GREMLIN Database
SACT - SacPA operon antiterminator
UniProt: P26212 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (264)
Sequences: 3643 (3156)
Seq/√Len: 194.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_K144_S4.6141.00
81_E132_W4.2751.00
249_K255_H3.0511.00
227_L262_G2.9691.00
185_K191_K2.9211.00
187_Y243_E2.9161.00
231_Q238_Y2.8101.00
231_Q258_E2.7771.00
237_A269_Q2.7601.00
103_E107_N2.7471.00
179_E251_E2.5171.00
73_D140_T2.4911.00
37_L41_N2.4721.00
241_A265_T2.4381.00
28_I33_K2.3301.00
131_L150_A2.2621.00
184_I202_L2.2351.00
74_I133_A2.1511.00
97_H156_H2.1151.00
26_P30_F2.0801.00
27_G30_F2.0781.00
7_L13_L2.0591.00
30_F33_K1.9951.00
183_K247_F1.9911.00
216_N254_L1.9901.00
77_Y136_H1.9851.00
241_A261_A1.9621.00
37_L40_M1.9581.00
11_A15_K1.9551.00
212_R260_E1.9121.00
39_P42_K1.8931.00
245_A261_A1.8221.00
237_A241_A1.7971.00
242_L258_E1.7871.00
178_K199_Y1.7651.00
128_E131_L1.7621.00
77_Y132_W1.7341.00
184_I268_V1.7261.00
14_I21_K1.6931.00
78_A133_A1.6761.00
131_L147_E1.6531.00
195_N271_L1.6521.00
188_F240_C1.5951.00
237_A268_V1.5761.00
105_I145_L1.5561.00
116_L151_G1.5451.00
19_Q23_V1.5211.00
7_L11_A1.5191.00
19_Q30_F1.5151.00
184_I240_C1.5071.00
182_E186_Q1.5041.00
180_M244_L1.5021.00
11_A16_E1.4931.00
41_N44_E1.4881.00
239_Q242_L1.4861.00
12_A15_K1.4851.00
134_I138_K1.4651.00
93_A156_H1.4651.00
20_E27_G1.4641.00
105_I146_P1.4591.00
229_F233_K1.4551.00
27_G31_Q1.4491.00
242_L261_A1.4011.00
11_A14_I1.3961.00
245_A264_I1.3881.00
246_E249_K1.3781.00
205_H267_H1.3761.00
7_L15_K1.3741.00
210_V214_E1.3721.00
224_E262_G1.3651.00
181_I199_Y1.3541.00
19_Q28_I1.3541.00
64_P67_H1.3531.00
230_I265_T1.3521.00
78_A129_I1.3501.00
26_P33_K1.3481.00
36_D40_M1.3471.00
10_N15_K1.3361.00
134_I150_A1.2891.00
16_E19_Q1.2791.00
198_S271_L1.2751.00
79_E86_L1.2671.00
241_A245_A1.2571.00
70_I140_T1.2331.00
21_K30_F1.2301.00
8_N16_E1.2251.00
89_H93_A1.2211.00
130_G150_A1.2191.00
8_N11_A1.2171.00
209_A213_L1.1981.00
219_L263_Y1.1871.00
20_E28_I1.1821.00
8_N15_K1.1731.00
19_Q33_K1.1721.00
192_V268_V1.1701.00
75_I95_S1.1671.00
102_I106_Q1.1631.00
126_E154_A1.1621.00
220_H259_S1.1591.00
45_K49_V1.1531.00
40_M44_E1.1421.00
10_N14_I1.1291.00
259_S262_G1.1231.00
184_I241_A1.1191.00
93_A97_H1.1171.00
67_H71_A1.1141.00
175_T251_E1.1071.00
74_I78_A1.1061.00
19_Q26_P1.0971.00
227_L258_E1.0961.00
206_L209_A1.0901.00
209_A257_P1.0871.00
225_E259_S1.0861.00
67_H99_S1.0841.00
146_P149_E1.0841.00
71_A75_I1.0811.00
38_I41_N1.0611.00
102_I145_L1.0581.00
37_L44_E1.0511.00
228_Y232_K1.0471.00
99_S103_E1.0451.00
26_P29_A1.0381.00
183_K186_Q1.0251.00
173_H210_V1.0221.00
209_A256_L1.0211.00
70_I141_L1.0131.00
23_V26_P1.0131.00
241_A268_V1.0121.00
224_E259_S1.0111.00
34_K37_L1.0091.00
37_L42_K1.0071.00
238_Y265_T1.0051.00
130_G154_A0.9971.00
242_L246_E0.9820.99
