PYRC - BACSU - GREMLIN Contacts

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PYRC - Dihydroorotase

UniProt:	P25995	Sequences: MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGMMYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	428 (418)
Sequences:	9039 (6414)
Seq/√Len:	313.7

ECOLI - PHYDA ALLB PYRC IADA GUAD CODA SSNA
BACSU - PYRC ALLB NAGA
HALSA - PYRC MTAD HUTI
SULSO - PYRC Q97VT3 Q97WS6 Q97XD4 Q97W09

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_I	46_A	4.551	1.00
49_L	411_V	3.827	1.00
414_I	419_L	3.811	1.00
221_E	247_A	3.578	1.00
384_E	405_S	3.356	1.00
8_G	51_V	3.295	1.00
10_I	20_A	3.282	1.00
412_A	419_L	3.268	1.00
25_T	30_T	3.260	1.00
348_Q	351_D	3.213	1.00
42_T	422_E	3.091	1.00
8_G	46_A	3.049	1.00
368_L	376_I	2.876	1.00
22_I	51_V	2.815	1.00
345_S	348_Q	2.814	1.00
31_A	370_T	2.793	1.00
9_W	17_K	2.769	1.00
6_K	43_V	2.718	1.00
283_P	287_A	2.672	1.00
365_Y	373_A	2.671	1.00
3_Y	414_I	2.563	1.00
367_T	372_Q	2.553	1.00
389_K	402_N	2.525	1.00
46_A	378_L	2.425	1.00
356_K	359_E	2.398	1.00
49_L	378_L	2.377	1.00
388_D	391_T	2.366	1.00
52_S	379_I	2.345	1.00
4_L	23_R	2.325	1.00
81_A	117_V	2.318	1.00
213_I	237_S	2.314	1.00
24_V	376_I	2.313	1.00
51_V	378_L	2.286	1.00
17_K	347_K	2.250	1.00
118_R	416_A	2.213	1.00
54_G	86_T	2.133	1.00
283_P	286_R	2.072	1.00
387_I	406_C	2.068	1.00
82_R	421_Y	2.042	1.00
255_V	259_H	2.030	1.00
245_K	299_D	2.015	1.00
9_W	19_Q	1.989	1.00
228_H	252_T	1.958	1.00
250_R	360_A	1.950	1.00
369_Q	372_Q	1.908	1.00
58_L	361_F	1.876	1.00
359_E	367_T	1.869	1.00
81_A	420_A	1.840	1.00
385_A	409_W	1.838	1.00
27_E	373_A	1.832	1.00
351_D	356_K	1.831	1.00
87_T	120_L	1.817	1.00
167_R	170_A	1.796	1.00
49_L	380_D	1.791	1.00
82_R	393_L	1.786	1.00
7_N	45_D	1.780	1.00
384_E	407_T	1.775	1.00
11_L	17_K	1.762	1.00
412_A	422_E	1.750	1.00
10_I	22_I	1.729	1.00
32_I	370_T	1.729	1.00
50_L	346_L	1.715	1.00
340_K	407_T	1.712	1.00
337_H	341_N	1.674	1.00
383_K	411_V	1.668	1.00
364_P	372_Q	1.659	1.00
52_S	350_I	1.656	1.00
243_D	247_A	1.651	1.00
20_A	32_I	1.647	1.00
217_V	251_V	1.643	1.00
380_D	383_K	1.642	1.00
44_I	414_I	1.636	1.00
351_D	355_I	1.631	1.00
105_E	109_N	1.630	1.00
217_V	240_V	1.626	1.00
210_S	236_E	1.623	1.00
23_R	41_E	1.615	1.00
