GREMLIN Database
PYRC - Dihydroorotase
UniProt: P25995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (418)
Sequences: 9039 (6414)
Seq/√Len: 313.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_I46_A4.5511.00
49_L411_V3.8271.00
414_I419_L3.8111.00
221_E247_A3.5781.00
384_E405_S3.3561.00
8_G51_V3.2951.00
10_I20_A3.2821.00
412_A419_L3.2681.00
25_T30_T3.2601.00
348_Q351_D3.2131.00
42_T422_E3.0911.00
8_G46_A3.0491.00
368_L376_I2.8761.00
22_I51_V2.8151.00
345_S348_Q2.8141.00
31_A370_T2.7931.00
9_W17_K2.7691.00
6_K43_V2.7181.00
283_P287_A2.6721.00
365_Y373_A2.6711.00
3_Y414_I2.5631.00
367_T372_Q2.5531.00
389_K402_N2.5251.00
46_A378_L2.4251.00
356_K359_E2.3981.00
49_L378_L2.3771.00
388_D391_T2.3661.00
52_S379_I2.3451.00
4_L23_R2.3251.00
81_A117_V2.3181.00
213_I237_S2.3141.00
24_V376_I2.3131.00
51_V378_L2.2861.00
17_K347_K2.2501.00
118_R416_A2.2131.00
54_G86_T2.1331.00
283_P286_R2.0721.00
387_I406_C2.0681.00
82_R421_Y2.0421.00
255_V259_H2.0301.00
245_K299_D2.0151.00
9_W19_Q1.9891.00
228_H252_T1.9581.00
250_R360_A1.9501.00
369_Q372_Q1.9081.00
58_L361_F1.8761.00
359_E367_T1.8691.00
81_A420_A1.8401.00
385_A409_W1.8381.00
27_E373_A1.8321.00
351_D356_K1.8311.00
87_T120_L1.8171.00
167_R170_A1.7961.00
49_L380_D1.7911.00
82_R393_L1.7861.00
7_N45_D1.7801.00
384_E407_T1.7751.00
11_L17_K1.7621.00
412_A422_E1.7501.00
10_I22_I1.7291.00
32_I370_T1.7291.00
50_L346_L1.7151.00
340_K407_T1.7121.00
337_H341_N1.6741.00
383_K411_V1.6681.00
364_P372_Q1.6591.00
52_S350_I1.6561.00
243_D247_A1.6511.00
20_A32_I1.6471.00
217_V251_V1.6431.00
380_D383_K1.6421.00
44_I414_I1.6361.00
351_D355_I1.6311.00
105_E109_N1.6301.00
217_V240_V1.6261.00
210_S236_E1.6231.00
23_R41_E1.6151.00
74_E78_K1.6101.00
55_F331_F1.6041.00
316_E319_L1.6001.00
386_V405_S1.5991.00
6_K21_D1.5911.00
141_K173_K1.5901.00
383_K409_W1.5841.00
214_A240_V1.5701.00
334_L349_L1.5551.00
235_K284_E1.5501.00
334_L353_M1.5441.00
62_F76_G1.5411.00
5_I378_L1.5391.00
8_G378_L1.5381.00
256_S259_H1.5371.00
419_L422_E1.5351.00
85_Y330_A1.5341.00
220_A227_Y1.5301.00
168_A175_I1.5141.00
350_I354_T1.5121.00
3_Y24_V1.5111.00
106_W110_R1.4991.00
263_C283_P1.4781.00
23_R31_A1.4561.00
232_I241_V1.4551.00
388_D402_N1.4521.00
380_D411_V1.4471.00
28_T373_A1.4441.00
162_Y222_A1.4421.00
138_E167_R1.4361.00
413_T421_Y1.4311.00
5_I24_V1.4301.00
242_R295_D1.4261.00
218_L222_A1.4221.00
239_R243_D1.4091.00
411_V423_E1.4021.00
72_T395_K1.3801.00
355_I359_E1.3751.00
23_R40_N1.3661.00
348_Q352_Y1.3521.00
339_V349_L1.3511.00
22_I368_L1.3481.00
300_F360_A1.3331.00
136_N139_A1.3231.00
214_A218_L1.3191.00
69_K309_T1.2971.00
