GREMLIN Database
FTSA - Cell division protein FtsA
UniProt: P28264 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (372)
Sequences: 7603 (4238)
Seq/√Len: 219.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_L179_E4.8201.00
240_D297_A4.5901.00
229_V301_E4.5701.00
223_H226_S3.7211.00
207_I302_I3.6651.00
253_E257_K3.5431.00
15_S211_G3.1931.00
22_G27_D3.1021.00
406_H410_E2.8781.00
218_V309_E2.7911.00
241_I286_F2.7021.00
336_S340_D2.6011.00
290_E293_N2.5961.00
22_G26_D2.5711.00
366_G378_Q2.5351.00
116_V120_P2.5351.00
335_M347_R2.5081.00
14_T212_G2.4751.00
401_E405_H2.4211.00
205_A218_V2.3471.00
209_I237_I2.3331.00
270_D285_T2.2841.00
174_E179_E2.2581.00
24_M27_D2.2371.00
287_T290_E2.2351.00
328_Q331_M2.2311.00
403_E406_H2.2041.00
237_I298_R2.2011.00
299_V333_G2.1671.00
296_E300_E2.1561.00
337_L340_D2.1511.00
406_H409_N2.1491.00
251_E254_R2.1431.00
205_A216_I2.1401.00
401_E406_H2.1081.00
56_S235_E2.1011.00
237_I299_V1.9441.00
307_S311_R1.9431.00
378_Q381_K1.9331.00
401_E409_N1.9311.00
39_S42_L1.8871.00
400_E403_E1.8651.00
291_A331_M1.8491.00
7_Y181_T1.8351.00
155_E173_V1.8211.00
254_R258_Q1.8151.00
8_V19_V1.8151.00
209_I214_T1.8141.00
241_I252_A1.7981.00
242_S249_T1.7911.00
240_D298_R1.7891.00
288_Q292_A1.7811.00
152_L181_T1.7711.00
51_D82_N1.7661.00
12_I169_L1.7641.00
295_I299_V1.7591.00
167_H171_R1.7561.00
272_I285_T1.7461.00
405_H409_N1.7461.00
307_S341_V1.7421.00
22_G25_T1.7131.00
322_F342_L1.7111.00
237_I295_I1.7101.00
114_A118_S1.6951.00
234_G328_Q1.6751.00
309_E312_S1.6701.00
295_I331_M1.6651.00
401_E407_H1.6401.00
30_N34_V1.6401.00
240_D295_I1.6381.00
400_E407_H1.6351.00
33_G45_G1.6331.00
293_N296_E1.6321.00
400_E406_H1.6301.00
110_V113_A1.6291.00
400_E409_N1.6171.00
299_V337_L1.6001.00
402_Q406_H1.6001.00
303_L341_V1.5871.00
202_L321_G1.5841.00
384_F388_E1.5791.00
379_G394_I1.5691.00
308_E312_S1.5581.00
94_A99_N1.5561.00
45_G49_D1.5401.00
251_E255_V1.5381.00
104_V108_R1.5301.00
117_V143_D1.5221.00
363_T367_L1.5071.00
241_I291_A1.5051.00
49_D52_E1.4861.00
237_I291_A1.4671.00
171_R174_E1.4571.00
239_K249_T1.4571.00
303_L307_S1.4571.00
203_G220_Q1.4521.00
19_V60_A1.4411.00
368_I376_R1.4361.00
242_S252_A1.4301.00
292_A336_S1.4291.00
214_T302_I1.4231.00
407_H410_E1.3931.00
300_E337_L1.3921.00
304_E308_E1.3781.00
377_I394_I1.3771.00
102_I107_V1.3771.00
290_E294_I1.3651.00
303_L334_V1.3641.00
247_T275_V1.3531.00
291_A328_Q1.3341.00
17_T115_Q1.3311.00
333_G336_S1.3231.00
115_Q118_S1.3091.00
218_V315_I1.2961.00
238_T253_E1.2931.00
232_L236_N1.2561.00
255_V271_E1.2531.00
274_E283_K1.2481.00
91_G95_V1.2431.00
218_V319_P1.2411.00
370_F374_N1.2381.00
186_Q215_T1.2351.00
371_A377_I1.2201.00
102_I110_V1.2151.00
172_C176_A1.2081.00
28_S34_V1.2031.00
170_L183_I1.2021.00
403_E407_H1.2011.00
109_R112_E1.1991.00
296_E333_G1.1921.00
247_T251_E1.1791.00
255_V286_F1.1781.00
404_Q407_H1.1771.00
238_T256_K1.1761.00
304_E307_S1.1741.00
244_G294_I1.1661.00
362_M366_G1.1601.00
