GREMLIN Database
PTFA - Fructose-specific phosphotransferase enzyme IIA component
UniProt: P26379 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (130)
Sequences: 2273 (1692)
Seq/√Len: 148.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_G26_E3.5981.00
11_D14_I2.9561.00
16_L92_V2.8951.00
31_I54_D2.8531.00
108_A111_D2.7501.00
39_E47_K2.7081.00
14_I34_P2.6001.00
99_E119_M2.3761.00
12_F16_L2.3631.00
15_A18_E2.3571.00
8_G92_V2.2721.00
100_V116_L2.1771.00
31_I51_A1.9951.00
17_K32_A1.8631.00
17_K30_L1.8231.00
6_I92_V1.7881.00
64_L100_V1.7511.00
6_I17_K1.7321.00
17_K21_G1.6931.00
63_F86_M1.6661.00
45_Q78_S1.6611.00
11_D15_A1.6331.00
35_F44_L1.6221.00
46_E50_Q1.6181.00
8_G13_P1.5951.00
87_D126_V1.5941.00
24_F102_S1.5631.00
19_S94_L1.5371.00
65_V73_Y1.5311.00
48_Y76_A1.5311.00
3_S31_I1.4631.00
20_S101_L1.3981.00
96_I124_F1.3961.00
13_P34_P1.3901.00
3_S55_I1.3841.00
45_Q75_A1.3821.00
89_A117_K1.3561.00
7_S48_Y1.3521.00
30_L101_L1.3481.00
64_L97_L1.3371.00
29_N57_E1.3081.00
43_T46_E1.2981.00
49_H53_K1.2901.00
49_H82_E1.2891.00
87_D110_K1.2881.00
68_F125_Q1.2751.00
118_A122_Q1.2301.00
33_V51_A1.1811.00
76_A88_M1.1501.00
8_G16_L1.1401.00
80_I88_M1.1391.00
114_N129_E1.1330.99
93_N124_F1.1250.99
20_S97_L1.1140.99
63_F76_A1.1060.99
21_G27_E1.1040.99
11_D34_P1.0980.99
8_G12_F1.0640.99
4_V96_I1.0560.99
50_Q54_D1.0550.99
5_I63_F1.0530.99
64_L96_I1.0450.99
73_Y127_C1.0380.99
68_F90_A1.0380.99
10_G19_S1.0200.99
62_L100_V1.0100.99
5_I51_A0.9980.99
36_F39_E0.9800.99
120_S123_S0.9730.98
120_S124_F0.9690.98
77_A127_C0.9680.98
3_S51_A0.9680.98
62_L109_L0.9460.98
2_I104_R0.9420.98
117_K129_E0.9380.98
3_S61_V0.9240.98
10_G22_M0.9210.98
117_K121_Q0.9050.98
8_G34_P0.9010.97
99_E103_L0.9000.97
96_I120_S0.8920.97
64_L92_V0.8810.97
4_V100_V0.8730.97
2_I60_E0.8630.97
6_I97_L0.8610.97
23_I94_L0.8520.96
45_Q49_H0.8420.96
11_D18_E0.8390.96
90_A125_Q0.8290.96
5_I55_I0.8280.96
113_L126_V0.8270.96
43_T47_K0.8170.95
33_V40_G0.8110.95
47_K50_Q0.8100.95
5_I48_Y0.8060.95
19_S70_G0.8020.95
5_I33_V0.7980.95
2_I109_L0.7970.95
72_P76_A0.7950.95
3_S29_N0.7900.95
126_V129_E0.7880.94
109_L113_L0.7830.94
83_D86_M0.7800.94
79_F82_E0.7790.94
41_I71_T0.7770.94
18_E21_G0.7720.94
92_V97_L0.7720.94
106_H111_D0.7660.94
50_Q53_K0.7590.93
14_I32_A0.7560.93
58_E61_V0.7540.93
45_Q82_E0.7530.93
55_I61_V0.7520.93
4_V101_L0.7510.93
55_I58_E0.7410.92
22_M37_K0.7360.92
36_F71_T0.7340.92
44_L71_T0.7300.92
27_E104_R0.7270.92
64_L93_N0.7260.92
14_I18_E0.7250.92
78_S82_E0.7190.91
71_T74_N0.7160.91
35_F73_Y0.7120.91
20_S30_L0.7120.91
96_I123_S0.7100.91
23_I102_S0.7090.91
40_G43_T0.6890.89
107_L115_N0.6880.89
75_A78_S0.6830.89
49_H83_D0.6810.89
29_N104_R0.6780.89
51_A54_D0.6770.89
24_F98_L0.6750.89
49_H79_F0.6740.88
12_F19_S0.6710.88
60_E85_R0.6670.88
88_M127_C0.6640.88
3_S60_E0.6620.88
46_E49_H0.6590.87
121_Q124_F0.6550.87
99_E115_N0.6350.85
33_V48_Y0.6340.85
19_S23_I0.6330.85
118_A121_Q0.6330.85
125_Q130_H0.6090.83
47_K51_A0.6070.83
48_Y75_A0.6050.82
68_F88_M0.5980.82
59_H108_A0.5980.82
117_K126_V0.5940.81
115_N118_A0.5910.81
35_F72_P0.5890.81
87_D113_L0.5880.81
7_S35_F0.5870.81
22_M74_N0.5830.80
116_L119_M0.5810.80
41_I44_L0.5810.80
11_D36_F0.5730.79
12_F15_A0.5720.79
60_E109_L0.5700.79
68_F127_C0.5600.77
119_M122_Q0.5600.77
12_F94_L0.5590.77
8_G14_I0.5560.77
89_A120_S0.5500.76
128_S131_L0.5500.76
87_D128_S0.5500.76
117_K124_F0.5490.76
111_D115_N0.5480.76
5_I61_V0.5480.76
101_L104_R0.5470.76
35_F71_T0.5440.75
62_L89_A0.5420.75
54_D114_N0.5390.75
3_S58_E0.5380.75
48_Y79_F0.5330.74
114_N118_A0.5330.74
35_F75_A0.5320.74
21_G25_G0.5290.73
56_P61_V0.5280.73
68_F130_H0.5260.73
93_N120_S0.5230.72
56_P60_E0.5220.72
119_M123_S0.5210.72
15_A19_S0.5200.72
15_A20_S0.5190.72
6_I30_L0.5180.72
20_S24_F0.5110.71
48_Y63_F0.5080.70
34_P44_L0.5040.70
68_F73_Y0.5030.70
11_D19_S0.5030.70
27_E30_L0.5020.69
2_I112_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iprA 2 0.9178 100 0.205 Contact Map
3mtqA 2 0.911 100 0.213 Contact Map
3lfhA 2 0.9658 100 0.217 Contact Map
1pdoA 2 0.8767 100 0.225 Contact Map
3bedA 4 0.8836 100 0.228 Contact Map
4tkzA 2 0.8699 100 0.231 Contact Map
3gx1A 2 0.8219 100 0.34 Contact Map
3gdwA 2 0.8904 100 0.36 Contact Map
3ct6A 2 0.8493 99.9 0.375 Contact Map
3b48A 2 0.8425 99.9 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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