74_E	78_K	1.610	1.00
55_F	331_F	1.604	1.00
316_E	319_L	1.600	1.00
386_V	405_S	1.599	1.00
6_K	21_D	1.591	1.00
141_K	173_K	1.590	1.00
383_K	409_W	1.584	1.00
214_A	240_V	1.570	1.00
334_L	349_L	1.555	1.00
235_K	284_E	1.550	1.00
334_L	353_M	1.544	1.00
62_F	76_G	1.541	1.00
5_I	378_L	1.539	1.00
8_G	378_L	1.538	1.00
256_S	259_H	1.537	1.00
419_L	422_E	1.535	1.00
85_Y	330_A	1.534	1.00
220_A	227_Y	1.530	1.00
168_A	175_I	1.514	1.00
350_I	354_T	1.512	1.00
3_Y	24_V	1.511	1.00
106_W	110_R	1.499	1.00
263_C	283_P	1.478	1.00
23_R	31_A	1.456	1.00
232_I	241_V	1.455	1.00
388_D	402_N	1.452	1.00
380_D	411_V	1.447	1.00
28_T	373_A	1.444	1.00
162_Y	222_A	1.442	1.00
138_E	167_R	1.436	1.00
413_T	421_Y	1.431	1.00
5_I	24_V	1.430	1.00
242_R	295_D	1.426	1.00
218_L	222_A	1.422	1.00
239_R	243_D	1.409	1.00
411_V	423_E	1.402	1.00
72_T	395_K	1.380	1.00
355_I	359_E	1.375	1.00
23_R	40_N	1.366	1.00
348_Q	352_Y	1.352	1.00
339_V	349_L	1.351	1.00
22_I	368_L	1.348	1.00
300_F	360_A	1.333	1.00
136_N	139_A	1.323	1.00
214_A	218_L	1.319	1.00
69_K	309_T	1.297	1.00
373_A	416_A	1.290	1.00
282_S	285_D	1.287	1.00
148_F	173_K	1.287	1.00
109_N	112_K	1.284	1.00
52_S	377_T	1.281	1.00
44_I	412_A	1.279	1.00
151_D	157_T	1.278	1.00
344_W	352_Y	1.275	1.00
50_L	381_L	1.269	1.00
58_L	300_F	1.268	1.00
217_V	244_A	1.268	1.00
157_T	160_M	1.265	1.00
42_T	419_L	1.264	1.00
243_D	246_K	1.258	1.00
241_V	253_A	1.250	1.00
71_E	76_G	1.245	1.00
260_L	289_L	1.244	1.00
262_L	333_L	1.243	1.00
167_R	171_I	1.242	1.00
127_I	133_E	1.241	1.00
276_M	324_I	1.238	1.00
206_S	236_E	1.233	1.00
78_K	393_L	1.231	1.00
51_V	376_I	1.229	1.00
110_R	113_E	1.217	1.00
221_E	249_I	1.212	1.00
52_S	55_F	1.211	1.00
220_A	249_I	1.207	1.00
287_A	291_E	1.195	1.00
168_A	173_K	1.192	1.00
325_V	396_G	1.184	1.00
4_L	40_N	1.182	1.00
21_D	33_G	1.173	1.00
235_K	288_A	1.158	1.00
415_A	420_A	1.157	1.00
38_T	41_E	1.152	1.00
18_T	34_K	1.151	1.00
291_E	295_D	1.150	1.00
165_M	225_C	1.150	1.00
176_V	230_C	1.150	1.00
56_V	358_C	1.144	1.00
3_Y	42_T	1.143	1.00
387_I	392_F	1.142	1.00
261_L	333_L	1.136	1.00
19_Q	47_K	1.123	1.00
172_D	362_G	1.104	1.00
263_C	266_D	1.103	1.00
10_I	368_L	1.100	1.00
234_T	237_S	1.099	1.00
55_F	353_M	1.095	1.00
242_R	297_T	1.092	1.00
5_I	51_V	1.089	1.00
