GREMLIN Database
CATA - Vegetative catalase
UniProt: P26901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (472)
Sequences: 3023 (1126)
Seq/√Len: 51.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_N242_E5.2861.00
441_V474_G4.1121.00
77_A118_E3.8621.00
63_Y296_V3.7641.00
88_L295_M3.2981.00
65_E85_R3.1751.00
218_E257_K3.0741.00
352_L372_F3.0551.00
426_R464_D3.0281.00
422_G426_R2.9871.00
61_H307_E2.9351.00
16_D19_N2.8581.00
218_E255_A2.8241.00
61_H354_I2.8041.00
201_W260_V2.7691.00
22_T29_T2.7431.00
264_P267_D2.6411.00
48_V345_V2.6361.00
186_A222_K2.6301.00
90_I113_V2.5931.00
84_K118_E2.5801.00
209_V262_I2.5671.00
137_A332_G2.5611.00
63_Y85_R2.5041.00
201_W213_Y2.4601.00
44_N340_A2.4481.00
422_G463_A2.4161.00
44_N336_A2.3991.00
224_L232_I2.3641.00
430_E433_R2.3511.00
78_F122_Y2.3361.00
416_D419_T2.2911.00
231_K235_E2.2891.00
20_S29_T2.2891.00
318_L324_V2.2591.00
99_L154_H2.2571.00
189_R243_D2.2481.00
428_M436_L2.2411.00
68_N291_E2.2381.00
429_S432_E2.2331.00
89_F308_V2.2051.00
181_D435_R2.1981.00
255_A294_R2.1631.00
469_K473_E2.1551.00
88_L113_V2.1401.00
89_F311_A2.1361.00
152_K245_F2.0421.00
209_V264_P2.0241.00
218_E294_R2.0031.00
257_K291_E2.0011.00
259_Y289_L1.9941.00
72_K290_I1.9781.00
187_T240_H1.9651.00
77_A119_E1.9591.00
21_M32_Q1.9451.00
172_L463_A1.9310.99
154_H241_T1.9070.99
90_I295_M1.8970.99
176_T467_Y1.8910.99
267_D270_T1.8900.99
345_V352_L1.8870.99
20_S36_L1.8730.99
187_T190_H1.8650.99
65_E296_V1.8250.99
278_V329_M1.8100.99
203_N207_E1.7950.99
104_T239_Y1.7920.99
192_H216_K1.7800.99
247_A252_D1.7720.99
65_E294_R1.7590.99
259_Y291_E1.7580.99
257_K294_R1.7520.99
17_N383_E1.7470.99
440_I471_V1.7430.99
124_I195_G1.7330.99
172_L459_H1.7180.99
124_I322_I1.7120.99
437_V470_R1.7110.99
159_T448_E1.7070.99
190_H222_K1.7060.99
39_K142_D1.7020.99
425_Y437_V1.6990.99
351_A371_R1.6980.99
230_A235_E1.6920.99
316_G338_H1.6870.99
58_A188_L1.6820.99
167_L386_S1.6700.98
242_E246_N1.6650.98
166_S456_Q1.6540.98
432_E435_R1.6390.98
68_N290_I1.6360.98
80_S84_K1.6360.98
450_E454_L1.6290.98
418_Y459_H1.6250.98
461_Y468_G1.6230.98
167_L455_R1.6220.98
431_D435_R1.6110.98
67_T257_K1.6090.98
63_Y298_D1.6080.98
190_H217_T1.6030.98
312_T345_V1.6020.98
104_T233_A1.5730.98
472_A476_G1.5630.98
61_H89_F1.5620.98
424_L428_M1.5610.98
189_R247_A1.5580.98
40_L141_P1.5560.98
36_L40_L1.5500.97
255_A296_V1.5430.97
264_P287_Y1.5330.97
87_P299_R1.5240.97
9_S38_E1.5230.97
29_T137_A1.5200.97
258_L292_V1.5180.97
