GREMLIN Database
SP0J - Stage 0 sporulation protein J
UniProt: P26497 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (252)
Sequences: 5114 (3733)
Seq/√Len: 235.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_E91_T4.1191.00
128_D132_K3.7931.00
197_K201_E3.3621.00
100_S103_L3.2231.00
198_V208_L3.1911.00
74_I81_F3.1691.00
51_K86_L3.0781.00
164_N192_E2.8121.00
168_L195_V2.6551.00
63_L92_V2.6551.00
31_L74_I2.5951.00
59_I84_A2.5921.00
125_Q166_Q2.5631.00
27_K30_D2.5331.00
148_S151_H2.4531.00
26_I94_A2.3901.00
46_A116_E2.3891.00
138_Q153_A2.3311.00
48_A86_L2.3251.00
26_I65_V2.3191.00
48_A52_E2.2341.00
167_Q171_E2.1791.00
47_L51_K2.1271.00
203_L211_L2.1091.00
81_F85_K2.1041.00
65_V94_A2.0821.00
66_R73_D2.0801.00
44_D86_L2.0781.00
99_L107_I2.0401.00
129_S133_H1.9881.00
47_L86_L1.9771.00
59_I93_P1.9691.00
28_I81_F1.9521.00
253_R264_F1.9341.00
121_L166_Q1.9171.00
187_N190_K1.9131.00
52_E55_L1.8981.00
63_L74_I1.8901.00
140_Q143_K1.8621.00
131_L141_L1.8561.00
31_L65_V1.7951.00
44_D48_A1.7681.00
32_R73_D1.7591.00
84_A89_L1.7511.00
207_Q210_Q1.7221.00
27_K91_T1.6771.00
196_Q200_A1.6561.00
169_I179_G1.6001.00
76_A111_E1.5681.00
84_A87_A1.5611.00
197_K211_L1.5611.00
66_R101_E1.5531.00
150_P153_A1.5411.00
125_Q170_A1.5341.00
168_L199_I1.5261.00
48_A51_K1.5231.00
32_R68_S1.5191.00
155_H176_M1.5181.00
60_L64_I1.5141.00
123_E147_K1.5061.00
119_S170_A1.5021.00
63_L94_A1.4831.00
194_L211_L1.4821.00
30_D71_G1.4811.00
178_H205_V1.4811.00
127_Y145_L1.4651.00
38_P108_A1.4341.00
34_N104_M1.4301.00
230_K238_E1.4211.00
139_E143_K1.4181.00
68_S73_D1.4091.00
78_E82_R1.4001.00
163_E166_Q1.3491.00
59_I92_V1.3471.00
181_T208_L1.3461.00
66_R104_M1.3431.00
34_N108_A1.3401.00
46_A49_E1.3331.00
165_I195_V1.3311.00
162_P192_E1.3281.00
236_E240_Y1.3021.00
54_V59_I1.2981.00
67_K98_E1.2771.00
258_G264_F1.2671.00
35_P73_D1.2561.00
123_E155_H1.2551.00
195_V199_I1.2541.00
75_V99_L1.2541.00
178_H181_T1.2491.00
106_E144_R1.2481.00
128_D160_T1.2461.00
192_E196_Q1.2361.00
43_D46_A1.2311.00
127_Y141_L1.2291.00
68_S71_G1.2201.00
167_Q170_A1.1991.00
57_H106_E1.1701.00
142_A152_I1.1691.00
32_R71_G1.1691.00
190_K193_P1.1491.00
233_V236_E1.1411.00
252_K261_E1.1391.00
185_L194_L1.1291.00
57_H103_L1.1231.00
28_I84_A1.1171.00
194_L215_L1.1171.00
51_K87_A1.1171.00
141_L152_I1.1141.00
164_N196_Q1.0961.00
198_V203_L1.0881.00
247_T262_I1.0871.00
184_G216_N1.0871.00
59_I87_A1.0671.00
51_K55_L1.0641.00
131_L138_Q1.0561.00
254_Q259_K1.0481.00
131_L156_L1.0411.00
29_A85_K1.0391.00
212_I216_N1.0381.00
174_L195_V1.0381.00
24_E96_V1.0361.00
54_V84_A1.0351.00
52_E56_Q1.0301.00
176_M180_R1.0271.00
235_K239_S1.0261.00
259_K263_E1.0261.00
40_K125_Q1.0191.00
204_N207_Q0.9961.00
