DPPA - BACSU - GREMLIN Contacts

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DPPA - D-aminopeptidase

UniProt:	P26902	Sequences: MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIAEAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLGYHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKEAEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPVLSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	274 (267)
Sequences:	600 (416)
Seq/√Len:	25.5

BACSU - DPPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_G	149_L	5.000	1.00
44_A	195_T	4.728	1.00
42_C	194_L	4.575	1.00
7_V	39_A	4.364	1.00
57_N	83_K	3.473	1.00
47_F	74_E	3.115	1.00
169_T	200_F	3.088	1.00
239_E	248_Q	3.032	1.00
125_Y	220_S	2.833	1.00
243_G	246_T	2.660	0.99
47_F	72_H	2.609	0.99
47_F	54_V	2.465	0.99
33_L	70_K	2.445	0.99
88_V	98_A	2.439	0.99
3_L	97_G	2.416	0.99
158_A	170_T	2.369	0.98
123_H	130_P	2.368	0.98
199_A	203_Q	2.287	0.98
169_T	197_K	2.219	0.97
132_G	135_G	2.191	0.97
43_I	75_A	2.175	0.97
125_Y	222_E	2.165	0.97
99_L	198_T	2.155	0.97
76_D	183_K	2.129	0.97
40_N	72_H	2.128	0.97
171_A	197_K	2.100	0.96
99_L	150_M	2.094	0.96
48_N	195_T	1.998	0.95
218_V	250_Q	1.991	0.95
6_S	103_Y	1.981	0.95
198_T	202_L	1.913	0.94
143_Y	253_D	1.891	0.93
29_E	32_R	1.882	0.93
44_A	48_N	1.869	0.93
121_V	221_I	1.814	0.92
165_I	168_V	1.803	0.92
45_E	49_S	1.802	0.92
150_M	198_T	1.798	0.92
185_L	193_L	1.798	0.92
24_G	29_E	1.754	0.91
46_A	50_G	1.729	0.90
88_V	137_N	1.722	0.90
106_R	132_G	1.717	0.90
45_E	198_T	1.705	0.89
13_S	38_E	1.678	0.88
73_P	188_A	1.668	0.88
36_T	67_M	1.658	0.88
48_N	199_A	1.647	0.88
15_L	31_G	1.634	0.87
16_P	182_V	1.623	0.87
99_L	149_L	1.621	0.87
135_G	160_E	1.603	0.86
4_Y	95_F	1.555	0.84
158_A	172_A	1.543	0.84
3_L	149_L	1.532	0.83
78_I	183_K	1.531	0.83
63_M	83_K	1.531	0.83
171_A	193_L	1.523	0.83
219_L	257_A	1.501	0.82
169_T	172_A	1.498	0.82
173_V	190_A	1.490	0.82
105_A	111_G	1.487	0.81
131_V	135_G	1.484	0.81
185_L	190_A	1.482	0.81
127_N	217_P	1.473	0.81
134_L	157_A	1.469	0.81
41_Y	45_E	1.469	0.81
40_N	75_A	1.464	0.80
222_E	243_G	1.462	0.80
142_G	210_P	1.449	0.80
132_G	160_E	1.439	0.79
105_A	156_R	1.436	0.79
6_S	87_M	1.426	0.79
135_G	164_L	1.425	0.79
32_R	67_M	1.421	0.78
175_Q	183_K	1.420	0.78
53_E	76_D	1.399	0.77
106_R	109_T	1.380	0.76
221_I	261_M	1.375	0.76
13_S	173_V	1.353	0.75
73_P	192_R	1.350	0.75
122_R	222_E	1.334	0.74
106_R	160_E	1.312	0.72
150_M	197_K	1.290	0.71
87_M	103_Y	1.288	0.71
54_V	74_E	1.282	0.71
155_D	175_Q	1.236	0.68
101_L	152_A	1.233	0.68
