SP5K - BACSU - GREMLIN Contacts

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SP5K - Stage V sporulation protein K

UniProt:	P27643	Sequences: MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAKHGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPGTGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILFIDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSRFPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGRFVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	322 (257)
Sequences:	18624 (9164)
Seq/√Len:	571.6

ECOLI - FTSH RUVB RARA
BACSU - SP5K FTSH YJOB RUVB YRVN
HALSA - CDCH Q9HPU1 Q9HPV0 Q9HHW2 PAN1 Q9HPG1 PAN2 Q9HNK6 RFCL CDC69
SULSO - Q980U9 Q97ZZ9 Q97V06 PAN Q97W25 Q97ZJ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
229_S	232_Q	5.170	1.00
160_F	199_A	3.446	1.00
237_A	278_V	3.432	1.00
198_L	219_F	3.328	1.00
234_M	238_K	3.132	1.00
230_V	258_D	3.082	1.00
250_Q	253_E	2.837	1.00
49_K	52_E	2.832	1.00
235_E	238_K	2.708	1.00
234_M	253_E	2.589	1.00
238_K	261_M	2.560	1.00
53_K	56_S	2.541	1.00
248_L	252_A	2.533	1.00
293_L	298_Q	2.414	1.00
54_E	114_K	2.269	1.00
63_E	226_P	2.237	1.00
53_K	115_L	2.233	1.00
55_M	62_E	2.223	1.00
246_Y	252_A	2.185	1.00
240_M	279_R	2.150	1.00
281_V	285_S	2.125	1.00
227_D	274_N	2.096	1.00
97_F	225_F	2.095	1.00
249_S	252_A	2.078	1.00
241_I	282_I	2.049	1.00
109_A	197_I	2.033	1.00
94_H	187_M	2.014	1.00
257_K	308_K	1.964	1.00
279_R	283_E	1.943	1.00
51_I	55_M	1.906	1.00
164_A	198_L	1.884	1.00
128_I	157_G	1.875	1.00
70_E	288_A	1.859	1.00
131_E	134_D	1.839	1.00
230_V	234_M	1.826	1.00
70_E	292_R	1.772	1.00
70_E	291_M	1.748	1.00
257_K	260_L	1.704	1.00
64_M	223_I	1.670	1.00
55_M	65_K	1.652	1.00
217_S	276_R	1.646	1.00
108_V	225_F	1.634	1.00
62_E	232_Q	1.632	1.00
242_D	245_E	1.631	1.00
244_R	282_I	1.623	1.00
247_Q	250_Q	1.618	1.00
185_K	189_D	1.598	1.00
235_E	239_R	1.594	1.00
250_Q	254_W	1.591	1.00
96_M	219_F	1.588	1.00
234_M	254_W	1.585	1.00
50_E	115_L	1.562	1.00
149_D	152_K	1.538	1.00
182_T	186_H	1.538	1.00
100_N	227_D	1.515	1.00
65_K	108_V	1.513	1.00
59_V	239_R	1.497	1.00
221_I	284_K	1.490	1.00
238_K	253_E	1.472	1.00
240_M	243_E	1.467	1.00
58_L	107_T	1.456	1.00
203_R	207_H	1.440	1.00
67_N	221_I	1.435	1.00
251_E	254_W	1.417	1.00
137_G	142_H	1.416	1.00
231_T	234_M	1.415	1.00
232_Q	235_E	1.407	1.00
150_L	153_K	1.405	1.00
69_K	73_A	1.393	1.00
252_A	257_K	1.384	1.00
138_E	142_H	1.380	1.00
255_K	258_D	1.370	1.00
248_L	251_E	1.362	1.00
57_A	114_K	1.354	1.00
54_E	57_A	1.350	1.00
300_L	303_D	1.341	1.00
