GREMLIN Database
DPPC - Dipeptide transport system permease protein DppC
UniProt: P26904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (252)
Sequences: 28207 (17586)
Seq/√Len: 1107.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V230_L2.8091.00
150_D200_R2.7741.00
216_K222_T2.4891.00
206_I211_Y2.4521.00
224_R228_K2.4251.00
220_A224_R2.4151.00
138_Y153_M2.3921.00
126_M184_I2.3551.00
206_I209_Y2.3501.00
130_I188_T2.3061.00
119_I258_F2.2941.00
221_K224_R2.2621.00
223_F227_R2.2291.00
86_S89_E2.2281.00
210_E213_L2.1251.00
272_V276_D2.1181.00
212_V230_L2.0621.00
212_V225_I2.0071.00
112_R273_M1.9941.00
243_T307_G1.9931.00
140_G203_V1.9831.00
96_A99_W1.9571.00
145_K222_T1.9391.00
141_V145_K1.8821.00
145_K149_I1.8711.00
108_D111_T1.8631.00
133_L137_I1.8451.00
195_M245_T1.8431.00
81_S84_R1.7841.00
103_D107_R1.7791.00
148_R152_I1.7781.00
211_Y233_N1.7681.00
143_G203_V1.7531.00
144_Y222_T1.7411.00
71_A117_A1.7141.00
206_I234_T1.7131.00
65_L69_V1.7061.00
100_F291_F1.6621.00
134_I137_I1.6621.00
110_F114_W1.6451.00
134_I192_W1.6441.00
98_H108_D1.6311.00
105_L112_R1.6111.00
207_K230_L1.6061.00
149_I153_M1.6031.00
109_V291_F1.6011.00
141_V149_I1.5801.00
131_D191_G1.5791.00
184_I188_T1.5631.00
122_F126_M1.5621.00
132_F242_M1.5481.00
202_Q205_Q1.5451.00
144_Y226_I1.5391.00
153_M196_A1.5221.00
57_A309_G1.5051.00
157_I196_A1.5041.00
115_Y118_R1.5031.00
104_E276_D1.4941.00
277_G288_R1.4921.00
107_R111_T1.4451.00
135_G195_M1.4251.00
274_A292_P1.4181.00
128_A242_M1.4141.00
205_Q209_Y1.4121.00
73_I76_F1.3991.00
139_G143_G1.3951.00
60_G302_A1.3831.00
155_R158_E1.3781.00
200_R204_L1.3751.00
214_A218_F1.3611.00
143_G207_K1.3381.00
89_E92_L1.3371.00
139_G199_V1.3271.00
135_G199_V1.3261.00
167_L171_L1.3221.00
67_L297_S1.3011.00
240_V311_Q1.3011.00
206_I212_V1.2871.00
58_M62_F1.2781.00
119_I122_F1.2761.00
100_F110_F1.2741.00
138_Y196_A1.2681.00
206_I230_L1.2671.00
140_G226_I1.2661.00
311_Q315_D1.2631.00
148_R151_S1.2581.00
188_T192_W1.2571.00
181_G185_V1.2531.00
198_I241_Q1.2461.00
113_T295_F1.2421.00
142_A153_M1.2411.00
310_L313_A1.2401.00
69_V73_I1.2351.00
286_W290_F1.2301.00
146_G207_K1.2171.00
239_I314_L1.2111.00
172_L186_A1.2101.00
55_K58_M1.1901.00
215_S229_N1.1861.00
123_V253_E1.1541.00
140_G231_L1.1541.00
107_R112_R1.1511.00
203_V234_T1.1471.00
95_S100_F1.1461.00
215_S225_I1.1291.00
160_L193_V1.1261.00
64_L298_L1.1071.00
309_G313_A1.1071.00
151_S155_R1.1031.00
107_R115_Y1.0981.00
215_S220_A1.0961.00
199_V238_I1.0911.00
213_L216_K1.0841.00
186_A190_T1.0801.00
199_V203_V1.0731.00
100_F113_T1.0721.00
292_P296_I1.0651.00
136_V199_V1.0601.00
179_G182_T1.0551.00
202_Q206_I1.0541.00
218_F229_N1.0501.00
74_G115_Y1.0491.00
67_L299_T1.0461.00
104_E280_T1.0431.00
224_R227_R1.0421.00
137_I140_G1.0391.00
