ASPG1 - BACSU - GREMLIN Contacts

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ASPG1 - L-asparaginase 1

UniProt:	P26900	Sequences: MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTMETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHAKKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTKSYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEMFDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIYEVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	329 (314)
Sequences:	3441 (2510)
Seq/√Len:	141.6

ECOLI - ASPG1 ASPG2
BACSU - ASPG1 ASPG2
HALSA - GATD
SULSO - GATD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_L	108_I	4.437	1.00
3_K	43_T	4.205	1.00
220_D	252_E	4.185	1.00
209_K	232_E	3.797	1.00
91_T	108_I	3.689	1.00
47_Q	68_A	3.483	1.00
99_L	106_I	3.395	1.00
142_V	154_A	3.283	1.00
220_D	249_K	3.055	1.00
5_L	76_Y	3.014	1.00
314_V	317_R	2.999	1.00
311_D	314_V	2.966	1.00
7_L	49_L	2.666	1.00
52_I	61_Y	2.660	1.00
149_I	167_S	2.438	1.00
305_A	318_I	2.438	1.00
228_G	302_L	2.333	1.00
80_V	133_A	2.297	1.00
45_E	76_Y	2.286	1.00
3_K	45_E	2.259	1.00
143_V	148_V	2.228	1.00
206_C	226_Y	2.226	1.00
73_Y	104_K	2.212	1.00
69_V	81_I	2.210	1.00
251_N	255_E	2.208	1.00
59_P	213_G	2.199	1.00
232_E	295_T	2.195	1.00
263_T	290_S	2.178	1.00
73_Y	102_A	2.155	1.00
8_T	14_A	2.152	1.00
73_Y	79_F	2.150	1.00
149_I	154_A	2.122	1.00
157_L	166_E	2.119	1.00
99_L	102_A	2.074	1.00
261_V	319_M	2.005	1.00
5_L	72_N	1.980	1.00
148_V	174_A	1.944	1.00
128_D	146_G	1.918	1.00
132_F	148_V	1.901	1.00
88_M	142_V	1.890	1.00
66_A	98_M	1.866	1.00
262_I	287_I	1.853	1.00
58_Q	61_Y	1.840	1.00
28_A	46_T	1.840	1.00
50_M	61_Y	1.832	1.00
7_L	68_A	1.807	1.00
305_A	315_V	1.805	1.00
56_N	241_F	1.791	1.00
62_W	212_P	1.775	1.00
312_L	316_K	1.766	1.00
96_S	152_T	1.761	1.00
261_V	290_S	1.737	1.00
233_S	262_I	1.726	1.00
7_L	47_Q	1.679	1.00
222_L	253_L	1.673	1.00
202_C	227_K	1.661	1.00
216_P	220_D	1.651	1.00
18_G	23_A	1.650	1.00
59_P	303_M	1.631	1.00
72_N	75_A	1.622	1.00
57_M	61_Y	1.612	1.00
312_L	315_V	1.602	1.00
62_W	300_P	1.601	1.00
128_D	143_V	1.600	1.00
109_T	144_F	1.580	1.00
261_V	302_L	1.571	1.00
157_L	164_A	1.564	1.00
249_K	252_E	1.548	1.00
94_A	98_M	1.527	1.00
83_H	91_T	1.518	1.00
207_L	295_T	1.514	1.00
204_D	215_K	1.493	1.00
29_D	33_S	1.483	1.00
216_P	249_K	1.466	1.00
127_T	131_R	1.463	1.00
69_V	106_I	1.442	1.00