62_E	235_E	1.329	1.00
289_Q	293_L	1.329	1.00
51_I	66_R	1.306	1.00
230_V	257_K	1.298	1.00
66_R	70_E	1.289	1.00
66_R	291_M	1.277	1.00
61_M	64_M	1.262	1.00
226_P	232_Q	1.261	1.00
79_Q	82_A	1.253	1.00
143_T	179_A	1.246	1.00
187_M	219_F	1.244	1.00
236_I	275_G	1.240	1.00
130_A	150_L	1.220	1.00
145_Q	149_D	1.217	1.00
230_V	261_M	1.209	1.00
75_I	78_N	1.208	1.00
241_I	244_R	1.194	1.00
299_Y	303_D	1.192	1.00
155_L	186_H	1.176	1.00
246_Y	249_S	1.173	1.00
42_E	45_H	1.169	1.00
248_L	253_E	1.168	1.00
237_A	282_I	1.166	1.00
62_E	66_R	1.165	1.00
163_E	218_R	1.161	1.00
202_S	207_H	1.155	1.00
293_L	296_G	1.152	1.00
151_I	194_F	1.150	1.00
98_K	224_D	1.147	1.00
299_Y	302_S	1.146	1.00
256_L	260_L	1.138	1.00
239_R	242_D	1.132	1.00
273_S	281_V	1.110	1.00
234_M	257_K	1.103	1.00
204_E	207_H	1.103	1.00
247_Q	304_L	1.101	1.00
151_I	186_H	1.097	1.00
126_H	154_S	1.097	1.00
76_F	79_Q	1.078	1.00
258_D	261_M	1.077	1.00
257_K	306_T	1.074	1.00
41_N	44_K	1.070	1.00
98_K	222_S	1.068	1.00
145_Q	148_R	1.053	1.00
112_I	197_I	1.051	1.00
63_E	67_N	1.049	1.00
247_Q	252_A	1.045	1.00
234_M	261_M	1.045	1.00
79_Q	83_E	1.040	1.00
49_K	53_K	1.040	1.00
142_H	145_Q	1.025	1.00
70_E	73_A	1.020	1.00
246_Y	250_Q	1.017	1.00
285_S	289_Q	1.013	1.00
78_N	81_R	1.013	1.00
158_I	197_I	1.013	1.00
109_A	127_L	1.008	1.00
76_F	80_K	1.008	1.00
292_R	296_G	1.002	1.00
257_K	261_M	0.999	1.00
116_F	123_S	0.988	1.00
186_H	196_L	0.987	1.00
163_E	201_Y	0.978	1.00
233_L	270_I	0.977	1.00
127_L	160_F	0.974	1.00
240_M	278_V	0.973	1.00
40_K	43_A	0.966	1.00
97_F	197_I	0.964	1.00
111_L	114_K	0.963	1.00
240_M	244_R	0.963	1.00
297_D	302_S	0.956	1.00
135_L	146_K	0.946	1.00
110_R	129_E	0.939	1.00
299_Y	305_M	0.936	1.00
168_A	183_L	0.925	1.00
287_R	291_M	0.925	1.00
255_K	259_Y	0.925	1.00
174_D	177_K	0.924	1.00
65_K	69_K	0.924	1.00
252_A	259_Y	0.913	1.00
55_M	111_L	0.911	1.00
132_R	161_I	0.907	1.00
128_I	159_L	0.904	1.00
48_L	292_R	0.903	1.00
139_Y	142_H	0.885	1.00
80_K	83_E	0.882	1.00
70_E	74_W	0.880	1.00
247_Q	251_E	0.878	1.00
247_Q	306_T	0.878	1.00
249_S	308_K	0.874	1.00
96_M	164_A	0.872	1.00
98_K	200_G	0.872	1.00
152_K	155_L	0.871	1.00
149_D	153_K	0.868	1.00
244_R	307_I	0.866	1.00
211_L	222_S	0.865	1.00
64_M	108_V	0.856	1.00
144_A	178_E	0.853	1.00
252_A	256_L	0.840	1.00
256_L	259_Y	0.835	1.00
126_H	157_G	0.833	1.00
137_G	145_Q	0.832	1.00
113_G	127_L	0.821	1.00
59_V	236_I	0.818	1.00
231_T	235_E	0.811	1.00
106_T	162_D	0.809	1.00
48_L	295_M	0.805	1.00
41_N	45_H	0.799	1.00
246_Y	251_E	0.798	1.00
52_E	55_M	0.797	1.00
248_L	254_W	0.796	1.00
