GREMLIN Database
PTFB - Fructose-specific phosphotransferase enzyme IIB component
UniProt: P26380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (154)
Sequences: 1637 (1114)
Seq/√Len: 89.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_S89_D4.3971.00
95_E133_T4.0421.00
67_A96_A2.9491.00
102_T140_K2.8951.00
90_I103_V2.7021.00
91_V95_E2.6141.00
125_E129_K2.6071.00
64_S68_K2.5411.00
91_V133_T2.4891.00
95_E137_K2.4841.00
84_F90_I2.3611.00
91_V130_A2.2501.00
115_R128_I2.1101.00
36_D92_S2.0881.00
63_V92_S1.9971.00
94_I134_L1.9551.00
64_S92_S1.9401.00
117_I123_V1.9101.00
140_K151_S1.8841.00
52_A58_A1.8541.00
84_F93_L1.8311.00
28_A81_M1.8011.00
88_S130_A1.7691.00
5_V79_T1.7431.00
88_S126_Q1.7061.00
27_A79_T1.6981.00
23_I56_V1.6891.00
44_R85_E1.6851.00
129_K133_T1.6701.00
115_R125_E1.6401.00
153_D156_Q1.6201.00
35_S85_E1.5691.00
9_I131_F1.5621.00
39_A62_S1.5131.00
111_E114_R1.4981.00
135_S155_V1.4480.99
133_T136_D1.4410.99
9_I105_V1.4150.99
116_Q122_S1.4060.99
105_V131_F1.4000.99
87_P108_M1.3870.99
102_T151_S1.3850.99
94_I100_I1.3810.99
9_I87_P1.3670.99
42_E45_K1.3640.99
140_K153_D1.3490.99
23_I31_I1.3450.99
11_D107_G1.3430.99
7_A90_I1.3350.99
102_T142_E1.3250.99
30_R59_S1.3190.99
107_G120_S1.2830.99
87_P130_A1.2590.98
5_V26_H1.2490.98
133_T137_K1.2230.98
124_T127_D1.1750.98
64_S96_A1.1710.98
126_Q129_K1.1710.98
114_R124_T1.1520.97
61_V69_A1.1270.97
144_R147_P1.1250.97
92_S95_E1.1190.97
144_R151_S1.1110.97
92_S96_A1.1110.97
132_E136_D1.1060.96
11_D109_R1.1040.96
21_R147_P1.0990.96
87_P131_F1.0980.96
135_S141_L1.0930.96
34_V66_M1.0870.96
30_R78_V1.0860.96
41_D44_R1.0810.96
14_I48_I1.0540.95
73_P76_E1.0400.95
21_R148_S1.0300.95
14_I58_A1.0280.95
65_K68_K1.0100.94
131_F141_L1.0090.94
37_D41_D1.0070.94
88_S92_S0.9690.93
63_V89_D0.9640.93
14_I33_V0.9550.92
91_V137_K0.9460.92
105_V143_L0.9400.92
36_D63_V0.9380.92
108_M131_F0.9360.92
108_M123_V0.9190.91
7_A100_I0.9140.91
126_Q130_A0.9130.90
29_D79_T0.9070.90
86_N89_D0.9010.90
69_A72_S0.8960.90
11_D14_I0.8920.89
34_V89_D0.8820.89
7_A84_F0.8790.89
5_V28_A0.8750.89
67_A71_H0.8750.89
7_A82_L0.8680.88
116_Q119_K0.8580.88
120_S145_Q0.8530.87
118_T121_V0.8510.87
61_V72_S0.8490.87
110_F113_H0.8480.87
40_Q62_S0.8420.87
108_M121_V0.8390.86
38_I44_R0.8370.86
14_I52_A0.8360.86
62_S65_K0.8310.86
110_F122_S0.8230.85
89_D92_S0.8100.84
68_K71_H0.8070.84
19_L23_I0.7980.83
131_F154_F0.7900.83
31_I52_A0.7900.83
94_I137_K0.7900.83
143_L157_I0.7890.83
46_T50_S0.7840.82
6_L81_M0.7810.82
101_K140_K0.7800.82
105_V141_L0.7740.82
135_S153_D0.7730.81
114_R127_D0.7670.81
