SP4FB - BACSU - GREMLIN Contacts

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SP4FB - Stage IV sporulation protein FB

UniProt:	P26937	Sequences: MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHELGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAWMLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNLKTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKNRELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKRTNSSMEELLLPY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (264)
Sequences:	1222 (965)
Seq/√Len:	59.4

BACSU - SP4FB
HALSA - Q9HNB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_G	93_Q	6.298	1.00
42_I	93_Q	5.041	1.00
171_G	188_F	4.511	1.00
50_L	85_A	4.409	1.00
95_I	126_L	3.939	1.00
84_F	88_I	3.051	1.00
60_R	71_E	3.023	1.00
56_W	86_V	2.816	1.00
43_H	47_H	2.712	1.00
167_C	188_F	2.675	1.00
97_L	101_A	2.618	1.00
56_W	72_V	2.492	1.00
160_L	199_Y	2.397	1.00
48_A	70_V	2.370	1.00
83_E	143_F	2.334	1.00
146_F	155_A	2.304	1.00
143_F	156_H	2.217	1.00
169_L	173_W	2.208	1.00
262_L	270_A	2.192	1.00
215_Y	220_E	2.183	1.00
161_K	164_L	2.168	1.00
101_A	118_F	2.160	1.00
43_H	129_N	2.102	1.00
54_F	85_A	2.084	1.00
54_F	82_E	2.035	1.00
39_I	118_F	2.017	1.00
238_V	250_I	2.015	1.00
98_Q	123_L	1.887	1.00
154_K	158_L	1.867	1.00
35_C	114_T	1.860	1.00
88_I	141_L	1.855	1.00
83_E	140_K	1.784	0.99
146_F	150_L	1.764	0.99
48_A	61_V	1.748	0.99
47_H	129_N	1.735	0.99
58_I	72_V	1.730	0.99
17_L	147_S	1.714	0.99
165_C	172_C	1.704	0.99
266_E	269_H	1.683	0.99
126_L	130_L	1.678	0.99
253_E	259_L	1.677	0.99
233_D	237_H	1.668	0.99
59_K	73_E	1.665	0.99
165_C	169_L	1.644	0.99
101_A	104_L	1.621	0.99
245_G	250_I	1.610	0.99
89_A	92_L	1.609	0.99
237_H	241_E	1.599	0.99
66_F	94_H	1.596	0.99
160_L	163_S	1.593	0.99
44_E	129_N	1.583	0.99
46_G	89_A	1.581	0.99
18_W	22_A	1.548	0.98
99_F	103_M	1.493	0.98
183_S	187_L	1.470	0.98
129_N	137_D	1.452	0.98
17_L	40_V	1.441	0.97
146_F	158_L	1.441	0.97
134_W	156_H	1.436	0.97
263_D	266_E	1.399	0.97
81_K	85_A	1.395	0.97
147_S	152_F	1.392	0.97
43_H	137_D	1.378	0.97
107_V	169_L	1.376	0.97
17_L	37_L	1.365	0.96
150_L	154_K	1.346	0.96
46_G	86_V	1.335	0.96
83_E	87_I	1.327	0.96
91_P	129_N	1.322	0.96
45_L	89_A	1.320	0.96
215_Y	219_R	1.317	0.96
140_K	156_H	1.317	0.96
44_E	137_D	1.317	0.96
57_R	73_E	1.311	0.96
48_A	52_V	1.304	0.95
44_E	47_H	1.285	0.95
87_I	144_L	1.281	0.95
238_V	242_F	1.279	0.95
95_I	130_L	1.279	0.95
87_I	141_L	1.277	0.95
17_L	64_L	1.274	0.95
36_L	40_V	1.241	0.94
253_E	257_Q	1.238	0.94
28_G	32_A	1.229	0.94