79_L122_Y1.5150.97
258_L295_M1.5100.97
263_M282_W1.5090.97
227_N438_E1.5040.97
122_Y213_Y1.5030.97
47_R52_V1.5010.97
73_Y290_I1.4970.97
315_P334_L1.4850.97
458_E462_K1.4720.97
434_T470_R1.4650.96
18_Q383_E1.4440.96
434_T438_E1.4430.96
41_A342_R1.4220.96
267_D287_Y1.4140.96
81_E84_K1.4030.95
247_A250_N1.3950.95
96_A147_Q1.3930.95
461_Y472_A1.3890.95
419_T423_D1.3730.95
271_Y286_D1.3580.95
457_I468_G1.3560.95
104_T224_L1.3520.94
460_F471_V1.3510.94
102_A105_V1.3240.94
85_R298_D1.3210.94
113_V295_M1.3120.93
65_E83_G1.3080.93
66_V82_V1.3060.93
246_N250_N1.3050.93
73_Y262_I1.3010.93
226_V442_N1.3000.93
433_R466_E1.2880.93
371_R375_N1.2820.93
177_I180_S1.2800.93
430_E434_T1.2750.92
111_F193_G1.2720.92
144_I147_Q1.2720.92
129_T174_Q1.2720.92
215_F295_M1.2690.92
154_H304_Y1.2670.92
263_M275_P1.2640.92
192_H217_T1.2590.92
150_D157_N1.2470.92
14_V35_H1.2420.91
36_L332_G1.2380.91
165_W175_V1.2280.91
201_W211_I1.2270.91
190_H219_Q1.2180.91
225_D228_T1.2170.91
143_F147_Q1.2160.91
147_Q160_A1.2000.90
122_Y322_I1.1940.90
466_E469_K1.1920.90
324_V334_L1.1830.89
260_V292_V1.1810.89
58_A241_T1.1770.89
70_V260_V1.1760.89
63_Y294_R1.1750.89
200_K208_G1.1690.89
352_L374_D1.1660.89
9_S365_Q1.1620.88
263_M287_Y1.1540.88
172_L421_A1.1510.88
425_Y470_R1.1430.88
88_L115_F1.1420.88
208_G265_L1.1420.88
472_A477_L1.1380.87
450_E453_K1.1350.87
71_T80_S1.1330.87
98_E149_R1.1320.87
454_L472_A1.1320.87
466_E470_R1.1300.87
70_V201_W1.1270.87
215_F258_L1.1240.87
465_P469_K1.1200.87
77_A84_K1.1160.86
58_A301_P1.1130.86
172_L418_Y1.1060.86
85_R296_V1.1060.86
152_K249_E1.1030.86
186_A228_T1.1020.86
454_L458_E1.0960.85
216_K289_L1.0950.85
186_A224_L1.0830.85
457_I475_L1.0820.85
343_Y369_Q1.0810.85
440_I460_F1.0730.84
231_K234_G1.0720.84
31_I37_L1.0700.84
77_A80_S1.0650.84
422_G468_G1.0620.84
9_S42_H1.0610.83
230_A234_G1.0600.83
271_Y287_Y1.0560.83
213_Y322_I1.0530.83
155_L242_E1.0520.83
444_M447_V1.0520.83
141_P335_F1.0510.83
29_T36_L1.0500.83
89_F354_I1.0430.82
124_I215_F1.0430.82
385_N390_P1.0430.82
184_I226_V1.0390.82
60_A244_L1.0380.82
184_I224_L1.0360.82
78_F319_V1.0360.82
275_P282_W1.0320.82
456_Q459_H1.0240.81
67_T294_R1.0230.81
152_K378_G1.0230.81
383_E392_E1.0220.81
243_D247_A1.0210.81
214_H289_L1.0200.81
113_V215_F1.0100.80
166_S452_I1.0060.80
186_A239_Y1.0050.80
85_R294_R1.0020.80
195_G199_F0.9980.79
441_V475_L0.9960.79
200_K323_D0.9920.79
58_A304_Y0.9870.79
273_F283_S0.9860.79
444_M456_Q0.9830.78
233_A237_P0.9790.78
