GREMLIN Database
IOLG - Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
UniProt: P26935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (307)
Sequences: 25541 (18959)
Seq/√Len: 1082.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_D85_K3.0671.00
80_E108_R2.7851.00
84_L112_E2.7641.00
191_S216_E2.7391.00
128_R179_D2.7281.00
4_R29_E2.6891.00
38_Q42_Q2.6651.00
147_E244_E2.6581.00
135_Q138_E2.6261.00
88_K112_E2.6251.00
107_M306_Y2.5921.00
190_E218_K2.4151.00
84_L88_K2.3801.00
74_S82_S2.3761.00
6_G61_L2.3671.00
80_E105_G2.3471.00
84_L108_R2.3331.00
137_K141_D2.3291.00
213_V315_C2.1591.00
87_I118_K2.1311.00
57_N60_S2.1301.00
317_K321_S2.1171.00
32_A55_Y2.1061.00
138_E142_N2.0981.00
78_A82_S2.0861.00
111_E115_K2.0321.00
289_D293_K2.0311.00
114_I303_W1.9641.00
80_E84_L1.9541.00
27_G292_Q1.9531.00
293_K296_E1.9381.00
135_Q139_A1.9301.00
83_V95_C1.9241.00
69_A287_F1.8991.00
15_K47_Q1.8921.00
53_T64_D1.8711.00
42_Q46_E1.8511.00
107_M111_E1.8441.00
87_I113_E1.8331.00
81_S85_K1.8321.00
74_S78_A1.8311.00
107_M310_V1.8301.00
112_E116_V1.7991.00
88_K116_V1.7561.00
37_N40_A1.7521.00
92_Y118_K1.7411.00
6_G67_V1.7141.00
145_I243_G1.6961.00
217_T223_I1.6941.00
103_A313_D1.6921.00
70_V86_A1.6531.00
102_T105_G1.6441.00
5_I69_A1.6361.00
83_V109_I1.6211.00
21_I71_L1.6171.00
62_L86_A1.6001.00
28_A288_I1.5991.00
121_V302_A1.5891.00
56_P60_S1.5851.00
63_A89_A1.5731.00
67_V91_K1.5671.00
190_E216_E1.5571.00
124_G283_E1.5261.00
136_L248_I1.5261.00
58_D85_K1.5221.00
139_A144_V1.5171.00
137_K183_W1.5101.00
88_K115_K1.5051.00
196_Y319_Q1.4931.00
43_K47_Q1.4671.00
112_E115_K1.4491.00
110_V306_Y1.4461.00
307_I310_V1.4401.00
60_S63_A1.4371.00
101_T105_G1.4301.00
110_V302_A1.4291.00
55_Y64_D1.4161.00
80_E109_I1.4121.00
59_D63_A1.3891.00
38_Q56_P1.3881.00
152_H240_E1.3821.00
149_L244_E1.3781.00
85_K88_K1.3551.00
185_V221_I1.3461.00
100_A106_C1.3441.00
87_I116_V1.3361.00
100_A109_I1.3181.00
60_S64_D1.3171.00
4_R31_V1.3051.00
85_K89_A1.2991.00
187_D218_K1.2961.00
240_E249_K1.2931.00
55_Y61_L1.2841.00
187_D219_G1.2781.00
103_A107_M1.2701.00
106_C306_Y1.2691.00
4_R68_D1.2611.00
286_D290_S1.2601.00
103_A310_V1.2601.00
41_A54_V1.2591.00
10_T33_V1.2511.00
34_T58_D1.2491.00
182_H307_I1.2451.00
189_Y217_T1.2371.00
286_D299_G1.2171.00
182_H217_T1.2141.00
289_D296_E1.2131.00
145_I246_G1.2091.00
43_K46_E1.2061.00
34_T61_L1.2021.00
27_G285_Q1.2021.00
72_V82_S1.1931.00
