GREMLIN Database
SP4FB - Stage IV sporulation protein FB
UniProt: P26937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (264)
Sequences: 1222 (965)
Seq/√Len: 59.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_G93_Q6.2981.00
42_I93_Q5.0411.00
171_G188_F4.5111.00
50_L85_A4.4091.00
95_I126_L3.9391.00
84_F88_I3.0511.00
60_R71_E3.0231.00
56_W86_V2.8161.00
43_H47_H2.7121.00
167_C188_F2.6751.00
97_L101_A2.6181.00
56_W72_V2.4921.00
160_L199_Y2.3971.00
48_A70_V2.3701.00
83_E143_F2.3341.00
146_F155_A2.3041.00
143_F156_H2.2171.00
169_L173_W2.2081.00
262_L270_A2.1921.00
215_Y220_E2.1831.00
161_K164_L2.1681.00
101_A118_F2.1601.00
43_H129_N2.1021.00
54_F85_A2.0841.00
54_F82_E2.0351.00
39_I118_F2.0171.00
238_V250_I2.0151.00
98_Q123_L1.8871.00
154_K158_L1.8671.00
35_C114_T1.8601.00
88_I141_L1.8551.00
83_E140_K1.7840.99
146_F150_L1.7640.99
48_A61_V1.7480.99
47_H129_N1.7350.99
58_I72_V1.7300.99
17_L147_S1.7140.99
165_C172_C1.7040.99
266_E269_H1.6830.99
126_L130_L1.6780.99
253_E259_L1.6770.99
233_D237_H1.6680.99
59_K73_E1.6650.99
165_C169_L1.6440.99
101_A104_L1.6210.99
245_G250_I1.6100.99
89_A92_L1.6090.99
237_H241_E1.5990.99
66_F94_H1.5960.99
160_L163_S1.5930.99
44_E129_N1.5830.99
46_G89_A1.5810.99
18_W22_A1.5480.98
99_F103_M1.4930.98
183_S187_L1.4700.98
129_N137_D1.4520.98
17_L40_V1.4410.97
146_F158_L1.4410.97
134_W156_H1.4360.97
263_D266_E1.3990.97
81_K85_A1.3950.97
147_S152_F1.3920.97
43_H137_D1.3780.97
107_V169_L1.3760.97
17_L37_L1.3650.96
150_L154_K1.3460.96
46_G86_V1.3350.96
83_E87_I1.3270.96
91_P129_N1.3220.96
45_L89_A1.3200.96
215_Y219_R1.3170.96
140_K156_H1.3170.96
44_E137_D1.3170.96
57_R73_E1.3110.96
48_A52_V1.3040.95
44_E47_H1.2850.95
87_I144_L1.2810.95
238_V242_F1.2790.95
95_I130_L1.2790.95
87_I141_L1.2770.95
17_L64_L1.2740.95
36_L40_V1.2410.94
253_E257_Q1.2380.94
28_G32_A1.2290.94
160_L198_E1.2250.94
9_L45_L1.2190.93
237_H240_A1.2090.93
62_F118_F1.1980.93
41_L63_L1.1890.93
233_D241_E1.1730.92
101_A119_T1.1630.92
230_K233_D1.1570.91
264_E270_A1.1520.91
91_P137_D1.1490.91
78_R82_E1.1410.91
69_T83_E1.1370.91
120_F127_F1.1360.91
9_L48_A1.1310.90
102_W119_T1.1250.90
58_I94_H1.1190.90
44_E91_P1.1170.90
122_N129_N1.1150.90
229_V238_V1.1130.90
30_M34_L1.1120.90
48_A58_I1.1000.89
107_V157_R1.0970.89
210_L213_R1.0960.89
97_L100_A1.0950.89
69_T143_F1.0950.89
12_H60_R1.0910.89
20_I61_V1.0740.88
192_A252_I1.0690.88
218_N222_E1.0690.88
104_L115_F1.0680.88
219_R234_K1.0630.88
46_G70_V1.0620.87
140_K143_F1.0580.87
21_A198_E1.0550.87
166_F187_L1.0470.87
69_T190_F1.0470.87
39_I125_I1.0360.86
32_A117_L1.0280.86
102_W106_E1.0240.86
130_L141_L1.0230.85
10_K18_W1.0220.85
261_Q266_E1.0200.85
43_H91_P1.0170.85
7_L52_V1.0140.85
145_L149_Q1.0110.85
125_I184_A1.0000.84
98_Q102_W1.0000.84
240_A272_F0.9980.84
76_G79_P0.9970.84
72_V94_H0.9960.84