161_V165_W0.9790.78
228_T231_K0.9760.78
283_S423_D0.9660.77
108_P144_I0.9650.77
102_A233_A0.9620.77
164_F329_M0.9610.77
232_I235_E0.9610.77
115_F124_I0.9610.77
247_A254_P0.9600.77
92_F188_L0.9580.77
87_P358_R0.9560.76
352_L375_N0.9520.76
426_R463_A0.9480.76
159_T387_F0.9440.76
59_G90_I0.9430.75
338_H349_H0.9390.75
144_I329_M0.9360.75
207_E266_E0.9330.75
176_T436_L0.9320.75
227_N231_K0.9320.75
429_S433_R0.9300.74
351_A372_F0.9280.74
306_A367_D0.9270.74
90_I215_F0.9250.74
314_S338_H0.9230.74
94_T101_S0.9230.74
96_A146_T0.9230.74
457_I461_Y0.9220.74
96_A156_K0.9200.74
18_Q392_E0.9200.74
453_K475_L0.9190.74
174_Q421_A0.9180.74
387_F452_I0.9130.73
461_Y469_K0.9130.73
69_D80_S0.9130.73
422_G464_D0.9090.73
44_N343_Y0.9070.73
66_V80_S0.9070.73
299_R302_E0.9050.72
425_Y436_L0.9030.72
459_H463_A0.9020.72
425_Y433_R0.9010.72
386_S455_R0.8960.72
273_F419_T0.8930.71
437_V471_V0.8930.71
184_I229_A0.8920.71
174_Q196_S0.8900.71
202_T323_D0.8900.71
177_I424_L0.8890.71
105_V237_P0.8880.71
216_K284_Q0.8880.71
440_I463_A0.8870.71
66_V70_V0.8830.71
414_H417_H0.8830.71
213_Y258_L0.8820.70
253_Y298_D0.8810.70
264_P271_Y0.8810.70
356_R359_N0.8810.70
78_F88_L0.8800.70
113_V258_L0.8780.70
162_W456_Q0.8770.70
423_D426_R0.8750.70
437_V474_G0.8720.70
447_V453_K0.8710.70
437_V467_Y0.8660.69
156_K237_P0.8620.69
184_I435_R0.8620.69
122_Y201_W0.8620.69
172_L456_Q0.8600.69
232_I239_Y0.8560.68
218_E296_V0.8560.68
66_V69_D0.8550.68
303_N367_D0.8550.68
22_T328_K0.8540.68
276_F326_P0.8530.68
284_Q289_L0.8530.68
150_D160_A0.8520.68
247_A253_Y0.8520.68
436_L440_I0.8460.67
169_P459_H0.8430.67
102_A237_P0.8410.67
406_I409_S0.8410.67
70_V122_Y0.8410.67
67_T82_V0.8350.66
17_N39_K0.8330.66
314_S349_H0.8330.66
146_T156_K0.8310.66
6_L17_N0.8300.66
266_E270_T0.8270.65
105_V233_A0.8270.65
42_H365_Q0.8250.65
338_H342_R0.8250.65
74_T79_L0.8240.65
5_K393_S0.8210.65
199_F334_L0.8180.65
128_N191_M0.8180.65
78_F84_K0.8150.64
429_S435_R0.8140.64
336_A340_A0.8130.64
266_E269_N0.8110.64
207_E264_P0.8110.64
195_G213_Y0.8090.64
157_N160_A0.8080.64
47_R148_K0.8080.64
124_I213_Y0.8070.64
299_R307_E0.8040.63
129_T143_F0.8030.63
41_A45_R0.8030.63
226_V230_A0.8010.63
64_F88_L0.7990.63
75_K320_P0.7990.63
463_A467_Y0.7970.63
188_L240_H0.7890.62
9_S350_Q0.7850.61
114_K313_F0.7820.61
168_S384_P0.7790.61
171_S456_Q0.7790.61
134_I164_F0.7770.61
31_I40_L0.7750.60
45_R343_Y0.7750.60
163_D382_Y0.7730.60
312_T341_H0.7720.60
272_R419_T0.7700.60