373_A416_A1.2901.00
282_S285_D1.2871.00
148_F173_K1.2871.00
109_N112_K1.2841.00
52_S377_T1.2811.00
44_I412_A1.2791.00
151_D157_T1.2781.00
344_W352_Y1.2751.00
50_L381_L1.2691.00
58_L300_F1.2681.00
217_V244_A1.2681.00
157_T160_M1.2651.00
42_T419_L1.2641.00
243_D246_K1.2581.00
241_V253_A1.2501.00
71_E76_G1.2451.00
260_L289_L1.2441.00
262_L333_L1.2431.00
167_R171_I1.2421.00
127_I133_E1.2411.00
276_M324_I1.2381.00
206_S236_E1.2331.00
78_K393_L1.2311.00
51_V376_I1.2291.00
110_R113_E1.2171.00
221_E249_I1.2121.00
52_S55_F1.2111.00
220_A249_I1.2071.00
287_A291_E1.1951.00
168_A173_K1.1921.00
325_V396_G1.1841.00
4_L40_N1.1821.00
21_D33_G1.1731.00
235_K288_A1.1581.00
415_A420_A1.1571.00
38_T41_E1.1521.00
18_T34_K1.1511.00
291_E295_D1.1501.00
165_M225_C1.1501.00
176_V230_C1.1501.00
56_V358_C1.1441.00
3_Y42_T1.1431.00
387_I392_F1.1421.00
261_L333_L1.1361.00
19_Q47_K1.1231.00
172_D362_G1.1041.00
263_C266_D1.1031.00
10_I368_L1.1001.00
234_T237_S1.0991.00
55_F353_M1.0951.00
242_R297_T1.0921.00
5_I51_V1.0891.00
138_E142_E1.0881.00
40_N43_V1.0831.00
10_I18_T1.0831.00
378_L412_A1.0831.00
8_G376_I1.0761.00
336_T407_T1.0691.00
109_N113_E1.0691.00
291_E294_L1.0671.00
108_Q112_K1.0651.00
62_F88_V1.0581.00
105_E143_A1.0571.00
253_A298_I1.0561.00
11_L50_L1.0561.00
33_G36_D1.0541.00
20_A34_K1.0511.00
181_D211_V1.0461.00
46_A51_V1.0441.00
293_L352_Y1.0431.00
77_A115_S1.0361.00
5_I414_I1.0351.00
123_A140_L1.0221.00
160_M163_E1.0221.00
288_A292_G1.0221.00
336_T404_I1.0151.00
37_A40_N1.0121.00
5_I376_I1.0111.00
165_M175_I1.0071.00
336_T340_K1.0061.00
378_L414_I1.0041.00
198_A268_P1.0021.00
58_L357_P1.0001.00
62_F77_A0.9991.00
336_T341_N0.9931.00
23_R35_L0.9921.00
188_G192_E0.9911.00
286_R290_I0.9881.00
122_Y149_T0.9871.00
72_T75_T0.9861.00
192_E196_S0.9841.00
100_T103_Q0.9751.00
346_L381_L0.9681.00
232_I237_S0.9651.00
106_W109_N0.9651.00
11_L350_I0.9641.00
122_Y147_A0.9621.00
217_V249_I0.9611.00
213_I229_V0.9571.00
399_T402_N0.9531.00
301_I334_L0.9531.00
330_A353_M0.9511.00
118_R365_Y0.9481.00
163_E166_K0.9441.00
166_K170_A0.9401.00
376_I414_I0.9391.00
349_L353_M0.9391.00
89_A122_Y0.9351.00
329_T387_I0.9341.00
303_T330_A0.9291.00
338_F342_G0.9281.00
187_G191_H0.9271.00
20_A368_L0.9231.00
101_K139_A0.9191.00
14_N367_T0.9181.00
87_T375_D0.9171.00
24_V414_I0.9151.00
188_G191_H0.9141.00
9_W50_L0.9121.00
157_T183_S0.9081.00
358_C366_G0.9061.00
4_L21_D0.9061.00
98_P104_M0.9061.00
315_T319_L0.8991.00
238_V292_G0.8951.00
162_Y166_K0.8931.00
284_E287_A0.8911.00
263_C286_R0.8881.00
226_H250_R0.8871.00
331_F335_Y0.8861.00
72_T114_T0.8861.00
242_R246_K0.8841.00
50_L379_I0.8841.00