138_E	142_E	1.088	1.00
40_N	43_V	1.083	1.00
10_I	18_T	1.083	1.00
378_L	412_A	1.083	1.00
8_G	376_I	1.076	1.00
336_T	407_T	1.069	1.00
109_N	113_E	1.069	1.00
291_E	294_L	1.067	1.00
108_Q	112_K	1.065	1.00
62_F	88_V	1.058	1.00
105_E	143_A	1.057	1.00
253_A	298_I	1.056	1.00
11_L	50_L	1.056	1.00
33_G	36_D	1.054	1.00
20_A	34_K	1.051	1.00
181_D	211_V	1.046	1.00
46_A	51_V	1.044	1.00
293_L	352_Y	1.043	1.00
77_A	115_S	1.036	1.00
5_I	414_I	1.035	1.00
123_A	140_L	1.022	1.00
160_M	163_E	1.022	1.00
288_A	292_G	1.022	1.00
336_T	404_I	1.015	1.00
37_A	40_N	1.012	1.00
5_I	376_I	1.011	1.00
165_M	175_I	1.007	1.00
336_T	340_K	1.006	1.00
378_L	414_I	1.004	1.00
198_A	268_P	1.002	1.00
58_L	357_P	1.000	1.00
62_F	77_A	0.999	1.00
336_T	341_N	0.993	1.00
23_R	35_L	0.992	1.00
188_G	192_E	0.991	1.00
286_R	290_I	0.988	1.00
122_Y	149_T	0.987	1.00
72_T	75_T	0.986	1.00
192_E	196_S	0.984	1.00
100_T	103_Q	0.975	1.00
346_L	381_L	0.968	1.00
232_I	237_S	0.965	1.00
106_W	109_N	0.965	1.00
11_L	350_I	0.964	1.00
122_Y	147_A	0.962	1.00
217_V	249_I	0.961	1.00
213_I	229_V	0.957	1.00
399_T	402_N	0.953	1.00
301_I	334_L	0.953	1.00
330_A	353_M	0.951	1.00
118_R	365_Y	0.948	1.00
163_E	166_K	0.944	1.00
166_K	170_A	0.940	1.00
376_I	414_I	0.939	1.00
349_L	353_M	0.939	1.00
89_A	122_Y	0.935	1.00
329_T	387_I	0.934	1.00
303_T	330_A	0.929	1.00
338_F	342_G	0.928	1.00
187_G	191_H	0.927	1.00
20_A	368_L	0.923	1.00
101_K	139_A	0.919	1.00
14_N	367_T	0.918	1.00
87_T	375_D	0.917	1.00
24_V	414_I	0.915	1.00
188_G	191_H	0.914	1.00
9_W	50_L	0.912	1.00
157_T	183_S	0.908	1.00
358_C	366_G	0.906	1.00
4_L	21_D	0.906	1.00
98_P	104_M	0.906	1.00
315_T	319_L	0.899	1.00
238_V	292_G	0.895	1.00
162_Y	166_K	0.893	1.00
284_E	287_A	0.891	1.00
263_C	286_R	0.888	1.00
226_H	250_R	0.887	1.00
331_F	335_Y	0.886	1.00
72_T	114_T	0.886	1.00
242_R	246_K	0.884	1.00
50_L	379_I	0.884	1.00
125_I	164_A	0.883	1.00
4_L	43_V	0.883	1.00
207_V	211_V	0.879	1.00
351_D	359_E	0.879	1.00
117_V	415_A	0.877	1.00
7_N	47_K	0.877	1.00
332_P	385_A	0.876	1.00
22_I	32_I	0.875	1.00
81_A	413_T	0.873	1.00
240_V	243_D	0.871	1.00
89_A	120_L	0.868	1.00
161_M	177_A	0.865	1.00
55_F	85_Y	0.864	1.00
18_T	32_I	0.863	1.00
264_D	282_S	0.860	1.00
137_F	148_F	0.860	1.00
235_K	239_R	0.860	1.00
