GREMLIN Database
DPPD - Dipeptide transport ATP-binding protein DppD
UniProt: P26905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (278)
Sequences: 45446 (28586)
Seq/√Len: 1714.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_E225_R4.4051.00
92_D175_D3.6301.00
9_N26_G3.5561.00
8_Q69_R3.3611.00
6_S30_D3.2971.00
12_V53_S3.0041.00
22_Q25_R2.9301.00
37_F227_A2.8291.00
69_R76_D2.6451.00
239_T242_D2.6261.00
38_A223_A2.5131.00
73_K175_D2.4861.00
227_A234_M2.4321.00
32_Y35_E2.4301.00
7_V10_L2.4141.00
148_R151_Q2.3821.00
220_A241_K2.3741.00
225_R237_I2.3541.00
76_D79_R2.3261.00
25_R233_K2.3201.00
13_S22_Q2.2751.00
6_S71_L2.2571.00
238_G243_I2.2231.00
51_S212_I2.2091.00
11_H67_D2.2081.00
11_H26_G2.1721.00
132_E135_S2.1561.00
33_K175_D2.1541.00
136_M171_I2.1461.00
81_S84_E2.0261.00
132_E173_E2.0131.00
125_S128_A2.0121.00
14_F49_V1.9961.00
56_G85_M1.9541.00
138_S146_G1.8691.00
38_A219_V1.8571.00
8_Q71_L1.8281.00
75_K84_E1.8051.00
213_T219_V1.7781.00
108_L112_D1.7511.00
134_L149_L1.7481.00
51_S178_I1.7151.00
151_Q155_Q1.6891.00
201_I207_V1.6631.00
14_F23_A1.6501.00
199_K202_Q1.6291.00
9_N28_S1.6241.00
12_V58_L1.6171.00
7_V29_F1.5961.00
11_H22_Q1.5791.00
115_G133_V1.5661.00
134_L146_G1.5431.00
13_S66_T1.5421.00
115_G129_A1.5361.00
242_D246_Q1.5351.00
135_S139_L1.5251.00
73_K92_D1.4891.00
119_L129_A1.4821.00
148_R156_F1.4811.00
12_V66_T1.4751.00
13_S20_T1.4751.00
10_L60_P1.4731.00
227_A237_I1.4671.00
7_V54_I1.4621.00
80_L84_E1.4541.00
199_K221_Q1.4531.00
15_T20_T1.4421.00
143_P147_E1.4411.00
111_G150_K1.4361.00
130_R134_L1.4351.00
111_G149_L1.4301.00
36_T202_Q1.4181.00
109_T112_D1.4061.00
11_H25_R1.3861.00
198_F209_V1.3781.00
195_L218_V1.3651.00
286_C292_C1.3621.00
31_L37_F1.3601.00
96_I179_A1.3501.00
101_M161_R1.3491.00
114_L137_L1.3221.00
8_Q30_D1.2951.00
112_D115_G1.2791.00
179_A209_V1.2761.00
36_T209_V1.2741.00
8_Q28_S1.2721.00
156_F164_I1.2681.00
238_G242_D1.2671.00
29_F50_T1.2481.00
39_I210_I1.2401.00
35_E224_D1.2401.00
29_F227_A1.2391.00
147_E151_Q1.2381.00
253_K257_G1.2291.00
75_K80_L1.2271.00
107_T154_H1.2051.00
109_T150_K1.2041.00
55_M95_M1.2001.00
130_R149_L1.1971.00
80_L85_M1.1791.00
56_G59_P1.1791.00
111_G115_G1.1791.00
113_Q168_M1.1761.00
9_N67_D1.1731.00
129_A133_V1.1651.00
131_K135_S1.1521.00
31_L176_I1.1281.00
108_L116_E1.1271.00
241_K245_Y1.1251.00
37_F225_R1.1201.00
211_L222_V1.1131.00
33_K73_K1.1111.00
53_S60_P1.1091.00
27_V50_T1.1061.00
114_L171_I1.0921.00
37_F237_I1.0891.00
284_P289_A1.0861.00
94_S169_A1.0781.00
128_A131_K1.0691.00
124_M129_A1.0661.00
137_L149_L1.0661.00
71_L76_D1.0611.00
226_V240_R1.0541.00
177_L207_V1.0471.00
33_K206_D1.0471.00
139_L200_E1.0431.00
50_T229_M1.0401.00
36_T223_A1.0371.00
127_K131_K1.0351.00
202_Q209_V1.0311.00
52_Q57_L1.0301.00
202_Q224_D1.0241.00
13_S25_R1.0231.00
118_L171_I1.0211.00
135_S138_S1.0101.00
111_G130_R1.0041.00
25_R287_P1.0001.00
143_P148_R0.9951.00
141_G200_E0.9921.00
115_G119_L0.9871.00
55_M178_I0.9861.00
