GREMLIN Database
PTFD - Fructose permease IID component
UniProt: P26382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (263)
Sequences: 1325 (825)
Seq/√Len: 50.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_T109_A5.8771.00
44_I54_R4.4411.00
253_N256_L4.1761.00
11_E46_K3.8791.00
8_T11_E3.3471.00
43_A80_A3.2341.00
259_C263_V3.2171.00
50_P53_K3.2171.00
243_L246_W3.1691.00
223_T226_N3.1641.00
56_E94_G2.9821.00
226_N229_D2.9581.00
239_G243_L2.8851.00
7_L80_A2.8261.00
268_G274_L2.7871.00
264_I268_G2.6201.00
128_G139_G2.6191.00
36_Y79_T2.5341.00
244_V261_I2.4721.00
7_L43_A2.4711.00
9_K160_K2.4371.00
45_K54_R2.3761.00
222_Q225_Q2.3041.00
156_Y160_K2.2801.00
51_G55_N2.2211.00
75_I109_A2.1671.00
225_Q229_D2.1291.00
18_R38_Y2.1191.00
205_I224_V2.1141.00
252_V260_G2.0281.00
12_I159_L1.8840.99
37_C58_L1.8830.99
84_E163_Y1.8730.99
65_F75_I1.8720.99
13_F160_K1.8620.99
232_M235_A1.8480.99
8_T46_K1.8130.99
240_L261_I1.7830.99
61_H83_E1.7640.99
43_A47_L1.7480.99
40_M44_I1.7430.99
161_Y164_V1.7320.99
86_M94_G1.7240.99
125_A143_F1.7220.99
53_K56_E1.6980.99
7_L11_E1.6940.99
267_L271_A1.6840.98
67_T75_I1.6580.98
23_L26_F1.6380.98
203_I274_L1.6180.98
205_I236_L1.5960.98
82_M96_A1.5920.98
237_P241_T1.5580.97
252_V256_L1.5110.97
65_F72_T1.5100.97
267_L270_W1.4950.97
61_H101_K1.4840.97
25_S34_M1.4660.96
75_I108_I1.4110.95
49_G52_A1.4100.95
137_I140_P1.4050.95
39_V76_F1.4010.95
86_M97_I1.3970.95
19_S72_T1.3870.95
63_E98_S1.3830.95
5_K88_N1.3730.95
7_L12_I1.3670.94
263_V267_L1.3490.94
15_M43_A1.3440.94
206_P274_L1.2980.93
54_R58_L1.2890.93
139_G142_L1.2870.92
89_N92_I1.2850.92
12_I160_K1.2830.92
59_Q62_L1.2780.92
142_L146_L1.2760.92
160_K164_V1.2680.92
48_Y57_A1.2680.92
244_V257_I1.2550.92
235_A239_G1.2470.91
6_R88_N1.2430.91
98_S102_I1.2350.91
22_L32_Q1.2170.90
197_V241_T1.2160.90
257_I261_I1.2030.90
129_A133_L1.1990.90
44_I57_A1.1930.89
32_Q109_A1.1800.89
203_I236_L1.1690.88
247_M252_V1.1650.88
73_A159_L1.1650.88
255_L259_C1.1560.88
165_K172_D1.1530.88
124_L146_L1.1510.88
247_M260_G1.1410.87
41_I58_L1.1330.87
65_F76_F1.1260.86
86_M89_N1.1240.86
16_F156_Y1.1220.86
27_N30_R1.1140.86
35_G163_Y1.1090.85
55_N59_Q1.1080.85
256_L260_G1.1070.85
141_L145_F1.1060.85
22_L72_T1.0970.85
238_L242_L1.0950.85
140_P143_F1.0900.84
26_F33_A1.0840.84
271_A274_L1.0840.84
52_A55_N1.0780.84
37_C41_I1.0770.84
30_R33_A1.0700.83
268_G273_F1.0620.83
86_M92_I1.0580.83
9_K13_F1.0420.82
10_K14_S1.0380.81
121_R143_F1.0250.81
226_N271_A1.0110.80
69_P192_V1.0080.79
71_L108_I1.0010.79
36_Y61_H1.0010.79
31_V116_F0.9990.79
80_A159_L0.9960.79
60_R101_K0.9950.79
32_Q67_T0.9910.78
153_S157_Y0.9890.78
139_G144_F0.9830.78
15_M159_L0.9830.78
165_K168_E0.9820.78
51_G54_R0.9810.78
226_N230_S0.9790.77
203_I240_L0.9760.77
57_A60_R0.9700.77
268_G271_A0.9650.76
