GREMLIN Database
DPPB - Dipeptide transport system permease protein DppB
UniProt: P26903 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (274)
Sequences: 25516 (16992)
Seq/√Len: 1026.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_D61_F3.0281.00
57_D65_F2.9151.00
28_K62_Q2.7381.00
195_M222_A2.7301.00
68_K72_T2.5061.00
43_E47_K2.4671.00
128_D192_R2.3871.00
115_L131_A2.3681.00
64_I68_K2.3651.00
208_K214_P2.3601.00
51_A56_D2.3431.00
198_V203_Y2.3381.00
96_V254_I2.3131.00
103_T176_T2.2601.00
216_K220_K2.2481.00
259_K263_E2.2371.00
20_T63_Y2.2351.00
198_V201_Q2.1641.00
212_L216_K2.1491.00
213_S216_K2.1221.00
215_F219_V2.0661.00
107_I180_A2.0381.00
204_I222_A2.0301.00
235_G291_V1.9701.00
89_M260_Y1.9341.00
33_S50_E1.9261.00
21_T63_Y1.9201.00
85_S88_D1.8401.00
202_D205_R1.8261.00
110_I114_V1.8141.00
122_R125_G1.8101.00
118_I122_R1.8031.00
117_V195_M1.7921.00
60_I64_I1.7881.00
45_V48_N1.7861.00
204_I217_I1.7711.00
46_Q50_E1.7641.00
122_R214_P1.7171.00
122_R127_L1.7101.00
126_F130_A1.6941.00
199_L222_A1.6861.00
120_A195_M1.6791.00
87_N91_E1.6401.00
198_V226_A1.6291.00
187_I237_L1.6231.00
121_L214_P1.6211.00
71_I74_D1.6171.00
48_N52_Y1.6061.00
86_V275_G1.5921.00
127_L131_A1.5881.00
47_K50_E1.5801.00
61_F65_F1.5731.00
78_S84_D1.5411.00
69_S74_D1.5201.00
111_S114_V1.5141.00
203_Y225_N1.5121.00
99_E103_T1.5091.00
47_K51_A1.5091.00
75_F275_G1.5021.00
111_S184_M1.4931.00
118_I127_L1.4901.00
84_D88_D1.4891.00
6_I10_W1.4871.00
121_L218_I1.4821.00
176_T180_A1.4621.00
109_V234_L1.4571.00
33_S36_N1.4481.00
92_R95_P1.4431.00
108_A183_P1.4401.00
261_F276_T1.4241.00
264_S272_V1.4111.00
206_T210_K1.4011.00
131_A188_A1.3841.00
19_I281_S1.3651.00
198_V222_A1.3571.00
65_F68_K1.3501.00
112_G191_T1.3451.00
198_V204_I1.3351.00
232_T295_Y1.3301.00
105_I234_L1.3261.00
116_G120_A1.3131.00
231_I298_L1.2991.00
10_W14_A1.2861.00
112_G187_I1.2731.00
96_V99_E1.2671.00
150_L178_A1.2651.00
75_F87_N1.2611.00
294_A297_L1.2591.00
145_I149_L1.2581.00
135_A188_A1.2571.00
115_L188_A1.2571.00
152_Q157_N1.2521.00
17_L21_T1.2471.00
58_P61_F1.2471.00
124_N128_D1.2431.00
84_D92_R1.2431.00
239_A284_L1.2411.00
192_R196_V1.2351.00
49_L53_Y1.2351.00
49_L52_Y1.2251.00
194_S197_E1.2201.00
190_L233_V1.2191.00
79_I263_E1.2171.00
197_E201_Q1.2161.00
180_A184_M1.2141.00
295_Y299_D1.2091.00
84_D89_M1.2061.00
120_A199_L1.2031.00
65_F69_S1.2031.00
57_D60_I1.2011.00
119_A131_A1.1991.00
24_F28_K1.1941.00
70_I75_F1.1841.00
73_F85_S1.1831.00
16_I282_V1.1741.00
173_V177_A1.1731.00
35_F46_Q1.1731.00
138_G185_A1.1691.00
126_F129_Y1.1521.00
116_G191_T1.1451.00
17_L63_Y1.1421.00
270_Y274_M1.1381.00
61_F64_I1.1291.00
178_A182_G1.1221.00
207_A217_I1.1131.00
133_S136_V1.1121.00
195_M226_A1.1081.00
207_A221_H1.1081.00
210_K221_H1.1071.00
67_L70_I1.0991.00
117_V218_I1.0981.00
191_T230_V1.0911.00
89_M272_V1.0891.00
77_P85_S1.0881.00
260_Y272_V1.0751.00
207_A212_L1.0601.00
293_L297_L1.0581.00
54_H57_D1.0541.00