20_F	79_S	1.225	0.67
142_G	211_L	1.214	0.66
84_P	89_E	1.214	0.66
169_T	204_N	1.205	0.66
189_K	193_L	1.199	0.65
38_E	184_C	1.191	0.65
92_D	146_V	1.186	0.65
55_L	95_F	1.183	0.64
3_L	51_C	1.181	0.64
217_P	257_A	1.173	0.64
49_S	202_L	1.172	0.64
41_Y	194_L	1.171	0.63
253_D	256_E	1.159	0.63
184_C	190_A	1.158	0.63
218_V	248_Q	1.148	0.62
230_E	241_K	1.141	0.61
97_G	202_L	1.104	0.59
145_D	204_N	1.104	0.59
9_M	21_V	1.101	0.59
142_G	148_V	1.100	0.59
88_V	140_V	1.094	0.58
30_R	69_E	1.082	0.57
2_K	53_E	1.070	0.56
123_H	222_E	1.063	0.56
88_V	141_A	1.062	0.56
4_Y	57_N	1.061	0.56
145_D	212_T	1.060	0.56
13_S	184_C	1.058	0.56
41_Y	51_C	1.046	0.55
105_A	157_A	1.035	0.54
114_S	179_R	1.032	0.54
98_A	141_A	1.026	0.53
42_C	51_C	1.022	0.53
134_L	168_V	1.020	0.53
2_K	94_T	1.019	0.53
141_A	146_V	1.011	0.52
100_F	148_V	0.998	0.51
46_A	51_C	0.996	0.51
63_M	137_N	0.987	0.50
42_C	101_L	0.985	0.50
108_S	245_T	0.985	0.50
114_S	226_Y	0.984	0.50
92_D	95_F	0.978	0.50
197_K	200_F	0.977	0.50
65_N	80_G	0.970	0.49
149_L	202_L	0.967	0.49
241_K	244_T	0.961	0.48
106_R	130_P	0.957	0.48
57_N	63_M	0.952	0.48
17_D	64_N	0.951	0.48
124_F	219_L	0.950	0.48
34_I	186_S	0.949	0.48
152_A	194_L	0.949	0.48
40_N	43_I	0.945	0.47
13_S	190_A	0.944	0.47
42_C	45_E	0.941	0.47
78_I	83_K	0.936	0.47
157_A	161_A	0.934	0.47
9_M	31_G	0.933	0.46
71_L	75_A	0.930	0.46
100_F	137_N	0.930	0.46
19_T	27_N	0.922	0.46
219_L	249_F	0.918	0.45
167_N	204_N	0.914	0.45
12_I	101_L	0.911	0.45
28_Y	35_M	0.908	0.45
260_A	264_M	0.900	0.44
54_V	72_H	0.899	0.44
87_M	137_N	0.889	0.43
100_F	138_A	0.887	0.43
178_S	247_V	0.882	0.43
171_A	185_L	0.880	0.43
192_R	196_E	0.879	0.43
134_L	165_I	0.877	0.42
143_Y	254_M	0.877	0.42
101_L	198_T	0.876	0.42
238_T	260_A	0.875	0.42
37_E	191_G	0.874	0.42
12_I	38_E	0.868	0.42
173_V	193_L	0.860	0.41
5_M	99_L	0.860	0.41
45_E	52_T	0.860	0.41
2_K	239_E	0.851	0.41
252_K	256_E	0.850	0.40
49_S	198_T	0.849	0.40
223_F	247_V	0.848	0.40
138_A	165_I	0.845	0.40
22_D	61_S	0.840	0.40
126_I	206_D	0.836	0.39
72_H	75_A	0.836	0.39
105_A	161_A	0.835	0.39
152_A	173_V	0.825	0.39
5_M	190_A	0.825	0.39
140_V	144_Y	0.816	0.38
139_Y	254_M	0.814	0.38
151_V	170_T	0.811	0.38
4_Y	63_M	0.805	0.37
121_V	265_T	0.801	0.37
59_S	87_M	0.798	0.37
103_Y	137_N	0.797	0.37
83_K	230_E	0.796	0.37
29_E	200_F	0.795	0.37
12_I	190_A	0.793	0.37
34_I	75_A	0.792	0.36
86_S	117_M	0.779	0.36
41_Y	49_S	0.778	0.36
30_R	67_M	0.773	0.35
8_D	11_G	0.771	0.35
49_S	54_V	0.769	0.35
220_S	248_Q	0.767	0.35
68_V	186_S	0.764	0.35
55_L	183_K	0.762	0.34
