GREMLIN Database
TAGB - Putative CDP-glycerol:glycerophosphate glycerophosphotransferase
UniProt: P27621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (347)
Sequences: 2652 (2189)
Seq/√Len: 117.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
365_D371_N5.0621.00
164_V170_A4.4341.00
336_D339_S4.2691.00
370_Q374_N3.6711.00
367_N370_Q3.6601.00
170_A186_K3.6591.00
42_K46_E3.3771.00
47_E50_Q3.2521.00
47_E51_G3.0311.00
115_K160_D2.9751.00
167_E362_K2.7201.00
31_V94_L2.7061.00
334_C343_E2.6651.00
298_F303_K2.5201.00
302_N357_S2.5151.00
47_E370_Q2.4671.00
190_P372_L2.4561.00
39_A104_D2.4271.00
34_L59_I2.4131.00
306_L334_C2.3631.00
166_S169_M2.2951.00
164_V186_K2.2931.00
137_E322_V2.2811.00
29_S99_K2.2211.00
249_F272_V2.2091.00
33_L98_S2.1951.00
237_Q338_E2.1791.00
31_V98_S2.1761.00
309_T325_Y2.1581.00
213_K246_Y2.0681.00
27_P116_R2.0511.00
167_E186_K2.0171.00
161_Y185_L1.9961.00
31_V97_N1.9921.00
302_N353_I1.9821.00
51_G374_N1.9821.00
289_T295_P1.9781.00
334_C340_L1.9741.00
324_N327_S1.8951.00
44_I124_V1.8911.00
37_F46_E1.8911.00
214_I247_V1.8781.00
58_N78_Y1.8751.00
241_Q345_Q1.8661.00
212_K247_V1.8541.00
137_E175_K1.8291.00
132_K220_T1.8221.00
27_P118_Q1.8201.00
309_T333_A1.8131.00
218_A294_V1.7871.00
239_I268_Y1.7681.00
222_R311_D1.7671.00
30_K99_K1.7511.00
203_I207_L1.7511.00
165_G189_V1.7501.00
120_K161_Y1.7421.00
302_N354_K1.6981.00
196_Y300_I1.6701.00
287_L298_F1.6511.00
215_I246_Y1.6451.00
102_I376_I1.6161.00
187_I372_L1.6161.00
307_F331_G1.5991.00
32_T57_L1.5941.00
28_E31_V1.5921.00
136_L178_G1.5901.00
163_T372_L1.5901.00
37_F42_K1.5901.00
103_T121_C1.5621.00
281_L294_V1.5601.00
337_S341_I1.5571.00
216_L284_A1.5521.00
247_V270_K1.5461.00
357_S361_N1.5351.00
179_I182_N1.5281.00
47_E373_L1.5251.00
103_T107_F1.5221.00
40_N189_V1.5111.00
286_I344_I1.5101.00
213_K245_E1.5061.00
167_E171_N1.5051.00
277_L294_V1.5021.00
34_L48_Y1.4841.00
236_E240_H1.4771.00
295_P307_F1.4731.00
201_K205_D1.4681.00
204_S207_L1.4521.00
242_L248_L1.4341.00
90_K94_L1.4201.00
60_L94_L1.4021.00
202_K206_T1.3971.00
354_K358_D1.3871.00
281_L284_A1.3781.00
367_N371_N1.3721.00
306_L343_E1.3721.00
161_Y375_F1.3581.00
291_Y311_D1.3561.00
288_I306_L1.3411.00
180_K183_Q1.3401.00
323_D360_W1.3251.00
93_Y97_N1.3201.00
288_I340_L1.3141.00
100_V377_E1.3131.00
203_I283_A1.3101.00
137_E176_S1.3071.00
277_L281_L1.3041.00
216_L280_L1.3041.00
99_K120_K1.3031.00
212_K245_E1.2901.00
220_T253_H1.2891.00
171_N175_K1.2791.00
298_F301_L1.2780.99
343_E346_T1.2770.99
368_S371_N1.2760.99
94_L97_N1.2680.99
323_D329_I1.2660.99
194_P279_D1.2630.99
351_S355_V1.2620.99
243_K268_Y1.2600.99
214_I249_F1.2510.99
339_S342_N1.2360.99
308_Y337_S1.2330.99
193_D366_G1.2320.99
20_F23_Q1.2320.99
342_N346_T1.2310.99
122_I376_I1.2300.99