60_G309_G1.0321.00
277_G289_L1.0271.00
64_L302_A1.0261.00
181_G184_I1.0251.00
273_M288_R1.0241.00
169_V186_A1.0241.00
163_L168_V1.0231.00
150_D154_M1.0221.00
109_V273_M1.0201.00
109_V288_R1.0171.00
192_W196_A1.0171.00
246_V303_F1.0161.00
156_I160_L1.0141.00
78_S111_T1.0081.00
118_R122_F0.9911.00
127_A188_T0.9901.00
102_T108_D0.9881.00
154_M196_A0.9881.00
215_S218_F0.9811.00
62_F66_F0.9801.00
122_F180_L0.9791.00
80_H97_D0.9791.00
150_D204_L0.9781.00
199_V234_T0.9761.00
63_I302_A0.9751.00
62_F65_L0.9721.00
216_K225_I0.9711.00
111_T115_Y0.9661.00
112_R288_R0.9631.00
59_A62_F0.9551.00
152_I156_I0.9521.00
236_G311_Q0.9491.00
127_A187_L0.9441.00
275_N279_P0.9411.00
287_W291_F0.9401.00
60_G305_V0.9391.00
61_L65_L0.9391.00
146_G208_N0.9381.00
60_G301_Y0.9381.00
127_A131_D0.9381.00
147_G150_D0.9371.00
113_T291_F0.9331.00
95_S98_H0.9311.00
149_I152_I0.9291.00
116_G273_M0.9291.00
176_M182_T0.9261.00
291_F294_F0.9231.00
122_F125_V0.9131.00
302_A306_L0.9121.00
220_A225_I0.9101.00
139_G203_V0.9061.00
165_Y252_A0.9061.00
66_F70_M0.9001.00
151_S154_M0.8981.00
63_I298_L0.8931.00
92_L95_S0.8901.00
222_T225_I0.8891.00
98_H102_T0.8841.00
88_T92_L0.8781.00
132_F136_V0.8751.00
147_G151_S0.8711.00
136_V238_I0.8671.00
157_I193_V0.8591.00
95_S99_W0.8561.00
303_F307_G0.8551.00
70_M114_W0.8521.00
187_L252_A0.8481.00
234_T237_A0.8481.00
239_I307_G0.8461.00
61_L306_L0.8441.00
80_H98_H0.8431.00
201_G204_L0.8411.00
133_L136_V0.8371.00
117_A299_T0.8371.00
178_P182_T0.8341.00
111_T114_W0.8281.00
112_R115_Y0.8261.00
102_T106_G0.8221.00
57_A305_V0.8181.00
177_G182_T0.8151.00
180_L184_I0.8121.00
165_Y169_V0.8121.00
222_T226_I0.8111.00
241_Q245_T0.8101.00
185_V188_T0.8081.00
203_V207_K0.8071.00
143_G204_L0.8021.00
114_W118_R0.8001.00
290_F294_F0.8001.00
80_H111_T0.8001.00
227_R230_L0.7981.00
213_L217_T0.7971.00
132_F137_I0.7941.00
276_D279_P0.7891.00
209_Y213_L0.7861.00
76_F286_W0.7861.00
91_N94_P0.7841.00
172_L182_T0.7751.00
57_A61_L0.7741.00
182_T185_V0.7711.00
120_S124_G0.7681.00
73_I77_L0.7681.00
138_Y192_W0.7661.00
206_I233_N0.7641.00
126_M258_F0.7631.00
273_M292_P0.7581.00
142_A150_D0.7581.00
125_V129_L0.7571.00
127_A249_A0.7561.00
132_F195_M0.7541.00
220_A229_N0.7501.00
72_V76_F0.7501.00
137_I141_V0.7481.00
275_N278_L0.7481.00
103_D285_H0.7461.00
296_I300_M0.7381.00
126_M129_L0.7371.00
99_W110_F0.7361.00
130_I184_I0.7361.00
70_M117_A0.7331.00
312_D318_L0.7291.00
202_Q237_A0.7231.00
199_V202_Q0.7211.00
79_P111_T0.7201.00
291_F295_F0.7191.00
68_F294_F0.7161.00
59_A63_I0.7151.00
276_D280_T0.7141.00
223_F226_I0.7121.00
161_Y193_V0.7111.00
94_P287_W0.7101.00
225_I230_L0.7091.00
114_W117_A0.7041.00
243_T303_F0.6981.00
56_L60_G0.6941.00
306_L310_L0.6941.00
90_Q94_P0.6931.00
89_E98_H0.6921.00
202_Q234_T0.6901.00
