GREMLIN Database
SP5K - Stage V sporulation protein K
UniProt: P27643 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (257)
Sequences: 18624 (9164)
Seq/√Len: 571.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_S232_Q5.1701.00
160_F199_A3.4461.00
237_A278_V3.4321.00
198_L219_F3.3281.00
234_M238_K3.1321.00
230_V258_D3.0821.00
250_Q253_E2.8371.00
49_K52_E2.8321.00
235_E238_K2.7081.00
234_M253_E2.5891.00
238_K261_M2.5601.00
53_K56_S2.5411.00
248_L252_A2.5331.00
293_L298_Q2.4141.00
54_E114_K2.2691.00
63_E226_P2.2371.00
53_K115_L2.2331.00
55_M62_E2.2231.00
246_Y252_A2.1851.00
240_M279_R2.1501.00
281_V285_S2.1251.00
227_D274_N2.0961.00
97_F225_F2.0951.00
249_S252_A2.0781.00
241_I282_I2.0491.00
109_A197_I2.0331.00
94_H187_M2.0141.00
257_K308_K1.9641.00
279_R283_E1.9431.00
51_I55_M1.9061.00
164_A198_L1.8841.00
128_I157_G1.8751.00
70_E288_A1.8591.00
131_E134_D1.8391.00
230_V234_M1.8261.00
70_E292_R1.7721.00
70_E291_M1.7481.00
257_K260_L1.7041.00
64_M223_I1.6701.00
55_M65_K1.6521.00
217_S276_R1.6461.00
108_V225_F1.6341.00
62_E232_Q1.6321.00
242_D245_E1.6311.00
244_R282_I1.6231.00
247_Q250_Q1.6181.00
185_K189_D1.5981.00
235_E239_R1.5941.00
250_Q254_W1.5911.00
96_M219_F1.5881.00
234_M254_W1.5851.00
50_E115_L1.5621.00
149_D152_K1.5381.00
182_T186_H1.5381.00
100_N227_D1.5151.00
65_K108_V1.5131.00
59_V239_R1.4971.00
221_I284_K1.4901.00
238_K253_E1.4721.00
240_M243_E1.4671.00
58_L107_T1.4561.00
203_R207_H1.4401.00
67_N221_I1.4351.00
251_E254_W1.4171.00
137_G142_H1.4161.00
231_T234_M1.4151.00
232_Q235_E1.4071.00
150_L153_K1.4051.00
69_K73_A1.3931.00
252_A257_K1.3841.00
138_E142_H1.3801.00
255_K258_D1.3701.00
248_L251_E1.3621.00
57_A114_K1.3541.00
54_E57_A1.3501.00
300_L303_D1.3411.00
62_E235_E1.3291.00
289_Q293_L1.3291.00
51_I66_R1.3061.00
230_V257_K1.2981.00
66_R70_E1.2891.00
66_R291_M1.2771.00
61_M64_M1.2621.00
226_P232_Q1.2611.00
79_Q82_A1.2531.00
143_T179_A1.2461.00
187_M219_F1.2441.00
236_I275_G1.2401.00
130_A150_L1.2201.00
145_Q149_D1.2171.00
230_V261_M1.2091.00
75_I78_N1.2081.00
241_I244_R1.1941.00
299_Y303_D1.1921.00
155_L186_H1.1761.00
246_Y249_S1.1731.00
42_E45_H1.1691.00
248_L253_E1.1681.00
237_A282_I1.1661.00
62_E66_R1.1651.00
163_E218_R1.1611.00
202_S207_H1.1551.00
293_L296_G1.1521.00
151_I194_F1.1501.00
98_K224_D1.1471.00
299_Y302_S1.1461.00
256_L260_L1.1381.00
239_R242_D1.1321.00
273_S281_V1.1101.00
234_M257_K1.1031.00
204_E207_H1.1031.00
247_Q304_L1.1011.00
151_I186_H1.0971.00
126_H154_S1.0971.00
76_F79_Q1.0781.00
258_D261_M1.0771.00
257_K306_T1.0741.00
41_N44_K1.0701.00
98_K222_S1.0681.00
145_Q148_R1.0531.00
112_I197_I1.0511.00
63_E67_N1.0491.00
247_Q252_A1.0451.00
234_M261_M1.0451.00
79_Q83_E1.0401.00
49_K53_K1.0401.00
142_H145_Q1.0251.00
70_E73_A1.0201.00
246_Y250_Q1.0171.00
285_S289_Q1.0131.00
