GREMLIN Database
TAGA - Putative N-acetylmannosaminyltransferase
UniProt: P27620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (232)
Sequences: 2520 (2073)
Seq/√Len: 136.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_R155_D3.6401.00
147_K151_R2.9081.00
106_F148_Q2.8691.00
104_R130_K2.8571.00
112_K136_D2.7611.00
106_F133_G2.6871.00
117_G195_N2.5141.00
112_K116_K2.4111.00
135_S148_Q2.3191.00
201_S205_R2.3051.00
47_A57_L2.2351.00
202_W206_L2.1781.00
50_D168_K2.1551.00
119_V123_S2.1301.00
143_T176_L2.0601.00
86_A89_D2.0311.00
221_W225_L2.0271.00
10_P58_S1.9861.00
93_E96_G1.9821.00
169_F173_Y1.9741.00
170_I184_G1.9631.00
157_V179_K1.9381.00
150_A178_P1.8881.00
187_G191_V1.8721.00
16_L93_E1.8531.00
115_I134_Y1.8451.00
121_K125_E1.8381.00
121_K124_S1.8151.00
170_I182_S1.8041.00
143_T147_K1.7641.00
159_V170_I1.7511.00
13_N82_Q1.7331.00
99_N128_N1.7211.00
117_G120_S1.7211.00
142_R169_F1.6941.00
146_A150_A1.6891.00
95_L122_I1.6731.00
147_K150_A1.6471.00
214_L224_M1.6141.00
142_R172_N1.6141.00
54_F58_S1.6101.00
43_I163_Y1.6061.00
49_K229_K1.6051.00
15_N18_S1.6021.00
88_Y188_S1.5871.00
23_L181_V1.5821.00
24_E101_K1.5811.00
17_T93_E1.5761.00
104_R132_A1.5581.00
91_F158_F1.5551.00
111_K114_V1.5421.00
19_F62_F1.4601.00
107_L122_I1.4521.00
48_I233_T1.4431.00
52_D168_K1.4291.00
45_F226_S1.4271.00
56_V168_K1.4251.00
111_K138_Y1.4191.00
98_A156_M1.4171.00
96_G100_K1.4011.00
24_E103_K1.3961.00
212_Y216_L1.3951.00
24_E97_V1.3921.00
21_D97_V1.3851.00
55_D59_S1.3841.00
41_P69_G1.3821.00
111_K195_N1.3751.00
115_I119_V1.3691.00
103_K155_D1.3561.00
224_M227_I1.3461.00
35_V170_I1.3421.00
88_Y191_V1.3211.00
97_V101_K1.3211.00
119_V134_Y1.3201.00
37_S60_S1.3071.00
117_G121_K1.3001.00
68_I71_V1.3001.00
29_D101_K1.2941.00
198_R209_E1.2881.00
214_L221_W1.2871.00
38_T43_I1.2841.00
91_F188_S1.2681.00
73_M230_Y1.2341.00
84_R204_I1.2261.00
91_F185_L1.2121.00
141_D144_L1.2011.00
5_T8_N1.1961.00
98_A105_I1.1820.99
150_A176_L1.1820.99
208_L211_F1.1800.99
43_I53_Y1.1770.99
106_F149_I1.1760.99
217_N220_R1.1680.99
38_T64_L1.1670.99
73_M234_V1.1640.99
157_V182_S1.1620.99
107_L189_F1.1490.99
33_G174_R1.1420.99
142_R146_A1.1410.99
25_K30_Q1.1380.99
99_N129_I1.1300.99
33_G182_S1.1280.99
102_K130_K1.1260.99
108_Y139_V1.1250.99
91_F192_F1.1220.99
197_K212_Y1.1180.99
203_M208_L1.1110.99
5_T10_P1.1010.99
86_A198_R1.0880.99
89_D198_R1.0850.99
157_V173_Y1.0810.99
22_Y25_K1.0800.99
59_S171_H1.0790.99
214_L225_L1.0780.99
28_I103_K1.0760.99