146_T160_A0.7680.60
166_S455_R0.7660.60
68_N82_V0.7640.59
427_L433_R0.7630.59
269_N404_Q0.7630.59
398_Q409_S0.7620.59
75_K206_G0.7610.59
23_A403_V0.7570.59
74_T201_W0.7570.59
180_S435_R0.7550.58
241_T304_Y0.7530.58
402_P406_I0.7510.58
80_S118_E0.7500.58
134_I329_M0.7490.58
190_H247_A0.7490.58
32_Q334_L0.7490.58
47_R53_V0.7480.58
245_F378_G0.7480.58
202_T206_G0.7470.58
8_T35_H0.7460.57
403_V406_I0.7410.57
139_K383_E0.7410.57
340_A343_Y0.7390.57
66_V71_T0.7380.57
57_G92_F0.7380.57
409_S412_Y0.7370.57
425_Y440_I0.7370.57
425_Y466_E0.7360.56
186_A240_H0.7350.56
199_F318_L0.7320.56
66_V292_V0.7310.56
347_A369_Q0.7300.56
99_L304_Y0.7270.56
195_G212_K0.7240.55
217_T221_V0.7220.55
356_R360_K0.7220.55
303_N306_A0.7210.55
441_V445_K0.7190.55
152_K302_E0.7180.55
317_T349_H0.7160.54
444_M475_L0.7160.54
127_N133_F0.7150.54
37_L335_F0.7150.54
67_T291_E0.7130.54
73_Y209_V0.7120.54
187_T222_K0.7100.54
30_L407_A0.7100.54
224_L239_Y0.7100.54
10_W350_Q0.7090.54
180_S432_E0.7060.53
131_V177_I0.7060.53
96_A143_F0.7050.53
47_R367_D0.7040.53
165_W171_S0.7040.53
96_A144_I0.7030.53
129_T178_L0.7030.53
113_V124_I0.7020.53
173_H281_V0.7020.53
96_A108_P0.7000.53
86_T115_F0.7000.53
234_G237_P0.7000.53
71_T81_E0.6980.53
461_Y465_P0.6970.52
181_D432_E0.6970.52
66_V81_E0.6970.52
105_V184_I0.6960.52
356_R373_D0.6950.52
96_A179_M0.6940.52
18_Q139_K0.6920.52
465_P471_V0.6910.52
400_A403_V0.6910.52
37_L40_L0.6890.52
59_G308_V0.6870.51
302_E377_G0.6870.51
401_Y407_A0.6870.51
281_V284_Q0.6850.51
47_R50_E0.6830.51
48_V352_L0.6820.51
249_E300_N0.6800.51
43_F348_N0.6800.51
408_D411_S0.6780.50
143_F178_L0.6780.50
180_S184_I0.6770.50
216_K259_Y0.6770.50
345_V349_H0.6760.50
129_T196_S0.6750.50
64_F258_L0.6750.50
291_E294_R0.6740.50
272_R286_D0.6740.50
219_Q254_P0.6740.50
445_K453_K0.6730.50
201_W262_I0.6730.50
114_K124_I0.6730.50
26_R274_D0.6720.50
200_K399_A0.6680.49
70_V292_V0.6680.49
96_A101_S0.6680.49
457_I477_L0.6660.49
98_E154_H0.6640.49
79_L292_V0.6630.49
36_L197_H0.6620.49
418_Y462_K0.6610.49
264_P270_T0.6610.49
155_L246_N0.6600.49
38_E365_Q0.6590.48
156_K238_D0.6570.48
456_Q460_F0.6560.48
204_A207_E0.6560.48
68_N292_V0.6550.48
122_Y315_P0.6550.48
79_L319_V0.6550.48
372_F375_N0.6540.48
364_Y390_P0.6530.48
101_S238_D0.6500.48
267_D271_Y0.6500.48
195_G214_H0.6500.48
65_E82_V0.6490.47
301_P308_V0.6490.47
143_F146_T0.6490.47
168_S386_S0.6480.47
390_P393_S0.6470.47
263_M268_A0.6470.47
75_K119_E0.6470.47
269_N402_P0.6450.47
32_Q331_Q0.6440.47