85_N89_T1.1371.00
396_V399_S1.1251.00
401_E410_E1.1161.00
82_N94_A1.1121.00
227_T305_I1.1041.00
92_V95_V1.0931.00
255_V273_F1.0841.00
185_L188_L1.0801.00
94_A101_E1.0791.00
212_G215_T1.0791.00
321_G346_V1.0781.00
73_R76_I1.0761.00
260_G295_I1.0751.00
309_E313_M1.0741.00
203_G315_I1.0731.00
364_G367_L1.0701.00
173_V183_I1.0701.00
247_T276_T1.0701.00
303_L337_L1.0671.00
392_Q397_S1.0661.00
405_H408_Q1.0651.00
363_T366_G1.0631.00
381_K384_F1.0551.00
247_T278_I1.0521.00
209_I334_V1.0491.00
25_T30_N1.0491.00
203_G320_G1.0391.00
54_V95_V1.0301.00
361_Y364_G1.0271.00
300_E304_E1.0251.00
390_A393_E1.0251.00
112_E115_Q1.0241.00
395_A399_S1.0051.00
336_S339_Q1.0041.00
404_Q409_N1.0031.00
324_L334_V1.0031.00
303_L306_V0.9881.00
161_G165_I0.9841.00
296_E337_L0.9801.00
295_I298_R0.9791.00
216_I309_E0.9761.00
288_Q332_P0.9711.00
57_I93_V0.9691.00
237_I328_Q0.9671.00
299_V334_V0.9671.00
174_E401_E0.9641.00
361_Y367_L0.9611.00
370_F373_R0.9611.00
237_I331_M0.9611.00
12_I112_E0.9611.00
57_I172_C0.9581.00
377_I392_Q0.9581.00
80_N83_Y0.9571.00
401_E408_Q0.9531.00
403_E409_N0.9461.00
310_L317_D0.9441.00
8_V153_E0.9421.00
209_I328_Q0.9401.00
360_Q385_K0.9381.00
57_I108_R0.9351.00
299_V302_I0.9331.00
173_V180_I0.9331.00
256_K328_Q0.9321.00
42_L53_T0.9311.00
337_L341_V0.9240.99
89_T95_V0.9230.99
250_E254_R0.9140.99
157_T183_I0.9120.99
361_Y365_V0.9110.99
166_L185_L0.9080.99
306_V338_A0.9050.99
20_I355_G0.9040.99
359_P366_G0.9040.99
390_A394_I0.9030.99
380_R383_G0.9000.99
360_Q366_G0.8990.99
35_G38_P0.8940.99
91_G94_A0.8920.99
394_I397_S0.8900.99
359_P364_G0.8880.99
402_Q407_H0.8880.99
380_R392_Q0.8860.99
14_T213_S0.8860.99
112_E116_V0.8850.99
113_A117_V0.8850.99
171_R175_R0.8850.99
392_Q396_V0.8800.99
333_G337_L0.8770.99
258_Q268_S0.8760.99
372_C397_S0.8750.99
384_F393_E0.8720.99
367_L371_A0.8680.99
228_R309_E0.8680.99
330_A350_S0.8680.99
382_I387_P0.8670.99
34_V37_V0.8620.99
204_V323_V0.8610.99
184_C189_A0.8610.99
366_G376_R0.8600.99
143_D146_K0.8570.99
209_I302_I0.8550.99
117_V120_P0.8540.99
107_V145_K0.8520.99
29_L34_V0.8520.99
272_I283_K0.8510.99
400_E410_E0.8510.99
86_I92_V0.8510.99
89_T92_V0.8500.99
402_Q405_H0.8490.99
190_A325_T0.8480.99
308_E311_R0.8470.99
60_A79_V0.8460.99
380_R396_V0.8420.99
303_L338_A0.8410.99
298_R301_E0.8410.99
239_K242_S0.8400.99
23_E30_N0.8400.99
68_V85_N0.8400.99
114_A117_V0.8400.99
379_G387_P0.8390.99
357_R361_Y0.8390.99
400_E405_H0.8370.99
358_D361_Y0.8340.99
23_E26_D0.8330.99
67_M73_R0.8290.99
167_H170_L0.8290.99
199_E202_L0.8260.99
187_P215_T0.8240.99
315_I318_L0.8190.99
386_M392_Q0.8190.99
170_L174_E0.8190.99
162_S165_I0.8170.99
218_V313_M0.8160.99
106_D110_V0.8140.99
30_N37_V0.8110.99
92_V101_E0.8090.99
403_E408_Q0.8090.99
42_L45_G0.8080.99
392_Q398_S0.8050.99
305_I309_E0.8050.99
339_Q345_N0.8040.99
163_K167_H0.8040.99
207_I306_V0.8040.99
108_R169_L0.8030.99
240_D294_I0.7990.98
158_L161_G0.7960.98
23_E27_D0.7950.98
289_Q293_N0.7900.98