168_L173_T0.9911.00
208_L211_L0.9831.00
208_L212_I0.9831.00
210_Q213_Q0.9821.00
137_T140_Q0.9701.00
25_E93_P0.9691.00
154_N180_R0.9681.00
111_E115_R0.9661.00
59_I63_L0.9651.00
42_F82_R0.9641.00
247_T265_F0.9611.00
42_F78_E0.9561.00
33_P81_F0.9521.00
210_Q214_Q0.9451.00
138_Q149_R0.9391.00
127_Y147_K0.9391.00
230_K235_K0.9361.00
56_Q144_R0.9361.00
203_L208_L0.9351.00
250_N261_E0.9051.00
31_L92_V0.9041.00
239_S243_N0.9031.00
34_N73_D0.9031.00
151_H155_H0.9001.00
84_A92_V0.9001.00
252_K259_K0.8900.99
28_I85_K0.8900.99
168_L174_L0.8880.99
181_T205_V0.8870.99
109_L126_A0.8860.99
241_L245_F0.8840.99
166_Q170_A0.8770.99
33_P78_E0.8690.99
31_L94_A0.8620.99
67_K70_K0.8620.99
64_I76_A0.8610.99
234_L253_R0.8570.99
238_E242_Q0.8460.99
163_E167_Q0.8420.99
235_K238_E0.8410.99
105_R129_S0.8380.99
206_R209_E0.8370.99
162_P165_I0.8310.99
54_V89_L0.8260.99
245_F262_I0.8220.99
99_L103_L0.8170.99
47_L87_A0.8160.99
51_K54_V0.8150.99
147_K151_H0.8050.99
52_E143_K0.8040.99
84_A93_P0.8020.99
23_V94_A0.7940.99
157_R183_L0.7940.99
56_Q143_K0.7920.99
27_K90_D0.7920.99
194_L208_L0.7860.99
60_L107_I0.7840.99
64_I95_I0.7740.99
168_L196_Q0.7700.98
151_H176_M0.7670.98
176_M181_T0.7660.98
205_V209_E0.7620.98
26_I30_D0.7560.98
230_K234_L0.7550.98
177_G206_R0.7530.98
50_L79_R0.7500.98
174_L179_G0.7480.98
253_R256_K0.7460.98
232_A236_E0.7400.98
62_P95_I0.7370.98
55_L87_A0.7370.98
63_L81_F0.7360.98
212_I215_L0.7350.98
233_V237_R0.7300.98
169_I174_L0.7200.98
120_P158_L0.7180.98
178_H182_L0.7170.98
149_R153_A0.7150.98
26_I31_L0.7140.97
211_L214_Q0.7110.97
131_L153_A0.7070.97
73_D104_M0.7050.97
231_D235_K0.7040.97
110_L114_Q0.7040.97
147_K152_I0.7030.97
24_E72_Y0.7030.97
60_L110_L0.7020.97
248_T263_E0.7010.97
39_R111_E0.6980.97
102_A133_H0.6960.97
253_R257_K0.6960.97
53_S110_L0.6950.97
261_E265_F0.6930.97
158_L166_Q0.6920.97
99_L104_M0.6880.97
257_K263_E0.6860.97
136_L144_R0.6860.97
175_S178_H0.6810.97
162_P187_N0.6800.97
51_K83_A0.6760.97
28_I92_V0.6750.96
226_K229_V0.6730.96
112_N115_R0.6710.96
185_L190_K0.6680.96
253_R265_F0.6610.96
138_Q142_A0.6600.96
186_K216_N0.6580.96
24_E67_K0.6570.96
59_I89_L0.6550.96
211_L215_L0.6540.96
190_K215_L0.6500.96
55_L89_L0.6490.96
246_G249_V0.6470.96
57_H107_I0.6450.95
249_V262_I0.6420.95
168_L171_E0.6400.95
134_L141_L0.6400.95
149_R177_G0.6350.95
41_H170_A0.6260.95
180_R183_L0.6250.95
165_I192_E0.6240.95
203_L207_Q0.6210.94
105_R134_L0.6210.94
121_L159_L0.6200.94
248_T265_F0.6190.94
21_E97_R0.6190.94
231_D234_L0.6180.94
174_L198_V0.6180.94
37_Q118_L0.6160.94
185_L212_I0.6150.94
47_L116_E0.6140.94
59_I107_I0.6110.94
154_N157_R0.6090.94
45_E48_A0.6060.94
37_Q78_E0.6060.94
239_S265_F0.6040.94
102_A106_E0.6020.93
235_K243_N0.6000.93
