GREMLIN Database
PYRDB - Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
UniProt: P25996 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (286)
Sequences: 5103 (2986)
Seq/√Len: 176.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_A279_Q3.7551.00
77_D112_H3.6261.00
5_K10_D3.5421.00
269_N275_E3.4991.00
3_E10_D3.0091.00
111_E155_V2.9211.00
146_A180_E2.8941.00
7_P161_Y2.8131.00
11_L259_A2.6341.00
172_T232_M2.5631.00
146_A181_A2.5621.00
289_Y295_C2.4801.00
222_A252_F2.3971.00
230_S258_S2.3371.00
244_Q248_D2.3321.00
153_K184_D2.3291.00
45_T79_V2.3241.00
188_M229_V2.2911.00
219_K251_E2.2901.00
223_I252_F2.2231.00
161_Y185_G2.1711.00
153_K160_V2.1591.00
145_A178_I2.0991.00
245_T248_D2.0861.00
13_N38_G2.0631.00
226_V237_I2.0101.00
219_K248_D1.9451.00
230_S237_I1.9041.00
179_E235_I1.8731.00
13_N277_I1.8731.00
24_F74_P1.8561.00
291_S294_E1.8441.00
243_V260_V1.8281.00
290_Q294_E1.7681.00
110_A122_L1.7611.00
95_I121_A1.7611.00
293_E296_I1.7501.00
282_S286_Q1.7301.00
283_V287_Y1.7171.00
219_K252_F1.6891.00
187_T240_M1.6811.00
250_L287_Y1.6701.00
179_E234_N1.6631.00
16_I41_M1.6501.00
175_A229_V1.6331.00
262_V276_I1.6281.00
253_L296_I1.6221.00
243_V252_F1.6061.00
76_L112_H1.5971.00
107_V155_V1.5821.00
63_A216_P1.5821.00
176_L180_E1.5741.00
247_E251_E1.5721.00
249_A276_I1.5621.00
9_L121_A1.5591.00
258_S296_I1.5481.00
284_L295_C1.5481.00
126_I145_A1.5431.00
247_E283_V1.5241.00
200_K287_Y1.5231.00
74_P78_S1.5041.00
170_N173_E1.5011.00
142_P173_E1.4921.00
253_L295_C1.4861.00
76_L113_I1.4711.00
98_V110_A1.4521.00
236_P258_S1.4481.00
16_I39_A1.4331.00
192_L221_V1.4321.00
103_V147_D1.4311.00
110_A152_V1.4281.00
15_I277_I1.4241.00
161_Y238_I1.4231.00
172_T228_E1.4181.00
46_T99_A1.4111.00
114_S156_S1.4091.00
189_I192_L1.4071.00
98_V109_V1.3981.00
114_S157_D1.3901.00
253_L292_I1.3811.00
186_L233_V1.3671.00
5_K8_G1.3541.00
249_A280_L1.3501.00
226_V239_G1.3501.00
96_A119_V1.3471.00
146_A150_K1.3411.00
194_G221_V1.3331.00
249_A260_V1.3231.00
78_S82_H1.2951.00
44_A97_N1.2831.00
108_E112_H1.2791.00
44_A99_A1.2771.00
197_L255_A1.2741.00
77_D81_H1.2581.00
107_V151_A1.2581.00
124_L152_V1.2551.00
281_P285_L1.2531.00
32_Y92_T1.2531.00
15_I276_I1.2521.00
64_G217_A1.2511.00
47_K101_S1.2431.00
143_E147_D1.2351.00
274_P278_E1.2321.00
177_A181_A1.2281.00
239_G252_F1.2271.00
250_L283_V1.2271.00
15_I243_V1.2181.00
108_E111_E1.2131.00
6_L259_A1.2091.00
41_M261_A1.2081.00
47_K109_V1.2011.00
42_I96_A1.1991.00
284_L289_Y1.1901.00
58_V69_I1.1881.00
250_L280_L1.1861.00
76_L109_V1.1851.00
152_V160_V1.1711.00
219_K223_I1.1671.00
275_E279_Q1.1421.00
224_R228_E1.1381.00
277_I281_P1.1331.00
149_T162_V1.1311.00
63_A269_N1.1311.00
103_V151_A1.1291.00
103_V107_V1.1251.00
200_K286_Q1.1241.00
113_I122_L1.1221.00
176_L232_M1.1151.00
246_A250_L1.1101.00
240_M261_A1.1051.00
122_L158_V1.0981.00
150_K181_A1.0971.00
102_Q105_D1.0951.00
230_S297_G1.0931.00
250_L254_L1.0911.00
80_L112_H1.0871.00
192_L218_V1.0761.00
12_K91_D1.0731.00
238_I259_A1.0731.00
16_I261_A1.0641.00
42_I79_V1.0621.00
168_V174_I1.0551.00
46_T50_R1.0511.00