160_L	198_E	1.225	0.94
9_L	45_L	1.219	0.93
237_H	240_A	1.209	0.93
62_F	118_F	1.198	0.93
41_L	63_L	1.189	0.93
233_D	241_E	1.173	0.92
101_A	119_T	1.163	0.92
230_K	233_D	1.157	0.91
264_E	270_A	1.152	0.91
91_P	137_D	1.149	0.91
78_R	82_E	1.141	0.91
69_T	83_E	1.137	0.91
120_F	127_F	1.136	0.91
9_L	48_A	1.131	0.90
102_W	119_T	1.125	0.90
58_I	94_H	1.119	0.90
44_E	91_P	1.117	0.90
122_N	129_N	1.115	0.90
229_V	238_V	1.113	0.90
30_M	34_L	1.112	0.90
48_A	58_I	1.100	0.89
107_V	157_R	1.097	0.89
210_L	213_R	1.096	0.89
97_L	100_A	1.095	0.89
69_T	143_F	1.095	0.89
12_H	60_R	1.091	0.89
20_I	61_V	1.074	0.88
192_A	252_I	1.069	0.88
218_N	222_E	1.069	0.88
104_L	115_F	1.068	0.88
219_R	234_K	1.063	0.88
46_G	70_V	1.062	0.87
140_K	143_F	1.058	0.87
21_A	198_E	1.055	0.87
166_F	187_L	1.047	0.87
69_T	190_F	1.047	0.87
39_I	125_I	1.036	0.86
32_A	117_L	1.028	0.86
102_W	106_E	1.024	0.86
130_L	141_L	1.023	0.85
10_K	18_W	1.022	0.85
261_Q	266_E	1.020	0.85
43_H	91_P	1.017	0.85
7_L	52_V	1.014	0.85
145_L	149_Q	1.011	0.85
125_I	184_A	1.000	0.84
98_Q	102_W	1.000	0.84
240_A	272_F	0.998	0.84
76_G	79_P	0.997	0.84
72_V	94_H	0.996	0.84
59_K	71_E	0.993	0.84
141_L	190_F	0.984	0.83
47_H	122_N	0.983	0.83
28_G	117_L	0.972	0.82
75_H	152_F	0.971	0.82
262_L	271_Y	0.969	0.82
63_L	140_K	0.966	0.82
17_L	20_I	0.964	0.82
165_C	173_W	0.957	0.81
133_I	191_L	0.956	0.81
117_L	121_Y	0.953	0.81
45_L	63_L	0.946	0.81
77_N	82_E	0.941	0.80
17_L	21_A	0.934	0.80
253_E	256_G	0.931	0.80
92_L	96_W	0.931	0.80
88_I	92_L	0.928	0.79
250_I	264_E	0.924	0.79
96_W	141_L	0.924	0.79
63_L	83_E	0.923	0.79
247_K	264_E	0.909	0.78
83_E	156_H	0.901	0.77
53_F	81_K	0.900	0.77
155_A	163_S	0.898	0.77
191_L	267_V	0.896	0.77
247_K	263_D	0.889	0.76
240_A	244_R	0.889	0.76
17_L	198_E	0.887	0.76
26_L	130_L	0.886	0.76
56_W	75_H	0.885	0.76
20_I	65_P	0.884	0.76
22_A	26_L	0.881	0.76
101_A	121_Y	0.879	0.76
142_L	162_T	0.871	0.75
43_H	122_N	0.871	0.75
90_G	135_P	0.863	0.74
66_F	136_L	0.858	0.74
76_G	140_K	0.858	0.74
267_V	270_A	0.854	0.73
101_A	141_L	0.854	0.73
98_Q	119_T	0.854	0.73
85_A	239_M	0.852	0.73
167_C	178_I	0.852	0.73
247_K	250_I	0.848	0.73
236_Y	240_A	0.848	0.73
98_Q	126_L	0.846	0.73
235_V	271_Y	0.841	0.72
123_L	127_F	0.840	0.72
56_W	89_A	0.839	0.72
83_E	134_W	0.837	0.72
231_A	259_L	0.836	0.72
64_L	69_T	0.833	0.72
181_Q	184_A	0.829	0.71
45_L	61_V	0.827	0.71
47_H	137_D	0.826	0.71
86_V	230_K	0.823	0.71
40_V	114_T	0.823	0.71
99_F	111_H	0.814	0.70
47_H	138_G	0.811	0.70
17_L	83_E	0.809	0.69
19_I	246_C	0.807	0.69
47_H	128_V	0.805	0.69
