GREMLIN Database
RL21 - 50S ribosomal protein L21
UniProt: P26908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (100)
Sequences: 2625 (1393)
Seq/√Len: 139.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_K37_D3.4001.00
61_K98_E3.3781.00
16_E99_K3.1341.00
67_R91_P2.8531.00
72_T85_K2.7931.00
28_E31_E2.7291.00
15_E18_Q2.6811.00
27_A62_V2.4541.00
21_Y94_K2.4031.00
34_T57_T2.2631.00
61_K96_T2.1791.00
60_A97_I2.1621.00
32_T59_T1.9831.00
35_F95_V1.9161.00
77_K82_V1.8171.00
40_F46_V1.7221.00
22_I95_V1.7051.00
66_G92_Y1.6541.00
19_T96_T1.6121.00
60_A95_V1.6001.00
75_R82_V1.6001.00
19_T94_K1.5551.00
63_E96_T1.5261.00
10_K23_E1.4591.00
7_T22_I1.4351.00
64_K94_K1.4231.00
73_V86_Q1.3701.00
59_T99_K1.3691.00
76_Y79_K1.3621.00
34_T59_T1.3461.00
32_T98_E1.3211.00
37_D52_T1.3191.00
24_K91_P1.2831.00
6_K52_T1.2641.00
5_I35_F1.2621.00
2_Y13_K1.2321.00
74_F83_H1.2061.00
7_T23_E1.1801.00
29_A64_K1.1731.00
35_F60_A1.1450.99
53_V56_A1.1350.99
62_V93_T1.1320.99
21_Y68_A1.1310.99
27_A31_E1.1090.99
48_V51_P1.0730.99
59_T98_E1.0550.99
40_F48_V1.0500.99
19_T63_E1.0460.99
22_I25_L1.0330.99
66_G94_K1.0260.99
73_V82_V1.0190.99
21_Y66_G1.0170.99
74_F85_K0.9730.98
8_G23_E0.9720.98
51_P55_G0.9610.98
20_V95_V0.9540.98
41_V56_A0.9460.98
76_Y83_H0.9230.97
77_K81_N0.8840.97
24_K65_Q0.8700.96
14_V18_Q0.8570.96
32_T61_K0.8510.96
23_E90_Q0.8350.95
5_I14_V0.8270.95
65_Q93_T0.8180.95
7_T12_I0.8150.95
21_Y64_K0.8070.94
12_I20_V0.8010.94
5_I58_V0.7590.92
43_G46_V0.7550.92
29_A65_Q0.7480.92
2_Y46_V0.7460.91
41_V100_I0.7420.91
47_K53_V0.7410.91
41_V53_V0.7380.91
7_T10_K0.7360.91
12_I23_E0.7340.91
73_V81_N0.7330.91
43_G47_K0.7310.91
49_G52_T0.7190.90
71_I86_Q0.7090.89
68_A92_Y0.7040.89
20_V97_I0.6970.88
26_A65_Q0.6940.88
66_G91_P0.6940.88
42_G45_N0.6930.88
72_T86_Q0.6930.88
73_V83_H0.6910.88
23_E92_Y0.6880.88
79_K82_V0.6750.87
21_Y92_Y0.6690.86
23_E88_H0.6640.86
25_L93_T0.6540.85
82_V86_Q0.6490.85
39_L51_P0.6400.84
42_G46_V0.6320.83
20_V60_A0.6300.83
50_N55_G0.6260.83
76_Y82_V0.6250.82
47_K54_E0.6210.82
37_D51_P0.6160.82
39_L49_G0.6140.81
4_I8_G0.6090.81
30_G61_K0.6080.81
75_R84_K0.6070.81
49_G53_V0.6060.80
33_V95_V0.6050.80
64_K92_Y0.5950.79
25_L33_V0.5930.79
76_Y81_N0.5930.79
7_T25_L0.5810.78
36_E57_T0.5800.78
7_T35_F0.5750.77
62_V65_Q0.5750.77
50_N53_V0.5740.77
49_G55_G0.5730.77
72_T75_R0.5710.76
3_A8_G0.5710.76
51_P54_E0.5680.76
8_G22_I0.5620.75
65_Q91_P0.5610.75
68_A83_H0.5590.75
28_E54_E0.5530.74
27_A33_V0.5530.74
12_I15_E0.5510.74
30_G75_R0.5480.74
35_F81_N0.5460.73
2_Y83_H0.5410.73
77_K80_K0.5390.72
72_T83_H0.5360.72
22_I60_A0.5310.71
66_G86_Q0.5300.71
72_T76_Y0.5270.71
38_V56_A0.5270.71
1_M16_E0.5260.70
45_N54_E0.5250.70
47_K50_N0.5250.70
51_P56_A0.5210.70
73_V88_H0.5170.69
4_I94_K0.5160.69
81_N84_K0.5150.69
24_K66_G0.5140.69
67_R82_V0.5110.68
14_V97_I0.5110.68
17_G98_E0.5090.68
63_E94_K0.5060.68
50_N54_E0.5020.67
76_Y80_K0.5010.67
92_Y95_V0.5010.67
2_Y81_N0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboT 1 1 100 0.055 Contact Map
4rb6V 1 0.9902 100 0.068 Contact Map
3j3wR 1 1 100 0.068 Contact Map
4tp9R 1 1 100 0.071 Contact Map
3j7yS 1 1 100 0.074 Contact Map
1vw4N 1 1 100 0.074 Contact Map
2zjrO 1 0.9216 100 0.095 Contact Map
2xhaA 1 0.8137 29.5 0.916 Contact Map
2y4xA 1 0.5392 27.5 0.917 Contact Map
4av2M 1 0.5294 15.6 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0054 seconds.