219_F	253_L	1.433	1.00
259_V	315_V	1.431	1.00
316_K	320_E	1.421	1.00
305_A	309_S	1.404	1.00
132_F	143_V	1.396	1.00
8_T	28_A	1.367	1.00
229_I	253_L	1.366	1.00
63_V	98_M	1.358	1.00
68_A	72_N	1.352	1.00
68_A	71_E	1.350	1.00
204_D	227_K	1.335	1.00
159_T	264_T	1.312	1.00
280_R	284_Q	1.302	1.00
62_W	94_A	1.297	1.00
103_K	137_V	1.296	1.00
120_T	123_K	1.295	1.00
27_K	30_E	1.286	1.00
219_F	249_K	1.286	1.00
138_G	186_Q	1.270	1.00
139_G	150_Q	1.266	1.00
263_T	295_T	1.264	1.00
251_N	285_D	1.260	1.00
49_L	68_A	1.260	1.00
204_D	217_E	1.245	1.00
252_E	256_S	1.237	1.00
220_D	223_K	1.237	1.00
158_R	268_E	1.234	1.00
66_A	70_K	1.229	1.00
124_K	128_D	1.222	1.00
147_R	163_D	1.216	1.00
47_Q	72_N	1.215	1.00
67_E	199_T	1.213	1.00
208_L	219_F	1.202	1.00
176_I	181_I	1.196	1.00
61_Y	64_E	1.177	1.00
138_G	183_Y	1.176	1.00
67_E	71_E	1.167	1.00
219_F	246_I	1.166	1.00
209_K	295_T	1.157	0.99
259_V	288_I	1.148	0.99
52_I	57_M	1.134	0.99
148_V	181_I	1.132	0.99
22_L	114_P	1.123	0.99
8_T	48_S	1.119	0.99
59_P	62_W	1.112	0.99
138_G	188_T	1.111	0.99
69_V	79_F	1.109	0.99
221_A	224_S	1.104	0.99
88_M	110_G	1.100	0.99
65_I	81_I	1.099	0.99
80_V	130_I	1.098	0.99
4_L	77_D	1.089	0.99
210_L	240_P	1.089	0.99
153_R	185_K	1.086	0.99
50_M	65_I	1.080	0.99
149_I	172_Y	1.066	0.99
250_V	287_I	1.065	0.99
309_S	318_I	1.065	0.99
205_V	306_L	1.062	0.99
81_I	108_I	1.058	0.99
45_E	72_N	1.050	0.99
204_D	226_Y	1.041	0.99
2_K	136_G	1.035	0.99
79_F	104_K	1.033	0.99
42_Y	134_C	1.024	0.99
80_V	134_C	1.019	0.99
222_L	258_I	1.015	0.99
254_I	260_V	1.011	0.99
302_L	315_V	1.006	0.99
85_T	110_G	1.000	0.98
70_K	197_V	0.997	0.98
55_T	238_G	0.995	0.98
141_Y	173_I	0.994	0.98
3_K	77_D	0.987	0.98
4_L	134_C	0.975	0.98
110_G	144_F	0.974	0.98
175_F	184_N	0.973	0.98
281_R	284_Q	0.971	0.98
203_T	307_G	0.970	0.98
87_T	234_Y	0.967	0.98
16_V	30_E	0.966	0.98
309_S	314_V	0.964	0.98
143_V	176_I	0.959	0.98
299_V	303_M	0.956	0.98
135_E	183_Y	0.955	0.98
113_I	162_Y	0.952	0.98
216_P	252_E	0.943	0.98
89_A	296_E	0.942	0.98
90_Y	265_Q	0.935	0.98
42_Y	130_I	0.933	0.98
265_Q	296_E	0.928	0.98
231_I	250_V	0.927	0.98
88_M	108_I	0.926	0.97
85_T	156_K	0.922	0.97
16_V	25_G	0.920	0.97
254_I	286_L	0.916	0.97
239_V	250_V	0.916	0.97
13_I	122_A	0.907	0.97
70_K	74_D	0.903	0.97
7_L	81_I	0.899	0.97
93_A	97_Y	0.895	0.97
86_D	235_G	0.892	0.97
155_I	295_T	0.885	0.97
78_G	105_P	0.884	0.97
210_L	246_I	0.883	0.97