313_K335_Y1.2290.99
213_K285_D1.2280.99
299_S305_I1.2250.99
126_H253_H1.2190.99
47_E369_S1.2170.99
44_I373_L1.2140.99
325_Y329_I1.2090.99
352_K355_V1.2020.99
170_A184_L1.1930.99
100_V120_K1.1930.99
200_K204_S1.1930.99
33_L62_T1.1850.99
48_Y53_Y1.1830.99
286_I306_L1.1810.99
335_Y339_S1.1750.99
90_K93_Y1.1720.99
215_I286_I1.1680.99
31_V60_L1.1660.99
48_Y57_L1.1590.99
41_A124_V1.1350.99
238_L337_S1.1320.99
232_P310_Y1.1260.99
28_E58_N1.1200.99
28_E97_N1.1140.99
312_L316_Q1.1050.99
223_D319_R1.1050.99
224_Y314_L1.0990.98
130_S189_V1.0940.98
100_V376_I1.0890.98
89_I93_Y1.0860.98
32_T48_Y1.0820.98
126_H293_S1.0760.98
159_Y162_L1.0660.98
133_K322_V1.0640.98
192_T297_E1.0630.98
287_L294_V1.0620.98
126_H220_T1.0580.98
102_I122_I1.0410.98
222_R291_Y1.0370.98
239_I266_S1.0350.98
167_E170_A1.0290.98
176_S322_V1.0270.98
311_D315_Y1.0260.98
62_T91_A1.0220.98
80_L94_L1.0210.98
31_V58_N1.0180.97
253_H292_S1.0150.97
164_V184_L1.0080.97
300_I361_N1.0070.97
286_I298_F1.0050.97
316_Q326_L1.0020.97
306_L340_L1.0010.97
39_A191_L0.9910.97
132_K253_H0.9820.97
132_K320_G0.9820.97
309_T329_I0.9740.97
188_G193_D0.9740.97
132_K293_S0.9720.97
128_N361_N0.9720.97
101_I121_C0.9670.97
41_A104_D0.9580.96
168_E359_R0.9570.96
49_E76_D0.9470.96
237_Q241_Q0.9440.96
234_T237_Q0.9430.96
34_L44_I0.9410.96
355_V358_D0.9410.96
76_D79_L0.9300.96
235_E248_L0.9290.96
234_T242_L0.9090.95
27_P119_T0.9040.95
136_L153_Q0.9000.95
132_K315_Y0.8990.95
299_S356_F0.8980.95
125_W173_F0.8960.95
33_L95_M0.8950.95
28_E99_K0.8950.95
25_V97_N0.8930.95
332_R343_E0.8890.95
41_A44_I0.8880.94
251_K276_A0.8840.94
43_A369_S0.8840.94
44_I369_S0.8830.94
185_L375_F0.8750.94
284_A298_F0.8730.94
48_Y59_I0.8720.94
233_F238_L0.8710.94
327_S359_R0.8710.94
321_L325_Y0.8710.94
40_N43_A0.8700.94
128_N165_G0.8660.94
130_S134_F0.8630.94
233_F337_S0.8600.93
116_R119_T0.8570.93
355_V359_R0.8560.93
307_F330_P0.8520.93
218_A287_L0.8510.93
45_L59_I0.8470.93
179_I183_Q0.8450.93
334_C339_S0.8420.93
217_Y248_L0.8420.93
192_T300_I0.8410.93
187_I375_F0.8410.93
329_I333_A0.8400.93
191_L297_E0.8390.93
312_L326_L0.8380.93
128_N189_V0.8300.92
326_L335_Y0.8280.92
41_A61_Y0.8280.92
124_V372_L0.8270.92
299_S353_I0.8250.92
337_S340_L0.8210.92
169_M173_F0.8210.92
161_Y164_V0.8200.92
315_Y320_G0.8190.92
165_G169_M0.8160.92
26_K97_N0.8110.91
218_A251_K0.8080.91
361_N364_S0.8050.91
121_C155_V0.8040.91
44_I48_Y0.7990.91
135_G138_D0.7980.91
239_I243_K0.7910.90
131_L295_P0.7900.90
204_S283_A0.7890.90
125_W162_L0.7850.90
220_T292_S0.7840.90
206_T279_D0.7790.90
220_T293_S0.7770.89
186_K363_Y0.7760.89
126_H132_K0.7750.89
101_I119_T0.7710.89
125_W177_F0.7710.89
172_I175_K0.7700.89
127_A297_E0.7700.89
309_T335_Y0.7690.89
243_K246_Y0.7690.89
323_D328_I0.7680.89
35_I62_T0.7670.89
128_N169_M0.7650.89