13_F156_Y0.9650.76
16_F155_K0.9640.76
154_T158_G0.9630.76
266_I270_W0.9600.76
44_I47_L0.9560.76
47_L88_N0.9520.75
85_E89_N0.9460.75
11_E14_S0.9410.75
208_V218_K0.9410.75
203_I237_P0.9340.74
131_L134_G0.9270.74
240_L262_F0.9200.73
36_Y40_M0.9190.73
111_V152_L0.9190.73
150_I196_L0.9140.72
37_C40_M0.9130.72
128_G146_L0.8970.71
30_R62_L0.8950.71
23_L31_V0.8910.71
14_S46_K0.8900.70
37_C45_K0.8900.70
61_H79_T0.8890.70
224_V230_S0.8850.70
240_L264_I0.8820.70
221_V225_Q0.8810.70
144_F148_N0.8800.70
204_N268_G0.8780.69
131_L184_G0.8730.69
122_P196_L0.8680.68
49_G53_K0.8650.68
20_N152_L0.8640.68
145_F149_A0.8550.67
96_A99_G0.8530.67
14_S18_R0.8510.67
205_I274_L0.8460.66
249_R271_A0.8440.66
222_Q226_N0.8400.66
27_N241_T0.8350.65
122_P150_I0.8350.65
65_F105_M0.8340.65
261_I265_G0.8260.65
150_I153_S0.8240.64
240_L244_V0.8220.64
125_A129_A0.8220.64
15_M80_A0.8180.64
19_S125_A0.8150.64
168_E171_Q0.8150.64
11_E84_E0.8080.63
260_G264_I0.8060.63
40_M47_L0.8040.63
138_A141_L0.8030.62
207_I236_L0.8020.62
52_A149_A0.7940.62
202_T234_G0.7930.61
53_K235_A0.7880.61
6_R49_G0.7870.61
221_V224_V0.7860.61
15_M38_Y0.7850.61
124_L150_I0.7730.59
74_P158_G0.7720.59
13_F17_I0.7700.59
225_Q228_L0.7620.58
205_I223_T0.7600.58
146_L228_L0.7550.58
260_G263_V0.7520.57
27_N69_P0.7440.57
74_P170_L0.7390.56
103_G154_T0.7380.56
245_A249_R0.7380.56
96_A100_M0.7330.55
22_L35_G0.7300.55
68_H116_F0.7280.55
35_G42_P0.7250.55
7_L47_L0.7240.54
20_N73_A0.7220.54
123_V127_L0.7210.54
48_Y109_A0.7200.54
265_G269_Y0.7190.54
47_L84_E0.7130.53
124_L145_F0.7130.53
108_I153_S0.7100.53
47_L75_I0.7030.52
115_I168_E0.7000.52
34_M62_L0.7000.52
246_W249_R0.6960.52
10_K17_I0.6890.51
184_G188_L0.6870.51
124_L141_L0.6840.50
19_S118_G0.6830.50
243_L260_G0.6830.50
45_K58_L0.6820.50
227_V230_S0.6770.50
196_L200_W0.6740.49
40_M98_S0.6730.49
237_P242_L0.6720.49
224_V227_V0.6710.49
5_K49_G0.6690.49
62_L144_F0.6640.48
207_I224_V0.6630.48
203_I206_P0.6630.48
260_G268_G0.6620.48
93_D182_T0.6610.48
263_V272_G0.6610.48
36_Y101_K0.6600.48
177_R180_K0.6580.48
89_N94_G0.6540.47
123_V139_G0.6530.47
33_A62_L0.6510.47
47_L87_A0.6500.47
26_F188_L0.6490.47
82_M161_Y0.6480.47
204_N269_Y0.6460.46
46_K163_Y0.6440.46
41_I54_R0.6430.46
242_L245_A0.6430.46
86_M93_D0.6420.46
95_K179_Q0.6420.46
25_S228_L0.6410.46
205_I228_L0.6390.46
19_S155_K0.6380.46
35_G125_A0.6350.45
63_E95_K0.6350.45
82_M234_G0.6310.45
110_G118_G0.6290.45
180_K187_I0.6290.45
208_V220_D0.6290.45
201_T237_P0.6270.45
210_S216_S0.6270.45
100_M188_L0.6260.44
120_I150_I0.6240.44
60_R87_A0.6210.44
202_T219_V0.6170.43
83_E194_G0.6160.43
192_V234_G0.6140.43
25_S38_Y0.6140.43
55_N99_G0.6130.43
73_A158_G0.6120.43
111_V114_P0.6100.43
158_G241_T0.6100.43
50_P55_N0.6070.42
6_R84_E0.6030.42
168_E264_I0.6020.42
123_V194_G0.6010.42
