GREMLIN Database
DPPA - D-aminopeptidase
UniProt: P26902 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (267)
Sequences: 600 (416)
Seq/√Len: 25.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_G149_L5.0001.00
44_A195_T4.7281.00
42_C194_L4.5751.00
7_V39_A4.3641.00
57_N83_K3.4731.00
47_F74_E3.1151.00
169_T200_F3.0881.00
239_E248_Q3.0321.00
125_Y220_S2.8331.00
243_G246_T2.6600.99
47_F72_H2.6090.99
47_F54_V2.4650.99
33_L70_K2.4450.99
88_V98_A2.4390.99
3_L97_G2.4160.99
158_A170_T2.3690.98
123_H130_P2.3680.98
199_A203_Q2.2870.98
169_T197_K2.2190.97
132_G135_G2.1910.97
43_I75_A2.1750.97
125_Y222_E2.1650.97
99_L198_T2.1550.97
76_D183_K2.1290.97
40_N72_H2.1280.97
171_A197_K2.1000.96
99_L150_M2.0940.96
48_N195_T1.9980.95
218_V250_Q1.9910.95
6_S103_Y1.9810.95
198_T202_L1.9130.94
143_Y253_D1.8910.93
29_E32_R1.8820.93
44_A48_N1.8690.93
121_V221_I1.8140.92
165_I168_V1.8030.92
45_E49_S1.8020.92
150_M198_T1.7980.92
185_L193_L1.7980.92
24_G29_E1.7540.91
46_A50_G1.7290.90
88_V137_N1.7220.90
106_R132_G1.7170.90
45_E198_T1.7050.89
13_S38_E1.6780.88
73_P188_A1.6680.88
36_T67_M1.6580.88
48_N199_A1.6470.88
15_L31_G1.6340.87
16_P182_V1.6230.87
99_L149_L1.6210.87
135_G160_E1.6030.86
4_Y95_F1.5550.84
158_A172_A1.5430.84
3_L149_L1.5320.83
78_I183_K1.5310.83
63_M83_K1.5310.83
171_A193_L1.5230.83
219_L257_A1.5010.82
169_T172_A1.4980.82
173_V190_A1.4900.82
105_A111_G1.4870.81
131_V135_G1.4840.81
185_L190_A1.4820.81
127_N217_P1.4730.81
134_L157_A1.4690.81
41_Y45_E1.4690.81
40_N75_A1.4640.80
222_E243_G1.4620.80
142_G210_P1.4490.80
132_G160_E1.4390.79
105_A156_R1.4360.79
6_S87_M1.4260.79
135_G164_L1.4250.79
32_R67_M1.4210.78
175_Q183_K1.4200.78
53_E76_D1.3990.77
106_R109_T1.3800.76
221_I261_M1.3750.76
13_S173_V1.3530.75
73_P192_R1.3500.75
122_R222_E1.3340.74
106_R160_E1.3120.72
150_M197_K1.2900.71
87_M103_Y1.2880.71
54_V74_E1.2820.71
155_D175_Q1.2360.68
101_L152_A1.2330.68
20_F79_S1.2250.67
142_G211_L1.2140.66
84_P89_E1.2140.66
169_T204_N1.2050.66
189_K193_L1.1990.65
38_E184_C1.1910.65
92_D146_V1.1860.65
55_L95_F1.1830.64
3_L51_C1.1810.64
217_P257_A1.1730.64
49_S202_L1.1720.64
41_Y194_L1.1710.63
253_D256_E1.1590.63
184_C190_A1.1580.63
218_V248_Q1.1480.62
230_E241_K1.1410.61
97_G202_L1.1040.59
145_D204_N1.1040.59
9_M21_V1.1010.59
142_G148_V1.1000.59
88_V140_V1.0940.58
30_R69_E1.0820.57
2_K53_E1.0700.56
123_H222_E1.0630.56
88_V141_A1.0620.56
4_Y57_N1.0610.56
145_D212_T1.0600.56
13_S184_C1.0580.56
41_Y51_C1.0460.55
105_A157_A1.0350.54
114_S179_R1.0320.54
98_A141_A1.0260.53
42_C51_C1.0220.53
134_L168_V1.0200.53
2_K94_T1.0190.53
141_A146_V1.0110.52
100_F148_V0.9980.51
46_A51_C0.9960.51
63_M137_N0.9870.50
42_C101_L0.9850.50
108_S245_T0.9850.50
114_S226_Y0.9840.50
92_D95_F0.9780.50
197_K200_F0.9770.50
65_N80_G0.9700.49
149_L202_L0.9670.49
241_K244_T0.9610.48
