GREMLIN Database
SBP - Small basic protein
UniProt: P28265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (106)
Sequences: 361 (166)
Seq/√Len: 16.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_D99_I2.7700.97
3_L106_L2.5190.95
63_F100_A2.4330.94
44_G47_A2.2440.91
46_R50_Q2.1620.89
14_I18_T2.0910.88
86_A89_F2.0360.86
85_L88_I2.0300.86
28_N82_D2.0300.86
29_Y86_A1.9240.83
31_S84_Y1.9220.83
20_L79_L1.8580.80
39_D94_R1.8170.79
75_L105_N1.7480.76
70_I100_A1.7230.75
38_L102_I1.7070.74
87_G91_F1.6830.73
40_T78_H1.6280.71
60_S64_F1.6160.70
70_I80_G1.6090.70
38_L42_I1.6020.69
86_A93_V1.5870.69
8_L23_P1.5750.68
4_P7_G1.5440.66
75_L95_L1.5410.66
59_V105_N1.5280.66
34_V99_I1.5110.65
26_Y84_Y1.4780.63
22_I85_L1.4570.62
44_G54_D1.4470.61
37_A54_D1.3990.59
80_G92_G1.3740.57
12_I107_L1.3650.57
80_G83_L1.3370.55
18_T77_V1.3350.55
94_R103_R1.2880.52
15_G47_A1.2800.52
32_L57_V1.2740.51
13_A52_T1.2700.51
6_L86_A1.2680.51
18_T71_S1.2150.48
10_L21_T1.1890.46
72_L86_A1.1860.46
64_F99_I1.1790.46
7_G100_A1.1630.45
90_A93_V1.1500.44
45_I95_L1.1310.43
61_G91_F1.1270.43
13_A17_M1.1270.43
40_T57_V1.1160.42
88_I93_V1.0940.41
5_V47_A1.0780.40
30_L74_F1.0750.40
61_G87_G1.0750.40
5_V12_I1.0690.40
13_A47_A1.0680.40
6_L10_L1.0670.39
5_V48_H1.0390.38
11_G96_F1.0220.37
44_G56_M1.0000.36
100_A104_R0.9800.35
40_T82_D0.9780.35
34_V81_V0.9760.35
29_Y88_I0.9530.33
66_I78_H0.9400.33
77_V82_D0.9350.32
34_V68_L0.9270.32
49_L55_E0.8920.30
46_R49_L0.8910.30
5_V106_L0.8900.30
53_Y87_G0.8900.30
60_S91_F0.8840.30
22_I49_L0.8710.29
35_L71_S0.8700.29
74_F82_D0.8610.29
29_Y89_F0.8600.29
9_V13_A0.8600.29
39_D103_R0.8420.28
56_M59_V0.8380.28
43_G103_R0.8340.27
93_V99_I0.8320.27
54_D107_L0.8310.27
3_L57_V0.8300.27
34_V97_Q0.8300.27
9_V57_V0.8290.27
4_P24_S0.8140.27
9_V77_V0.8050.26
91_F103_R0.7950.26
40_T64_F0.7880.25
85_L93_V0.7860.25
73_A86_A0.7800.25
73_A90_A0.7730.25
7_G96_F0.7670.24
7_G11_G0.7540.24
52_T105_N0.7360.23
37_A85_L0.7320.23
44_G48_H0.7290.23
16_L57_V0.7150.22
3_L90_A0.7140.22
36_A62_F0.7110.22
5_V101_V0.7020.22
3_L105_N0.7020.22
9_V24_S0.6950.22
21_T85_L0.6930.21
34_V75_L0.6880.21
22_I30_L0.6850.21
38_L53_Y0.6840.21
60_S87_G0.6770.21
33_A42_I0.6760.21
12_I83_L0.6720.21
14_I21_T0.6700.21
19_N78_H0.6660.20
34_V93_V0.6640.20
29_Y37_A0.6630.20
40_T99_I0.6610.20
50_Q95_L0.6560.20
41_L74_F0.6520.20
35_L95_L0.6490.20
45_I67_I0.6480.20
34_V108_T0.6470.20
17_M26_Y0.6440.20
33_A41_L0.6430.20
28_N59_V0.6420.20
10_L23_P0.6420.20
82_D85_L0.6340.19
10_L48_H0.6220.19
30_L44_G0.6190.19
6_L108_T0.6140.18
14_I71_S0.6140.18
5_V51_G0.6030.18
37_A89_F0.5890.18
19_N26_Y0.5840.17
32_L40_T0.5820.17
73_A93_V0.5810.17
34_V51_G0.5780.17
46_R95_L0.5770.17
49_L102_I0.5750.17
35_L40_T0.5620.17
10_L51_G0.5620.17
45_I51_G0.5540.16
26_Y91_F0.5490.16
90_A97_Q0.5410.16
40_T77_V0.5360.16
34_V45_I0.5270.16
35_L73_A0.5260.16
61_G84_Y0.5210.15
51_G78_H0.5170.15
32_L37_A0.5140.15
26_Y87_G0.5140.15
42_I107_L0.5130.15
30_L88_I0.5130.15
60_S104_R0.5120.15
73_A83_L0.5100.15
82_D93_V0.5100.15
52_T83_L0.5090.15
57_V67_I0.5070.15
47_A71_S0.5060.15
48_H81_V0.5030.15
26_Y56_M0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eneA 2 0.8347 19.2 0.94 Contact Map
4umwA 1 0.9008 9.5 0.948 Contact Map
3j08A 2 0.9917 9.2 0.948 Contact Map
3j09A 2 0.9752 8.5 0.949 Contact Map
3nd0A 2 0.8099 6.1 0.952 Contact Map
4r23A 1 0.0248 6 0.952 Contact Map
4gb32 4 0.4215 5.5 0.953 Contact Map
4rr3G 1 0.405 5.5 0.953 Contact Map
3w4tA 1 0.9174 5.5 0.953 Contact Map
1ncqB 4 0.4298 5.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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