GREMLIN Database
GSIB - Glucose starvation-inducible protein B
UniProt: P26907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (96)
Sequences: 41303 (36151)
Seq/√Len: 3689.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_K81_S3.1821.00
34_Q37_G2.8951.00
22_K41_S2.8191.00
74_E77_G2.7651.00
26_K42_K2.6101.00
66_K82_E2.4141.00
29_Y41_S2.3971.00
25_D41_S2.3611.00
69_Y81_S2.3481.00
65_D81_S2.2691.00
43_N65_D2.2321.00
69_Y77_G2.1741.00
29_Y37_G2.1361.00
42_K64_H2.0091.00
39_A43_N1.8051.00
39_A69_Y1.7211.00
62_K84_H1.6751.00
69_Y74_E1.6671.00
39_A72_I1.6451.00
79_A83_N1.6011.00
22_K44_H1.4601.00
23_N64_H1.3521.00
29_Y34_Q1.3371.00
15_K18_E1.3031.00
27_E64_H1.2491.00
28_F32_I1.2271.00
18_E21_S1.2201.00
95_K98_E1.2121.00
46_K62_K1.1841.00
39_A65_D1.1841.00
25_D29_Y1.1451.00
45_D61_S1.1201.00
82_E104_H1.1101.00
19_T49_Y1.0911.00
49_Y57_G1.0861.00
109_Y114_S1.0801.00
65_D69_Y1.0771.00
36_G72_I1.0761.00
79_A112_I1.0731.00
37_G40_T1.0701.00
23_N27_E1.0661.00
39_A68_F1.0631.00
44_H48_F1.0621.00
19_T45_D1.0511.00
59_A89_Y1.0441.00
84_H88_F1.0371.00
49_Y61_S1.0241.00
49_Y58_E0.9841.00
58_E61_S0.9771.00
30_Q71_E0.9681.00
22_K48_F0.9551.00
59_A85_D0.9501.00
90_Q98_E0.9451.00
20_T60_T0.9411.00
77_G80_T0.9381.00
83_N105_D0.9081.00
42_K68_F0.9041.00
35_K71_E0.8941.00
98_E102_K0.8921.00
81_S84_H0.8881.00
66_K85_D0.8851.00
99_A106_K0.8661.00
63_N67_E0.8541.00
30_Q68_F0.8481.00
89_Y101_S0.8391.00
84_H87_E0.8381.00
107_E111_E0.8361.00
46_K61_S0.8281.00
30_Q35_K0.8211.00
30_Q64_H0.8151.00
63_N85_D0.8101.00
35_K68_F0.8061.00
79_A109_Y0.8051.00
68_F72_I0.8031.00
67_E71_E0.8021.00
27_E30_Q0.7911.00
77_G81_S0.7861.00
26_K38_E0.7831.00
33_G73_G0.7781.00
44_H47_E0.7741.00
22_K45_D0.7701.00
37_G41_S0.7671.00
41_S44_H0.7581.00
89_Y97_G0.7571.00
30_Q38_E0.7511.00
23_N61_S0.7501.00
62_K88_F0.7481.00
43_N83_N0.7411.00
70_Q78_E0.7391.00
76_G112_I0.7301.00
103_N107_E0.7231.00
108_F112_I0.7231.00
27_E31_E0.7151.00
67_E70_Q0.7121.00
30_Q42_K0.7061.00
70_Q75_K0.7061.00
70_Q82_E0.7051.00
18_E58_E0.7011.00
79_A105_D0.6981.00
86_K102_K0.6871.00
62_K85_D0.6791.00
36_G76_G0.6621.00
96_G100_T0.6601.00
46_K65_D0.6491.00
89_Y92_I0.6451.00
35_K75_K0.6441.00
105_D109_Y0.6441.00
70_Q111_E0.6301.00
107_E110_Q0.6301.00
41_S81_S0.6241.00
69_Y72_I0.6151.00
24_H27_E0.6141.00
27_E67_E0.6121.00
35_K72_I0.6111.00
40_T44_H0.6061.00
23_N45_D0.6041.00
47_E87_E0.6011.00
40_T80_T0.6001.00
39_A74_E0.5871.00
80_T84_H0.5851.00
109_Y112_I0.5841.00
29_Y32_I0.5811.00
66_K78_E0.5751.00
45_D48_F0.5641.00
94_R97_G0.5591.00
63_N104_H0.5491.00
100_T104_H0.5451.00
45_D85_D0.5401.00
83_N87_E0.5371.00
48_F88_F0.5301.00
43_N47_E0.5231.00
82_E108_F0.5181.00
35_K39_A0.5181.00
85_D89_Y0.5091.00
49_Y89_Y0.5081.00
86_K90_Q0.5071.00
104_H107_E0.5051.00
42_K61_S0.5051.00
23_N58_E0.5051.00
56_G96_G0.5041.00
43_N69_Y0.5031.00
38_E68_F0.5021.00
96_G99_A0.5021.00
18_E22_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pziA 1 0.8943 99.5 0.189 Contact Map
4l9pA 1 0.9024 99.4 0.235 Contact Map
2vsyA 1 0.7724 99.4 0.241 Contact Map
3q7aA 1 0.9024 99.4 0.241 Contact Map
3dssA 1 0.9024 99.4 0.242 Contact Map
4j8eA 2 0.6911 99.4 0.242 Contact Map
3ulqA 1 1 99.4 0.243 Contact Map
4j8fA 2 0.935 99.4 0.244 Contact Map
4jhrA 2 1 99.4 0.245 Contact Map
1dceA 1 0.9024 99.4 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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