90_Q116_V1.1911.00
58_D82_S1.1911.00
86_A93_V1.1811.00
148_P241_I1.1801.00
72_V83_V1.1761.00
178_I311_T1.1731.00
108_R111_E1.1701.00
87_I112_E1.1661.00
152_H226_E1.1621.00
32_A61_L1.1611.00
285_Q289_D1.1551.00
110_V303_W1.1481.00
45_V54_V1.1401.00
39_E42_Q1.1401.00
238_Q249_K1.1361.00
195_I216_E1.1331.00
301_T304_D1.1151.00
65_E91_K1.1151.00
182_H304_D1.1151.00
99_L106_C1.1121.00
288_I292_Q1.1091.00
23_N281_D1.1081.00
61_L67_V1.0981.00
5_I28_A1.0951.00
111_E114_I1.0871.00
317_K320_E1.0861.00
58_D62_L1.0811.00
313_D317_K1.0811.00
75_W78_A1.0801.00
108_R112_E1.0801.00
94_F124_G1.0721.00
94_F283_E1.0691.00
106_C309_A1.0661.00
193_Q214_V1.0661.00
32_A67_V1.0561.00
139_A142_N1.0521.00
110_V114_I1.0471.00
133_Y183_W1.0401.00
3_L292_Q1.0401.00
105_G108_R1.0351.00
181_L223_I1.0331.00
151_I223_I1.0311.00
62_L85_K1.0301.00
66_N91_K1.0231.00
27_G289_D1.0211.00
3_L69_A1.0111.00
92_Y291_I1.0081.00
138_E141_D1.0031.00
84_L109_I0.9991.00
29_E51_N0.9991.00
314_A317_K0.9991.00
17_H71_L0.9981.00
95_C121_V0.9971.00
8_I82_S0.9931.00
62_L89_A0.9911.00
145_I248_I0.9911.00
100_A105_G0.9831.00
41_A56_P0.9831.00
151_I185_V0.9821.00
104_E107_M0.9821.00
3_L291_I0.9731.00
249_K257_S0.9651.00
19_N23_N0.9641.00
282_V285_Q0.9621.00
286_D296_E0.9551.00
53_T66_N0.9541.00
281_D285_Q0.9541.00
19_N47_Q0.9531.00
128_R304_D0.9511.00
145_I148_P0.9501.00
64_D67_V0.9481.00
286_D289_D0.9471.00
92_Y295_G0.9431.00
109_I121_V0.9411.00
189_Y215_I0.9401.00
148_P243_G0.9381.00
39_E43_K0.9331.00
82_S85_K0.9311.00
129_Y286_D0.9251.00
40_A43_K0.9221.00
136_L250_L0.9201.00
55_Y60_S0.9181.00
41_A45_V0.9161.00
99_L302_A0.9161.00
104_E108_R0.9161.00
148_P185_V0.9141.00
297_V301_T0.9131.00
10_T35_D0.9081.00
83_V93_V0.9081.00
42_Q54_V0.8981.00
103_A306_Y0.8981.00
33_V44_V0.8881.00
99_L121_V0.8861.00
38_Q41_A0.8841.00
80_E100_A0.8831.00
144_V260_K0.8811.00
126_M279_A0.8811.00
122_Q287_F0.8791.00
71_L284_I0.8761.00
314_A318_A0.8741.00
134_V299_G0.8711.00
303_W307_I0.8681.00
5_I21_I0.8631.00
113_E116_V0.8621.00
78_A81_S0.8611.00
316_V320_E0.8611.00
187_D307_I0.8581.00
35_D41_A0.8571.00
38_Q54_V0.8541.00
101_T166_T0.8541.00
290_S293_K0.8531.00
212_I224_N0.8481.00
83_V87_I0.8391.00
87_I93_V0.8381.00
72_V86_A0.8341.00
107_M110_V0.8331.00
42_Q45_V0.8271.00
113_E121_V0.8241.00
95_C99_L0.8231.00
134_V138_E0.8181.00
31_V66_N0.8181.00
15_K43_K0.8151.00
151_I181_L0.8151.00
310_V314_A0.8151.00
76_G172_D0.8121.00