77_T237_E1.0730.99
105_I158_F1.0700.99
160_A189_F1.0640.99
107_L118_V1.0620.99
42_E224_M1.0610.99
34_A61_N1.0600.99
94_L156_M1.0450.99
158_F189_F1.0440.99
118_V189_F1.0390.99
116_K120_S1.0350.99
106_F135_S1.0320.99
227_I231_A1.0310.99
39_V70_V1.0130.98
198_R204_I1.0070.98
42_E187_G1.0050.98
51_R55_D1.0030.98
173_Y176_L1.0020.98
33_G180_A1.0010.98
199_A204_I0.9980.98
45_F233_T0.9970.98
113_D116_K0.9890.98
92_K125_E0.9760.98
41_P68_I0.9650.98
19_F64_L0.9610.98
14_S19_F0.9540.98
43_I57_L0.9540.98
23_L36_I0.9530.98
120_S124_S0.9530.98
200_P212_Y0.9430.97
111_K115_I0.9380.97
201_S204_I0.9330.97
142_R173_Y0.9300.97
21_D25_K0.9280.97
95_L105_I0.9240.97
95_L158_F0.9180.97
11_Y39_V0.9120.97
145_V148_Q0.9100.97
88_Y92_K0.9000.97
232_L236_K0.8990.97
199_A209_E0.8960.97
135_S138_Y0.8940.96
42_E46_A0.8900.96
71_V84_R0.8900.96
39_V43_I0.8880.96
41_P226_S0.8860.96
185_L189_F0.8710.96
136_D139_V0.8690.96
203_M206_L0.8670.96
104_R153_N0.8670.96
197_K216_L0.8610.96
148_Q152_A0.8590.96
42_E226_S0.8580.96
157_V180_A0.8580.96
57_L63_I0.8490.95
98_A103_K0.8460.95
132_A152_A0.8440.95
64_L90_V0.8390.95
68_I207_N0.8380.95
41_P224_M0.8370.95
46_A50_D0.8330.95
19_F23_L0.8320.95
107_L119_V0.8140.94
68_I72_M0.8130.94
46_A163_Y0.8120.94
110_A115_I0.8100.94
16_L20_I0.8050.94
196_V217_N0.8050.94
52_D172_N0.8040.94
36_I181_V0.8010.94
47_A53_Y0.7990.94
14_S22_Y0.7920.93
61_N174_R0.7920.93
36_I183_I0.7910.93
41_P227_I0.7870.93
51_R54_F0.7860.93
35_V174_R0.7830.93
137_G187_G0.7800.93
148_Q151_R0.7780.93
199_A212_Y0.7770.93
35_V60_S0.7750.92
91_F95_L0.7700.92
233_T236_K0.7650.92
89_D209_E0.7610.92
157_V169_F0.7560.92
114_V193_S0.7550.91
38_T163_Y0.7540.91
7_H237_E0.7530.91
162_G166_Q0.7510.91
135_S139_V0.7430.91
97_V103_K0.7340.90
177_F182_S0.7320.90
39_V63_I0.7300.90
158_F185_L0.7280.90
12_V22_Y0.7250.90
108_Y149_I0.7240.90
15_N82_Q0.7230.90
108_Y135_S0.7220.90
190_D195_N0.7220.90
155_D180_A0.7210.90
231_A235_L0.7180.89
15_N83_S0.7170.89
88_Y187_G0.7160.89
76_L235_L0.7150.89
16_L19_F0.7120.89
228_P232_L0.7060.89
20_I97_V0.7050.88
168_K171_H0.7050.88
42_E227_I0.7040.88
19_F85_I0.7030.88
65_P71_V0.7000.88
36_I64_L0.6990.88
187_G224_M0.6990.88
117_G193_S0.6970.88
225_L228_P0.6940.88
19_F90_V0.6930.88
133_G152_A0.6930.88
86_A204_I0.6880.87
89_D204_I0.6840.87
19_F36_I0.6820.87
174_R182_S0.6800.87
116_K119_V0.6740.86
211_F215_I0.6700.86
74_S79_N0.6700.86
97_V100_K0.6660.85
150_A177_F0.6640.85
108_Y157_V0.6630.85
46_A226_S0.6630.85
78_N82_Q0.6620.85