59_K71_E0.9930.84
141_L190_F0.9840.83
47_H122_N0.9830.83
28_G117_L0.9720.82
75_H152_F0.9710.82
262_L271_Y0.9690.82
63_L140_K0.9660.82
17_L20_I0.9640.82
165_C173_W0.9570.81
133_I191_L0.9560.81
117_L121_Y0.9530.81
45_L63_L0.9460.81
77_N82_E0.9410.80
17_L21_A0.9340.80
253_E256_G0.9310.80
92_L96_W0.9310.80
88_I92_L0.9280.79
250_I264_E0.9240.79
96_W141_L0.9240.79
63_L83_E0.9230.79
247_K264_E0.9090.78
83_E156_H0.9010.77
53_F81_K0.9000.77
155_A163_S0.8980.77
191_L267_V0.8960.77
247_K263_D0.8890.76
240_A244_R0.8890.76
17_L198_E0.8870.76
26_L130_L0.8860.76
56_W75_H0.8850.76
20_I65_P0.8840.76
22_A26_L0.8810.76
101_A121_Y0.8790.76
142_L162_T0.8710.75
43_H122_N0.8710.75
90_G135_P0.8630.74
66_F136_L0.8580.74
76_G140_K0.8580.74
267_V270_A0.8540.73
101_A141_L0.8540.73
98_Q119_T0.8540.73
85_A239_M0.8520.73
167_C178_I0.8520.73
247_K250_I0.8480.73
236_Y240_A0.8480.73
98_Q126_L0.8460.73
235_V271_Y0.8410.72
123_L127_F0.8400.72
56_W89_A0.8390.72
83_E134_W0.8370.72
231_A259_L0.8360.72
64_L69_T0.8330.72
181_Q184_A0.8290.71
45_L61_V0.8270.71
47_H137_D0.8260.71
86_V230_K0.8230.71
40_V114_T0.8230.71
99_F111_H0.8140.70
47_H138_G0.8110.70
17_L83_E0.8090.69
19_I246_C0.8070.69
47_H128_V0.8050.69
46_G82_E0.7960.68
81_K148_K0.7960.68
12_H62_F0.7940.68
43_H138_G0.7930.68
60_R133_I0.7920.68
45_L48_A0.7910.68
64_L94_H0.7900.67
252_I255_S0.7830.67
50_L70_V0.7820.67
264_E272_F0.7780.66
250_I263_D0.7680.65
95_I99_F0.7660.65
41_L65_P0.7630.65
34_L169_L0.7610.65
258_K261_Q0.7580.64
122_N137_D0.7560.64
24_G179_P0.7520.64
199_Y202_R0.7480.63
246_C249_P0.7450.63
26_L65_P0.7450.63
41_L45_L0.7370.62
48_A94_H0.7360.62
238_V264_E0.7350.62
200_R204_Y0.7330.62
127_F162_T0.7300.61
167_C197_E0.7290.61
134_W155_A0.7280.61
239_M242_F0.7250.61
234_K270_A0.7210.60
136_L227_L0.7190.60
17_L146_F0.7190.60
142_L146_F0.7190.60
47_H91_P0.7180.60
232_E254_K0.7170.60
264_E271_Y0.7140.60
166_F170_L0.7090.59
226_P235_V0.7080.59
144_L234_K0.7040.59
246_C250_I0.7030.58
14_H198_E0.7000.58
242_F247_K0.6970.58
17_L150_L0.6960.58
13_V242_F0.6940.57
191_L198_E0.6930.57
39_I151_P0.6880.57
164_L167_C0.6860.57
20_I186_V0.6860.57
174_V178_I0.6830.56
83_E155_A0.6830.56
171_G185_W0.6810.56
183_S188_F0.6760.55
32_A36_L0.6760.55
116_E120_F0.6750.55
268_L271_Y0.6720.55
229_V233_D0.6710.55
32_A114_T0.6700.55
239_M267_V0.6690.55
165_C254_K0.6680.55
167_C174_V0.6650.54
228_T252_I0.6640.54
29_H114_T0.6640.54
252_I258_K0.6630.54
57_R166_F0.6620.54
42_I126_L0.6600.54
19_I189_V0.6590.54
74_E86_V0.6590.54
88_I118_F0.6580.53
49_A92_L0.6580.53
160_L202_R0.6550.53
154_K226_P0.6540.53
245_G267_V0.6520.53
241_E274_D0.6490.52
91_P122_N0.6480.52
152_F209_F0.6480.52
69_T191_L0.6480.52
56_W77_N0.6450.52
131_L267_V0.6450.52
134_W143_F0.6440.52
237_H274_D0.6440.52
34_L38_L0.6430.52
258_K271_Y0.6420.52
165_C234_K0.6410.52