125_I164_A0.8831.00
4_L43_V0.8831.00
207_V211_V0.8791.00
351_D359_E0.8791.00
117_V415_A0.8771.00
7_N47_K0.8771.00
332_P385_A0.8761.00
22_I32_I0.8751.00
81_A413_T0.8731.00
240_V243_D0.8711.00
89_A120_L0.8681.00
161_M177_A0.8651.00
55_F85_Y0.8641.00
18_T32_I0.8631.00
264_D282_S0.8601.00
137_F148_F0.8601.00
235_K239_R0.8601.00
275_K278_P0.8591.00
195_F199_N0.8591.00
51_V414_I0.8581.00
275_K320_A0.8571.00
162_Y223_A0.8541.00
216_D227_Y0.8501.00
56_V87_T0.8481.00
266_D274_Y0.8441.00
309_T312_E0.8411.00
7_N19_Q0.8401.00
81_A415_A0.8401.00
174_A226_H0.8391.00
367_T370_T0.8391.00
23_R33_G0.8351.00
23_R30_T0.8281.00
103_Q106_W0.8271.00
93_N96_P0.8271.00
35_L38_T0.8261.00
352_Y356_K0.8221.00
138_E170_A0.8171.00
366_G375_D0.8111.00
218_L221_E0.8101.00
214_A243_D0.8101.00
196_S199_N0.8101.00
294_L348_Q0.8091.00
244_A249_I0.8071.00
101_K105_E0.8051.00
194_T198_A0.8041.00
310_E314_N0.8031.00
377_T410_P0.8021.00
255_V289_L0.8021.00
409_W423_E0.7961.00
301_I352_Y0.7951.00
102_E105_E0.7941.00
158_A181_D0.7921.00
194_T199_N0.7911.00
207_V222_A0.7901.00
334_L338_F0.7891.00
190_V318_K0.7881.00
20_A33_G0.7831.00
344_W348_Q0.7781.00
90_A107_V0.7771.00
239_R242_R0.7771.00
11_L347_K0.7771.00
23_R38_T0.7761.00
315_T321_P0.7751.00
335_Y340_K0.7720.99
74_E116_C0.7710.99
58_L89_A0.7700.99
159_G163_E0.7660.99
89_A361_F0.7660.99
55_F330_A0.7640.99
158_A215_R0.7640.99
182_N186_Y0.7600.99
354_T357_P0.7580.99
69_K312_E0.7580.99
62_F327_L0.7560.99
15_G347_K0.7540.99
290_I343_S0.7540.99
138_E171_I0.7530.99
44_I419_L0.7510.99
149_T152_G0.7500.99
325_V392_F0.7490.99
56_V365_Y0.7480.99
57_D60_V0.7480.99
389_K392_F0.7470.99
49_L412_A0.7470.99
55_F377_T0.7470.99
118_R121_P0.7460.99
153_V158_A0.7450.99
305_H308_H0.7440.99
172_D226_H0.7440.99
64_E68_E0.7430.99
27_E416_A0.7390.99
335_Y346_L0.7390.99
49_L382_E0.7380.99
292_G297_T0.7370.99
165_M169_A0.7370.99
236_E239_R0.7360.99
312_E321_P0.7360.99
265_E283_P0.7360.99
331_F379_I0.7330.99
58_L302_A0.7310.99
3_Y419_L0.7290.99
80_A88_V0.7270.99
294_L297_T0.7240.99
165_M168_A0.7230.99
335_Y349_L0.7220.99
118_R415_A0.7220.99
115_S119_V0.7190.99
335_Y381_L0.7180.99
77_A116_C0.7170.99
326_G329_T0.7170.99
190_V195_F0.7160.99
335_Y338_F0.7160.99
220_A250_R0.7150.99
258_H324_I0.7150.99
137_F171_I0.7150.99
70_K308_H0.7140.99
355_I367_T0.7130.99
331_F349_L0.7110.99
135_T140_L0.7080.99
229_V232_I0.7080.99
356_K360_A0.7080.99
329_T332_P0.7050.99
231_H304_D0.7050.99
379_I410_P0.7050.99
4_L38_T0.7040.99
285_D288_A0.7040.99
211_V214_A0.7030.99
252_T360_A0.7000.99
335_Y379_I0.6960.99
287_A290_I0.6950.99
44_I378_L0.6910.99
12_N17_K0.6910.99