87_A118_G0.6010.42
207_I273_F0.6000.42
55_N58_L0.6000.42
79_T83_E0.5990.42
146_L262_F0.5980.42
64_W97_I0.5980.42
209_V227_V0.5910.41
133_L208_V0.5900.41
248_L251_G0.5900.41
99_G102_I0.5890.41
178_I198_S0.5880.41
181_L188_L0.5880.41
59_Q138_A0.5870.40
184_G195_A0.5850.40
110_G162_G0.5830.40
87_A119_T0.5820.40
77_G194_G0.5820.40
17_I20_N0.5820.40
114_P151_R0.5810.40
80_A84_E0.5810.40
216_S227_V0.5800.40
11_E43_A0.5800.40
199_K234_G0.5790.40
185_A254_P0.5770.39
242_L257_I0.5770.39
136_N139_G0.5770.39
142_L145_F0.5740.39
247_M251_G0.5730.39
176_N179_Q0.5730.39
103_G109_A0.5720.39
118_G121_R0.5720.39
25_S109_A0.5710.39
201_T241_T0.5690.39
64_W178_I0.5690.39
27_N33_A0.5690.39
48_Y104_L0.5680.39
5_K47_L0.5680.39
56_E95_K0.5670.38
132_A196_L0.5670.38
42_P271_A0.5660.38
110_G126_A0.5650.38
49_G54_R0.5650.38
95_K249_R0.5650.38
31_V68_H0.5640.38
231_I251_G0.5630.38
33_A228_L0.5620.38
68_H72_T0.5620.38
68_H122_P0.5620.38
114_P200_W0.5610.38
149_A153_S0.5580.38
12_I39_V0.5560.37
70_W73_A0.5550.37
210_S220_D0.5520.37
225_Q230_S0.5520.37
100_M170_L0.5520.37
23_L69_P0.5520.37
203_I264_I0.5510.37
6_R53_K0.5490.37
99_G103_G0.5470.37
28_F33_A0.5460.36
16_F20_N0.5460.36
23_L197_V0.5450.36
66_N189_G0.5440.36
8_T84_E0.5420.36
23_L28_F0.5420.36
7_L84_E0.5410.36
141_L239_G0.5410.36
156_Y159_L0.5400.36
130_S143_F0.5380.36
118_G241_T0.5380.36
126_A151_R0.5370.36
270_W273_F0.5360.35
138_A142_L0.5360.35
254_P258_I0.5360.35
252_V255_L0.5360.35
157_Y161_Y0.5360.35
208_V223_T0.5350.35
192_V233_P0.5350.35
186_S190_L0.5350.35
236_L272_G0.5340.35
236_L239_G0.5330.35
152_L191_F0.5310.35
259_C273_F0.5300.35
149_A273_F0.5300.35
5_K12_I0.5280.35
103_G202_T0.5270.35
87_A230_S0.5260.35
141_L270_W0.5260.35
217_G221_V0.5260.35
50_P54_R0.5250.34
97_I118_G0.5230.34
180_K265_G0.5220.34
11_E15_M0.5220.34
85_E167_M0.5220.34
141_L161_Y0.5210.34
78_V230_S0.5210.34
132_A136_N0.5170.34
114_P230_S0.5150.34
26_F254_P0.5150.34
61_H103_G0.5140.33
56_E161_Y0.5140.33
65_F108_I0.5140.33
9_K181_L0.5130.33
77_G83_E0.5110.33
15_M18_R0.5100.33
97_I126_A0.5070.33
88_N229_D0.5070.33
123_V235_A0.5050.33
25_S29_E0.5040.33
19_S25_S0.5040.33
75_I79_T0.5040.33
176_N185_A0.5030.32
226_N267_L0.5020.32
5_K251_G0.5010.32
103_G265_G0.5000.32
64_W110_G0.5000.32
127_L191_F0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pf6A 2 0.1964 14.7 0.973 Contact Map
4afiA 2 0.2473 14.6 0.973 Contact Map
1oahA 2 0.32 12.2 0.974 Contact Map
2xq0A 1 0.2873 5.6 0.978 Contact Map
2h3oA 1 0.16 5.3 0.978 Contact Map
4hygA 3 0.3127 5.1 0.978 Contact Map
2vwaA 1 0.2036 4.2 0.979 Contact Map
3b60A 2 0.6145 4 0.979 Contact Map
3k9aA 3 0.08 3.9 0.979 Contact Map
2rr7A 1 0.1964 3.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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