283_P289_A0.9791.00
54_I210_I0.9781.00
45_C229_M0.9761.00
32_Y225_R0.9701.00
7_V70_I0.9701.00
242_D245_Y0.9681.00
261_R264_L0.9651.00
130_R150_K0.9621.00
186_L194_I0.9601.00
126_K129_A0.9581.00
12_V49_V0.9541.00
32_Y208_S0.9511.00
93_I176_I0.9501.00
24_V53_S0.9491.00
177_L209_V0.9391.00
233_K287_P0.9281.00
53_S70_I0.9211.00
115_G130_R0.9171.00
128_A132_E0.9141.00
111_G133_V0.9071.00
23_A49_V0.9071.00
39_I227_A0.9051.00
136_M139_L0.9041.00
134_L138_S0.8971.00
82_D85_M0.8971.00
10_L53_S0.8941.00
125_S129_A0.8931.00
279_L282_P0.8901.00
39_I50_T0.8871.00
72_F92_D0.8851.00
199_K222_V0.8821.00
94_S174_P0.8801.00
191_Q215_D0.8791.00
173_E207_V0.8791.00
4_V72_F0.8791.00
142_I148_R0.8741.00
141_G193_Q0.8721.00
250_P253_K0.8711.00
104_L161_R0.8701.00
234_M237_I0.8641.00
132_E136_M0.8581.00
191_Q218_V0.8571.00
36_T199_K0.8551.00
27_V234_M0.8541.00
108_L113_Q0.8481.00
253_K294_N0.8471.00
136_M167_A0.8451.00
225_R236_E0.8341.00
223_A226_V0.8311.00
122_K132_E0.8301.00
276_P279_L0.8291.00
243_I252_T0.8261.00
31_L208_S0.8251.00
244_F247_P0.8231.00
289_A295_R0.8161.00
75_K92_D0.8161.00
152_Y155_Q0.8141.00
91_A122_K0.8111.00
5_L54_I0.8101.00
26_G233_K0.8071.00
218_V222_V0.8071.00
105_N108_L0.8061.00
12_V24_V0.8031.00
117_A168_M0.7991.00
179_A198_F0.7991.00
53_S58_L0.7991.00
96_I166_I0.7981.00
4_V73_K0.7971.00
40_V219_V0.7891.00
24_V27_V0.7871.00
240_R244_F0.7821.00
52_Q58_L0.7801.00
195_L221_Q0.7791.00
124_M128_A0.7781.00
228_V247_P0.7781.00
285_G289_A0.7771.00
117_A172_C0.7761.00
282_P287_P0.7751.00
283_P290_A0.7711.00
292_C296_M0.7691.00
259_V263_D0.7651.00
287_P290_A0.7651.00
211_L223_A0.7641.00
252_T256_L0.7621.00
109_T152_Y0.7611.00
31_L210_I0.7601.00
176_I210_I0.7601.00
288_F292_C0.7601.00
9_N12_V0.7581.00
156_F160_M0.7571.00
14_F58_L0.7571.00
83_K86_R0.7501.00
122_K129_A0.7481.00
153_P164_I0.7471.00
133_V149_L0.7451.00
110_V164_I0.7341.00
192_A196_E0.7321.00
76_D80_L0.7311.00
15_T19_G0.7301.00
40_V228_V0.7301.00
176_I208_S0.7271.00
249_H252_T0.7271.00
114_L133_V0.7261.00
122_K125_S0.7241.00
96_I169_A0.7221.00
270_T274_G0.7211.00
36_T222_V0.7211.00
136_M170_L0.7201.00
286_C289_A0.7201.00
289_A293_P0.7141.00
57_L97_F0.7111.00
36_T224_D0.7111.00
52_Q95_M0.7101.00
278_D282_P0.7071.00
273_D293_P0.7071.00
286_C291_R0.7061.00
196_E200_E0.7051.00
140_V167_A0.7051.00
196_E221_Q0.7051.00
288_F291_R0.7051.00
258_S261_R0.7021.00
285_G288_F0.7001.00
148_R160_M0.6981.00
178_I210_I0.6981.00
37_F210_I0.6961.00
72_F77_L0.6951.00
131_K138_S0.6931.00
60_P66_T0.6931.00
197_L200_E0.6921.00
250_P254_G0.6921.00
183_T218_V0.6901.00
138_S143_P0.6901.00
274_G277_P0.6901.00
102_T161_R0.6891.00
69_R79_R0.6861.00
119_L126_K0.6851.00
77_L93_I0.6841.00
254_G258_S0.6831.00
4_V176_I0.6821.00
257_G270_T0.6821.00
181_E214_H0.6821.00
278_D281_S0.6801.00
223_A240_R0.6791.00
277_P283_P0.6761.00
267_A270_T0.6761.00
54_I70_I0.6751.00
115_G149_L0.6751.00
216_L244_F0.6741.00
240_R251_Y0.6741.00
142_I160_M0.6731.00
72_F176_I0.6681.00