63_V	67_E	0.882	0.97
36_S	42_Y	0.882	0.97
60_E	64_E	0.881	0.97
96_S	151_G	0.881	0.97
250_V	254_I	0.871	0.96
217_E	221_A	0.865	0.96
36_S	127_T	0.865	0.96
70_K	199_T	0.864	0.96
222_L	256_S	0.862	0.96
76_Y	104_K	0.859	0.96
119_K	124_K	0.859	0.96
158_R	269_E	0.855	0.96
210_L	231_I	0.852	0.96
160_K	236_S	0.849	0.96
107_V	141_Y	0.841	0.96
153_R	297_A	0.839	0.96
238_G	279_G	0.839	0.96
219_F	250_V	0.838	0.95
89_A	265_Q	0.834	0.95
6_M	126_I	0.827	0.95
93_A	152_T	0.826	0.95
310_S	314_V	0.825	0.95
263_T	298_I	0.824	0.95
69_V	73_Y	0.824	0.95
55_T	278_V	0.821	0.95
59_P	212_P	0.819	0.95
132_F	183_Y	0.817	0.95
254_I	285_D	0.809	0.95
5_L	47_Q	0.807	0.94
159_T	270_G	0.801	0.94
222_L	225_M	0.800	0.94
217_E	224_S	0.800	0.94
14_A	82_T	0.799	0.94
132_F	176_I	0.799	0.94
102_A	106_I	0.798	0.94
15_S	24_P	0.797	0.94
56_N	278_V	0.796	0.94
6_M	82_T	0.794	0.94
210_L	239_V	0.793	0.94
153_R	292_N	0.793	0.94
223_K	226_Y	0.791	0.94
147_R	172_Y	0.790	0.94
5_L	45_E	0.788	0.94
124_K	162_Y	0.787	0.94
43_T	77_D	0.787	0.94
96_S	150_Q	0.787	0.94
205_V	230_V	0.786	0.94
158_R	161_S	0.785	0.94
159_T	266_C	0.784	0.94
139_G	173_I	0.784	0.94
314_V	318_I	0.779	0.93
145_D	163_D	0.777	0.93
13_I	111_S	0.777	0.93
37_K	40_N	0.775	0.93
298_I	319_M	0.774	0.93
41_D	134_C	0.773	0.93
41_D	127_T	0.771	0.93
107_V	133_A	0.770	0.93
295_T	298_I	0.768	0.93
313_P	317_R	0.764	0.93
155_I	294_N	0.764	0.93
93_A	300_P	0.761	0.93
156_K	235_G	0.761	0.93
288_I	319_M	0.759	0.92
48_S	51_N	0.758	0.92
210_L	234_Y	0.757	0.92
147_R	166_E	0.751	0.92
157_L	267_L	0.749	0.92
38_L	130_I	0.748	0.92
7_L	72_N	0.747	0.92
262_I	273_M	0.745	0.92
53_D	56_N	0.744	0.92
293_M	301_K	0.743	0.92
248_S	252_E	0.742	0.92
252_E	255_E	0.741	0.92
100_Q	196_T	0.740	0.92
86_D	238_G	0.737	0.91
228_G	298_I	0.735	0.91
76_Y	79_F	0.735	0.91
121_D	156_K	0.735	0.91
81_I	95_L	0.734	0.91
73_Y	99_L	0.733	0.91
115_I	122_A	0.732	0.91
9_T	83_H	0.728	0.91
69_V	99_L	0.728	0.91
208_L	218_M	0.726	0.91
208_L	214_L	0.725	0.91
50_M	64_E	0.723	0.91
184_N	291_R	0.722	0.90
177_N	236_S	0.722	0.90
37_K	123_K	0.716	0.90
274_S	279_G	0.716	0.90
141_Y	148_V	0.715	0.90
214_L	246_I	0.715	0.90
115_I	120_T	0.715	0.90
66_A	94_A	0.713	0.90
97_Y	304_W	0.711	0.90
259_V	312_L	0.710	0.90
254_I	287_I	0.710	0.90
216_P	219_F	0.707	0.90
13_I	82_T	0.705	0.89
294_N	297_A	0.704	0.89
59_P	63_V	0.703	0.89
229_I	250_V	0.703	0.89