134_I188_T0.6901.00
88_T91_N0.6871.00
135_G139_G0.6821.00
95_S294_F0.6801.00
298_L302_A0.6801.00
64_L303_F0.6771.00
79_P110_F0.6751.00
67_L298_L0.6741.00
131_D188_T0.6731.00
311_Q318_L0.6731.00
251_F254_S0.6661.00
55_K59_A0.6611.00
154_M157_I0.6611.00
93_P287_W0.6591.00
60_G63_I0.6561.00
113_T292_P0.6531.00
253_E257_S0.6491.00
142_A154_M0.6481.00
191_G194_G0.6461.00
99_W108_D0.6451.00
134_I138_Y0.6441.00
289_L293_A0.6431.00
300_M304_N0.6411.00
290_F293_A0.6401.00
128_A245_T0.6381.00
190_T193_V0.6371.00
87_L90_Q0.6341.00
86_S90_Q0.6311.00
63_I67_L0.6261.00
145_K226_I0.6251.00
183_I253_E0.6241.00
144_Y207_K0.6231.00
80_H284_G0.6211.00
91_N285_H0.6201.00
58_M61_L0.6171.00
128_A246_V0.6171.00
165_Y168_V0.6171.00
204_L207_K0.6141.00
220_A223_F0.6131.00
153_M157_I0.6091.00
195_M199_V0.6071.00
178_P181_G0.6061.00
121_L125_V0.6051.00
252_A255_F0.6041.00
152_I155_R0.5991.00
251_F255_F0.5991.00
249_A252_A0.5991.00
75_P118_R0.5981.00
144_Y227_R0.5971.00
157_I192_W0.5971.00
129_L133_L0.5961.00
254_S272_V0.5901.00
146_G204_L0.5881.00
195_M241_Q0.5871.00
168_V190_T0.5861.00
132_F238_I0.5861.00
274_A296_I0.5831.00
78_S115_Y0.5801.00
194_G245_T0.5771.00
146_G150_D0.5761.00
70_M74_G0.5741.00
71_A293_A0.5741.00
155_R159_V0.5731.00
160_L192_W0.5731.00
182_T186_A0.5721.00
117_A121_L0.5711.00
171_L175_L0.5691.00
124_G249_A0.5681.00
273_M276_D0.5681.00
254_S275_N0.5671.00
126_M181_G0.5641.00
240_V243_T0.5621.00
142_A200_R0.5571.00
189_V192_W0.5571.00
227_R232_P0.5551.00
118_R121_L0.5521.00
250_I254_S0.5481.00
305_V309_G0.5451.00
191_G245_T0.5451.00
135_G196_A0.5431.00
143_G150_D0.5421.00
158_E161_Y0.5411.00
273_M277_G0.5371.00
308_D311_Q0.5361.00
75_P115_Y0.5361.00
173_M177_G0.5351.00
165_Y189_V0.5351.00
123_V183_I0.5341.00
74_G77_L0.5321.00
91_N288_R0.5281.00
193_V196_A0.5281.00
212_V216_K0.5271.00
198_I202_Q0.5261.00
154_M158_E0.5251.00
221_K225_I0.5241.00
92_L102_T0.5231.00
128_A132_F0.5221.00
254_S276_D0.5201.00
123_V184_I0.5201.00
138_Y141_V0.5201.00
185_V189_V0.5191.00
67_L71_A0.5191.00
287_W290_F0.5151.00
68_F72_V0.5141.00
56_L305_V0.5131.00
112_R276_D0.5071.00
112_R116_G0.5071.00
194_G241_Q0.5061.00
84_R88_T0.5031.00
129_L132_F0.5011.00
167_L170_I0.5011.00
116_G272_V0.5001.00
247_P300_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.7906 99.9 0.644 Contact Map
3d31C 2 0.7219 99.9 0.658 Contact Map
3tuiA 2 0.6344 99.9 0.67 Contact Map
3rlfF 1 0.9281 99.9 0.67 Contact Map
2onkC 2 0.7406 99.9 0.675 Contact Map
4tquN 1 0.8094 99.9 0.695 Contact Map
3rlfG 1 0.7906 99.9 0.695 Contact Map
4ymuD 2 0.6438 99.9 0.701 Contact Map
3j9pD 4 0.7688 73.4 0.94 Contact Map
2kogA 1 0.2437 27.5 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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