276_T280_Y1.0521.00
36_N46_Q1.0521.00
141_I146_L1.0471.00
12_M285_I1.0291.00
153_Q157_N1.0271.00
262_V266_N1.0211.00
191_T195_M1.0201.00
99_E172_M1.0191.00
9_F13_A1.0171.00
134_L138_G1.0041.00
25_V28_K1.0041.00
48_N51_A1.0031.00
114_V117_V0.9931.00
31_P34_P0.9921.00
117_V223_L0.9881.00
12_M15_T0.9871.00
20_T66_Y0.9841.00
216_K219_V0.9731.00
194_S198_V0.9721.00
18_V22_L0.9711.00
69_S72_T0.9671.00
287_M291_V0.9641.00
147_A178_A0.9611.00
238_V287_M0.9561.00
113_L191_T0.9531.00
88_D92_R0.9511.00
228_M295_Y0.9471.00
208_K217_I0.9421.00
212_L217_I0.9391.00
104_A180_A0.9381.00
132_M188_A0.9351.00
54_H65_F0.9321.00
93_G260_Y0.9321.00
10_W13_A0.9301.00
104_A179_L0.9291.00
128_D196_V0.9281.00
75_F90_L0.9271.00
205_R208_K0.9261.00
99_E102_M0.9221.00
184_M188_A0.9211.00
129_Y133_S0.9191.00
100_L249_E0.9141.00
89_M92_R0.9141.00
231_I291_V0.9131.00
91_E95_P0.9131.00
130_A134_L0.9061.00
86_V272_V0.9041.00
191_T226_A0.9001.00
91_E94_F0.8981.00
261_F264_S0.8911.00
14_A17_L0.8881.00
104_A108_A0.8831.00
34_P37_E0.8791.00
214_P217_I0.8781.00
64_I67_L0.8751.00
21_T25_V0.8691.00
226_A229_P0.8691.00
172_M176_T0.8661.00
95_P99_E0.8651.00
173_V176_T0.8631.00
286_I290_L0.8551.00
143_N248_I0.8541.00
207_A210_K0.8531.00
86_V260_Y0.8531.00
150_L174_L0.8441.00
51_A57_D0.8391.00
77_P83_S0.8381.00
19_I23_T0.8371.00
116_G195_M0.8341.00
113_L230_V0.8341.00
177_A180_A0.8311.00
109_V187_I0.8301.00
120_A196_V0.8281.00
129_Y132_M0.8211.00
88_D91_E0.8181.00
44_A48_N0.8141.00
80_K267_Q0.8121.00
114_V118_I0.8111.00
103_T254_I0.8111.00
262_V265_I0.8071.00
205_R209_A0.8051.00
124_N129_Y0.8051.00
90_L279_F0.8031.00
263_E266_N0.8011.00
127_L130_A0.7971.00
78_S269_D0.7961.00
16_I285_I0.7961.00
9_F289_F0.7941.00
27_M31_P0.7911.00
296_G302_I0.7911.00
264_S273_I0.7901.00
233_V237_L0.7841.00
43_E46_Q0.7821.00
44_A47_K0.7791.00
154_F174_L0.7761.00
143_N147_A0.7721.00
109_V114_V0.7711.00
260_Y276_T0.7691.00
28_K59_L0.7641.00
32_G35_F0.7641.00
275_G278_V0.7611.00
21_T59_L0.7611.00
179_L248_I0.7601.00
139_I185_A0.7571.00
94_F283_I0.7561.00
135_A185_A0.7551.00
97_S101_G0.7551.00
12_M289_F0.7521.00
102_M106_V0.7511.00
115_L184_M0.7461.00
282_V286_I0.7451.00
239_A287_M0.7431.00
112_G116_G0.7421.00
25_V59_L0.7391.00
68_K71_I0.7381.00
38_E49_L0.7381.00
212_L221_H0.7381.00
128_D132_M0.7371.00
194_S226_A0.7371.00
90_L275_G0.7311.00
295_Y302_I0.7311.00
274_M278_V0.7301.00
217_I222_A0.7301.00
107_I176_T0.7301.00
214_P218_I0.7281.00
219_V222_A0.7261.00
290_L294_A0.7251.00
17_L67_L0.7211.00
157_N174_L0.7201.00
70_I278_V0.7161.00
263_E267_Q0.7151.00
275_G279_F0.7141.00
20_T24_F0.7131.00
271_P275_G0.7081.00
183_P186_I0.7071.00
280_Y284_L0.7061.00
73_F77_P0.7051.00
7_K10_W0.7051.00
260_Y264_S0.7011.00
193_S196_V0.7001.00
149_L153_Q0.6961.00
109_V113_L0.6961.00
110_I113_L0.6941.00
122_R218_I0.6931.00
119_A128_D0.6901.00
235_G287_M0.6851.00
274_M277_T0.6811.00
155_A174_L0.6791.00
121_L219_V0.6781.00