240_E247_I0.8101.00
21_I28_A0.8091.00
6_G32_A0.8091.00
151_I241_I0.8071.00
27_G288_I0.8071.00
21_I284_I0.8071.00
146_G246_G0.8061.00
146_G243_G0.8041.00
45_V50_L0.8011.00
194_V315_C0.7981.00
17_H284_I0.7971.00
122_Q290_S0.7971.00
14_G73_T0.7931.00
189_Y218_K0.7931.00
4_R67_V0.7921.00
152_H224_N0.7901.00
95_C109_I0.7901.00
195_I222_V0.7881.00
35_D40_A0.7881.00
182_H308_A0.7871.00
6_G34_T0.7831.00
153_C239_C0.7801.00
64_D91_K0.7801.00
189_Y311_T0.7781.00
77_P165_T0.7741.00
154_A238_Q0.7731.00
113_E118_K0.7721.00
147_E219_G0.7671.00
178_I312_T0.7661.00
289_D295_G0.7661.00
8_I74_S0.7651.00
169_A227_I0.7641.00
260_K263_R0.7621.00
69_A92_Y0.7621.00
140_L243_G0.7591.00
215_I223_I0.7571.00
256_I259_R0.7541.00
87_I121_V0.7521.00
8_I58_D0.7511.00
113_E302_A0.7491.00
238_Q251_P0.7471.00
106_C110_V0.7451.00
7_V18_I0.7441.00
245_D261_E0.7411.00
167_D171_V0.7411.00
193_Q318_A0.7411.00
13_I17_H0.7371.00
31_V64_D0.7361.00
191_S322_G0.7361.00
287_F291_I0.7351.00
125_F175_V0.7331.00
170_V312_T0.7331.00
168_M208_K0.7281.00
13_I280_Y0.7271.00
31_V67_V0.7261.00
153_C177_E0.7251.00
175_V308_A0.7211.00
306_Y310_V0.7161.00
80_E112_E0.7141.00
31_V53_T0.7131.00
13_I73_T0.7121.00
99_L123_V0.7111.00
141_D186_N0.7111.00
280_Y283_E0.7091.00
127_R130_D0.7081.00
181_L217_T0.7071.00
61_L64_D0.7051.00
14_G19_N0.7041.00
292_Q295_G0.7021.00
8_I34_T0.7021.00
172_D229_V0.7021.00
79_H95_C0.7021.00
214_V222_V0.7001.00
174_L227_I0.6981.00
290_S298_S0.6981.00
18_I30_I0.6971.00
209_D230_N0.6941.00
134_V282_V0.6931.00
6_G70_V0.6921.00
290_S296_E0.6901.00
123_V305_G0.6891.00
133_Y180_V0.6851.00
154_A226_E0.6821.00
84_L87_I0.6811.00
302_A305_G0.6791.00
242_V247_I0.6751.00
194_V213_V0.6741.00
304_D307_I0.6721.00
156_R226_E0.6721.00
147_E245_D0.6711.00
185_V217_T0.6701.00
197_P216_E0.6691.00
81_S108_R0.6691.00
87_I109_I0.6681.00
5_I288_I0.6661.00
150_M222_V0.6661.00
309_A313_D0.6631.00
90_Q118_K0.6611.00
213_V225_A0.6591.00
128_R183_W0.6571.00
10_T41_A0.6561.00
44_V47_Q0.6541.00
37_N42_Q0.6481.00
95_C123_V0.6471.00
94_F122_Q0.6461.00
263_R266_T0.6461.00
15_K19_N0.6441.00
97_K176_H0.6371.00
69_A291_I0.6371.00
83_V121_V0.6371.00
137_K184_L0.6341.00
217_T221_I0.6331.00
4_R66_N0.6321.00
260_K264_F0.6321.00
182_H311_T0.6311.00
174_L177_E0.6311.00
191_S195_I0.6301.00
170_V211_Q0.6271.00
140_L241_I0.6261.00
260_K265_S0.6241.00
5_I71_L0.6241.00
125_F308_A0.6231.00
18_I44_V0.6181.00