46_G	82_E	0.796	0.68
81_K	148_K	0.796	0.68
12_H	62_F	0.794	0.68
43_H	138_G	0.793	0.68
60_R	133_I	0.792	0.68
45_L	48_A	0.791	0.68
64_L	94_H	0.790	0.67
252_I	255_S	0.783	0.67
50_L	70_V	0.782	0.67
264_E	272_F	0.778	0.66
250_I	263_D	0.768	0.65
95_I	99_F	0.766	0.65
41_L	65_P	0.763	0.65
34_L	169_L	0.761	0.65
258_K	261_Q	0.758	0.64
122_N	137_D	0.756	0.64
24_G	179_P	0.752	0.64
199_Y	202_R	0.748	0.63
246_C	249_P	0.745	0.63
26_L	65_P	0.745	0.63
41_L	45_L	0.737	0.62
48_A	94_H	0.736	0.62
238_V	264_E	0.735	0.62
200_R	204_Y	0.733	0.62
127_F	162_T	0.730	0.61
167_C	197_E	0.729	0.61
134_W	155_A	0.728	0.61
239_M	242_F	0.725	0.61
234_K	270_A	0.721	0.60
136_L	227_L	0.719	0.60
17_L	146_F	0.719	0.60
142_L	146_F	0.719	0.60
47_H	91_P	0.718	0.60
232_E	254_K	0.717	0.60
264_E	271_Y	0.714	0.60
166_F	170_L	0.709	0.59
226_P	235_V	0.708	0.59
144_L	234_K	0.704	0.59
246_C	250_I	0.703	0.58
14_H	198_E	0.700	0.58
242_F	247_K	0.697	0.58
17_L	150_L	0.696	0.58
13_V	242_F	0.694	0.57
191_L	198_E	0.693	0.57
39_I	151_P	0.688	0.57
164_L	167_C	0.686	0.57
20_I	186_V	0.686	0.57
174_V	178_I	0.683	0.56
83_E	155_A	0.683	0.56
171_G	185_W	0.681	0.56
183_S	188_F	0.676	0.55
32_A	36_L	0.676	0.55
116_E	120_F	0.675	0.55
268_L	271_Y	0.672	0.55
229_V	233_D	0.671	0.55
32_A	114_T	0.670	0.55
239_M	267_V	0.669	0.55
165_C	254_K	0.668	0.55
167_C	174_V	0.665	0.54
228_T	252_I	0.664	0.54
29_H	114_T	0.664	0.54
252_I	258_K	0.663	0.54
57_R	166_F	0.662	0.54
42_I	126_L	0.660	0.54
19_I	189_V	0.659	0.54
74_E	86_V	0.659	0.54
88_I	118_F	0.658	0.53
49_A	92_L	0.658	0.53
160_L	202_R	0.655	0.53
154_K	226_P	0.654	0.53
245_G	267_V	0.652	0.53
241_E	274_D	0.649	0.52
91_P	122_N	0.648	0.52
152_F	209_F	0.648	0.52
69_T	191_L	0.648	0.52
56_W	77_N	0.645	0.52
131_L	267_V	0.645	0.52
134_W	143_F	0.644	0.52
237_H	274_D	0.644	0.52
34_L	38_L	0.643	0.52
258_K	271_Y	0.642	0.52
165_C	234_K	0.641	0.52
229_V	272_F	0.641	0.52
84_F	187_L	0.640	0.51
70_V	94_H	0.640	0.51
33_L	238_V	0.640	0.51
158_L	250_I	0.640	0.51
175_L	261_Q	0.635	0.51
49_A	257_Q	0.634	0.51
233_D	238_V	0.633	0.51
142_L	218_N	0.632	0.51
266_E	272_F	0.629	0.50
36_L	121_Y	0.626	0.50
147_S	150_L	0.618	0.49
44_E	135_P	0.617	0.49
84_F	148_K	0.616	0.49
127_F	186_V	0.615	0.49
71_E	227_L	0.614	0.49
224_L	249_P	0.612	0.48
63_L	68_G	0.612	0.48
69_T	92_L	0.612	0.48
100_A	106_E	0.610	0.48
104_L	165_C	0.608	0.48
54_F	89_A	0.606	0.48
157_R	161_K	0.606	0.48
68_G	83_E	0.602	0.47
236_Y	254_K	0.601	0.47
129_N	138_G	0.599	0.47
136_L	150_L	0.597	0.47
36_L	86_V	0.596	0.47
30_M	41_L	0.596	0.47