366_R377_G0.6430.47
165_W179_M0.6410.47
161_V443_A0.6400.46
95_V133_F0.6390.46
77_A81_E0.6390.46
453_K477_L0.6380.46
331_Q334_L0.6370.46
438_E442_N0.6350.46
278_V332_G0.6340.46
87_P354_I0.6330.46
173_H182_R0.6310.46
187_T239_Y0.6310.46
470_R474_G0.6310.46
10_W317_T0.6300.45
176_T424_L0.6300.45
42_H366_R0.6300.45
56_K98_E0.6290.45
52_V350_Q0.6280.45
131_V199_F0.6280.45
115_F322_I0.6280.45
437_V441_V0.6280.45
233_A238_D0.6260.45
359_N362_N0.6250.45
218_E259_Y0.6250.45
366_R381_Y0.6200.44
37_L45_R0.6190.44
108_P147_Q0.6180.44
209_V287_Y0.6170.44
176_T425_Y0.6170.44
162_W440_I0.6160.44
56_K238_D0.6160.44
15_G397_K0.6150.44
184_I439_N0.6140.44
166_S444_M0.6130.44
126_G195_G0.6130.44
150_D379_S0.6120.44
135_R417_H0.6100.43
308_V354_I0.6080.43
182_R214_H0.6070.43
317_T350_Q0.6060.43
119_E319_V0.6060.43
194_F221_V0.6060.43
71_T82_V0.6050.43
90_I124_I0.6040.43
325_S330_L0.6040.43
461_Y477_L0.6040.43
160_A178_L0.6040.43
117_T319_V0.6030.43
92_F191_M0.6010.42
128_N133_F0.6000.42
194_F214_H0.6000.42
179_M440_I0.5980.42
96_A160_A0.5980.42
177_I192_H0.5980.42
453_K457_I0.5970.42
21_M409_S0.5970.42
172_L462_K0.5960.42
262_I290_I0.5950.42
426_R433_R0.5930.42
162_W167_L0.5930.42
59_G89_F0.5930.42
97_G237_P0.5920.42
147_Q165_W0.5920.42
364_Y385_N0.5920.42
291_E296_V0.5910.41
453_K476_G0.5910.41
4_N362_N0.5900.41
398_Q401_Y0.5900.41
192_H284_Q0.5900.41
67_T70_V0.5890.41
56_K149_R0.5890.41
247_A251_G0.5890.41
179_M460_F0.5890.41
168_S383_E0.5880.41
458_E461_Y0.5880.41
38_E41_A0.5870.41
201_W209_V0.5860.41
41_A338_H0.5860.41
454_L476_G0.5850.41
189_R219_Q0.5840.41
341_H443_A0.5840.41
143_F175_V0.5840.41
186_A190_H0.5830.41
70_V262_I0.5810.40
213_Y260_V0.5810.40
101_S237_P0.5800.40
67_T83_G0.5790.40
284_Q427_L0.5790.40
9_S363_N0.5770.40
196_S278_V0.5770.40
270_T273_F0.5750.40
351_A373_D0.5750.40
52_V343_Y0.5740.40
244_L254_P0.5740.40
188_L224_L0.5740.40
443_A446_P0.5730.40
70_V213_Y0.5730.40
205_E266_E0.5720.40
37_L334_L0.5710.39
307_E354_I0.5680.39
190_H252_D0.5680.39
70_V79_L0.5670.39
166_S457_I0.5650.39
65_E81_E0.5640.39
57_G188_L0.5640.39
12_A317_T0.5630.39
53_V144_I0.5610.38
248_I254_P0.5600.38
268_A275_P0.5590.38
96_A240_H0.5580.38
406_I410_V0.5580.38
245_F249_E0.5560.38
443_A447_V0.5560.38
434_T466_E0.5550.38
8_T12_A0.5550.38
74_T80_S0.5540.38
94_T240_H0.5530.38
134_I141_P0.5520.38
203_N209_V0.5510.37
192_H221_V0.5500.37
108_P143_F0.5500.37
425_Y446_P0.5500.37
440_I456_Q0.5500.37
18_Q168_S0.5500.37