161_M165_M0.6870.99
98_P103_Q0.6870.99
116_C121_P0.6870.99
339_V342_G0.6870.99
111_I121_P0.6860.99
385_A410_P0.6850.99
42_T412_A0.6850.99
329_T392_F0.6840.99
67_G95_R0.6820.99
210_S240_V0.6820.99
230_C254_E0.6810.99
266_D404_I0.6800.99
17_K50_L0.6790.99
206_S282_S0.6760.99
81_A116_C0.6750.99
206_S210_S0.6750.99
189_S201_L0.6730.99
104_M108_Q0.6730.99
3_Y44_I0.6710.99
385_A408_G0.6700.99
78_K116_C0.6670.99
32_I368_L0.6660.98
290_I338_F0.6650.98
107_V110_R0.6640.98
80_A327_L0.6640.98
87_T118_R0.6640.98
37_A41_E0.6620.98
70_K312_E0.6620.98
210_S214_A0.6590.98
74_E114_T0.6590.98
98_P107_V0.6580.98
328_E393_L0.6560.98
338_F341_N0.6560.98
190_V196_S0.6560.98
133_E136_N0.6550.98
77_A88_V0.6550.98
337_H340_K0.6530.98
141_K148_F0.6530.98
59_H231_H0.6510.98
89_A363_L0.6510.98
391_T402_N0.6500.98
332_P410_P0.6500.98
304_D307_P0.6490.98
238_V298_I0.6480.98
332_P409_W0.6470.98
229_V241_V0.6470.98
99_D126_T0.6460.98
150_D153_V0.6440.98
6_K45_D0.6440.98
124_S129_Q0.6420.98
114_T117_V0.6410.98
332_P335_Y0.6410.98
278_P281_R0.6390.98
412_A421_Y0.6390.98
163_E167_R0.6360.98
176_V361_F0.6350.98
293_L298_I0.6350.98
226_H360_A0.6350.98
122_Y176_V0.6340.98
122_Y125_I0.6330.98
123_A145_A0.6330.98
272_T320_A0.6320.98
392_F402_N0.6310.98
325_V398_N0.6310.98
158_A183_S0.6300.98
333_L337_H0.6290.98
102_E106_W0.6290.98
195_F198_A0.6290.98
410_P413_T0.6290.98
9_W18_T0.6280.98
5_I44_I0.6270.98
21_D38_T0.6260.98
213_I217_V0.6250.98
146_F165_M0.6250.98
276_M280_L0.6230.98
3_Y41_E0.6220.98
224_N250_R0.6210.98
14_N355_I0.6210.98
30_T370_T0.6200.98
407_T410_P0.6180.98
365_Y375_D0.6180.98
7_N21_D0.6170.98
12_N18_T0.6140.97
156_Q160_M0.6140.97
60_V85_Y0.6130.97
299_D302_A0.6110.97
213_I232_I0.6110.97
10_I32_I0.6090.97
52_S354_T0.6090.97
290_I294_L0.6090.97
158_A162_Y0.6090.97
108_Q111_I0.6080.97
68_E72_T0.6080.97
150_D155_I0.6080.97
36_D41_E0.6070.97
67_G70_K0.6070.97
143_A146_F0.6060.97
62_F90_A0.6050.97
245_K297_T0.6020.97
56_V357_P0.6020.97
104_M145_A0.6000.97
271_D279_P0.6000.97
125_I129_Q0.6000.97
151_D155_I0.5990.97
110_R114_T0.5980.97
227_Y249_I0.5980.97
397_K402_N0.5960.97
333_L406_C0.5950.97
64_E110_R0.5940.97
13_E17_K0.5930.97
82_R328_E0.5910.97
335_Y339_V0.5910.97
238_V253_A0.5900.97
9_W382_E0.5900.97
177_A227_Y0.5840.97
284_E288_A0.5820.96
154_G157_T0.5810.96
118_R375_D0.5800.96
232_I298_I0.5780.96
274_Y278_P0.5770.96
97_V124_S0.5760.96
31_A38_T0.5750.96
5_I8_G0.5750.96
166_K192_E0.5750.96
241_V244_A0.5740.96
339_V344_W0.5730.96
338_F343_S0.5730.96
337_H404_I0.5720.96
375_D415_A0.5710.96
105_E108_Q0.5710.96
339_V345_S0.5710.96
172_D250_R0.5700.96