88_L127_A0.7650.89
281_L287_L0.7650.89
49_E53_Y0.7620.89
347_P350_Y0.7580.88
233_F340_L0.7580.88
328_I359_R0.7560.88
312_L335_Y0.7560.88
20_F24_W0.7470.88
42_K276_A0.7450.87
313_K316_Q0.7450.87
348_F351_S0.7440.87
130_S296_F0.7430.87
161_Y183_Q0.7410.87
103_T106_Y0.7410.87
211_R247_V0.7390.87
200_K283_A0.7380.87
348_F353_I0.7340.87
239_I267_D0.7330.87
336_D340_L0.7330.87
173_F184_L0.7310.86
215_I248_L0.7300.86
111_S254_P0.7300.86
22_L25_V0.7300.86
88_L91_A0.7280.86
40_N191_L0.7270.86
195_Y300_I0.7250.86
21_F25_V0.7250.86
251_K273_S0.7210.86
162_L179_I0.7200.86
195_Y301_L0.7190.86
25_V28_E0.7180.85
104_D124_V0.7160.85
161_Y376_I0.7140.85
341_I345_Q0.7120.85
19_A23_Q0.7120.85
92_V96_F0.7110.85
253_H293_S0.7100.85
307_F325_Y0.7060.84
168_E172_I0.7030.84
330_P356_F0.6980.84
148_D152_F0.6950.84
34_L41_A0.6910.83
350_Y353_I0.6900.83
364_S368_S0.6880.83
17_A21_F0.6870.83
356_F360_W0.6870.83
166_S300_I0.6860.83
35_I86_I0.6850.83
146_K149_I0.6820.82
192_T196_Y0.6820.82
43_A194_P0.6800.82
127_A293_S0.6780.82
41_A45_L0.6770.82
45_L49_E0.6750.82
193_D371_N0.6710.81
242_L341_I0.6710.81
130_S165_G0.6700.81
49_E52_Q0.6700.81
296_F323_D0.6690.81
126_H292_S0.6690.81
349_N352_K0.6680.81
122_I372_L0.6660.81
132_K292_S0.6660.81
203_I206_T0.6650.81
130_S297_E0.6640.81
45_L61_Y0.6640.81
373_L377_E0.6630.81
151_R155_V0.6620.80
51_G54_S0.6590.80
338_E341_I0.6560.80
163_T190_P0.6550.80
316_Q320_G0.6530.80
245_E345_Q0.6530.80
106_Y155_V0.6500.79
115_K121_C0.6480.79
183_Q375_F0.6480.79
126_H189_V0.6480.79
91_A112_V0.6450.79
252_L260_I0.6440.79
202_K205_D0.6430.79
184_L318_K0.6410.78
241_Q341_I0.6400.78
220_T291_Y0.6400.78
245_E268_Y0.6390.78
21_F89_I0.6390.78
214_I284_A0.6390.78
291_Y315_Y0.6380.78
31_V34_L0.6380.78
97_N116_R0.6320.77
168_E323_D0.6280.77
174_K184_L0.6280.77
105_N138_D0.6270.77
131_L322_V0.6270.77
332_R350_Y0.6270.77
175_K322_V0.6250.77
128_N166_S0.6240.76
45_L77_A0.6220.76
26_K116_R0.6210.76
170_A174_K0.6210.76
237_Q342_N0.6200.76
164_V169_M0.6200.76
149_I152_F0.6190.76
27_P97_N0.6170.76
130_S176_S0.6160.76
69_A73_P0.6150.75
123_Q159_Y0.6140.75
307_F329_I0.6110.75
32_T35_I0.6110.75
33_L91_A0.6100.75
139_I149_I0.6090.75
106_Y123_Q0.6060.74
369_S373_L0.6060.74
251_K271_D0.6050.74
58_N62_T0.6010.74
34_L45_L0.6000.74
106_Y156_Y0.6000.74
238_L268_Y0.5990.74
193_D369_S0.5990.74
37_F45_L0.5990.74
237_Q240_H0.5980.73
134_F176_S0.5980.73
106_Y121_C0.5970.73
132_K291_Y0.5970.73
351_S354_K0.5970.73
44_I372_L0.5970.73
235_E337_S0.5960.73
238_L341_I0.5950.73
252_L299_S0.5940.73
30_K54_S0.5940.73
189_V192_T0.5920.73
249_F280_L0.5920.73
128_N131_L0.5890.72
124_V127_A0.5880.72
36_S104_D0.5830.72
24_W117_K0.5830.72
312_L321_L0.5830.72
139_I150_K0.5820.71
187_I371_N0.5820.71
212_K244_E0.5810.71