275_K	278_P	0.859	1.00
195_F	199_N	0.859	1.00
51_V	414_I	0.858	1.00
275_K	320_A	0.857	1.00
162_Y	223_A	0.854	1.00
216_D	227_Y	0.850	1.00
56_V	87_T	0.848	1.00
266_D	274_Y	0.844	1.00
309_T	312_E	0.841	1.00
7_N	19_Q	0.840	1.00
81_A	415_A	0.840	1.00
174_A	226_H	0.839	1.00
367_T	370_T	0.839	1.00
23_R	33_G	0.835	1.00
23_R	30_T	0.828	1.00
103_Q	106_W	0.827	1.00
93_N	96_P	0.827	1.00
35_L	38_T	0.826	1.00
352_Y	356_K	0.822	1.00
138_E	170_A	0.817	1.00
366_G	375_D	0.811	1.00
218_L	221_E	0.810	1.00
214_A	243_D	0.810	1.00
196_S	199_N	0.810	1.00
294_L	348_Q	0.809	1.00
244_A	249_I	0.807	1.00
101_K	105_E	0.805	1.00
194_T	198_A	0.804	1.00
310_E	314_N	0.803	1.00
377_T	410_P	0.802	1.00
255_V	289_L	0.802	1.00
409_W	423_E	0.796	1.00
301_I	352_Y	0.795	1.00
102_E	105_E	0.794	1.00
158_A	181_D	0.792	1.00
194_T	199_N	0.791	1.00
207_V	222_A	0.790	1.00
334_L	338_F	0.789	1.00
190_V	318_K	0.788	1.00
20_A	33_G	0.783	1.00
344_W	348_Q	0.778	1.00
90_A	107_V	0.777	1.00
239_R	242_R	0.777	1.00
11_L	347_K	0.777	1.00
23_R	38_T	0.776	1.00
315_T	321_P	0.775	1.00
335_Y	340_K	0.772	0.99
74_E	116_C	0.771	0.99
58_L	89_A	0.770	0.99
159_G	163_E	0.766	0.99
89_A	361_F	0.766	0.99
55_F	330_A	0.764	0.99
158_A	215_R	0.764	0.99
182_N	186_Y	0.760	0.99
354_T	357_P	0.758	0.99
69_K	312_E	0.758	0.99
62_F	327_L	0.756	0.99
15_G	347_K	0.754	0.99
290_I	343_S	0.754	0.99
138_E	171_I	0.753	0.99
44_I	419_L	0.751	0.99
149_T	152_G	0.750	0.99
325_V	392_F	0.749	0.99
56_V	365_Y	0.748	0.99
57_D	60_V	0.748	0.99
389_K	392_F	0.747	0.99
49_L	412_A	0.747	0.99
55_F	377_T	0.747	0.99
118_R	121_P	0.746	0.99
153_V	158_A	0.745	0.99
305_H	308_H	0.744	0.99
172_D	226_H	0.744	0.99
64_E	68_E	0.743	0.99
27_E	416_A	0.739	0.99
335_Y	346_L	0.739	0.99
49_L	382_E	0.738	0.99
292_G	297_T	0.737	0.99
165_M	169_A	0.737	0.99
236_E	239_R	0.736	0.99
312_E	321_P	0.736	0.99
265_E	283_P	0.736	0.99
331_F	379_I	0.733	0.99
58_L	302_A	0.731	0.99
3_Y	419_L	0.729	0.99
80_A	88_V	0.727	0.99
294_L	297_T	0.724	0.99
165_M	168_A	0.723	0.99
335_Y	349_L	0.722	0.99
118_R	415_A	0.722	0.99
115_S	119_V	0.719	0.99
335_Y	381_L	0.718	0.99
77_A	116_C	0.717	0.99
326_G	329_T	0.717	0.99
190_V	195_F	0.716	0.99
335_Y	338_F	0.716	0.99
220_A	250_R	0.715	0.99
258_H	324_I	0.715	0.99