199_N202_N0.5700.96
393_L421_Y0.5700.96
237_S241_V0.5690.96
267_I317_M0.5690.96
13_E347_K0.5690.96
198_A202_N0.5680.96
174_A177_A0.5660.96
189_S192_E0.5660.96
12_N367_T0.5650.96
353_M357_P0.5650.96
244_A248_G0.5650.96
35_L41_E0.5640.96
36_D40_N0.5630.96
200_G203_G0.5630.96
286_R289_L0.5630.96
258_H276_M0.5610.96
392_F396_G0.5590.96
262_L400_P0.5590.96
332_P338_F0.5590.96
189_S199_N0.5580.96
141_K171_I0.5580.96
285_D292_G0.5570.96
63_R70_K0.5560.95
87_T358_C0.5560.95
153_V156_Q0.5540.95
27_E418_K0.5540.95
296_G299_D0.5540.95
188_G204_I0.5530.95
245_K248_G0.5520.95
231_H254_E0.5510.95
86_T375_D0.5510.95
86_T413_T0.5490.95
58_L360_A0.5480.95
211_V215_R0.5480.95
194_T197_K0.5480.95
382_E407_T0.5480.95
13_E355_I0.5470.95
177_A216_D0.5470.95
9_W20_A0.5440.95
70_K309_T0.5440.95
261_L337_H0.5430.95
238_V297_T0.5430.95
168_A225_C0.5420.95
61_H231_H0.5420.95
77_A81_A0.5410.95
400_P403_G0.5410.95
169_A223_A0.5400.95
189_S202_N0.5390.95
308_H312_E0.5370.95
232_I253_A0.5370.95
294_L343_S0.5370.95
120_L123_A0.5340.94
390_E402_N0.5340.94
143_A147_A0.5340.94
107_V111_I0.5330.94
324_I400_P0.5330.94
60_V327_L0.5330.94
134_M167_R0.5320.94
39_D43_V0.5310.94
310_E389_K0.5310.94
151_D154_G0.5300.94
153_V161_M0.5280.94
273_N310_E0.5280.94
328_E331_F0.5260.94
15_G369_Q0.5260.94
79_A327_L0.5250.94
29_I372_Q0.5250.94
392_F399_T0.5250.94
29_I32_I0.5250.94
56_V366_G0.5250.94
332_P407_T0.5240.94
119_V122_Y0.5240.94
73_I114_T0.5230.94
288_A291_E0.5210.94
117_V123_A0.5210.94
97_V129_Q0.5200.94
120_L124_S0.5180.93
277_N322_F0.5180.93
107_V112_K0.5170.93
51_V368_L0.5150.93
323_G328_E0.5140.93
385_A406_C0.5130.93
55_F354_T0.5130.93
23_R37_A0.5130.93
19_Q34_K0.5120.93
64_E72_T0.5110.93
136_N140_L0.5110.93
87_T366_G0.5090.93
274_Y280_L0.5080.93
302_A305_H0.5080.93
129_Q153_V0.5070.93
303_T308_H0.5070.93
14_N369_Q0.5060.93
181_D215_R0.5060.93
169_A195_F0.5060.93
59_H254_E0.5060.93
116_C119_V0.5050.93
162_Y207_V0.5050.93
335_Y341_N0.5050.93
122_Y129_Q0.5030.92
4_L35_L0.5020.92
238_V242_R0.5010.92
272_T275_K0.5010.92
200_G277_N0.5010.92
9_W47_K0.5010.92
159_G162_Y0.5000.92
22_I376_I0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dc8A 3 0.9836 100 0.267 Contact Map
3mpgA 2 0.9953 100 0.267 Contact Map
2ftyA 3 0.9953 100 0.27 Contact Map
3griA 1 0.986 100 0.274 Contact Map
4lcqA 3 0.9953 100 0.28 Contact Map
3hm7A 2 0.979 100 0.287 Contact Map
2z00A 2 0.9813 100 0.289 Contact Map
1gkrA 3 0.9883 100 0.29 Contact Map
3sfwA 3 0.9953 100 0.293 Contact Map
2ftwA 3 0.9953 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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