98_A	151_V	0.758	0.34
37_E	70_K	0.756	0.34
4_Y	55_L	0.754	0.34
91_L	95_F	0.749	0.34
44_A	72_H	0.748	0.34
31_G	38_E	0.747	0.33
108_S	119_F	0.737	0.33
214_P	217_P	0.736	0.33
55_L	148_V	0.735	0.33
4_Y	238_T	0.735	0.33
242_T	248_Q	0.732	0.32
6_S	59_S	0.727	0.32
249_F	257_A	0.725	0.32
70_K	172_A	0.723	0.32
13_S	34_I	0.720	0.32
46_A	190_A	0.719	0.32
91_L	141_A	0.715	0.31
59_S	230_E	0.714	0.31
155_D	176_T	0.708	0.31
106_R	135_G	0.704	0.31
51_C	202_L	0.704	0.31
15_L	182_V	0.703	0.31
202_L	205_K	0.702	0.31
128_D	218_V	0.701	0.31
126_I	202_L	0.699	0.30
197_K	201_A	0.698	0.30
59_S	103_Y	0.696	0.30
28_Y	154_D	0.694	0.30
66_L	77_L	0.692	0.30
91_L	158_A	0.692	0.30
85_F	91_L	0.691	0.30
38_E	190_A	0.691	0.30
66_L	187_P	0.691	0.30
43_I	72_H	0.691	0.30
29_E	33_L	0.690	0.30
221_I	247_V	0.689	0.30
86_S	120_G	0.689	0.30
45_E	202_L	0.686	0.30
142_G	212_T	0.685	0.30
5_M	42_C	0.685	0.30
180_S	238_T	0.682	0.29
139_Y	211_L	0.681	0.29
45_E	191_G	0.677	0.29
101_L	245_T	0.676	0.29
42_C	49_S	0.673	0.29
89_E	177_I	0.672	0.29
41_Y	191_G	0.672	0.29
4_Y	79_S	0.671	0.29
99_L	152_A	0.670	0.29
223_F	232_A	0.669	0.29
129_R	163_E	0.669	0.29
112_V	182_V	0.668	0.29
55_L	237_G	0.667	0.28
193_L	197_K	0.667	0.28
131_V	204_N	0.665	0.28
122_R	245_T	0.665	0.28
68_V	190_A	0.664	0.28
40_N	74_E	0.664	0.28
162_E	212_T	0.662	0.28
25_K	61_S	0.661	0.28
15_L	118_I	0.659	0.28
43_I	54_V	0.658	0.28
173_V	185_L	0.653	0.28
140_V	254_M	0.652	0.28
196_E	200_F	0.651	0.28
90_G	144_Y	0.650	0.27
35_M	39_A	0.646	0.27
9_M	137_N	0.646	0.27
161_A	247_V	0.644	0.27
9_M	108_S	0.643	0.27
6_S	88_V	0.643	0.27
33_L	37_E	0.642	0.27
238_T	264_M	0.641	0.27
92_D	103_Y	0.640	0.27
232_A	247_V	0.640	0.27
34_I	37_E	0.639	0.27
35_M	102_G	0.639	0.27
92_D	253_D	0.639	0.27
76_D	175_Q	0.638	0.27
79_S	140_V	0.638	0.27
125_Y	195_T	0.638	0.27
20_F	27_N	0.636	0.27
63_M	89_E	0.636	0.27
149_L	205_K	0.634	0.27
84_P	234_L	0.633	0.26
64_N	113_M	0.632	0.26
106_R	142_G	0.629	0.26
137_N	232_A	0.629	0.26
123_H	244_T	0.626	0.26
204_N	208_V	0.621	0.26
44_A	54_V	0.617	0.26
235_M	260_A	0.614	0.25
96_R	242_T	0.613	0.25
129_R	204_N	0.612	0.25
45_E	71_L	0.612	0.25
104_H	133_E	0.607	0.25
77_L	236_P	0.607	0.25
101_L	149_L	0.605	0.25
195_T	199_A	0.604	0.25
86_S	251_A	0.603	0.25
30_R	121_V	0.602	0.25
57_N	78_I	0.600	0.25
107_A	245_T	0.599	0.25
195_T	200_F	0.599	0.25
232_A	258_Y	0.598	0.25
98_A	148_V	0.598	0.25
45_E	195_T	0.597	0.24
59_S	64_N	0.596	0.24
204_N	207_K	0.595	0.24
66_L	143_Y	0.594	0.24
134_L	231_W	0.594	0.24