16_E21_K0.9820.99
192_V271_L0.9820.99
127_Y150_A0.9690.99
74_I136_H0.9680.99
98_L153_I0.9670.99
77_Y81_E0.9660.99
157_I161_K0.9640.99
10_N13_L0.9640.99
241_A264_I0.9580.99
40_M46_I0.9540.99
21_K26_P0.9510.99
44_E49_V0.9490.99
241_A244_L0.9490.99
46_I49_V0.9450.99
43_V47_F0.9400.99
238_Y258_E0.9390.99
67_H70_I0.9380.99
124_K127_Y0.9380.99
130_G133_A0.9350.99
135_G144_S0.9350.99
177_I203_V0.9350.99
138_K141_L0.9330.99
20_E32_K0.9300.99
20_E33_K0.9290.99
177_I180_M0.9270.99
244_L268_V0.9220.99
79_E82_L0.9190.99
8_N14_I0.9150.99
12_A29_A0.9140.99
238_Y242_L0.9110.99
248_L252_Y0.9070.99
127_Y154_A0.9050.99
72_E92_I0.9020.99
98_L137_V0.9000.99
199_Y203_V0.8970.99
91_H95_S0.8960.99
127_Y131_L0.8950.99
78_A157_I0.8910.99
90_I160_A0.8900.99
227_L238_Y0.8890.99
209_A212_R0.8880.99
262_G265_T0.8870.99
179_E247_F0.8870.99
110_L146_P0.8770.99
154_A158_H0.8770.99
137_V145_L0.8730.99
70_I74_I0.8720.99
26_P31_Q0.8670.99
240_C244_L0.8650.99
25_G31_Q0.8610.99
230_I262_G0.8580.99
16_E20_E0.8550.99
72_E91_H0.8490.98
12_A23_V0.8460.98
76_S91_H0.8440.98
82_L132_W0.8440.98
46_I50_R0.8360.98
71_A98_L0.8360.98
134_I153_I0.8340.98
132_W135_G0.8340.98
244_L247_F0.8330.98
27_G33_K0.8290.98
46_I53_N0.8290.98
67_H102_I0.8280.98
269_Q272_Q0.8260.98
133_A136_H0.8260.98
138_K145_L0.8170.98
40_M43_V0.8150.98
210_V252_Y0.8140.98
185_K192_V0.8110.98
188_F192_V0.8080.98
245_A256_L0.8080.98
185_K195_N0.8040.98
70_I136_H0.8040.98
69_E72_E0.8030.98
132_W136_H0.8010.98
20_E30_F0.8000.98
15_K18_D0.8000.98
187_Y240_C0.7960.98
127_Y151_G0.7940.98
201_R270_R0.7930.98
131_L135_G0.7930.98
267_H270_R0.7900.98
204_T208_Y0.7890.98
116_L152_Y0.7860.97
183_K187_Y0.7850.97
263_Y267_H0.7850.97
180_M247_F0.7840.97
36_D41_N0.7830.97
12_A38_I0.7790.97
246_E250_N0.7790.97
247_F251_E0.7770.97
21_K33_K0.7760.97
237_A272_Q0.7750.97
213_L254_L0.7750.97
184_I188_F0.7740.97
69_E73_D0.7730.97
237_A265_T0.7710.97
113_N119_I0.7690.97
113_N151_G0.7640.97
84_A266_L0.7590.97
225_E229_F0.7590.97
202_L264_I0.7590.97
122_L147_E0.7570.97
160_A209_A0.7470.97
31_Q37_L0.7410.96
180_M268_V0.7410.96
106_Q142_G0.7400.96
208_Y211_S0.7370.96
14_I23_V0.7330.96
176_M180_M0.7300.96
179_E182_E0.7290.96
225_E233_K0.7260.96
177_I206_L0.7180.96
170_A174_T0.7130.96
238_Y241_A0.7070.95
86_L157_I0.7060.95
197_I201_R0.7030.95
41_N45_K0.7020.95
114_K155_L0.7010.95
23_V30_F0.7000.95
134_I137_V0.6990.95
84_A161_K0.6950.95
80_G83_A0.6920.95
101_A105_I0.6900.95
72_E76_S0.6890.95
20_E26_P0.6890.95
97_H101_A0.6880.95
54_E57_K0.6880.95
39_P43_V0.6880.95
31_Q35_N0.6880.95
37_L43_V0.6860.94
104_R152_Y0.6850.94
125_K128_E0.6840.94
149_E263_Y0.6840.94
236_F241_A0.6830.94
44_E47_F0.6790.94
119_I151_G0.6770.94
28_I31_Q0.6770.94
201_R267_H0.6760.94
9_N15_K0.6750.94
201_R271_L0.6710.94
207_R211_S0.6690.94
177_I181_I0.6680.94
