161.00
250_Y298_V2.7021.00
242_R297_H2.6891.00
403_R534_I2.6861.00
44_K48_F2.6341.00
411_M441_T2.6231.00
425_R428_T2.5841.00
46_I50_E2.5761.00
192_Y195_Q2.5491.00
39_D42_K2.4871.00
51_R64_E2.4741.00
41_L68_V2.4701.00
193_K619_D2.4661.00
463_N466_R2.4541.00
22_I90_V2.4301.00
426_Y455_P2.4161.00
690_D694_T2.4101.00
421_D424_Q2.3981.00
43_H46_I2.3871.00
48_F68_V2.3861.00
52_L61_L2.3571.00
57_T60_D2.3551.00
653_K656_G2.3521.00
473_E476_Q2.3511.00
497_E501_E2.3261.00
477_K502_L2.3181.00
476_Q498_G2.3121.00
45_T115_Y2.2961.00
375_K378_E2.2941.00
420_E452_K2.2861.00
68_V148_L2.2721.00
30_R80_F2.2711.00
42_K46_I2.2601.00
38_D147_F2.2541.00
307_V323_L2.2521.00
426_Y478_G2.2101.00
97_I381_F2.1951.00
160_S163_E2.1851.00
44_K68_V2.1821.00
155_N164_K2.1271.00
633_S768_E2.1231.00
79_M82_F2.1141.00
142_G146_E2.1031.00
746_T751_E2.0741.00
709_R712_E2.0601.00
412_E565_D2.0501.00
425_R430_Q2.0361.00
76_V144_I2.0281.00
741_R755_E2.0241.00
77_T144_I1.9851.00
79_M144_I1.9711.00
425_R432_V1.9671.00
731_M756_G1.9631.00
254_I547_R1.9581.00
138_A154_L1.9551.00
496_G499_V1.9511.00
117_N366_K1.9391.00
240_F269_A1.9281.00
640_A685_L1.9271.00
315_I329_Y1.9171.00
48_F115_Y1.9121.00
90_V94_D1.9071.00
19_Y87_M1.9061.00
18_R94_D1.8921.00
19_Y94_D1.8881.00
412_E416_K1.8781.00
564_D567_T1.8701.00
32_D44_K1.8671.00
686_E690_D1.8661.00
552_E555_M1.8641.00
114_V124_V1.8631.00
696_Y712_E1.8621.00
421_D425_R1.8501.00
238_N242_R1.8451.00
19_Y90_V1.8400.99
32_D36_L1.8340.99
33_Y36_L1.8220.99
444_L448_L1.8190.99
624_R700_E1.8160.99
146_E152_V1.8140.99
410_T413_G1.8090.99
238_N297_H1.8080.99
125_H364_Y1.8080.99
697_N701_E1.7980.99
694_T698_E1.7900.99
73_S81_P1.7680.99
409_R559_D1.7640.99
420_E423_A1.7610.99
261_L290_I1.7520.99
507_V526_S1.7240.99
68_V115_Y1.7180.99
52_L60_D1.7180.99
642_Y656_G1.7080.99
632_K689_M1.7020.99
430_Q534_I1.7010.99
81_P111_T1.6980.99
161_K190_V1.6970.99
37_S41_L1.6910.99
48_F64_E1.6850.99
62_L90_V1.6790.99
74_R80_F1.6730.99
632_K693_I1.6620.99
65_A115_Y1.6590.99
416_K566_S1.6500.99
498_G502_L1.6440.99
48_F61_L1.6420.99
536_Q570_Q1.6340.99
15_T18_R1.6290.99
237_A290_I1.6110.99
375_K391_T1.6010.99
22_I63_V1.5990.99
424_Q428_T1.5870.98
122_K365_E1.5860.98
84_V395_N1.5860.98
48_F52_L1.5830.98
691_R694_T1.5730.98
141_M145_F1.5690.98
110_S145_F1.5680.98
418_V510_T1.5650.98
411_M415_F1.5610.98
123_G173_T1.5570.98
680_E683_E1.5550.98
410_T542_E1.5520.98
89_G112_L1.5430.98
307_V316_V1.5420.98
127_V180_L1.5380.98
312_Q346_Q1.5380.98
73_S144_I1.5330.98
425_R506_A1.5330.98
240_F273_F1.5240.98
58_T93_H1.5200.98
33_Y64_E1.5150.98
238_N342_G1.5050.98
190_V196_M1.5040.98
23_A27_D1.4980.98
114_V172_I1.4870.98
122_K202_H1.4800.98
196_M619_D1.4730.98
120_T365_E1.4690.97
49_K120_T1.4570.97
253_D256_T1.4540.97
122_K200_P1.4540.97
162_D165_R1.4520.97
316_V323_L1.4500.97
206_I367_L1.4430.97
91_A392_I1.4300.97
631_I692_I1.4260.97
249_D264_E1.4230.97
45_T65_A1.4220.97
