GREMLIN Database
TAGD - Glycerol-3-phosphate cytidylyltransferase
UniProt: P27623 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (123)
Sequences: 2936 (1802)
Seq/√Len: 162.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_V28_G3.6091.00
52_Y70_P2.9341.00
9_T41_N2.3371.00
43_Q74_W2.3121.00
25_K66_D2.2671.00
54_H117_I2.2371.00
30_Y67_E2.1631.00
5_I34_A2.0821.00
79_Q82_I2.0171.00
101_F105_Q2.0091.00
19_K57_L1.9441.00
22_E64_Y1.9331.00
99_F103_K1.9261.00
35_I56_K1.8541.00
3_K30_Y1.8411.00
19_K22_E1.7801.00
51_S54_H1.7361.00
56_K60_E1.7031.00
56_K68_V1.6881.00
100_D104_D1.6821.00
13_L62_I1.6791.00
37_T70_P1.6751.00
23_R26_Q1.6691.00
52_Y56_K1.6561.00
102_L105_Q1.6111.00
57_L60_E1.5881.00
22_E57_L1.5821.00
24_A90_V1.5561.00
37_T72_K1.5011.00
56_K70_P1.4921.00
18_I58_I1.4681.00
93_D112_P1.4671.00
39_E43_Q1.4321.00
15_W54_H1.4171.00
12_L50_H1.4061.00
19_K23_R1.4011.00
119_T123_K1.3991.00
78_K82_I1.3961.00
42_L47_K1.3711.00
73_N79_Q1.3351.00
15_W117_I1.3271.00
25_K30_Y1.2911.00
50_H54_H1.2881.00
19_K114_T1.2851.00
13_L18_I1.2581.00
13_L58_I1.2411.00
99_F102_L1.2321.00
15_W58_I1.2261.00
4_V90_V1.2141.00
24_A31_L1.2021.00
95_W98_K1.2001.00
95_W105_Q1.1891.00
78_K105_Q1.1841.00
39_E72_K1.1471.00
49_Y123_K1.1441.00
121_K124_E1.1351.00
78_K101_F1.1341.00
10_F20_L1.1121.00
85_N104_D1.0830.99
93_D110_Y1.0710.99
102_L106_C1.0420.99
23_R111_L1.0260.99
97_G103_K1.0230.99
81_I89_F1.0120.99
98_K102_L1.0030.99
13_L59_L1.0000.99
27_L109_V0.9950.99
36_S40_F0.9900.99
121_K125_E0.9820.99
82_I104_D0.9710.99
22_E26_Q0.9630.99
35_I59_L0.9600.99
20_L113_R0.9430.99
114_T117_I0.9430.99
21_L64_Y0.9280.98
27_L88_V0.9260.98
23_R112_P0.9190.98
27_L90_V0.9190.98
97_G102_L0.9040.98
96_E100_D0.8990.98
28_G90_V0.8930.98
41_N44_K0.8840.98
97_G101_F0.8790.98
34_A69_I0.8770.98
78_K104_D0.8760.98
3_K67_E0.8670.98
42_L46_K0.8670.98
37_T52_Y0.8520.97
76_Q89_F0.8440.97
21_L24_A0.8420.97
15_W19_K0.8330.97
99_F105_Q0.8290.97
25_K63_R0.8200.97
33_V59_L0.8110.96
50_H122_I0.8060.96
95_W110_Y0.7980.96
97_G105_Q0.7970.96
50_H58_I0.7870.96
101_F104_D0.7820.96
89_F97_G0.7720.95
98_K105_Q0.7710.95
15_W18_I0.7590.95
60_E67_E0.7580.95
27_L111_L0.7570.95
4_V27_L0.7560.95
61_T64_Y0.7480.94
6_T10_F0.7390.94
6_T20_L0.7340.94
40_F71_E0.7290.94
18_I62_I0.7290.94
36_S71_E0.7180.93
112_P115_E0.7170.93
95_W102_L0.6970.92
15_W50_H0.6960.92
95_W100_D0.6880.91
98_K101_F0.6880.91
7_Y89_F0.6880.91
97_G100_D0.6850.91
7_Y34_A0.6810.91
18_I61_T0.6800.91
34_A80_D0.6790.91
95_W99_F0.6760.91
65_V68_V0.6740.91
90_V111_L0.6660.90
88_V107_E0.6620.90
53_E70_P0.6550.89
79_Q83_D0.6540.89
7_Y91_M0.6530.89
7_Y71_E0.6520.89
18_I64_Y0.6510.89
3_K86_I0.6480.89
36_S44_K0.6300.87
57_L61_T0.6300.87
82_I107_E0.6280.87
98_K106_C0.6210.87
22_E61_T0.6180.86
15_W57_L0.6150.86
116_G121_K0.6140.86
97_G104_D0.6130.86
6_T21_L0.6110.86
59_L68_V0.6110.86
22_E63_R0.6060.85
117_I121_K0.5990.85
42_L48_A0.5990.85
67_E70_P0.5980.85
15_W114_T0.5960.84
85_N105_Q0.5960.84
41_N46_K0.5950.84
93_D111_L0.5940.84
33_V65_V0.5910.84
5_I89_F0.5860.83
82_I100_D0.5850.83
88_V109_V0.5810.83
37_T71_E0.5800.83
35_I68_V0.5790.83
82_I85_N0.5750.82
123_K126_I0.5740.82
3_K87_D0.5730.82
58_I62_I0.5700.82
23_R114_T0.5680.81
8_G11_D0.5630.81
32_V86_I0.5620.81
81_I86_I0.5600.81
28_G88_V0.5510.80
71_E91_M0.5510.80
78_K81_I0.5460.79
4_V88_V0.5460.79
109_V112_P0.5440.79
32_V84_H0.5440.79
44_K74_W0.5420.78
93_D113_R0.5410.78
5_I81_I0.5360.78
49_Y121_K0.5350.78
22_E60_E0.5340.77
81_I106_C0.5300.77
96_E99_F0.5230.76
3_K84_H0.5230.76
89_F110_Y0.5160.75
41_N45_Q0.5160.75
19_K110_Y0.5150.75
54_H58_I0.5050.73
36_S47_K0.5040.73
78_K100_D0.5020.73
19_K115_E0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3elbA 2 0.9922 100 0.33 Contact Map
4mvcA 2 1 100 0.4 Contact Map
3hl4A 2 1 99.9 0.427 Contact Map
1cozA 2 0.9767 99.9 0.466 Contact Map
2b7lA 2 0.8915 99.9 0.482 Contact Map
3glvA 2 0.8682 99.8 0.532 Contact Map
3k9wA 5 0.9612 99.7 0.616 Contact Map
3do8A 2 0.8915 99.6 0.625 Contact Map
3nbkA 5 0.9612 99.6 0.637 Contact Map
3op1A 4 0.9922 99.6 0.639 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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