391_I397_S0.7880.98
84_I101_E0.7880.98
202_L320_G0.7860.98
379_G382_I0.7840.98
195_L323_V0.7840.98
55_H80_N0.7790.98
157_T185_L0.7780.98
385_K389_E0.7750.98
11_D212_G0.7720.98
383_G388_E0.7720.98
88_D157_T0.7710.98
312_S382_I0.7690.98
9_S368_I0.7680.98
191_G219_F0.7680.98
7_Y152_L0.7660.98
317_D341_V0.7660.98
74_K181_T0.7650.98
112_E119_V0.7640.98
255_V291_A0.7600.98
388_E396_V0.7560.98
261_H268_S0.7550.98
346_V353_Y0.7540.98
402_Q409_N0.7540.98
387_P394_I0.7530.98
258_Q271_E0.7530.98
302_I334_V0.7520.98
388_E392_Q0.7470.98
391_I394_I0.7450.98
380_R388_E0.7430.98
381_K390_A0.7420.98
359_P365_V0.7420.98
359_P368_I0.7390.97
111_M115_Q0.7390.97
395_A398_S0.7380.97
74_K77_V0.7380.97
208_D212_G0.7370.97
159_I187_P0.7370.97
115_Q119_V0.7350.97
356_V365_V0.7320.97
392_Q395_A0.7320.97
159_I215_T0.7310.97
212_G234_G0.7310.97
286_F291_A0.7310.97
106_D109_R0.7290.97
404_Q410_E0.7240.97
379_G393_E0.7210.97
388_E393_E0.7190.97
79_V83_Y0.7170.97
103_Q106_D0.7160.97
357_R360_Q0.7150.97
388_E394_I0.7150.97
310_L315_I0.7130.97
393_E398_S0.7130.97
54_V57_I0.7130.97
187_P217_A0.7110.97
306_V341_V0.7080.97
75_A231_P0.7050.97
19_V115_Q0.7050.97
379_G390_A0.7030.97
235_E249_T0.7020.97
86_I89_T0.7000.97
365_V371_A0.6990.96
234_G256_K0.6970.96
73_R77_V0.6960.96
383_G386_M0.6960.96
278_I281_N0.6920.96
401_E404_Q0.6910.96
367_L374_N0.6910.96
260_G331_M0.6890.96
10_L155_E0.6880.96
374_N378_Q0.6880.96
34_V110_V0.6880.96
346_V349_A0.6880.96
245_L294_I0.6850.96
49_D53_T0.6840.96
379_G384_F0.6830.96
404_Q408_Q0.6820.96
385_K392_Q0.6810.96
362_M367_L0.6790.96
74_K78_G0.6780.96
254_R257_K0.6780.96
78_G84_I0.6760.96
384_F390_A0.6750.96
17_T30_N0.6730.96
57_I107_V0.6710.96
400_E404_Q0.6690.96
385_K388_E0.6670.95
390_A396_V0.6660.95
357_R367_L0.6650.95
375_A378_Q0.6650.95
289_Q292_A0.6640.95
260_G292_A0.6630.95
379_G395_A0.6610.95
31_I34_V0.6610.95
89_T93_V0.6600.95
33_G49_D0.6590.95
359_P362_M0.6590.95
362_M383_G0.6580.95
300_E303_L0.6550.95
287_T292_A0.6520.95
58_R62_D0.6520.95
366_G371_A0.6510.95
107_V110_V0.6510.95
166_L183_I0.6500.95
84_I94_A0.6490.95
390_A397_S0.6470.95
207_I228_R0.6470.95
390_A399_S0.6460.95
324_L338_A0.6440.94
88_D92_V0.6430.94
358_D371_A0.6430.94
54_V107_V0.6410.94
382_I385_K0.6410.94
379_G391_I0.6390.94
380_R386_M0.6390.94
384_F389_E0.6380.94
61_F169_L0.6370.94
81_G84_I0.6360.94
232_L305_I0.6360.94
211_G215_T0.6350.94
362_M370_F0.6350.94
379_G383_G0.6340.94
11_D208_D0.6340.94
389_E393_E0.6330.94
247_T255_V0.6330.94
214_T306_V0.6320.94
372_C377_I0.6300.94
76_I83_Y0.6300.94
397_S408_Q0.6270.94
317_D343_Q0.6250.94
253_E256_K0.6240.94
277_V281_N0.6240.94
335_M339_Q0.6230.93
400_E408_Q0.6230.93
109_R175_R0.6200.93
155_E169_L0.6180.93
214_T232_L0.6170.93
21_V144_P0.6160.93
34_V102_I0.6150.93
69_G75_A0.6150.93
357_R370_F0.6150.93
81_G86_I0.6130.93
380_R385_K0.6120.93
66_R69_G0.6110.93
27_D32_I0.6090.93
365_V370_F0.6090.93
236_N239_K0.6080.93
108_R112_E0.6060.93
300_E341_V0.6050.92