700_E708_M1.4170.97
159_M163_E1.4160.97
786_R789_V1.4140.97
113_P120_T1.4110.97
29_I33_Y1.4040.97
309_E323_L1.3990.97
598_Q753_Q1.3950.97
421_D506_A1.3930.97
45_T48_F1.3880.96
773_K777_K1.3880.96
49_K119_L1.3860.96
411_M444_L1.3760.96
20_E24_N1.3740.96
40_A43_H1.3690.96
58_T202_H1.3680.96
406_L536_Q1.3610.96
428_T432_V1.3600.96
60_D63_V1.3590.96
163_E166_E1.3540.96
203_F368_A1.3520.96
415_F445_I1.3490.96
56_A60_D1.3450.96
33_Y44_K1.3450.96
86_L112_L1.3410.96
200_P365_E1.3360.96
23_A83_K1.3350.96
180_L360_Y1.3350.96
429_G477_K1.3330.95
72_A76_V1.3300.95
72_A144_I1.3290.95
716_V771_V1.3230.95
143_K146_E1.3210.95
698_E702_Q1.3170.95
30_R74_R1.3100.95
123_G202_H1.3080.95
598_Q747_N1.3070.95
661_I688_I1.3040.95
93_H117_N1.3010.95
723_K766_S1.3000.95
111_T141_M1.2990.95
257_K305_D1.2940.95
730_A759_M1.2940.95
424_Q427_M1.2900.95
165_R169_A1.2880.95
426_Y432_V1.2830.94
66_F89_G1.2820.94
27_D80_F1.2760.94
457_Q479_A1.2720.94
541_M554_T1.2680.94
36_L47_E1.2680.94
201_L365_E1.2670.94
32_D35_N1.2660.94
572_K576_R1.2610.94
139_E146_E1.2610.94
243_T272_A1.2580.94
135_S139_E1.2560.94
118_A150_L1.2550.94
556_A560_R1.2540.94
69_V111_T1.2530.94
639_I685_L1.2530.94
42_K147_F1.2510.94
52_L120_T1.2500.94
605_Q608_E1.2490.94
232_K235_V1.2470.94
643_T652_W1.2440.93
415_F444_L1.2370.93
162_D166_E1.2350.93
24_N83_K1.2310.93
45_T68_V1.2310.93
24_N28_A1.2300.93
26_I90_V1.2270.93
615_F619_D1.2260.93
473_E494_K1.2230.93
476_Q494_K1.2220.93
628_E693_I1.2170.93
47_E51_R1.2120.93
161_K165_R1.2090.92
723_K770_E1.2040.92
662_N668_E1.1980.92
131_E164_K1.1960.92
80_F83_K1.1950.92
416_K420_E1.1940.92
649_P652_W1.1940.92
415_F418_V1.1920.92
425_R534_I1.1910.92
423_A426_Y1.1900.92
73_S76_V1.1870.92
135_S156_L1.1830.92
96_N388_Q1.1810.92
637_R768_E1.1810.92
138_A152_V1.1810.92
613_Q616_E1.1790.92
193_K196_M1.1770.91
314_V325_K1.1730.91
269_A290_I1.1710.91
457_Q463_N1.1680.91
422_V449_L1.1670.91
73_S79_M1.1650.91
43_H47_E1.1650.91
175_S198_Q1.1630.91
22_I25_D1.1630.91
421_D536_Q1.1620.91
693_I697_N1.1580.91
636_E640_A1.1580.91
156_L159_M1.1570.91
237_A269_A1.1550.91
407_I578_V1.1480.90
421_D534_I1.1380.90
233_L289_H1.1370.90
419_A452_K1.1370.90
114_V205_V1.1360.90
624_R628_E1.1350.90
308_V313_V1.1340.90
500_K532_P1.1300.90
151_T170_A1.1300.90
301_Q304_V1.1270.90
550_G554_T1.1270.90
44_K64_E1.1260.90
159_M164_K1.1260.90
422_V510_T1.1250.89
719_A774_F1.1230.89
175_S360_Y1.1200.89
473_E498_G1.1180.89
49_K53_E1.1160.89
110_S114_V1.1160.89
416_K565_D1.1120.89
608_E612_K1.1100.89
635_L689_M1.1090.89
471_I507_V1.1080.89
403_R536_Q1.1070.89
494_K526_S1.1070.89
27_D30_R1.1040.89
28_A63_V1.0970.88
232_K236_Q1.0970.88
25_D28_A1.0960.88
627_V771_V1.0950.88
557_M561_F1.0840.88
146_E151_T1.0830.88
639_I684_M1.0780.87
111_T145_F1.0780.87
426_Y502_L1.0620.87
237_A241_V1.0540.86
31_G35_N1.0540.86
76_V79_M1.0490.86
138_A146_E1.0460.86
81_P89_G1.0450.86
26_I29_I1.0440.86
257_K304_V1.0440.86
