GREMLIN Database
PTFC - Fructose permease IIC component
UniProt: P26381 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (247)
Sequences: 1424 (895)
Seq/√Len: 56.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_N133_G5.1421.00
43_D46_T4.9931.00
209_I230_C4.9821.00
219_F223_G3.9211.00
12_I36_L3.5451.00
39_L44_L3.4511.00
121_R124_Q3.3461.00
29_R55_E3.3371.00
14_A146_A3.2701.00
212_L227_L3.0701.00
124_Q128_A2.9271.00
12_I40_V2.7971.00
212_L226_A2.7931.00
173_D177_K2.7021.00
125_Y133_G2.6881.00
208_Y226_A2.6781.00
165_Q169_G2.5081.00
120_H123_D2.5051.00
34_C47_G2.4891.00
6_I10_L2.4091.00
36_L40_V2.2791.00
132_K136_I2.2761.00
206_F238_V2.1711.00
121_R125_Y2.1251.00
14_A150_M2.1241.00
125_Y130_N2.0971.00
3_S7_I2.0721.00
41_L85_T2.0041.00
9_L37_V1.9781.00
177_K181_I1.9551.00
204_K208_Y1.9101.00
125_Y137_M1.8871.00
133_G136_I1.8801.00
8_L40_V1.8781.00
35_T44_L1.8561.00
124_Q127_K1.8470.99
10_L154_L1.8330.99
74_I104_G1.8200.99
125_Y128_A1.8120.99
10_L150_M1.8120.99
46_T50_L1.7920.99
13_A153_T1.7820.99
214_A224_F1.7780.99
130_N136_I1.7620.99
45_K49_I1.7570.99
206_F235_Y1.7470.99
216_F220_N1.7180.99
206_F234_L1.6570.99
15_I27_T1.6110.99
121_R137_M1.5970.98
83_V93_G1.5940.98
162_S165_Q1.5900.98
53_T57_M1.5850.98
220_N223_G1.5620.98
167_F170_N1.5160.98
181_I184_G1.5120.98
177_K180_Q1.5050.98
31_L35_T1.4960.98
126_A129_G1.4420.97
3_S158_L1.4360.97
46_T84_I1.4150.97
235_Y238_V1.3970.96
107_L152_P1.3610.96
7_I154_L1.3600.96
92_E95_A1.3490.96
23_D29_R1.3460.96
126_A134_I1.3330.95
122_A138_H1.2700.94
75_A81_I1.2610.94
216_F222_V1.2600.94
218_D221_L1.2560.94
126_A133_G1.2510.94
213_L217_T1.2300.93
103_A168_L1.2220.93
150_M154_L1.2050.92
4_L8_L1.1860.92
75_A101_A1.1860.92
122_A126_A1.1820.91
245_H248_V1.1780.91
174_V178_G1.1770.91
32_V35_T1.1740.91
29_R32_V1.1600.91
155_I163_A1.1550.90
47_G51_G1.1480.90
146_A150_M1.1440.90
59_L102_A1.1360.90
163_A166_A1.1270.89
67_A112_R1.1260.89
66_L183_G1.1240.89
225_G228_G1.1200.89
71_D74_I1.1190.89
166_A169_G1.1190.89
70_P101_A1.1160.89
216_F219_F1.1100.89
12_I33_A1.0980.88
111_V144_F1.0940.88
244_A247_A1.0750.87
171_I175_I1.0640.86
136_I140_T1.0590.86
219_F224_F1.0430.85
108_T112_R1.0380.85
96_V100_L1.0250.84
212_L219_F1.0220.84
246_G249_A1.0110.83
199_N207_F1.0090.83
239_M242_Q1.0080.83
59_L73_A1.0080.83
101_A191_Y1.0070.83
4_L7_I1.0040.83
41_L84_I1.0020.83
59_L76_S0.9980.83
178_G182_G0.9960.83
245_H249_A0.9940.82
6_I154_L0.9890.82
221_L225_G0.9750.81
126_A130_N0.9730.81
9_L77_V0.9680.81
9_L41_L0.9640.80
46_T49_I0.9620.80
5_Q40_V0.9600.80
5_Q85_T0.9490.79
83_V186_I0.9150.77
122_A137_M0.9130.77
45_K48_I0.9050.76