108_P224_L0.5490.37
92_F193_G0.5490.37
217_T222_K0.5490.37
30_L33_D0.5490.37
124_I258_L0.5480.37
436_L439_N0.5480.37
448_E452_I0.5470.37
210_W326_P0.5460.37
14_V19_N0.5460.37
92_F297_L0.5450.37
445_K475_L0.5440.37
386_S452_I0.5430.37
405_G409_S0.5430.37
86_T319_V0.5430.37
16_D397_K0.5430.37
269_N403_V0.5420.37
8_T34_V0.5420.37
197_H325_S0.5420.37
40_L45_R0.5410.36
61_H116_Y0.5410.36
436_L467_Y0.5400.36
271_Y283_S0.5400.36
318_L334_L0.5390.36
306_A371_R0.5390.36
399_A403_V0.5370.36
63_Y87_P0.5370.36
97_G105_V0.5360.36
179_M417_H0.5350.36
128_N183_G0.5350.36
102_A146_T0.5340.36
219_Q247_A0.5340.36
312_T349_H0.5330.36
348_N381_Y0.5330.36
72_K75_K0.5320.36
69_D82_V0.5320.36
122_Y318_L0.5310.36
223_N435_R0.5300.35
95_V127_N0.5300.35
227_N230_A0.5290.35
265_L269_N0.5290.35
97_G156_K0.5290.35
444_M453_K0.5270.35
88_L215_F0.5270.35
421_A467_Y0.5260.35
119_E320_P0.5250.35
184_I232_I0.5250.35
403_V407_A0.5250.35
176_T471_V0.5250.35
457_I472_A0.5240.35
53_V340_A0.5240.35
95_V128_N0.5240.35
12_A34_V0.5240.35
40_L314_S0.5210.35
387_F451_E0.5210.35
267_D286_D0.5200.34
451_E455_R0.5200.34
351_A375_N0.5190.34
194_F349_H0.5190.34
195_G198_T0.5180.34
139_K168_S0.5170.34
323_D396_D0.5170.34
233_A239_Y0.5170.34
374_D377_G0.5160.34
61_H87_P0.5160.34
126_G196_S0.5160.34
96_A158_P0.5160.34
75_K202_T0.5160.34
108_P174_Q0.5150.34
101_S108_P0.5140.34
159_T447_V0.5140.34
456_Q471_V0.5130.34
131_V424_L0.5120.34
66_V78_F0.5120.34
316_G349_H0.5110.34
307_E310_Q0.5110.34
188_L191_M0.5100.34
385_N455_R0.5100.34
150_D153_T0.5090.33
194_F284_Q0.5080.33
75_K203_N0.5080.33
428_M435_R0.5070.33
122_Y262_I0.5070.33
176_T421_A0.5060.33
366_R375_N0.5060.33
224_L228_T0.5050.33
77_A204_A0.5050.33
460_F467_Y0.5050.33
58_A155_L0.5040.33
43_F381_Y0.5040.33
108_P129_T0.5030.33
437_V468_G0.5030.33
75_K397_K0.5020.33
104_T232_I0.5020.33
454_L477_L0.5010.33
76_A322_I0.5010.33
121_N357_A0.5010.33
305_F367_D0.5000.33
275_P325_S0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ttvA 4 0.9979 100 0.183 Contact Map
4cabA 4 0.9938 100 0.184 Contact Map
1sy7A 4 0.9917 100 0.19 Contact Map
2isaA 5 0.9938 100 0.19 Contact Map
2j2mA 4 0.9896 100 0.19 Contact Map
1si8A 4 0.9793 100 0.19 Contact Map
4qolA 4 0.9896 100 0.191 Contact Map
1qwlA 4 0.9979 100 0.193 Contact Map
2iufA 4 0.9876 100 0.195 Contact Map
1m7sA 4 0.9855 100 0.197 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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