50_E53_E1.0440.86
204_A367_L1.0440.86
456_H480_V1.0420.86
710_E714_V1.0410.85
576_R580_S1.0410.85
20_E83_K1.0380.85
59_D93_H1.0370.85
573_M576_R1.0350.85
700_E705_K1.0330.85
694_T697_N1.0290.85
16_L20_E1.0270.85
25_D63_V1.0270.85
624_R712_E1.0260.85
786_R790_V1.0240.85
145_F150_L1.0240.85
447_K450_K1.0230.84
108_L111_T1.0230.84
69_V81_P1.0220.84
29_I64_E1.0200.84
428_T534_I1.0190.84
304_V725_M1.0180.84
259_V299_A1.0180.84
403_R506_A1.0180.84
383_N590_F1.0180.84
627_V716_V1.0160.84
569_I574_V1.0150.84
497_E500_K1.0130.84
247_E251_T1.0110.84
687_L691_R1.0110.84
477_K499_V1.0110.84
788_E791_Q1.0110.84
49_K121_G1.0100.84
91_A390_V1.0080.84
198_Q364_Y1.0050.83
237_A273_F1.0000.83
624_R709_R0.9980.83
499_V502_L0.9930.83
23_A86_L0.9920.83
725_M729_D0.9920.83
635_L688_I0.9910.83
170_A173_T0.9910.83
382_R388_Q0.9910.83
720_V767_I0.9900.82
69_V148_L0.9880.82
246_A298_V0.9860.82
719_A723_K0.9860.82
731_M752_Y0.9860.82
267_T271_K0.9840.82
69_V144_I0.9810.82
34_E80_F0.9800.82
37_S68_V0.9800.82
429_G498_G0.9800.82
350_M728_I0.9780.82
27_D86_L0.9780.82
227_A230_S0.9770.82
758_A762_H0.9760.82
39_D43_H0.9730.81
32_D64_E0.9720.81
56_A64_E0.9680.81
416_K452_K0.9680.81
4_I8_M0.9640.81
15_T19_Y0.9600.80
589_N592_S0.9550.80
415_F441_T0.9550.80
140_Q152_V0.9530.80
785_E789_V0.9510.80
70_R80_F0.9500.80
630_M716_V0.9490.80
494_K506_A0.9490.80
51_R61_L0.9490.80
127_V206_I0.9440.79
23_A26_I0.9440.79
135_S465_E0.9430.79
40_A47_E0.9430.79
465_E469_Q0.9410.79
22_I94_D0.9400.79
87_M90_V0.9390.79
42_K68_V0.9390.79
47_E68_V0.9390.79
679_K687_L0.9380.79
622_N625_E0.9350.79
546_M574_V0.9320.78
708_M712_E0.9310.78
406_L568_P0.9300.78
240_F244_L0.9270.78
13_K20_E0.9260.78
418_V445_I0.9240.78
787_E791_Q0.9230.78
722_S770_E0.9220.78
254_I548_R0.9220.78
295_K300_M0.9200.78
153_G170_A0.9200.78
73_S82_F0.9200.78
42_K76_V0.9160.77
637_R765_E0.9140.77
419_A448_L0.9140.77
382_R386_N0.9120.77
55_G60_D0.9110.77
657_L661_I0.9070.77
437_V510_T0.9050.76
192_Y710_E0.9050.76
46_I54_K0.9040.76
610_I763_M0.9040.76
737_G740_L0.9030.76
640_A681_P0.9030.76
96_N390_V0.9020.76
48_F51_R0.9010.76
409_R558_L0.9010.76
79_M140_Q0.9000.76
276_D280_D0.9000.76
406_L574_V0.9000.76
29_I32_D0.8990.76
165_R194_E0.8990.76
739_H742_A0.8980.76
300_M329_Y0.8960.76
635_L692_I0.8950.76
427_M452_K0.8940.75
750_R753_Q0.8930.75
420_E424_Q0.8920.75
157_N164_K0.8910.75
784_L789_V0.8900.75
411_M542_E0.8860.75
555_M559_D0.8860.75
55_G61_L0.8860.75
51_R55_G0.8850.75
7_K10_D0.8830.75
655_D659_D0.8830.75
622_N709_R0.8820.74
252_Y298_V0.8810.74
29_I86_L0.8780.74
46_I49_K0.8760.74
109_T138_A0.8760.74
289_H292_Q0.8750.74
430_Q506_A0.8730.74
6_N11_P0.8730.74
747_N750_R0.8730.74
782_N785_E0.8720.74
457_Q473_E0.8720.74
279_F287_N0.8690.73
123_G199_R0.8670.73
240_F272_A0.8670.73
689_M693_I0.8670.73
617_V720_V0.8660.73
413_G567_T0.8660.73
398_V535_T0.8650.73
26_I31_G0.8630.73
409_R555_M0.8630.73
10_D13_K0.8630.73