78_N81_R1.0131.00
158_I197_I1.0131.00
109_A127_L1.0081.00
76_F80_K1.0081.00
292_R296_G1.0021.00
257_K261_M0.9991.00
116_F123_S0.9881.00
186_H196_L0.9871.00
163_E201_Y0.9781.00
233_L270_I0.9771.00
127_L160_F0.9741.00
240_M278_V0.9731.00
40_K43_A0.9661.00
97_F197_I0.9641.00
111_L114_K0.9631.00
240_M244_R0.9631.00
297_D302_S0.9561.00
135_L146_K0.9461.00
110_R129_E0.9391.00
299_Y305_M0.9361.00
168_A183_L0.9251.00
287_R291_M0.9251.00
255_K259_Y0.9251.00
174_D177_K0.9241.00
65_K69_K0.9241.00
252_A259_Y0.9131.00
55_M111_L0.9111.00
132_R161_I0.9071.00
128_I159_L0.9041.00
48_L292_R0.9031.00
139_Y142_H0.8851.00
80_K83_E0.8821.00
70_E74_W0.8801.00
247_Q251_E0.8781.00
247_Q306_T0.8781.00
249_S308_K0.8741.00
96_M164_A0.8721.00
98_K200_G0.8721.00
152_K155_L0.8711.00
149_D153_K0.8681.00
244_R307_I0.8661.00
211_L222_S0.8651.00
64_M108_V0.8561.00
144_A178_E0.8531.00
252_A256_L0.8401.00
256_L259_Y0.8351.00
126_H157_G0.8331.00
137_G145_Q0.8321.00
113_G127_L0.8211.00
59_V236_I0.8181.00
231_T235_E0.8111.00
106_T162_D0.8091.00
48_L295_M0.8051.00
41_N45_H0.7991.00
246_Y251_E0.7981.00
52_E55_M0.7971.00
248_L254_W0.7961.00
297_D300_L0.7961.00
57_A111_L0.7951.00
87_K92_A0.7951.00
246_Y257_K0.7941.00
194_F198_L0.7911.00
172_E176_G0.7831.00
201_Y218_R0.7821.00
246_Y253_E0.7801.00
269_P272_F0.7801.00
57_A107_T0.7741.00
51_I73_A0.7701.00
68_I108_V0.7691.00
237_A281_V0.7671.00
177_K181_D0.7661.00
148_R186_H0.7601.00
228_Y233_L0.7601.00
59_V235_E0.7591.00
196_L200_G0.7551.00
86_L90_K0.7551.00
286_I307_I0.7541.00
297_D301_K0.7531.00
77_V80_K0.7521.00
247_Q254_W0.7501.00
41_N49_K0.7491.00
280_N284_K0.7461.00
67_N70_E0.7441.00
151_I155_L0.7421.00
247_Q257_K0.7411.00
296_G303_D0.7371.00
196_L201_Y0.7371.00
184_V188_E0.7371.00
260_L278_V0.7341.00
96_M207_H0.7281.00
234_M258_D0.7261.00
131_E185_K0.7231.00
174_D178_E0.7211.00
67_N223_I0.7201.00
203_R206_D0.7201.00
254_W257_K0.7171.00
238_K250_Q0.7151.00
128_I153_K0.7121.00
288_A292_R0.7091.00
194_F201_Y0.7091.00
292_R310_Q0.7091.00
123_S126_H0.7071.00
280_N283_E0.7061.00
91_Q110_R0.7051.00
74_W287_R0.7051.00
55_M58_L0.7021.00
66_R69_K0.7011.00
96_M198_L0.7001.00
147_T151_I0.6991.00
203_R208_F0.6961.00
127_L158_I0.6941.00
107_T111_L0.6941.00
162_D218_R0.6901.00
255_K304_L0.6881.00
175_F178_E0.6871.00
198_L201_Y0.6861.00
170_G208_F0.6861.00
168_A210_S0.6851.00
283_E287_R0.6831.00
45_H48_L0.6821.00
188_E279_R0.6791.00
233_L269_P0.6791.00
270_I273_S0.6771.00
64_M67_N0.6771.00
274_N278_V0.6731.00
161_I198_L0.6721.00
111_L115_L0.6711.00
251_E301_K0.6661.00
167_L183_L0.6631.00
46_G49_K0.6601.00
300_L304_L0.6601.00
247_Q253_E0.6601.00
302_S305_M0.6591.00
40_K44_K0.6511.00
44_K48_L0.6511.00
241_I252_A0.6501.00
77_V81_R0.6501.00
169_R177_K0.6501.00
303_D306_T0.6411.00
56_S242_D0.6371.00
42_E46_G0.6341.00