297_D	300_L	0.796	1.00
57_A	111_L	0.795	1.00
87_K	92_A	0.795	1.00
246_Y	257_K	0.794	1.00
194_F	198_L	0.791	1.00
172_E	176_G	0.783	1.00
201_Y	218_R	0.782	1.00
246_Y	253_E	0.780	1.00
269_P	272_F	0.780	1.00
57_A	107_T	0.774	1.00
51_I	73_A	0.770	1.00
68_I	108_V	0.769	1.00
237_A	281_V	0.767	1.00
177_K	181_D	0.766	1.00
148_R	186_H	0.760	1.00
228_Y	233_L	0.760	1.00
59_V	235_E	0.759	1.00
196_L	200_G	0.755	1.00
86_L	90_K	0.755	1.00
286_I	307_I	0.754	1.00
297_D	301_K	0.753	1.00
77_V	80_K	0.752	1.00
247_Q	254_W	0.750	1.00
41_N	49_K	0.749	1.00
280_N	284_K	0.746	1.00
67_N	70_E	0.744	1.00
151_I	155_L	0.742	1.00
247_Q	257_K	0.741	1.00
296_G	303_D	0.737	1.00
196_L	201_Y	0.737	1.00
184_V	188_E	0.737	1.00
260_L	278_V	0.734	1.00
96_M	207_H	0.728	1.00
234_M	258_D	0.726	1.00
131_E	185_K	0.723	1.00
174_D	178_E	0.721	1.00
67_N	223_I	0.720	1.00
203_R	206_D	0.720	1.00
254_W	257_K	0.717	1.00
238_K	250_Q	0.715	1.00
128_I	153_K	0.712	1.00
288_A	292_R	0.709	1.00
194_F	201_Y	0.709	1.00
292_R	310_Q	0.709	1.00
123_S	126_H	0.707	1.00
280_N	283_E	0.706	1.00
91_Q	110_R	0.705	1.00
74_W	287_R	0.705	1.00
55_M	58_L	0.702	1.00
66_R	69_K	0.701	1.00
96_M	198_L	0.700	1.00
147_T	151_I	0.699	1.00
203_R	208_F	0.696	1.00
127_L	158_I	0.694	1.00
107_T	111_L	0.694	1.00
162_D	218_R	0.690	1.00
255_K	304_L	0.688	1.00
175_F	178_E	0.687	1.00
198_L	201_Y	0.686	1.00
170_G	208_F	0.686	1.00
168_A	210_S	0.685	1.00
283_E	287_R	0.683	1.00
45_H	48_L	0.682	1.00
188_E	279_R	0.679	1.00
233_L	269_P	0.679	1.00
270_I	273_S	0.677	1.00
64_M	67_N	0.677	1.00
274_N	278_V	0.673	1.00
161_I	198_L	0.672	1.00
111_L	115_L	0.671	1.00
251_E	301_K	0.666	1.00
167_L	183_L	0.663	1.00
46_G	49_K	0.660	1.00
300_L	304_L	0.660	1.00
247_Q	253_E	0.660	1.00
302_S	305_M	0.659	1.00
40_K	44_K	0.651	1.00
44_K	48_L	0.651	1.00
241_I	252_A	0.650	1.00
77_V	81_R	0.650	1.00
169_R	177_K	0.650	1.00
303_D	306_T	0.641	1.00
56_S	242_D	0.637	1.00
42_E	46_G	0.634	1.00
140_I	175_F	0.632	1.00
164_A	210_S	0.630	1.00
187_M	196_L	0.626	1.00
250_Q	255_K	0.625	1.00
195_I	201_Y	0.621	1.00
202_S	205_M	0.618	1.00
80_K	293_L	0.618	1.00
289_Q	292_R	0.616	1.00
135_L	143_T	0.616	1.00
230_V	254_W	0.615	1.00
58_L	61_M	0.615	1.00
129_E	189_D	0.615	1.00
306_T	310_Q	0.614	1.00
255_K	306_T	0.614	1.00
57_A	124_K	0.614	1.00
270_I	277_F	0.613	1.00
156_G	193_E	0.613	1.00
183_L	187_M	0.612	1.00
48_L	51_I	0.611	1.00
194_F	200_G	0.611	1.00
244_R	286_I	0.609	1.00
188_E	218_R	0.606	1.00
128_I	150_L	0.605	1.00
194_F	199_A	0.603	1.00
256_L	261_M	0.603	1.00
70_E	287_R	0.602	1.00
71_I	74_W	0.599	1.00