173_D176_T0.9050.76
102_A106_A0.9040.76
49_I52_G0.8980.75
54_L76_S0.8970.75
9_L40_V0.8890.75
71_D149_V0.8870.75
118_F144_F0.8830.74
38_G51_G0.8800.74
101_A142_M0.8790.74
131_I135_E0.8790.74
231_L234_L0.8770.74
71_D108_T0.8750.74
133_G137_M0.8750.74
63_N145_Q0.8750.74
244_A248_V0.8670.73
19_A70_P0.8670.73
208_Y230_C0.8650.73
88_Q92_E0.8650.73
49_I82_L0.8620.72
158_L162_S0.8580.72
4_L237_Q0.8530.72
234_L238_V0.8470.71
132_K135_E0.8460.71
172_P178_G0.8460.71
48_I51_G0.8430.71
229_L233_L0.8420.71
163_A167_F0.8410.71
33_A76_S0.8360.70
78_I82_L0.8350.70
56_L195_I0.8340.70
99_A102_A0.8310.70
114_I144_F0.8240.69
34_C66_L0.8220.69
58_A75_A0.8210.69
243_S248_V0.8200.69
123_D127_K0.8090.68
33_A77_V0.8090.68
91_G173_D0.7990.67
16_T33_A0.7990.67
91_G218_D0.7940.66
121_R136_I0.7920.66
31_L52_G0.7900.66
7_I10_L0.7890.66
78_I100_L0.7830.65
76_S80_T0.7830.65
9_L153_T0.7800.65
13_A194_V0.7790.65
154_L158_L0.7780.65
49_I56_L0.7710.64
37_V81_I0.7690.64
244_A249_A0.7690.64
162_S166_A0.7680.64
166_A170_N0.7650.63
169_G173_D0.7640.63
128_A133_G0.7640.63
203_L208_Y0.7610.63
132_K243_S0.7600.63
126_A131_I0.7590.63
205_P208_Y0.7550.62
217_T220_N0.7540.62
5_Q9_L0.7530.62
182_G186_I0.7500.62
56_L139_I0.7500.62
240_Q243_S0.7480.61
167_F208_Y0.7480.61
193_M198_M0.7480.61
217_T224_F0.7430.61
75_A82_L0.7400.61
7_I242_Q0.7400.61
55_E105_Q0.7390.61
216_F223_G0.7370.60
79_S83_V0.7290.60
12_I77_V0.7290.60
242_Q246_G0.7250.59
202_Y241_K0.7240.59
102_A105_Q0.7200.59
55_E197_M0.7120.58
13_A77_V0.7100.57
78_I156_V0.7100.57
156_V164_V0.7080.57
26_Q76_S0.7060.57
213_L227_L0.7020.57
243_S246_G0.6950.56
16_T28_H0.6890.55
70_P105_Q0.6880.55
113_T116_V0.6870.55
8_L11_I0.6850.55
172_P210_G0.6810.54
5_Q41_L0.6800.54
64_V68_M0.6770.54
86_A97_A0.6770.54
213_L231_L0.6760.54
233_L241_K0.6740.54
205_P233_L0.6740.54
75_A79_S0.6710.53
106_A109_I0.6690.53
155_I192_A0.6670.53
123_D134_I0.6610.52
4_L247_A0.6610.52
4_L147_L0.6610.52
116_V119_I0.6590.52
3_S6_I0.6590.52
147_L152_P0.6550.52
155_I227_L0.6530.51
164_V186_I0.6510.51
83_V89_G0.6500.51
56_L100_L0.6490.51
59_L71_D0.6480.51
34_C80_T0.6480.51
121_R133_G0.6410.50
21_V68_M0.6410.50
18_I142_M0.6400.50
87_D241_K0.6390.50
147_L151_I0.6380.50
23_D93_G0.6350.49
60_G125_Y0.6340.49
9_L12_I0.6340.49
243_S247_A0.6330.49
150_M168_L0.6330.49
105_Q109_I0.6330.49
84_I89_G0.6320.49
13_A17_G0.6320.49
91_G184_G0.6290.49
157_A191_Y0.6280.49
78_I81_I0.6270.48
5_Q8_L0.6270.48
31_L34_C0.6260.48
35_T39_L0.6240.48
54_L75_A0.6230.48
37_V84_I0.6230.48
81_I157_A0.6200.48
60_G178_G0.6200.48
59_L108_T0.6170.47
30_P207_F0.6150.47
106_A179_L0.6140.47
63_N149_V0.6130.47