141_L	184_A	0.596	0.47
39_I	94_H	0.595	0.46
100_A	223_K	0.594	0.46
39_I	97_L	0.594	0.46
154_K	157_R	0.593	0.46
24_G	264_E	0.593	0.46
146_F	162_T	0.589	0.46
18_W	86_V	0.589	0.46
157_R	203_H	0.589	0.46
17_L	155_A	0.586	0.45
56_W	141_L	0.585	0.45
7_L	166_F	0.583	0.45
114_T	168_L	0.583	0.45
65_P	83_E	0.582	0.45
228_T	269_H	0.581	0.45
230_K	254_K	0.581	0.45
200_R	258_K	0.580	0.45
62_F	128_V	0.580	0.45
39_I	147_S	0.578	0.45
191_L	210_L	0.575	0.44
53_F	85_A	0.574	0.44
226_P	251_I	0.573	0.44
67_G	132_P	0.572	0.44
159_N	164_L	0.571	0.44
17_L	152_F	0.571	0.44
64_L	70_V	0.571	0.44
189_V	193_V	0.569	0.44
110_I	185_W	0.568	0.43
143_F	195_L	0.568	0.43
162_T	165_C	0.568	0.43
12_H	86_V	0.567	0.43
69_T	235_V	0.567	0.43
223_K	247_K	0.566	0.43
28_G	40_V	0.564	0.43
68_G	159_N	0.564	0.43
172_C	236_Y	0.563	0.43
218_N	221_L	0.562	0.43
43_H	128_V	0.561	0.43
40_V	68_G	0.561	0.43
122_N	138_G	0.558	0.42
174_V	181_Q	0.558	0.42
252_I	272_F	0.556	0.42
19_I	104_L	0.555	0.42
38_L	239_M	0.555	0.42
22_A	127_F	0.553	0.42
63_L	156_H	0.551	0.42
162_T	237_H	0.549	0.41
19_I	158_L	0.546	0.41
96_W	244_R	0.545	0.41
231_A	254_K	0.543	0.41
107_V	115_F	0.543	0.41
57_R	205_I	0.542	0.41
19_I	259_L	0.539	0.40
239_M	258_K	0.537	0.40
40_V	73_E	0.537	0.40
88_I	267_V	0.536	0.40
60_R	235_V	0.535	0.40
106_E	165_C	0.534	0.40
23_L	115_F	0.532	0.40
61_V	163_S	0.530	0.39
34_L	42_I	0.529	0.39
129_N	136_L	0.529	0.39
88_I	130_L	0.528	0.39
68_G	195_L	0.525	0.39
13_V	116_E	0.523	0.39
152_F	205_I	0.522	0.39
188_F	218_N	0.522	0.39
39_I	101_A	0.521	0.38
5_L	214_Y	0.519	0.38
31_K	221_L	0.518	0.38
105_A	119_T	0.517	0.38
37_L	241_E	0.517	0.38
45_L	104_L	0.516	0.38
86_V	190_F	0.515	0.38
129_N	135_P	0.515	0.38
37_L	40_V	0.514	0.38
141_L	215_Y	0.512	0.37
94_H	143_F	0.511	0.37
32_A	40_V	0.510	0.37
254_K	261_Q	0.510	0.37
103_M	106_E	0.509	0.37
37_L	68_G	0.508	0.37
52_V	255_S	0.508	0.37
14_H	64_L	0.504	0.37
157_R	199_Y	0.503	0.37
117_L	120_F	0.502	0.36
145_L	257_Q	0.502	0.36
34_L	246_C	0.501	0.36
24_G	89_A	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b4rA	2	0.7083	100	0.45	Contact Map
2ef7A	3	0.2639	98.3	0.874	Contact Map
3i8nA	2	0.2604	98.2	0.878	Contact Map
3nqrA	2	0.2569	98.2	0.878	Contact Map
3gbyA	2	0.2639	98.2	0.879	Contact Map
3fhmA	2	0.2812	98.1	0.879	Contact Map
2p9mA	2	0.2708	98.1	0.879	Contact Map
2yziA	2	0.2674	98.1	0.88	Contact Map
3lv9A	2	0.2639	98.1	0.88	Contact Map
3ocoA	2	0.2882	98.1	0.88	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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