229_V272_F0.6410.52
84_F187_L0.6400.51
70_V94_H0.6400.51
33_L238_V0.6400.51
158_L250_I0.6400.51
175_L261_Q0.6350.51
49_A257_Q0.6340.51
233_D238_V0.6330.51
142_L218_N0.6320.51
266_E272_F0.6290.50
36_L121_Y0.6260.50
147_S150_L0.6180.49
44_E135_P0.6170.49
84_F148_K0.6160.49
127_F186_V0.6150.49
71_E227_L0.6140.49
224_L249_P0.6120.48
63_L68_G0.6120.48
69_T92_L0.6120.48
100_A106_E0.6100.48
104_L165_C0.6080.48
54_F89_A0.6060.48
157_R161_K0.6060.48
68_G83_E0.6020.47
236_Y254_K0.6010.47
129_N138_G0.5990.47
136_L150_L0.5970.47
36_L86_V0.5960.47
30_M41_L0.5960.47
141_L184_A0.5960.47
39_I94_H0.5950.46
100_A223_K0.5940.46
39_I97_L0.5940.46
154_K157_R0.5930.46
24_G264_E0.5930.46
146_F162_T0.5890.46
18_W86_V0.5890.46
157_R203_H0.5890.46
17_L155_A0.5860.45
56_W141_L0.5850.45
7_L166_F0.5830.45
114_T168_L0.5830.45
65_P83_E0.5820.45
228_T269_H0.5810.45
230_K254_K0.5810.45
200_R258_K0.5800.45
62_F128_V0.5800.45
39_I147_S0.5780.45
191_L210_L0.5750.44
53_F85_A0.5740.44
226_P251_I0.5730.44
67_G132_P0.5720.44
159_N164_L0.5710.44
17_L152_F0.5710.44
64_L70_V0.5710.44
189_V193_V0.5690.44
110_I185_W0.5680.43
143_F195_L0.5680.43
162_T165_C0.5680.43
12_H86_V0.5670.43
69_T235_V0.5670.43
223_K247_K0.5660.43
28_G40_V0.5640.43
68_G159_N0.5640.43
172_C236_Y0.5630.43
218_N221_L0.5620.43
43_H128_V0.5610.43
40_V68_G0.5610.43
122_N138_G0.5580.42
174_V181_Q0.5580.42
252_I272_F0.5560.42
19_I104_L0.5550.42
38_L239_M0.5550.42
22_A127_F0.5530.42
63_L156_H0.5510.42
162_T237_H0.5490.41
19_I158_L0.5460.41
96_W244_R0.5450.41
231_A254_K0.5430.41
107_V115_F0.5430.41
57_R205_I0.5420.41
19_I259_L0.5390.40
239_M258_K0.5370.40
40_V73_E0.5370.40
88_I267_V0.5360.40
60_R235_V0.5350.40
106_E165_C0.5340.40
23_L115_F0.5320.40
61_V163_S0.5300.39
34_L42_I0.5290.39
129_N136_L0.5290.39
88_I130_L0.5280.39
68_G195_L0.5250.39
13_V116_E0.5230.39
152_F205_I0.5220.39
188_F218_N0.5220.39
39_I101_A0.5210.38
5_L214_Y0.5190.38
31_K221_L0.5180.38
105_A119_T0.5170.38
37_L241_E0.5170.38
45_L104_L0.5160.38
86_V190_F0.5150.38
129_N135_P0.5150.38
37_L40_V0.5140.38
141_L215_Y0.5120.37
94_H143_F0.5110.37
32_A40_V0.5100.37
254_K261_Q0.5100.37
103_M106_E0.5090.37
37_L68_G0.5080.37
52_V255_S0.5080.37
14_H64_L0.5040.37
157_R199_Y0.5030.37
117_L120_F0.5020.36
145_L257_Q0.5020.36
34_L246_C0.5010.36
24_G89_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.7083 100 0.45 Contact Map
2ef7A 3 0.2639 98.3 0.874 Contact Map
3i8nA 2 0.2604 98.2 0.878 Contact Map
3nqrA 2 0.2569 98.2 0.878 Contact Map
3gbyA 2 0.2639 98.2 0.879 Contact Map
3fhmA 2 0.2812 98.1 0.879 Contact Map
2p9mA 2 0.2708 98.1 0.879 Contact Map
2yziA 2 0.2674 98.1 0.88 Contact Map
3lv9A 2 0.2639 98.1 0.88 Contact Map
3ocoA 2 0.2882 98.1 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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