246_A276_I1.0501.00
283_V286_Q1.0501.00
199_L250_L1.0431.00
283_V289_Y1.0370.99
244_Q265_A1.0350.99
87_L120_H1.0330.99
278_E282_S1.0270.99
216_P244_Q1.0230.99
226_V252_F1.0210.99
164_L229_V1.0130.99
141_N144_M1.0000.99
247_E279_Q0.9990.99
138_F170_N0.9910.99
223_I255_A0.9900.99
81_H84_L0.9860.99
18_A263_G0.9830.99
151_A154_E0.9830.99
67_N191_T0.9820.99
37_L273_C0.9800.99
69_I73_N0.9750.99
162_V183_A0.9700.99
62_G201_T0.9690.99
7_P185_G0.9570.99
147_D150_K0.9510.99
107_V111_E0.9430.99
171_I229_V0.9390.99
246_A283_V0.9370.99
6_L161_Y0.9270.99
74_P82_H0.9260.99
147_D151_A0.9220.99
71_L99_A0.9220.99
16_I259_A0.9220.99
102_Q132_K0.9160.99
12_K92_T0.9140.99
25_G79_V0.9120.99
9_L93_P0.9080.99
31_F40_I0.9050.99
161_Y187_T0.9030.99
216_P219_K0.8920.98
104_D108_E0.8910.98
191_T214_S0.8890.98
100_G123_E0.8870.98
188_M225_M0.8850.98
114_S158_V0.8810.98
189_I222_A0.8750.98
198_D201_T0.8740.98
29_S89_Q0.8720.98
189_I218_V0.8640.98
6_L238_I0.8640.98
124_L162_V0.8640.98
47_K108_E0.8640.98
202_G287_Y0.8570.98
266_N273_C0.8540.98
62_G198_D0.8460.98
142_P177_A0.8440.98
17_P37_L0.8400.98
282_S285_L0.8370.98
150_K154_E0.8350.98
279_Q283_V0.8330.98
138_F141_N0.8250.97
107_V154_E0.8250.97
41_M187_T0.8200.97
96_A113_I0.8200.97
254_L287_Y0.8100.97
48_E101_S0.8070.97
258_S297_G0.8070.97
196_R199_L0.8050.97
101_S109_V0.8040.97
80_L113_I0.8030.97
15_I262_V0.8030.97
118_N158_V0.8020.97
228_E232_M0.8020.97
18_A261_A0.8000.97
175_A233_V0.8000.97
220_P224_R0.7960.97
128_C131_V0.7960.97
172_T229_V0.7950.97
278_E281_P0.7930.97
17_P273_C0.7930.97
226_V255_A0.7920.97
58_V65_M0.7890.97
41_M97_N0.7890.97
144_M147_D0.7870.97
202_G254_L0.7840.97
74_P79_V0.7830.97
78_S81_H0.7810.96
221_V224_R0.7800.96
143_E146_A0.7760.96
65_M264_T0.7740.96
129_P212_G0.7720.96
178_I186_L0.7670.96
222_A239_G0.7640.96
15_I260_V0.7640.96
50_R101_S0.7620.96
176_L179_E0.7600.96
69_I72_Q0.7430.95
172_T176_L0.7420.95
83_E87_L0.7410.95
98_V124_L0.7400.95
52_G75_G0.7400.95
4_V258_S0.7350.95
113_I118_N0.7310.95
141_N170_N0.7300.95
171_I225_M0.7290.95
186_L229_V0.7290.95
115_K118_N0.7280.95
250_L279_Q0.7280.95
128_C137_A0.7230.95
194_G197_L0.7200.94
179_E233_V0.7200.94
254_L283_V0.7200.94
289_Y292_I0.7190.94
196_R251_E0.7170.94
11_L39_A0.7170.94
136_I140_T0.7130.94
210_T227_Y0.7100.94
27_E31_F0.7090.94
61_T213_L0.7090.94
44_A98_V0.7060.94
164_L186_L0.7060.94
169_A172_T0.7050.94
15_I249_A0.7040.94
292_I296_I0.7020.94
53_N57_R0.7020.94
224_R227_Y0.7010.94
249_A279_Q0.7000.94
132_K135_G0.7000.94
47_K105_D0.7000.94
189_I225_M0.6990.94
262_V265_A0.6990.94
27_E30_R0.6980.94
283_V295_C0.6980.94
250_L295_C0.6930.93
26_K83_E0.6930.93
151_A155_V0.6930.93
26_K78_S0.6930.93
76_L80_L0.6900.93
193_I228_E0.6880.93
186_L237_I0.6820.93
93_P120_H0.6820.93
191_T212_G0.6780.93
153_K181_A0.6760.92
281_P284_L0.6750.92
85_P88_E0.6740.92
11_L121_A0.6720.92
104_D107_V0.6700.92
284_L292_I0.6670.92
173_E177_A0.6650.92
121_A261_A0.6640.92
107_V152_V0.6640.92
230_S234_N0.6630.92
164_L225_M0.6630.92
197_L200_K0.6620.92
219_K226_V0.6600.91
216_P248_D0.6600.91