76_A107_I0.5990.93
248_T251_I0.5980.93
241_L249_V0.5970.93
127_Y155_H0.5950.93
238_E251_I0.5940.93
61_Q111_E0.5930.93
32_R35_P0.5900.93
123_E127_Y0.5890.93
189_N193_P0.5880.93
250_N263_E0.5870.93
139_E149_R0.5870.93
65_V74_I0.5850.93
36_Y101_E0.5810.92
127_Y151_H0.5810.92
138_Q141_L0.5810.92
33_P74_I0.5810.92
109_L130_L0.5800.92
36_Y104_M0.5790.92
37_Q42_F0.5780.92
103_L106_E0.5770.92
45_E49_E0.5740.92
60_L76_A0.5730.92
124_A159_L0.5710.92
254_Q257_K0.5700.92
49_E52_E0.5690.91
118_L122_E0.5680.91
37_Q108_A0.5670.91
248_T264_F0.5660.91
177_G205_V0.5660.91
157_R180_R0.5650.91
198_V211_L0.5650.91
28_I90_D0.5650.91
76_A112_N0.5640.91
158_L180_R0.5620.91
47_L54_V0.5610.91
142_A149_R0.5580.91
33_P82_R0.5570.91
30_D69_L0.5570.91
173_T199_I0.5570.91
39_R115_R0.5560.91
15_Q18_L0.5550.90
50_L83_A0.5540.90
127_Y175_S0.5520.90
66_R75_V0.5520.90
36_Y73_D0.5510.90
157_R184_G0.5500.90
194_L203_L0.5490.90
42_F79_R0.5470.90
103_L107_I0.5460.90
24_E95_I0.5460.90
237_R251_I0.5460.90
181_T212_I0.5450.90
121_L170_A0.5440.90
127_Y131_L0.5430.89
237_R243_N0.5430.89
30_D70_K0.5420.89
29_A90_D0.5420.89
239_S242_Q0.5370.89
237_R240_Y0.5360.89
194_L197_K0.5360.89
240_Y244_Y0.5360.89
219_V223_T0.5350.89
17_D20_E0.5350.89
238_E246_G0.5340.89
228_P232_A0.5320.89
154_N178_H0.5320.89
236_E242_Q0.5300.88
205_V208_L0.5300.88
74_I78_E0.5290.88
61_Q76_A0.5290.88
77_G80_R0.5280.88
193_P197_K0.5280.88
104_M110_L0.5280.88
245_F251_I0.5270.88
79_R116_E0.5270.88
202_Q207_Q0.5260.88
162_P188_K0.5250.88
218_N228_P0.5230.88
137_T142_A0.5230.88
158_L161_L0.5220.88
178_H208_L0.5210.87
180_R209_E0.5200.87
180_R184_G0.5190.87
50_L54_V0.5190.87
161_L179_G0.5180.87
177_G209_E0.5180.87
64_I107_I0.5180.87
128_D166_Q0.5170.87
214_Q221_R0.5160.87
25_E94_A0.5160.87
234_L251_I0.5150.87
242_Q248_T0.5150.87
153_A157_R0.5150.87
119_S122_E0.5140.87
20_E23_V0.5140.87
141_L151_H0.5130.87
188_K192_E0.5120.87
243_N248_T0.5110.86
14_N265_F0.5110.86
162_P190_K0.5090.86
229_V232_A0.5080.86
139_E204_N0.5080.86
22_T25_E0.5070.86
121_L125_Q0.5060.86
109_L118_L0.5060.86
46_A79_R0.5040.86
76_A115_R0.5040.86
31_L81_F0.5040.86
145_L151_H0.5030.86
46_A122_E0.5010.85
189_N192_E0.5000.85
236_E245_F0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4umkA 2 0.6844 100 0.237 Contact Map
1vz0A 3 0.6809 100 0.257 Contact Map
1r71A 2 0.3936 99.9 0.603 Contact Map
1vk1A 1 0.6418 99.9 0.64 Contact Map
1xw3A 1 0.3617 99.8 0.647 Contact Map
1yzsA 1 0.3723 99.8 0.647 Contact Map
3mkyB 2 0.3865 99.8 0.658 Contact Map
1zx4A 2 0.5745 98.7 0.816 Contact Map
2hwjA 5 0.6348 97.2 0.873 Contact Map
3vwbA 1 0.4007 92.9 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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