137_F	171_I	0.715	0.99
70_K	308_H	0.714	0.99
355_I	367_T	0.713	0.99
331_F	349_L	0.711	0.99
135_T	140_L	0.708	0.99
229_V	232_I	0.708	0.99
356_K	360_A	0.708	0.99
329_T	332_P	0.705	0.99
231_H	304_D	0.705	0.99
379_I	410_P	0.705	0.99
4_L	38_T	0.704	0.99
285_D	288_A	0.704	0.99
211_V	214_A	0.703	0.99
252_T	360_A	0.700	0.99
335_Y	379_I	0.696	0.99
287_A	290_I	0.695	0.99
44_I	378_L	0.691	0.99
12_N	17_K	0.691	0.99
161_M	165_M	0.687	0.99
98_P	103_Q	0.687	0.99
116_C	121_P	0.687	0.99
339_V	342_G	0.687	0.99
111_I	121_P	0.686	0.99
385_A	410_P	0.685	0.99
42_T	412_A	0.685	0.99
329_T	392_F	0.684	0.99
67_G	95_R	0.682	0.99
210_S	240_V	0.682	0.99
230_C	254_E	0.681	0.99
266_D	404_I	0.680	0.99
17_K	50_L	0.679	0.99
206_S	282_S	0.676	0.99
81_A	116_C	0.675	0.99
206_S	210_S	0.675	0.99
189_S	201_L	0.673	0.99
104_M	108_Q	0.673	0.99
3_Y	44_I	0.671	0.99
385_A	408_G	0.670	0.99
78_K	116_C	0.667	0.99
32_I	368_L	0.666	0.98
290_I	338_F	0.665	0.98
107_V	110_R	0.664	0.98
80_A	327_L	0.664	0.98
87_T	118_R	0.664	0.98
37_A	41_E	0.662	0.98
70_K	312_E	0.662	0.98
210_S	214_A	0.659	0.98
74_E	114_T	0.659	0.98
98_P	107_V	0.658	0.98
328_E	393_L	0.656	0.98
338_F	341_N	0.656	0.98
190_V	196_S	0.656	0.98
133_E	136_N	0.655	0.98
77_A	88_V	0.655	0.98
337_H	340_K	0.653	0.98
141_K	148_F	0.653	0.98
59_H	231_H	0.651	0.98
89_A	363_L	0.651	0.98
391_T	402_N	0.650	0.98
332_P	410_P	0.650	0.98
304_D	307_P	0.649	0.98
238_V	298_I	0.648	0.98
332_P	409_W	0.647	0.98
229_V	241_V	0.647	0.98
99_D	126_T	0.646	0.98
150_D	153_V	0.644	0.98
6_K	45_D	0.644	0.98
124_S	129_Q	0.642	0.98
114_T	117_V	0.641	0.98
332_P	335_Y	0.641	0.98
278_P	281_R	0.639	0.98
412_A	421_Y	0.639	0.98
163_E	167_R	0.636	0.98
176_V	361_F	0.635	0.98
293_L	298_I	0.635	0.98
226_H	360_A	0.635	0.98
122_Y	176_V	0.634	0.98
122_Y	125_I	0.633	0.98
123_A	145_A	0.633	0.98
272_T	320_A	0.632	0.98
392_F	402_N	0.631	0.98
325_V	398_N	0.631	0.98
158_A	183_S	0.630	0.98
333_L	337_H	0.629	0.98
102_E	106_W	0.629	0.98
195_F	198_A	0.629	0.98
410_P	413_T	0.629	0.98
9_W	18_T	0.628	0.98
5_I	44_I	0.627	0.98
21_D	38_T	0.626	0.98
213_I	217_V	0.625	0.98
146_F	165_M	0.625	0.98
276_M	280_L	0.623	0.98
3_Y	41_E	0.622	0.98
224_N	250_R	0.621	0.98
14_N	355_I	0.621	0.98
30_T	370_T	0.620	0.98