402_Q408_Q0.6050.92
385_K394_I0.6050.92
153_E178_I0.6050.92
348_V351_P0.6050.92
372_C376_R0.6040.92
385_K391_I0.6030.92
217_A235_E0.6020.92
391_I396_V0.6010.92
381_K388_E0.5980.92
207_I216_I0.5980.92
11_D14_T0.5960.92
205_A306_V0.5960.92
187_P213_S0.5890.91
25_T28_S0.5850.91
69_G73_R0.5850.91
14_T211_G0.5850.91
388_E391_I0.5840.91
75_A81_G0.5840.91
384_F392_Q0.5810.91
368_I374_N0.5800.91
369_Q372_C0.5800.91
347_R350_S0.5790.91
47_I250_E0.5780.91
389_E392_Q0.5770.91
335_M348_V0.5750.90
57_I61_F0.5750.90
365_V375_A0.5740.90
232_L301_E0.5730.90
383_G394_I0.5730.90
387_P390_A0.5720.90
12_I108_R0.5710.90
373_R377_I0.5700.90
88_D91_G0.5700.90
377_I395_A0.5690.90
390_A398_S0.5690.90
386_M399_S0.5680.90
386_M394_I0.5670.90
208_D215_T0.5640.90
32_I37_V0.5640.90
27_D34_V0.5640.90
362_M368_I0.5640.90
70_F73_R0.5640.90
241_I273_F0.5630.90
218_V310_L0.5620.89
35_G60_A0.5610.89
379_G386_M0.5610.89
380_R384_F0.5590.89
159_I169_L0.5590.89
77_V173_V0.5560.89
186_Q213_S0.5560.89
191_G195_L0.5550.89
393_E396_V0.5550.89
10_L153_E0.5540.89
52_E55_H0.5540.89
398_S405_H0.5540.89
246_R250_E0.5530.89
83_Y91_G0.5510.89
394_I398_S0.5500.88
89_T156_G0.5500.88
402_Q410_E0.5490.88
31_I55_H0.5490.88
78_G82_N0.5480.88
381_K396_V0.5480.88
361_Y368_I0.5470.88
389_E395_A0.5460.88
384_F397_S0.5460.88
6_L148_L0.5460.88
386_M391_I0.5450.88
339_Q347_R0.5440.88
247_T277_V0.5440.88
106_D112_E0.5430.88
205_A310_L0.5410.88
78_G81_G0.5410.88
70_F74_K0.5400.88
391_I398_S0.5400.88
215_T234_G0.5400.88
365_V376_R0.5390.87
166_L188_L0.5380.87
90_N95_V0.5370.87
306_V342_L0.5370.87
395_A400_E0.5350.87
295_I328_Q0.5330.87
60_A93_V0.5330.87
384_F394_I0.5320.87
24_M30_N0.5310.87
102_I106_D0.5310.87
389_E394_I0.5310.87
8_V21_V0.5310.87
108_R111_M0.5300.87
302_I305_I0.5300.87
190_A211_G0.5290.86
159_I212_G0.5290.86
173_V178_I0.5250.86
272_I284_Q0.5250.86
9_S355_G0.5250.86
77_V80_N0.5250.86
30_N38_P0.5240.86
379_G385_K0.5230.86
379_G392_Q0.5180.85
8_V150_V0.5150.85
10_L75_A0.5150.85
95_V100_K0.5150.85
216_I228_R0.5150.85
22_G368_I0.5140.85
16_N56_S0.5130.85
382_I396_V0.5130.85
386_M395_A0.5120.85
15_S213_S0.5120.85
351_P355_G0.5120.85
382_I386_M0.5120.85
383_G392_Q0.5110.85
57_I111_M0.5100.84
30_N33_G0.5100.84
360_Q365_V0.5090.84
360_Q372_C0.5090.84
104_V145_K0.5080.84
110_V120_P0.5080.84
288_Q336_S0.5080.84
48_V243_I0.5070.84
363_T380_R0.5070.84
393_E397_S0.5060.84
260_G288_Q0.5030.84
292_A331_M0.5010.83
80_N84_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d2fA 1 0.9205 100 0.351 Contact Map
4fl9A 1 0.9159 100 0.355 Contact Map
4jneA 2 0.9182 100 0.364 Contact Map
3wqtA 2 0.8136 100 0.369 Contact Map
2v7yA 1 0.8318 100 0.398 Contact Map
4rtfD 1 0.6705 100 0.416 Contact Map
3wt0A 1 0.8591 100 0.448 Contact Map
4a2aA 1 0.8227 100 0.463 Contact Map
4kboA 1 0.75 100 0.472 Contact Map
3i33A 1 0.7523 100 0.475 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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