282_V	287_I	0.702	0.89
214_L	219_F	0.701	0.89
9_T	65_I	0.701	0.89
53_D	278_V	0.700	0.89
55_T	234_Y	0.698	0.89
168_I	268_E	0.697	0.89
210_L	214_L	0.693	0.89
97_Y	301_K	0.692	0.89
17_E	21_G	0.692	0.89
100_Q	198_D	0.691	0.88
214_L	240_P	0.690	0.88
234_Y	240_P	0.687	0.88
109_T	129_A	0.687	0.88
107_V	132_F	0.687	0.88
6_M	130_I	0.687	0.88
17_E	116_T	0.683	0.88
198_D	308_Q	0.683	0.88
254_I	257_G	0.682	0.88
239_V	246_I	0.681	0.88
26_V	115_I	0.679	0.88
150_Q	173_I	0.679	0.88
230_V	261_V	0.679	0.88
89_A	154_A	0.678	0.88
138_G	141_Y	0.678	0.88
235_G	238_G	0.677	0.87
141_Y	183_Y	0.674	0.87
92_S	142_V	0.674	0.87
62_W	91_T	0.673	0.87
150_Q	153_R	0.671	0.87
311_D	318_I	0.669	0.87
174_A	183_Y	0.668	0.87
112_Q	164_A	0.667	0.87
203_T	227_K	0.665	0.87
64_E	68_A	0.662	0.86
311_D	317_R	0.662	0.86
248_S	251_N	0.661	0.86
212_P	296_E	0.661	0.86
14_A	28_A	0.659	0.86
181_I	184_N	0.658	0.86
108_I	151_G	0.654	0.86
155_I	267_L	0.652	0.85
153_R	301_K	0.650	0.85
304_W	308_Q	0.650	0.85
66_A	197_V	0.649	0.85
218_M	226_Y	0.646	0.85
274_S	283_N	0.645	0.85
222_L	249_K	0.642	0.85
72_N	76_Y	0.640	0.84
183_Y	186_Q	0.639	0.84
2_K	77_D	0.639	0.84
90_Y	299_V	0.639	0.84
227_K	258_I	0.636	0.84
63_V	200_S	0.634	0.84
309_S	312_L	0.628	0.83
70_K	100_Q	0.627	0.83
5_L	69_V	0.626	0.83
144_F	149_I	0.624	0.83
97_Y	297_A	0.623	0.83
114_P	117_F	0.623	0.83
309_S	315_V	0.622	0.83
297_A	301_K	0.622	0.83
21_G	24_P	0.620	0.82
110_G	156_K	0.619	0.82
281_R	285_D	0.619	0.82
112_Q	156_K	0.618	0.82
92_S	154_A	0.616	0.82
8_T	15_S	0.613	0.82
93_A	301_K	0.610	0.81
206_C	215_K	0.609	0.81
97_Y	152_T	0.609	0.81
29_D	45_E	0.609	0.81
147_R	175_F	0.607	0.81
132_F	181_I	0.607	0.81
82_T	126_I	0.607	0.81
35_V	130_I	0.606	0.81
15_S	22_L	0.606	0.81
188_T	191_E	0.605	0.81
72_N	79_F	0.603	0.81
7_L	69_V	0.603	0.81
112_Q	235_G	0.599	0.80
271_E	289_R	0.598	0.80
67_E	200_S	0.597	0.80
163_D	166_E	0.597	0.80
236_S	262_I	0.592	0.80
118_Q	146_G	0.590	0.79
167_S	171_P	0.589	0.79
75_A	103_K	0.588	0.79
184_N	189_E	0.587	0.79
141_Y	174_A	0.586	0.79
129_A	143_V	0.585	0.79
41_D	130_I	0.585	0.79
93_A	151_G	0.585	0.79
253_L	258_I	0.584	0.79
216_P	245_D	0.584	0.79
22_L	117_F	0.583	0.78
14_A	51_N	0.582	0.78
282_V	285_D	0.582	0.78
128_D	179_D	0.582	0.78
17_E	22_L	0.582	0.78
228_G	306_L	0.582	0.78
27_K	115_I	0.580	0.78
67_E	203_T	0.579	0.78
15_S	55_T	0.578	0.78
4_L	130_I	0.577	0.78