106_R130_P0.9570.48
57_N63_M0.9520.48
17_D64_N0.9510.48
124_F219_L0.9500.48
34_I186_S0.9490.48
152_A194_L0.9490.48
40_N43_I0.9450.47
13_S190_A0.9440.47
42_C45_E0.9410.47
78_I83_K0.9360.47
157_A161_A0.9340.47
9_M31_G0.9330.46
71_L75_A0.9300.46
100_F137_N0.9300.46
19_T27_N0.9220.46
219_L249_F0.9180.45
167_N204_N0.9140.45
12_I101_L0.9110.45
28_Y35_M0.9080.45
260_A264_M0.9000.44
54_V72_H0.8990.44
87_M137_N0.8890.43
100_F138_A0.8870.43
178_S247_V0.8820.43
171_A185_L0.8800.43
192_R196_E0.8790.43
134_L165_I0.8770.42
143_Y254_M0.8770.42
101_L198_T0.8760.42
238_T260_A0.8750.42
37_E191_G0.8740.42
12_I38_E0.8680.42
173_V193_L0.8600.41
5_M99_L0.8600.41
45_E52_T0.8600.41
2_K239_E0.8510.41
252_K256_E0.8500.40
49_S198_T0.8490.40
223_F247_V0.8480.40
138_A165_I0.8450.40
22_D61_S0.8400.40
126_I206_D0.8360.39
72_H75_A0.8360.39
105_A161_A0.8350.39
152_A173_V0.8250.39
5_M190_A0.8250.39
140_V144_Y0.8160.38
139_Y254_M0.8140.38
151_V170_T0.8110.38
4_Y63_M0.8050.37
121_V265_T0.8010.37
59_S87_M0.7980.37
103_Y137_N0.7970.37
83_K230_E0.7960.37
29_E200_F0.7950.37
12_I190_A0.7930.37
34_I75_A0.7920.36
86_S117_M0.7790.36
41_Y49_S0.7780.36
30_R67_M0.7730.35
8_D11_G0.7710.35
49_S54_V0.7690.35
220_S248_Q0.7670.35
68_V186_S0.7640.35
55_L183_K0.7620.34
98_A151_V0.7580.34
37_E70_K0.7560.34
4_Y55_L0.7540.34
91_L95_F0.7490.34
44_A72_H0.7480.34
31_G38_E0.7470.33
108_S119_F0.7370.33
214_P217_P0.7360.33
55_L148_V0.7350.33
4_Y238_T0.7350.33
242_T248_Q0.7320.32
6_S59_S0.7270.32
249_F257_A0.7250.32
70_K172_A0.7230.32
13_S34_I0.7200.32
46_A190_A0.7190.32
91_L141_A0.7150.31
59_S230_E0.7140.31
155_D176_T0.7080.31
106_R135_G0.7040.31
51_C202_L0.7040.31
15_L182_V0.7030.31
202_L205_K0.7020.31
128_D218_V0.7010.31
126_I202_L0.6990.30
197_K201_A0.6980.30
59_S103_Y0.6960.30
28_Y154_D0.6940.30
66_L77_L0.6920.30
91_L158_A0.6920.30
85_F91_L0.6910.30
38_E190_A0.6910.30
66_L187_P0.6910.30
43_I72_H0.6910.30
29_E33_L0.6900.30
221_I247_V0.6890.30
86_S120_G0.6890.30
45_E202_L0.6860.30
142_G212_T0.6850.30
5_M42_C0.6850.30
180_S238_T0.6820.29
139_Y211_L0.6810.29
45_E191_G0.6770.29
101_L245_T0.6760.29
42_C49_S0.6730.29
89_E177_I0.6720.29
41_Y191_G0.6720.29
4_Y79_S0.6710.29
99_L152_A0.6700.29
223_F232_A0.6690.29
129_R163_E0.6690.29
112_V182_V0.6680.29
55_L237_G0.6670.28
193_L197_K0.6670.28
131_V204_N0.6650.28
122_R245_T0.6650.28
68_V190_A0.6640.28
40_N74_E0.6640.28
162_E212_T0.6620.28
25_K61_S0.6610.28
15_L118_I0.6590.28
43_I54_V0.6580.28
173_V185_L0.6530.28
140_V254_M0.6520.28
196_E200_F0.6510.28
90_G144_Y0.6500.27
35_M39_A0.6460.27
9_M137_N0.6460.27
161_A247_V0.6440.27
9_M108_S0.6430.27
6_S88_V0.6430.27
33_L37_E0.6420.27
238_T264_M0.6410.27
92_D103_Y0.6400.27
232_A247_V0.6400.27
34_I37_E0.6390.27
35_M102_G0.6390.27
92_D253_D0.6390.27
76_D175_Q0.6380.27
79_S140_V0.6380.27
125_Y195_T0.6380.27