8_N54_F0.6620.85
71_V74_S0.6580.85
20_I24_E0.6560.85
146_A176_L0.6540.84
95_L99_N0.6540.84
45_F229_K0.6510.84
103_K156_M0.6480.84
144_L148_Q0.6470.84
74_S81_L0.6460.84
191_V199_A0.6450.84
219_W224_M0.6420.83
137_G191_V0.6400.83
79_N82_Q0.6390.83
72_M75_R0.6360.83
69_G137_G0.6340.83
104_R152_A0.6310.82
160_A185_L0.6300.82
191_V196_V0.6290.82
135_S145_V0.6270.82
123_S128_N0.6260.82
41_P234_V0.6250.82
53_Y57_L0.6250.82
69_G72_M0.6240.82
87_G185_L0.6220.81
37_S57_L0.6200.81
92_K96_G0.6200.81
16_L90_V0.6190.81
146_A173_Y0.6140.81
230_Y234_V0.6110.80
96_G125_E0.6090.80
188_S191_V0.6090.80
110_A190_D0.6070.80
108_Y145_V0.6050.80
87_G184_G0.6040.79
52_D55_D0.5990.79
157_V177_F0.5970.79
217_N224_M0.5900.78
33_G178_P0.5870.78
25_K175_H0.5870.78
190_D220_R0.5860.77
74_S78_N0.5860.77
106_F145_V0.5840.77
99_N122_I0.5830.77
6_I73_M0.5830.77
71_V75_R0.5820.77
110_A114_V0.5800.77
88_Y137_G0.5780.76
177_F180_A0.5780.76
147_K176_L0.5770.76
72_M207_N0.5770.76
40_N43_I0.5770.76
102_K128_N0.5760.76
66_D213_R0.5760.76
116_K134_Y0.5740.76
44_A70_V0.5730.76
235_L238_E0.5720.76
71_V83_S0.5710.76
96_G99_N0.5690.75
38_T86_A0.5690.75
30_Q34_A0.5690.75
214_L222_K0.5670.75
169_F214_L0.5660.75
55_D58_S0.5640.75
99_N126_Y0.5640.75
114_V190_D0.5610.74
144_L147_K0.5590.74
38_T42_E0.5570.74
139_V145_V0.5550.74
120_S123_S0.5520.73
115_I118_V0.5510.73
24_E29_D0.5510.73
161_L169_F0.5460.72
113_D119_V0.5460.72
113_D134_Y0.5440.72
45_F48_I0.5440.72
202_W205_R0.5420.72
69_G73_M0.5410.72
122_I129_I0.5360.71
99_N127_P0.5310.70
53_Y56_V0.5300.70
69_G136_D0.5280.70
72_M76_L0.5260.70
52_D56_V0.5260.70
87_G198_R0.5260.70
6_I70_V0.5240.69
229_K233_T0.5240.69
138_Y165_H0.5230.69
102_K129_I0.5230.69
71_V86_A0.5230.69
9_I44_A0.5220.69
169_F177_F0.5200.69
157_V170_I0.5170.68
231_A234_V0.5160.68
206_L215_I0.5160.68
37_S63_I0.5140.68
55_D120_S0.5140.68
28_I180_A0.5130.68
122_I192_F0.5110.67
10_P63_I0.5100.67
40_N66_D0.5050.66
48_I237_E0.5050.66
68_I84_R0.5030.66
51_R124_S0.5020.66
35_V182_S0.5000.66
211_F214_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jgiA 2 0.75 85.4 0.934 Contact Map
1y80A 1 0.4492 78 0.939 Contact Map
2zayA 1 0.4609 69.6 0.943 Contact Map
3cnbA 1 0.4688 68.6 0.944 Contact Map
4r3uC 1 0.4844 63.5 0.946 Contact Map
3g40A 2 0.6367 62.4 0.946 Contact Map
2qv0A 2 0.4688 55.1 0.948 Contact Map
1jbeA 1 0.4688 52.9 0.949 Contact Map
4le1A 2 0.5 51.3 0.949 Contact Map
3cu5A 2 0.5 49.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.