80_T84_I0.6130.47
199_N204_K0.6110.47
160_S194_V0.6090.47
71_D105_Q0.6080.46
54_L74_I0.6080.46
12_I16_T0.6070.46
85_T157_A0.6060.46
19_A194_V0.6060.46
118_F121_R0.6050.46
104_G148_R0.6000.46
45_K169_G0.5980.45
242_Q245_H0.5960.45
231_L235_Y0.5940.45
154_L159_I0.5940.45
51_G210_G0.5930.45
113_T120_H0.5920.45
57_M79_S0.5900.44
60_G99_A0.5890.44
226_A229_L0.5880.44
199_N205_P0.5840.44
52_G182_G0.5830.44
15_I169_G0.5820.44
127_K246_G0.5820.44
238_V241_K0.5820.44
230_C233_L0.5770.43
82_L85_T0.5760.43
74_I149_V0.5760.43
82_L164_V0.5760.43
139_I142_M0.5740.43
104_G145_Q0.5730.43
53_T218_D0.5700.42
55_E216_F0.5690.42
103_A177_K0.5690.42
122_A239_M0.5690.42
60_G98_V0.5660.42
92_E157_A0.5630.42
10_L158_L0.5620.41
34_C41_L0.5580.41
240_Q244_A0.5580.41
129_G132_K0.5570.41
218_D248_V0.5540.41
109_I113_T0.5530.40
7_I135_E0.5530.40
135_E139_I0.5520.40
66_L196_N0.5520.40
104_G221_L0.5490.40
105_Q198_M0.5480.40
105_Q108_T0.5470.40
47_G81_I0.5460.40
72_T79_S0.5460.40
75_A104_G0.5450.40
52_G225_G0.5440.40
17_G149_V0.5430.39
118_F227_L0.5420.39
44_L48_I0.5410.39
35_T48_I0.5400.39
47_G64_V0.5400.39
237_Q241_K0.5400.39
124_Q242_Q0.5390.39
213_L219_F0.5390.39
52_G72_T0.5390.39
36_L47_G0.5380.39
21_V112_R0.5380.39
176_T179_L0.5360.39
67_A141_A0.5350.39
124_Q241_K0.5350.39
122_A134_I0.5340.39
227_L242_Q0.5340.39
113_T183_G0.5330.38
91_G94_I0.5320.38
16_T73_A0.5320.38
242_Q248_V0.5320.38
156_V188_V0.5320.38
56_L228_G0.5310.38
68_M72_T0.5300.38
6_I157_A0.5290.38
16_T27_T0.5280.38
30_P94_I0.5280.38
77_V81_I0.5270.38
180_Q220_N0.5270.38
43_D247_A0.5270.38
5_Q155_I0.5250.38
37_V80_T0.5250.38
62_M83_V0.5240.37
105_Q220_N0.5230.37
78_I102_A0.5220.37
209_I227_L0.5220.37
35_T55_E0.5210.37
233_L240_Q0.5200.37
74_I153_T0.5200.37
71_D98_V0.5190.37
189_V236_Q0.5180.37
58_A70_P0.5180.37
95_A98_V0.5170.37
81_I194_V0.5170.37
52_G214_A0.5160.37
9_L94_I0.5120.36
25_G59_L0.5100.36
90_I130_N0.5100.36
173_D218_D0.5090.36
24_E62_M0.5080.36
218_D231_L0.5070.36
109_I112_R0.5060.36
207_F223_G0.5060.36
48_I53_T0.5050.36
127_K249_A0.5050.36
17_G94_I0.5040.35
162_S173_D0.5040.35
19_A207_F0.5000.35
87_D114_I0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7aA 1 0 55 0.955 Contact Map
4k1cA 4 0.632 51.1 0.956 Contact Map
4kjrA 3 0.4833 47.2 0.957 Contact Map
3qnqA 2 0.8587 44.5 0.958 Contact Map
3l1lA 2 0.8699 34.8 0.96 Contact Map
3giaA 1 0.8996 28.6 0.962 Contact Map
3qe7A 2 0.7807 28 0.962 Contact Map
2jlnA 1 0.8104 20.1 0.965 Contact Map
4a01A 2 0.1599 18.7 0.965 Contact Map
2cavA 3 0.0595 11.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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