122_I161_Y0.5810.71
15_L18_I0.5800.71
72_F79_L0.5800.71
272_V280_L0.5790.71
42_K61_Y0.5770.71
272_V275_Y0.5770.71
131_L307_F0.5760.71
69_A79_L0.5750.70
237_Q337_S0.5740.70
18_I21_F0.5730.70
105_N221_F0.5720.70
218_A366_G0.5720.70
287_L305_I0.5710.70
130_S295_P0.5710.70
156_Y159_Y0.5680.70
285_D303_K0.5670.69
40_N126_H0.5670.69
267_D270_K0.5660.69
147_T150_K0.5650.69
58_N63_Q0.5650.69
59_I63_Q0.5650.69
71_S74_N0.5650.69
106_Y127_A0.5640.69
14_F17_A0.5640.69
40_N293_S0.5640.69
101_I107_F0.5640.69
28_E98_S0.5640.69
40_N127_A0.5640.69
243_K267_D0.5630.69
252_L256_I0.5630.69
60_L91_A0.5620.69
177_F189_V0.5620.69
357_S364_S0.5620.69
200_K282_M0.5610.69
107_F112_V0.5610.69
320_G323_D0.5600.68
195_Y278_F0.5580.68
125_W134_F0.5570.68
122_I377_E0.5570.68
31_V35_I0.5560.68
188_G371_N0.5560.68
22_L116_R0.5550.68
103_T123_Q0.5540.68
32_T100_V0.5540.68
314_L318_K0.5520.67
165_G295_P0.5500.67
14_F19_A0.5500.67
165_G173_F0.5490.67
43_A278_F0.5480.67
26_K29_S0.5470.67
155_V252_L0.5470.67
101_I115_K0.5470.67
127_A130_S0.5460.67
365_D368_S0.5460.67
40_N104_D0.5440.66
110_T121_C0.5440.66
304_P366_G0.5440.66
18_I22_L0.5430.66
101_I113_L0.5400.66
221_F255_A0.5390.66
76_D80_L0.5380.65
280_L284_A0.5370.65
27_P99_K0.5370.65
315_Y319_R0.5360.65
153_Q157_S0.5350.65
264_Y267_D0.5350.65
302_N358_D0.5340.65
125_W176_S0.5330.65
326_L333_A0.5310.64
96_F123_Q0.5310.64
353_I356_F0.5310.64
261_D265_S0.5300.64
100_V122_I0.5280.64
47_E52_Q0.5280.64
22_L27_P0.5260.64
316_Q321_L0.5250.64
238_L248_L0.5240.63
192_T295_P0.5240.63
172_I322_V0.5230.63
157_S182_N0.5230.63
193_D330_P0.5220.63
214_I283_A0.5210.63
106_Y134_F0.5210.63
21_F97_N0.5210.63
289_T307_F0.5210.63
354_K357_S0.5190.63
44_I47_E0.5190.63
204_S210_Q0.5180.63
209_I247_V0.5180.63
303_K353_I0.5170.62
156_Y179_I0.5150.62
20_F25_V0.5140.62
131_L321_L0.5140.62
134_F173_F0.5140.62
115_K119_T0.5130.62
205_D349_N0.5120.62
102_I373_L0.5100.61
58_N61_Y0.5080.61
131_L137_E0.5080.61
305_I331_G0.5070.61
202_K346_T0.5070.61
15_L19_A0.5060.61
296_F299_S0.5050.61
130_S322_V0.5040.60
33_L94_L0.5040.60
95_M98_S0.5040.60
121_C254_P0.5020.60
218_A278_F0.5020.60
135_G155_V0.5010.60
37_F43_A0.5010.60
193_D331_G0.5010.60
295_P305_I0.5010.60
340_L343_E0.5000.60
319_R322_V0.5000.60
146_K150_K0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0.9711 100 0.285 Contact Map
1vgvA 2 0.8714 99.3 0.835 Contact Map
4nesA 2 0.8425 99.3 0.836 Contact Map
3dzcA 2 0.8766 99.2 0.847 Contact Map
3ot5A 2 0.8766 99.1 0.851 Contact Map
4hwgA 5 0.8478 99.1 0.851 Contact Map
4fkzA 2 0.8714 99.1 0.853 Contact Map
1v4vA 2 0.8714 99 0.859 Contact Map
3froA 3 0.8898 98.7 0.872 Contact Map
3c48A 2 0.8898 98.7 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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