32_R	69_E	0.594	0.24
145_D	207_K	0.590	0.24
33_L	78_I	0.588	0.24
251_A	257_A	0.588	0.24
136_L	258_Y	0.588	0.24
20_F	38_E	0.588	0.24
223_F	263_V	0.587	0.24
13_S	45_E	0.586	0.24
7_V	118_I	0.586	0.24
12_I	35_M	0.582	0.24
157_A	170_T	0.581	0.24
15_L	30_R	0.577	0.23
128_D	225_N	0.574	0.23
149_L	201_A	0.573	0.23
93_D	144_Y	0.571	0.23
88_V	103_Y	0.571	0.23
88_V	144_Y	0.568	0.23
249_F	256_E	0.568	0.23
239_E	242_T	0.566	0.23
73_P	189_K	0.565	0.23
2_K	91_L	0.564	0.23
61_S	249_F	0.563	0.23
38_E	178_S	0.562	0.23
109_T	114_S	0.562	0.23
153_G	157_A	0.557	0.22
176_T	230_E	0.556	0.22
82_V	176_T	0.553	0.22
129_R	218_V	0.551	0.22
40_N	73_P	0.551	0.22
84_P	256_E	0.550	0.22
53_E	73_P	0.549	0.22
9_M	245_T	0.549	0.22
144_Y	171_A	0.548	0.22
142_G	147_P	0.544	0.22
35_M	58_D	0.544	0.22
53_E	126_I	0.543	0.22
87_M	90_G	0.541	0.22
15_L	221_I	0.541	0.22
200_F	212_T	0.540	0.22
137_N	148_V	0.538	0.21
154_D	176_T	0.537	0.21
149_L	208_V	0.536	0.21
173_V	201_A	0.536	0.21
46_A	127_N	0.536	0.21
116_S	124_F	0.536	0.21
151_V	157_A	0.535	0.21
102_G	111_G	0.533	0.21
81_D	155_D	0.533	0.21
150_M	193_L	0.531	0.21
51_C	194_L	0.531	0.21
200_F	242_T	0.531	0.21
205_K	210_P	0.530	0.21
2_K	212_T	0.530	0.21
48_N	53_E	0.530	0.21
66_L	206_D	0.529	0.21
12_I	40_N	0.529	0.21
101_L	184_C	0.528	0.21
54_V	202_L	0.527	0.21
126_I	218_V	0.526	0.21
91_L	180_S	0.525	0.21
80_G	87_M	0.522	0.21
42_C	46_A	0.519	0.21
235_M	238_T	0.519	0.21
76_D	189_K	0.518	0.20
179_R	182_V	0.518	0.20
93_D	207_K	0.517	0.20
27_N	30_R	0.517	0.20
159_K	163_E	0.515	0.20
74_E	166_P	0.514	0.20
32_R	181_A	0.514	0.20
2_K	95_F	0.512	0.20
3_L	49_S	0.512	0.20
105_A	244_T	0.511	0.20
36_T	79_S	0.511	0.20
145_D	155_D	0.509	0.20
63_M	258_Y	0.509	0.20
117_M	232_A	0.509	0.20
107_A	217_P	0.509	0.20
38_E	187_P	0.508	0.20
15_L	114_S	0.508	0.20
159_K	162_E	0.507	0.20
242_T	246_T	0.507	0.20
255_L	259_Q	0.507	0.20
122_R	145_D	0.504	0.20
56_V	97_G	0.503	0.20
46_A	99_L	0.502	0.20
33_L	203_Q	0.501	0.20
155_D	159_K	0.500	0.20
193_L	196_E	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hi9A	5	0.9964	100	0.035	Contact Map
1q6zA	4	0.7409	75	0.958	Contact Map
3eyaA	5	0.7628	71.5	0.959	Contact Map
2pgnA	4	0.7664	66.6	0.961	Contact Map
2uz1A	4	0.7664	65.1	0.961	Contact Map
4k9qA	4	0.7445	65.1	0.961	Contact Map
1v5eA	4	0.7518	63.1	0.962	Contact Map
4q9dA	4	0.7482	63.1	0.962	Contact Map
2ihtA	4	0.7482	62.3	0.962	Contact Map
2panA	3	0.7518	62.1	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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