63_Y67_L0.6781.00
28_K270_Y0.6751.00
103_T106_V0.6711.00
105_I238_V0.6701.00
12_M18_V0.6701.00
104_A245_S0.6681.00
191_T194_S0.6681.00
23_T277_T0.6681.00
45_V49_L0.6681.00
201_Q205_R0.6671.00
215_F218_I0.6651.00
108_A180_A0.6641.00
24_F27_M0.6621.00
111_S115_L0.6591.00
22_L25_V0.6591.00
66_Y70_I0.6551.00
111_S180_A0.6501.00
119_A132_M0.6501.00
20_T278_V0.6501.00
9_F12_M0.6481.00
174_L177_A0.6461.00
70_I73_F0.6451.00
90_L276_T0.6421.00
13_A17_L0.6381.00
273_I277_T0.6351.00
100_L176_T0.6351.00
23_T27_M0.6331.00
74_D85_S0.6321.00
112_G188_A0.6301.00
130_A133_S0.6271.00
11_A15_T0.6251.00
245_S248_I0.6221.00
98_F102_M0.6201.00
293_L296_G0.6161.00
74_D87_N0.6161.00
194_S229_P0.6161.00
35_F50_E0.6141.00
143_N146_L0.6141.00
261_F265_I0.6131.00
101_G245_S0.6131.00
7_K13_A0.6121.00
131_A135_A0.6111.00
284_L288_L0.6071.00
186_I237_L0.6051.00
124_N199_L0.6041.00
185_A188_A0.6031.00
103_T173_V0.6031.00
79_I271_P0.6021.00
14_A18_V0.6011.00
296_G303_K0.5991.00
182_G185_A0.5961.00
34_P38_E0.5961.00
35_F38_E0.5951.00
152_Q156_V0.5941.00
7_K11_A0.5911.00
183_P240_S0.5911.00
125_G128_D0.5911.00
89_M93_G0.5911.00
95_P98_F0.5901.00
249_E253_A0.5881.00
147_A251_I0.5871.00
106_V110_I0.5871.00
212_L215_F0.5851.00
204_I208_K0.5851.00
195_M199_L0.5831.00
13_A18_V0.5831.00
121_L199_L0.5831.00
143_N181_V0.5781.00
187_I233_V0.5771.00
250_K259_K0.5761.00
186_I233_V0.5761.00
247_V250_K0.5751.00
289_F293_L0.5741.00
250_K262_V0.5741.00
10_W293_L0.5721.00
70_I74_D0.5721.00
190_L194_S0.5701.00
132_M135_A0.5681.00
237_L240_S0.5671.00
247_V251_I0.5671.00
246_F250_K0.5661.00
102_M238_V0.5641.00
198_V225_N0.5631.00
105_I237_L0.5591.00
219_V224_R0.5591.00
187_I191_T0.5591.00
32_G268_R0.5561.00
183_P237_L0.5551.00
154_F157_N0.5511.00
31_P35_F0.5511.00
146_L181_V0.5491.00
29_V33_S0.5471.00
174_L178_A0.5431.00
237_L245_S0.5361.00
22_L26_L0.5331.00
248_I251_I0.5331.00
196_V199_L0.5311.00
135_A184_M0.5301.00
261_F280_Y0.5301.00
181_V184_M0.5281.00
94_F98_F0.5281.00
186_I190_L0.5281.00
25_V29_V0.5251.00
246_F262_V0.5251.00
119_A192_R0.5251.00
35_F49_L0.5231.00
23_T28_K0.5181.00
125_G130_A0.5161.00
29_V94_F0.5161.00
227_L231_I0.5161.00
80_K84_D0.5161.00
99_E254_I0.5151.00
67_L71_I0.5151.00
31_P36_N0.5141.00
178_A248_I0.5111.00
115_L118_I0.5101.00
12_M29_V0.5091.00
120_A128_D0.5071.00
46_Q49_L0.5061.00
8_R11_A0.5021.00
213_S217_I0.5011.00
59_L62_Q0.5001.00
29_V32_G0.5001.00
105_I109_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6786 99.9 0.639 Contact Map
4tquM 1 0.8442 99.9 0.648 Contact Map
3rlfF 1 0.8312 99.8 0.668 Contact Map
4ymuD 2 0.6818 99.8 0.681 Contact Map
2onkC 2 0.8052 99.8 0.685 Contact Map
3d31C 2 0.789 99.8 0.688 Contact Map
4tquN 1 0.8377 99.7 0.703 Contact Map
3rlfG 1 0.8539 99.7 0.703 Contact Map
4ltoA 3 0.3344 11.4 0.958 Contact Map
4cbcA 3 0.2987 7.4 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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