13_S67_D0.6681.00
230_Y233_K0.6671.00
5_L176_I0.6671.00
34_G208_S0.6661.00
5_L72_F0.6631.00
263_D266_G0.6621.00
199_K203_R0.6551.00
249_H253_K0.6541.00
55_M93_I0.6521.00
33_K208_S0.6511.00
9_N68_G0.6501.00
121_H172_C0.6441.00
70_I78_C0.6431.00
279_L283_P0.6421.00
293_P296_M0.6331.00
104_L164_I0.6321.00
277_P290_A0.6311.00
48_S52_Q0.6301.00
280_F283_P0.6281.00
282_P285_G0.6261.00
196_E199_K0.6241.00
228_V243_I0.6231.00
111_G114_L0.6211.00
279_L284_P0.6171.00
166_I194_I0.6151.00
271_P275_T0.6131.00
290_A294_N0.6131.00
69_R78_C0.6121.00
242_D248_Q0.6111.00
126_K130_R0.6091.00
281_S285_G0.6071.00
230_Y235_A0.6071.00
273_D276_P0.6061.00
151_Q156_F0.6031.00
286_C293_P0.6021.00
114_L117_A0.6011.00
294_N297_V0.6001.00
42_E45_C0.5991.00
278_D283_P0.5991.00
127_K130_R0.5981.00
24_V50_T0.5971.00
243_I247_P0.5971.00
77_L80_L0.5961.00
284_P287_P0.5961.00
274_G278_D0.5951.00
53_S66_T0.5951.00
103_A165_V0.5951.00
109_T113_Q0.5921.00
104_L113_Q0.5921.00
286_C290_A0.5901.00
131_K134_L0.5891.00
269_L272_I0.5851.00
26_G67_D0.5841.00
281_S284_P0.5841.00
117_A120_R0.5811.00
99_D102_T0.5801.00
291_R295_R0.5781.00
292_C295_R0.5771.00
272_I275_T0.5771.00
4_V208_S0.5761.00
130_R133_V0.5741.00
11_H66_T0.5741.00
110_V156_F0.5741.00
113_Q153_P0.5731.00
35_E237_I0.5711.00
266_G270_T0.5681.00
132_E139_L0.5661.00
82_D86_R0.5651.00
71_L74_N0.5651.00
238_G244_F0.5641.00
170_L207_V0.5641.00
219_V223_A0.5641.00
247_P252_T0.5621.00
118_L122_K0.5611.00
77_L85_M0.5601.00
283_P288_F0.5541.00
284_P288_F0.5531.00
219_V226_V0.5521.00
280_F287_P0.5491.00
220_A239_T0.5441.00
235_A287_P0.5431.00
289_A296_M0.5431.00
290_A293_P0.5421.00
289_A292_C0.5421.00
272_I276_P0.5371.00
118_L124_M0.5351.00
81_S85_M0.5331.00
285_G290_A0.5311.00
293_P297_V0.5301.00
118_L123_K0.5291.00
285_G292_C0.5281.00
110_V114_L0.5261.00
258_S262_L0.5251.00
290_A295_R0.5241.00
30_D237_I0.5221.00
271_P276_P0.5221.00
257_G260_P0.5221.00
246_Q250_P0.5221.00
274_G279_L0.5221.00
235_A249_H0.5181.00
45_C276_P0.5151.00
240_R243_I0.5151.00
29_F37_F0.5151.00
283_P287_P0.5151.00
118_L172_C0.5131.00
137_L148_R0.5131.00
110_V137_L0.5111.00
275_T278_D0.5101.00
287_P294_N0.5091.00
282_P286_C0.5081.00
230_Y254_G0.5071.00
251_Y255_L0.5061.00
198_F222_V0.5061.00
279_L285_G0.5051.00
259_V262_L0.5051.00
122_K173_E0.5041.00
43_S181_E0.5041.00
276_P290_A0.5031.00
7_V50_T0.5031.00
276_P283_P0.5011.00
162_Q185_A0.5011.00
284_P290_A0.5011.00
276_P282_P0.5011.00
114_L168_M0.5001.00
123_K129_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ry2A 2 0.7134 100 0.227 Contact Map
3tuiC 2 0.9522 100 0.233 Contact Map
4f4cA 1 0.6866 100 0.24 Contact Map
4fwiB 1 0.9224 100 0.241 Contact Map
4u00A 1 0.7164 100 0.246 Contact Map
2oljA 2 0.7224 100 0.247 Contact Map
4huqB 1 0.8209 100 0.254 Contact Map
4mkiB 2 0.8388 100 0.254 Contact Map
4q9hA 1 0.7254 100 0.255 Contact Map
1b0uA 2 0.7373 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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