290_S	298_I	0.575	0.78
231_I	239_V	0.574	0.77
226_Y	258_I	0.572	0.77
53_D	88_M	0.572	0.77
219_F	251_N	0.571	0.77
62_W	95_L	0.571	0.77
64_E	71_E	0.570	0.77
8_T	46_T	0.569	0.77
61_Y	65_I	0.568	0.77
54_S	83_H	0.567	0.77
177_N	180_G	0.567	0.77
306_L	309_S	0.566	0.76
259_V	306_L	0.566	0.76
63_V	201_L	0.563	0.76
137_V	141_Y	0.563	0.76
238_G	282_V	0.562	0.76
228_G	259_V	0.562	0.76
73_Y	76_Y	0.562	0.76
233_S	239_V	0.562	0.76
17_E	117_F	0.561	0.76
155_I	296_E	0.560	0.76
57_M	91_T	0.560	0.76
290_S	319_M	0.559	0.76
14_A	31_L	0.559	0.76
66_A	99_L	0.557	0.75
92_S	108_I	0.557	0.75
53_D	151_G	0.556	0.75
225_M	256_S	0.553	0.75
186_Q	190_P	0.551	0.75
144_F	164_A	0.549	0.74
227_K	310_S	0.548	0.74
131_R	179_D	0.547	0.74
160_K	270_G	0.547	0.74
174_A	181_I	0.546	0.74
82_T	139_G	0.546	0.74
30_E	173_I	0.544	0.74
228_G	263_T	0.544	0.74
222_L	229_I	0.541	0.73
128_D	176_I	0.541	0.73
85_T	149_I	0.540	0.73
45_E	77_D	0.538	0.73
112_Q	144_F	0.538	0.73
36_S	39_D	0.535	0.72
222_L	226_Y	0.535	0.72
113_I	119_K	0.533	0.72
60_E	256_S	0.533	0.72
46_T	49_L	0.533	0.72
4_L	44_M	0.532	0.72
54_S	237_G	0.530	0.72
132_F	141_Y	0.530	0.72
315_V	319_M	0.528	0.71
225_M	232_E	0.528	0.71
253_L	260_V	0.527	0.71
69_V	95_L	0.527	0.71
209_K	296_E	0.526	0.71
63_V	94_A	0.526	0.71
129_A	132_F	0.524	0.71
43_T	248_S	0.523	0.71
49_L	65_I	0.522	0.71
247_L	251_N	0.522	0.71
207_L	299_V	0.520	0.70
41_D	44_M	0.519	0.70
38_L	42_Y	0.518	0.70
249_K	253_L	0.518	0.70
211_H	303_M	0.518	0.70
305_A	310_S	0.516	0.70
276_Y	282_V	0.516	0.70
223_K	255_E	0.516	0.70
22_L	25_G	0.516	0.70
100_Q	195_F	0.516	0.70
2_K	42_Y	0.513	0.69
41_D	131_R	0.511	0.69
169_N	292_N	0.510	0.69
223_K	252_E	0.510	0.69
63_V	199_T	0.507	0.68
65_I	68_A	0.507	0.68
6_M	203_T	0.507	0.68
172_Y	175_F	0.502	0.68
293_M	297_A	0.501	0.67
155_I	164_A	0.501	0.67
86_D	276_Y	0.500	0.67
53_D	238_G	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q0mA	2	0.9909	100	0.032	Contact Map
1wlsA	2	0.9878	100	0.04	Contact Map
2d6fA	2	0.9878	100	0.048	Contact Map
1zq1A	2	0.9909	100	0.048	Contact Map
2himA	4	0.9666	100	0.059	Contact Map
4r8kA	3	0.9848	100	0.073	Contact Map
1nnsA	4	0.9574	100	0.095	Contact Map
1wsaA	4	0.9422	100	0.098	Contact Map
3nxkA	4	0.9514	100	0.1	Contact Map
1agxA	4	0.9544	100	0.1	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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