20_F27_N0.6360.27
63_M89_E0.6360.27
149_L205_K0.6340.27
84_P234_L0.6330.26
64_N113_M0.6320.26
106_R142_G0.6290.26
137_N232_A0.6290.26
123_H244_T0.6260.26
204_N208_V0.6210.26
44_A54_V0.6170.26
235_M260_A0.6140.25
96_R242_T0.6130.25
129_R204_N0.6120.25
45_E71_L0.6120.25
104_H133_E0.6070.25
77_L236_P0.6070.25
101_L149_L0.6050.25
195_T199_A0.6040.25
86_S251_A0.6030.25
30_R121_V0.6020.25
57_N78_I0.6000.25
107_A245_T0.5990.25
195_T200_F0.5990.25
232_A258_Y0.5980.25
98_A148_V0.5980.25
45_E195_T0.5970.24
59_S64_N0.5960.24
204_N207_K0.5950.24
66_L143_Y0.5940.24
134_L231_W0.5940.24
32_R69_E0.5940.24
145_D207_K0.5900.24
33_L78_I0.5880.24
251_A257_A0.5880.24
136_L258_Y0.5880.24
20_F38_E0.5880.24
223_F263_V0.5870.24
13_S45_E0.5860.24
7_V118_I0.5860.24
12_I35_M0.5820.24
157_A170_T0.5810.24
15_L30_R0.5770.23
128_D225_N0.5740.23
149_L201_A0.5730.23
93_D144_Y0.5710.23
88_V103_Y0.5710.23
88_V144_Y0.5680.23
249_F256_E0.5680.23
239_E242_T0.5660.23
73_P189_K0.5650.23
2_K91_L0.5640.23
61_S249_F0.5630.23
38_E178_S0.5620.23
109_T114_S0.5620.23
153_G157_A0.5570.22
176_T230_E0.5560.22
82_V176_T0.5530.22
129_R218_V0.5510.22
40_N73_P0.5510.22
84_P256_E0.5500.22
53_E73_P0.5490.22
9_M245_T0.5490.22
144_Y171_A0.5480.22
142_G147_P0.5440.22
35_M58_D0.5440.22
53_E126_I0.5430.22
87_M90_G0.5410.22
15_L221_I0.5410.22
200_F212_T0.5400.22
137_N148_V0.5380.21
154_D176_T0.5370.21
149_L208_V0.5360.21
173_V201_A0.5360.21
46_A127_N0.5360.21
116_S124_F0.5360.21
151_V157_A0.5350.21
102_G111_G0.5330.21
81_D155_D0.5330.21
150_M193_L0.5310.21
51_C194_L0.5310.21
200_F242_T0.5310.21
205_K210_P0.5300.21
2_K212_T0.5300.21
48_N53_E0.5300.21
66_L206_D0.5290.21
12_I40_N0.5290.21
101_L184_C0.5280.21
54_V202_L0.5270.21
126_I218_V0.5260.21
91_L180_S0.5250.21
80_G87_M0.5220.21
42_C46_A0.5190.21
235_M238_T0.5190.21
76_D189_K0.5180.20
179_R182_V0.5180.20
93_D207_K0.5170.20
27_N30_R0.5170.20
159_K163_E0.5150.20
74_E166_P0.5140.20
32_R181_A0.5140.20
2_K95_F0.5120.20
3_L49_S0.5120.20
105_A244_T0.5110.20
36_T79_S0.5110.20
145_D155_D0.5090.20
63_M258_Y0.5090.20
117_M232_A0.5090.20
107_A217_P0.5090.20
38_E187_P0.5080.20
15_L114_S0.5080.20
159_K162_E0.5070.20
242_T246_T0.5070.20
255_L259_Q0.5070.20
122_R145_D0.5040.20
56_V97_G0.5030.20
46_A99_L0.5020.20
33_L203_Q0.5010.20
155_D159_K0.5000.20
193_L196_E0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hi9A 5 0.9964 100 0.035 Contact Map
1q6zA 4 0.7409 75 0.958 Contact Map
3eyaA 5 0.7628 71.5 0.959 Contact Map
2pgnA 4 0.7664 66.6 0.961 Contact Map
2uz1A 4 0.7664 65.1 0.961 Contact Map
4k9qA 4 0.7445 65.1 0.961 Contact Map
1v5eA 4 0.7518 63.1 0.962 Contact Map
4q9dA 4 0.7482 63.1 0.962 Contact Map
2ihtA 4 0.7482 62.3 0.962 Contact Map
2panA 3 0.7518 62.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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