216_E222_V0.6161.00
286_D298_S0.6151.00
195_I214_V0.6141.00
125_F179_D0.6141.00
179_D308_A0.6131.00
44_V48_Y0.6121.00
176_H179_D0.6101.00
126_M280_Y0.6081.00
15_K40_A0.6071.00
153_C181_L0.6071.00
194_V211_Q0.6041.00
70_V91_K0.6031.00
155_H173_T0.5981.00
179_D183_W0.5961.00
14_G44_V0.5961.00
122_Q286_D0.5951.00
59_D81_S0.5951.00
184_L241_I0.5931.00
136_L184_L0.5901.00
139_A258_L0.5901.00
208_K316_V0.5901.00
228_Y231_C0.5891.00
33_V54_V0.5881.00
55_Y65_E0.5881.00
289_D292_Q0.5871.00
72_V79_H0.5871.00
15_K48_Y0.5871.00
91_K118_K0.5871.00
182_H187_D0.5851.00
58_D86_A0.5831.00
210_P228_Y0.5801.00
193_Q216_E0.5801.00
214_V224_N0.5791.00
28_A69_A0.5771.00
178_I315_C0.5761.00
71_L94_F0.5761.00
81_S84_L0.5731.00
308_A312_T0.5721.00
170_V213_V0.5711.00
11_G14_G0.5701.00
11_G73_T0.5691.00
13_I96_E0.5671.00
261_E264_F0.5671.00
34_T55_Y0.5671.00
15_K44_V0.5671.00
200_S209_D0.5641.00
110_V113_E0.5621.00
127_R179_D0.5611.00
134_V183_W0.5591.00
17_H21_I0.5571.00
312_T316_V0.5561.00
215_I225_A0.5551.00
143_H243_G0.5551.00
77_P101_T0.5521.00
144_V147_E0.5511.00
140_L184_L0.5501.00
36_V74_S0.5501.00
12_A16_E0.5491.00
68_D292_Q0.5461.00
96_E124_G0.5421.00
196_Y211_Q0.5411.00
73_T96_E0.5401.00
122_Q283_E0.5391.00
150_M242_V0.5391.00
278_A281_D0.5381.00
150_M224_N0.5371.00
102_T313_D0.5351.00
97_K172_D0.5341.00
88_K108_R0.5331.00
83_V113_E0.5311.00
17_H73_T0.5301.00
131_S282_V0.5281.00
181_L225_A0.5281.00
99_L109_I0.5271.00
210_P226_E0.5271.00
171_V313_D0.5251.00
7_V71_L0.5241.00
7_V30_I0.5211.00
3_L28_A0.5211.00
212_I226_E0.5201.00
32_A53_T0.5201.00
104_E313_D0.5181.00
74_S79_H0.5171.00
46_E54_V0.5171.00
123_V176_H0.5161.00
137_K186_N0.5151.00
59_D89_A0.5111.00
259_R264_F0.5101.00
33_V41_A0.5101.00
10_T44_V0.5101.00
134_V137_K0.5091.00
169_A173_T0.5071.00
182_H189_Y0.5061.00
249_K259_R0.5041.00
192_V311_T0.5041.00
129_Y300_P0.5031.00
34_T56_P0.5011.00
150_M210_P0.5001.00
19_N22_T0.5001.00
148_P221_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mz0A 4 0.9709 100 0.172 Contact Map
4miyA 4 0.9709 100 0.181 Contact Map
3ec7A 6 0.9651 100 0.183 Contact Map
1h6dA 8 0.9651 100 0.197 Contact Map
3ceaA 4 0.9448 100 0.208 Contact Map
3ezyA 4 0.9477 100 0.213 Contact Map
4mkxA 4 0.9448 100 0.214 Contact Map
3euwA 4 0.9419 100 0.216 Contact Map
1zh8A 2 0.9012 100 0.217 Contact Map
3moiA 2 0.9302 100 0.22 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.