32_I69_A0.7540.80
21_R25_V0.7520.80
45_K60_A0.7450.79
109_R114_R0.7450.79
70_F99_P0.7340.78
142_E151_S0.7330.78
32_I84_F0.7240.77
36_D62_S0.7220.77
24_K55_N0.7140.76
30_R80_A0.7120.76
6_L26_H0.7120.76
81_M149_D0.7110.76
44_R48_I0.7100.76
38_I48_I0.7090.76
130_A133_T0.7050.75
94_I103_V0.7040.75
13_F83_L0.7040.75
67_A92_S0.7030.75
43_M47_L0.7000.75
68_K72_S0.6980.74
71_H96_A0.6890.73
29_D78_V0.6800.73
99_P137_K0.6770.72
69_A73_P0.6760.72
36_D89_D0.6720.72
24_K83_L0.6710.72
70_F93_L0.6690.71
129_K132_E0.6580.70
115_R157_I0.6560.70
31_I83_L0.6560.70
63_V96_A0.6510.69
59_S69_A0.6500.69
121_V143_L0.6490.69
45_K49_L0.6480.69
49_L60_A0.6470.69
123_V131_F0.6450.69
119_K149_D0.6440.68
38_I104_N0.6400.68
19_L51_V0.6320.67
16_G106_G0.6280.66
47_L52_A0.6260.66
61_V65_K0.6220.66
49_L58_A0.6190.65
34_V63_V0.6180.65
65_K69_A0.6180.65
40_Q83_L0.6080.64
11_D85_E0.6040.63
83_L122_S0.5970.63
105_V154_F0.5910.62
69_A74_R0.5870.61
82_L90_I0.5870.61
56_V81_M0.5860.61
37_D85_E0.5860.61
34_V93_L0.5850.61
19_L53_P0.5850.61
79_T143_L0.5840.61
141_L157_I0.5820.61
114_R122_S0.5820.61
61_V75_Y0.5820.61
62_S93_L0.5810.60
123_V128_I0.5810.60
107_G145_Q0.5800.60
64_S67_A0.5750.60
37_D44_R0.5750.60
126_Q155_V0.5750.60
66_M70_F0.5720.59
100_I131_F0.5720.59
83_L154_F0.5700.59
5_V27_A0.5680.59
113_H124_T0.5680.59
59_S75_Y0.5650.58
94_I139_V0.5640.58
73_P80_A0.5620.58
109_R120_S0.5610.58
24_K27_A0.5590.58
103_V139_V0.5560.57
9_I30_R0.5520.57
17_Q107_G0.5510.56
14_I28_A0.5480.56
18_I23_I0.5480.56
123_V155_V0.5470.56
20_T122_S0.5460.56
24_K28_A0.5450.56
135_S154_F0.5440.56
71_H99_P0.5420.55
25_V148_S0.5340.54
144_R149_D0.5320.54
129_K136_D0.5310.54
93_L98_V0.5290.53
66_M80_A0.5280.53
14_I83_L0.5240.53
37_D42_E0.5200.52
67_A100_I0.5190.52
6_L20_T0.5180.52
72_S75_Y0.5180.52
29_D96_A0.5150.52
118_T143_L0.5140.51
136_D155_V0.5140.51
14_I107_G0.5130.51
20_T52_A0.5120.51
108_M122_S0.5070.50
62_S66_M0.5060.50
59_S78_V0.5060.50
8_R12_R0.5050.50
11_D108_M0.5040.50
93_L97_G0.5040.50
65_K112_N0.5030.50
34_V67_A0.5020.50
32_I73_P0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bleA 3 0.9877 100 0.035 Contact Map
3lfjA 1 1 100 0.038 Contact Map
1nrzA 2 0.9939 100 0.054 Contact Map
1vsqC 1 1 100 0.055 Contact Map
3p3vA 1 0.9755 100 0.085 Contact Map
3eyeA 1 0.9325 100 0.095 Contact Map
3hl4A 2 0.4908 34.4 0.936 Contact Map
3co8A 2 0.8344 29.3 0.938 Contact Map
3dnfA 2 0.6564 22.9 0.942 Contact Map
2wk1A 2 0.454 21.3 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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