303_D307_V0.8610.73
685_L689_M0.8610.73
681_P685_L0.8590.73
416_K448_L0.8590.73
507_V578_V0.8580.72
151_T166_E0.8570.72
785_E788_E0.8570.72
766_S770_E0.8540.72
32_D47_E0.8530.72
166_E169_A0.8530.72
257_K299_A0.8510.72
785_E790_V0.8500.72
15_T388_Q0.8500.72
438_A441_T0.8440.71
350_M725_M0.8400.71
90_V93_H0.8390.71
692_I776_M0.8380.71
261_L269_A0.8370.71
762_H766_S0.8360.70
741_R751_E0.8360.70
647_E651_E0.8360.70
246_A252_Y0.8360.70
45_T52_L0.8350.70
205_V368_A0.8340.70
476_Q501_E0.8330.70
508_V534_I0.8300.70
786_R791_Q0.8300.70
167_A173_T0.8300.70
551_A571_S0.8280.70
580_S584_R0.8280.70
631_I776_M0.8280.70
231_T347_N0.8270.70
476_Q499_V0.8270.70
61_L64_E0.8260.70
636_E639_I0.8250.69
286_L737_G0.8220.69
48_F65_A0.8200.69
394_T398_V0.8200.69
729_D733_Q0.8180.69
245_K248_K0.8180.69
444_L447_K0.8170.69
8_M11_P0.8170.69
240_F290_I0.8160.69
469_Q473_E0.8150.69
164_K197_V0.8130.68
55_G59_D0.8120.68
33_Y74_R0.8110.68
173_T199_R0.8100.68
44_K115_Y0.8090.68
113_P121_G0.8080.68
79_M108_L0.8070.68
76_V142_G0.8070.68
599_Y739_H0.8060.68
300_M337_I0.8060.68
10_D21_K0.8050.68
167_A170_A0.8030.67
19_Y91_A0.8030.67
733_Q736_Q0.8020.67
639_I681_P0.8020.67
426_Y429_G0.7990.67
551_A562_G0.7980.67
426_Y479_A0.7980.67
784_L790_V0.7980.67
636_E689_M0.7980.67
362_R601_D0.7950.67
200_P615_F0.7940.66
757_F761_E0.7930.66
644_P647_E0.7900.66
447_K451_N0.7900.66
577_A580_S0.7890.66
442_S482_I0.7880.66
26_I62_L0.7850.66
476_Q500_K0.7840.66
61_L90_V0.7780.65
266_M277_N0.7770.65
367_L387_M0.7770.65
15_T96_N0.7760.65
711_F780_I0.7760.65
592_S596_L0.7750.65
413_G564_D0.7730.64
634_S772_A0.7720.64
29_I63_V0.7710.64
362_R597_L0.7700.64
32_D40_A0.7690.64
560_R572_K0.7690.64
404_P571_S0.7680.64
142_G152_V0.7680.64
379_E383_N0.7660.64
142_G150_L0.7650.64
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394_T535_T0.5090.36
703_F708_M0.5080.36
30_R70_R0.5080.36
21_K325_K0.5080.36
655_D701_E0.5080.36
234_Y293_A0.5080.36
63_V68_V0.5070.36
337_I550_G0.5070.36
783_N788_E0.5050.36
246_A250_Y0.5050.36
5_L13_K0.5050.36
280_D319_F0.5050.36
655_D673_K0.5050.36
766_S769_D0.5050.36
414_K511_E0.5040.36
11_P592_S0.5030.36
392_I404_P0.5030.36
176_T218_R0.5030.36
435_G513_H0.5030.36
775_V779_E0.5020.35
125_H204_A0.5020.35
298_V507_V0.5010.35
532_P756_G0.5010.35
441_T444_L0.5010.35
16_L693_I0.5010.35
88_G100_M0.5010.35
643_T657_L0.5010.35
355_I561_F0.5000.35
12_T19_Y0.5000.35
295_K379_E0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nktA 3 0.9156 100 0.057 Contact Map
2ipcA 2 0.9263 100 0.231 Contact Map
1tf5A 1 0.9203 100 0.332 Contact Map
2fsfA 2 0.8157 100 0.357 Contact Map
4ys0A 1 0.9037 100 0.425 Contact Map
2eyqA 1 0.6587 100 0.867 Contact Map
4ljyA 1 0.4946 100 0.873 Contact Map
4nhoA 1 0.4935 100 0.887 Contact Map
4a2wA 1 0.5957 100 0.893 Contact Map
4w7sA 2 0.4958 100 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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