227_D	272_F	0.595	1.00
298_Q	302_S	0.593	1.00
54_E	58_L	0.591	1.00
101_P	163_E	0.591	1.00
53_K	114_K	0.590	1.00
259_Y	308_K	0.588	1.00
253_E	257_K	0.588	1.00
275_G	280_N	0.584	1.00
214_G	218_R	0.584	1.00
306_T	309_S	0.584	1.00
53_K	57_A	0.583	1.00
247_Q	255_K	0.583	1.00
43_A	46_G	0.582	1.00
251_E	255_K	0.581	1.00
136_V	175_F	0.581	1.00
240_M	282_I	0.580	1.00
183_L	186_H	0.580	1.00
196_L	199_A	0.579	1.00
48_L	296_G	0.578	1.00
68_I	72_Y	0.577	1.00
103_T	225_F	0.577	1.00
73_A	292_R	0.575	1.00
140_I	174_D	0.575	1.00
56_S	115_L	0.574	1.00
68_I	95_M	0.572	1.00
136_V	182_T	0.570	0.99
286_I	291_M	0.563	0.99
241_I	246_Y	0.562	0.99
202_S	208_F	0.560	0.99
299_Y	306_T	0.560	0.99
148_R	152_K	0.560	0.99
151_I	154_S	0.556	0.99
138_E	145_Q	0.556	0.99
252_A	260_L	0.554	0.99
217_S	280_N	0.553	0.99
163_E	184_V	0.551	0.99
52_E	56_S	0.551	0.99
195_I	198_L	0.550	0.99
74_W	78_N	0.549	0.99
193_E	199_A	0.549	0.99
284_K	287_R	0.545	0.99
57_A	242_D	0.545	0.99
133_A	148_R	0.545	0.99
250_Q	257_K	0.544	0.99
63_E	66_R	0.544	0.99
207_H	210_S	0.542	0.99
72_Y	75_I	0.541	0.99
251_E	257_K	0.541	0.99
292_R	305_M	0.540	0.99
301_K	304_L	0.539	0.99
55_M	59_V	0.538	0.99
239_R	243_E	0.537	0.99
247_Q	259_Y	0.537	0.99
195_I	200_G	0.536	0.99
251_E	309_S	0.535	0.99
47_I	50_E	0.533	0.99
230_V	269_P	0.533	0.99
54_E	115_L	0.531	0.99
192_H	196_L	0.528	0.99
254_W	258_D	0.527	0.99
146_K	149_D	0.523	0.99
112_I	116_F	0.523	0.99
154_S	157_G	0.522	0.99
192_H	200_G	0.520	0.99
298_Q	301_K	0.518	0.99
40_K	292_R	0.518	0.99
136_V	179_A	0.518	0.99
148_R	182_T	0.517	0.99
254_W	309_S	0.517	0.99
233_L	237_A	0.516	0.99
184_V	189_D	0.515	0.99
230_V	271_K	0.514	0.99
130_A	161_I	0.514	0.99
58_L	111_L	0.514	0.99
173_K	177_K	0.513	0.99
228_Y	236_I	0.513	0.99
152_K	186_H	0.510	0.99
161_I	164_A	0.510	0.99
106_T	218_R	0.510	0.99
82_A	85_G	0.508	0.99
94_H	219_F	0.506	0.99
270_I	278_V	0.505	0.99
182_T	185_K	0.505	0.99
109_A	160_F	0.503	0.99
246_Y	255_K	0.503	0.99
101_P	201_Y	0.502	0.99
205_M	208_F	0.501	0.99
99_G	102_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cf2A	3	0.7702	100	0.391	Contact Map
4cr2J	1	0.8789	100	0.403	Contact Map
2ce7A	3	0.7484	100	0.406	Contact Map
4ww0A	4	0.7547	100	0.417	Contact Map
4ko8A	3	0.9255	100	0.422	Contact Map
4cr2L	1	0.8944	100	0.423	Contact Map
2zanA	1	0.7547	100	0.427	Contact Map
4cr2M	1	0.8882	100	0.437	Contact Map
2qp9X	1	0.736	100	0.438	Contact Map
3cf0A	3	0.7826	100	0.439	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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