110_A148_L0.6590.91
126_I162_V0.6590.91
171_I232_M0.6550.91
187_T261_A0.6510.91
35_S91_D0.6480.91
229_V233_V0.6480.91
253_L260_V0.6470.91
178_I237_I0.6470.91
39_A261_A0.6450.91
11_L16_I0.6440.90
50_R99_A0.6440.90
77_D108_E0.6420.90
7_P121_A0.6390.90
253_L297_G0.6370.90
6_L236_P0.6340.90
119_V122_L0.6330.90
19_S43_K0.6320.90
249_A253_L0.6280.89
160_V184_D0.6270.89
48_E108_E0.6270.89
186_L235_I0.6250.89
26_K74_P0.6230.89
37_L277_I0.6210.89
110_A155_V0.6210.89
79_V113_I0.6200.89
67_N212_G0.6170.89
21_C267_F0.6170.89
6_L258_S0.6140.88
142_P146_A0.6110.88
46_T73_N0.6100.88
23_G43_K0.6070.88
88_E120_H0.6040.87
6_L11_L0.6020.87
273_C277_I0.6020.87
228_E231_Q0.5990.87
265_A272_A0.5980.87
121_A187_T0.5980.87
84_L88_E0.5970.87
149_T183_A0.5950.87
70_G73_N0.5950.87
276_I279_Q0.5940.87
3_E12_K0.5920.86
127_S212_G0.5910.86
93_P121_A0.5910.86
227_Y231_Q0.5910.86
62_G200_K0.5900.86
173_E176_L0.5890.86
165_S168_V0.5890.86
17_P31_F0.5890.86
123_E187_T0.5870.86
22_F28_F0.5870.86
48_E77_D0.5860.86
80_L84_L0.5860.86
66_L194_G0.5850.86
272_A275_E0.5840.86
196_R219_K0.5830.86
287_Y295_C0.5830.86
67_N73_N0.5800.85
223_I239_G0.5790.85
61_T64_G0.5790.85
52_G70_G0.5780.85
193_I210_T0.5780.85
184_D236_P0.5710.84
156_S160_V0.5700.84
39_A93_P0.5690.84
253_L284_L0.5690.84
79_V96_A0.5670.84
137_A140_T0.5660.84
223_I226_V0.5660.84
8_G159_P0.5650.84
280_L284_L0.5620.83
107_V148_L0.5610.83
67_N127_S0.5590.83
85_P89_Q0.5580.83
84_L87_L0.5580.83
110_A158_V0.5560.83
28_F266_N0.5550.83
127_S130_N0.5550.83
40_I92_T0.5540.83
164_L188_M0.5530.82
44_A121_A0.5520.82
243_V249_A0.5490.82
124_L149_T0.5480.82
65_M267_F0.5470.82
166_P190_N0.5470.82
67_N71_L0.5450.82
153_K183_A0.5450.82
68_A208_N0.5440.81
219_K222_A0.5400.81
32_Y40_I0.5400.81
69_I264_T0.5390.81
39_A259_A0.5390.81
200_K247_E0.5390.81
20_G263_G0.5380.81
70_G125_N0.5380.81
83_E96_A0.5370.81
97_N123_E0.5360.81
136_I139_G0.5340.80
284_L296_I0.5310.80
225_M229_V0.5300.80
223_I227_Y0.5300.80
262_V273_C0.5300.80
145_A149_T0.5280.80
70_G212_G0.5280.80
102_Q128_C0.5280.80
121_A161_Y0.5270.79
131_V136_I0.5260.79
68_A72_Q0.5230.79
110_A114_S0.5220.79
42_I45_T0.5180.78
174_I178_I0.5170.78
28_F83_E0.5170.78
76_L79_V0.5170.78
84_L118_N0.5160.78
146_A177_A0.5160.78
71_L128_C0.5160.78
45_T96_A0.5150.78
110_A156_S0.5140.78
7_P236_P0.5130.78
11_L93_P0.5120.77
227_Y251_E0.5110.77
128_C136_I0.5090.77
17_P22_F0.5090.77
41_M240_M0.5060.77
203_K209_K0.5050.76
140_T168_V0.5040.76
81_H85_P0.5030.76
103_V144_M0.5030.76
145_A148_L0.5020.76
124_L160_V0.5020.76
29_S33_D0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cq8A 1 0.9357 100 0.386 Contact Map
4ef8A 2 0.9614 100 0.389 Contact Map
1tv5A 3 0.9325 100 0.394 Contact Map
1ep3A 2 0.9743 100 0.402 Contact Map
4oqvA 1 0.9132 100 0.426 Contact Map
1jubA 2 0.9582 100 0.442 Contact Map
2e6fA 2 0.9614 100 0.449 Contact Map
1gteA 4 0.9904 100 0.461 Contact Map
3oixA 3 0.9421 100 0.464 Contact Map
1f76A 1 0.8682 100 0.519 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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