7_L12_A0.6640.93
167_M170_A0.6640.93
174_T203_V0.6580.93
24_M30_F0.6540.93
20_E35_N0.6540.93
11_A24_M0.6540.93
198_S202_L0.6520.93
192_V198_S0.6520.93
251_E254_L0.6490.93
63_L99_S0.6480.93
20_E31_Q0.6470.93
22_I27_G0.6470.93
227_L231_Q0.6450.92
33_K37_L0.6440.92
20_E23_V0.6440.92
248_L254_L0.6420.92
30_F37_L0.6410.92
7_L16_E0.6410.92
78_A132_W0.6410.92
136_H139_E0.6400.92
21_K25_G0.6380.92
78_A136_H0.6380.92
102_I137_V0.6360.92
86_L90_I0.6360.92
67_H106_Q0.6350.92
225_E262_G0.6340.92
12_A33_K0.6230.91
178_K182_E0.6210.91
105_I110_L0.6210.91
239_Q243_E0.6190.91
236_F239_Q0.6180.91
103_E106_Q0.6180.91
176_M206_L0.6120.90
9_N16_E0.6110.90
31_Q34_K0.6110.90
76_S79_E0.6110.90
77_Y129_I0.6110.90
182_E193_D0.6100.90
105_I149_E0.6070.90
229_F232_K0.6070.90
169_S172_K0.6050.90
113_N148_D0.6050.90
82_L86_L0.6040.90
183_K244_L0.6020.90
12_A28_I0.6020.90
19_Q22_I0.5960.89
183_K243_E0.5960.89
182_E185_K0.5950.89
73_D77_Y0.5930.89
89_H160_A0.5920.89
58_Q61_Q0.5920.89
219_L259_S0.5920.89
43_V46_I0.5910.89
173_H203_V0.5880.89
188_F191_K0.5870.89
241_A254_L0.5870.89
133_A157_I0.5860.88
113_N118_E0.5850.88
188_F244_L0.5830.88
269_Q273_D0.5820.88
71_A95_S0.5810.88
82_L126_E0.5800.88
234_Y269_Q0.5790.88
76_S80_G0.5780.88
136_H140_T0.5770.88
175_T179_E0.5710.87
137_V141_L0.5690.87
117_H121_A0.5690.87
238_Y261_A0.5660.87
205_H263_Y0.5660.87
15_K21_K0.5660.87
127_Y147_E0.5650.87
22_I30_F0.5640.86
242_L245_A0.5630.86
148_D151_G0.5600.86
66_E140_T0.5600.86
153_I156_H0.5540.86
38_I45_K0.5520.85
10_N30_F0.5470.85
14_I22_I0.5450.85
65_E69_E0.5440.84
231_Q262_G0.5410.84
229_F234_Y0.5410.84
25_G30_F0.5380.84
131_L144_S0.5370.84
176_M252_Y0.5370.84
227_L259_S0.5340.83
127_Y158_H0.5340.83
224_E228_Y0.5330.83
75_I133_A0.5310.83
181_I185_K0.5290.83
81_E125_K0.5280.83
180_M241_A0.5280.83
181_I268_V0.5260.82
213_L257_P0.5210.82
195_N273_D0.5210.82
124_K154_A0.5190.82
204_T259_S0.5170.81
126_E155_L0.5160.81
249_K252_Y0.5140.81
106_Q135_G0.5130.81
248_L256_L0.5120.81
82_L129_I0.5110.81
27_G39_P0.5110.81
12_A21_K0.5110.81
21_K28_I0.5110.81
27_G35_N0.5100.81
74_I77_Y0.5090.80
104_R149_E0.5070.80
102_I143_V0.5070.80
173_H177_I0.5070.80
90_I209_A0.5060.80
12_A30_F0.5040.80
174_T199_Y0.5040.80
130_G157_I0.5030.80
212_R219_L0.5030.80
28_I35_N0.5000.79
240_C268_V0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6iA 2 0.9601 100 0.332 Contact Map
1h99A 2 0.7971 100 0.361 Contact Map
3sqnA 2 0.9239 100 0.459 Contact Map
3rioA 1 0.5978 99.9 0.599 Contact Map
3ufeA 2 0.3877 99.7 0.667 Contact Map
3nufA 2 0.4275 92.1 0.902 Contact Map
1auuA 2 0.1993 89.7 0.907 Contact Map
1l1cA 2 0.1957 89.5 0.908 Contact Map
1wwpA 2 0.2572 9.3 0.954 Contact Map
1wtyA 4 0.2609 8.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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