140_I175_F0.6321.00
164_A210_S0.6301.00
187_M196_L0.6261.00
250_Q255_K0.6251.00
195_I201_Y0.6211.00
202_S205_M0.6181.00
80_K293_L0.6181.00
289_Q292_R0.6161.00
135_L143_T0.6161.00
230_V254_W0.6151.00
58_L61_M0.6151.00
129_E189_D0.6151.00
306_T310_Q0.6141.00
255_K306_T0.6141.00
57_A124_K0.6141.00
270_I277_F0.6131.00
156_G193_E0.6131.00
183_L187_M0.6121.00
48_L51_I0.6111.00
194_F200_G0.6111.00
244_R286_I0.6091.00
188_E218_R0.6061.00
128_I150_L0.6051.00
194_F199_A0.6031.00
256_L261_M0.6031.00
70_E287_R0.6021.00
71_I74_W0.5991.00
227_D272_F0.5951.00
298_Q302_S0.5931.00
54_E58_L0.5911.00
101_P163_E0.5911.00
53_K114_K0.5901.00
259_Y308_K0.5881.00
253_E257_K0.5881.00
275_G280_N0.5841.00
214_G218_R0.5841.00
306_T309_S0.5841.00
53_K57_A0.5831.00
247_Q255_K0.5831.00
43_A46_G0.5821.00
251_E255_K0.5811.00
136_V175_F0.5811.00
240_M282_I0.5801.00
183_L186_H0.5801.00
196_L199_A0.5791.00
48_L296_G0.5781.00
68_I72_Y0.5771.00
103_T225_F0.5771.00
73_A292_R0.5751.00
140_I174_D0.5751.00
56_S115_L0.5741.00
68_I95_M0.5721.00
136_V182_T0.5700.99
286_I291_M0.5630.99
241_I246_Y0.5620.99
202_S208_F0.5600.99
299_Y306_T0.5600.99
148_R152_K0.5600.99
151_I154_S0.5560.99
138_E145_Q0.5560.99
252_A260_L0.5540.99
217_S280_N0.5530.99
163_E184_V0.5510.99
52_E56_S0.5510.99
195_I198_L0.5500.99
74_W78_N0.5490.99
193_E199_A0.5490.99
284_K287_R0.5450.99
57_A242_D0.5450.99
133_A148_R0.5450.99
250_Q257_K0.5440.99
63_E66_R0.5440.99
207_H210_S0.5420.99
72_Y75_I0.5410.99
251_E257_K0.5410.99
292_R305_M0.5400.99
301_K304_L0.5390.99
55_M59_V0.5380.99
239_R243_E0.5370.99
247_Q259_Y0.5370.99
195_I200_G0.5360.99
251_E309_S0.5350.99
47_I50_E0.5330.99
230_V269_P0.5330.99
54_E115_L0.5310.99
192_H196_L0.5280.99
254_W258_D0.5270.99
146_K149_D0.5230.99
112_I116_F0.5230.99
154_S157_G0.5220.99
192_H200_G0.5200.99
298_Q301_K0.5180.99
40_K292_R0.5180.99
136_V179_A0.5180.99
148_R182_T0.5170.99
254_W309_S0.5170.99
233_L237_A0.5160.99
184_V189_D0.5150.99
230_V271_K0.5140.99
130_A161_I0.5140.99
58_L111_L0.5140.99
173_K177_K0.5130.99
228_Y236_I0.5130.99
152_K186_H0.5100.99
161_I164_A0.5100.99
106_T218_R0.5100.99
82_A85_G0.5080.99
94_H219_F0.5060.99
270_I278_V0.5050.99
182_T185_K0.5050.99
109_A160_F0.5030.99
246_Y255_K0.5030.99
101_P201_Y0.5020.99
205_M208_F0.5010.99
99_G102_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cf2A 3 0.7702 100 0.391 Contact Map
4cr2J 1 0.8789 100 0.403 Contact Map
2ce7A 3 0.7484 100 0.406 Contact Map
4ww0A 4 0.7547 100 0.417 Contact Map
4ko8A 3 0.9255 100 0.422 Contact Map
4cr2L 1 0.8944 100 0.423 Contact Map
2zanA 1 0.7547 100 0.427 Contact Map
4cr2M 1 0.8882 100 0.437 Contact Map
2qp9X 1 0.736 100 0.438 Contact Map
3cf0A 3 0.7826 100 0.439 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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