407_T	410_P	0.618	0.98
365_Y	375_D	0.618	0.98
7_N	21_D	0.617	0.98
12_N	18_T	0.614	0.97
156_Q	160_M	0.614	0.97
60_V	85_Y	0.613	0.97
299_D	302_A	0.611	0.97
213_I	232_I	0.611	0.97
10_I	32_I	0.609	0.97
52_S	354_T	0.609	0.97
290_I	294_L	0.609	0.97
158_A	162_Y	0.609	0.97
108_Q	111_I	0.608	0.97
68_E	72_T	0.608	0.97
150_D	155_I	0.608	0.97
36_D	41_E	0.607	0.97
67_G	70_K	0.607	0.97
143_A	146_F	0.606	0.97
62_F	90_A	0.605	0.97
245_K	297_T	0.602	0.97
56_V	357_P	0.602	0.97
104_M	145_A	0.600	0.97
271_D	279_P	0.600	0.97
125_I	129_Q	0.600	0.97
151_D	155_I	0.599	0.97
110_R	114_T	0.598	0.97
227_Y	249_I	0.598	0.97
397_K	402_N	0.596	0.97
333_L	406_C	0.595	0.97
64_E	110_R	0.594	0.97
13_E	17_K	0.593	0.97
82_R	328_E	0.591	0.97
335_Y	339_V	0.591	0.97
238_V	253_A	0.590	0.97
9_W	382_E	0.590	0.97
177_A	227_Y	0.584	0.97
284_E	288_A	0.582	0.96
154_G	157_T	0.581	0.96
118_R	375_D	0.580	0.96
232_I	298_I	0.578	0.96
274_Y	278_P	0.577	0.96
97_V	124_S	0.576	0.96
31_A	38_T	0.575	0.96
5_I	8_G	0.575	0.96
166_K	192_E	0.575	0.96
241_V	244_A	0.574	0.96
339_V	344_W	0.573	0.96
338_F	343_S	0.573	0.96
337_H	404_I	0.572	0.96
375_D	415_A	0.571	0.96
105_E	108_Q	0.571	0.96
339_V	345_S	0.571	0.96
172_D	250_R	0.570	0.96
199_N	202_N	0.570	0.96
393_L	421_Y	0.570	0.96
237_S	241_V	0.569	0.96
267_I	317_M	0.569	0.96
13_E	347_K	0.569	0.96
198_A	202_N	0.568	0.96
174_A	177_A	0.566	0.96
189_S	192_E	0.566	0.96
12_N	367_T	0.565	0.96
353_M	357_P	0.565	0.96
244_A	248_G	0.565	0.96
35_L	41_E	0.564	0.96
36_D	40_N	0.563	0.96
200_G	203_G	0.563	0.96
286_R	289_L	0.563	0.96
258_H	276_M	0.561	0.96
392_F	396_G	0.559	0.96
262_L	400_P	0.559	0.96
332_P	338_F	0.559	0.96
189_S	199_N	0.558	0.96
141_K	171_I	0.558	0.96
285_D	292_G	0.557	0.96
63_R	70_K	0.556	0.95
87_T	358_C	0.556	0.95
153_V	156_Q	0.554	0.95
27_E	418_K	0.554	0.95
296_G	299_D	0.554	0.95
188_G	204_I	0.553	0.95
245_K	248_G	0.552	0.95
231_H	254_E	0.551	0.95
86_T	375_D	0.551	0.95
86_T	413_T	0.549	0.95
58_L	360_A	0.548	0.95
211_V	215_R	0.548	0.95
194_T	197_K	0.548	0.95
382_E	407_T	0.548	0.95
13_E	355_I	0.547	0.95
177_A	216_D	0.547	0.95
9_W	20_A	0.544	0.95
70_K	309_T	0.544	0.95
261_L	337_H	0.543	0.95
238_V	297_T	0.543	0.95
168_A	225_C	0.542	0.95
61_H	231_H	0.542	0.95
77_A	81_A	0.541	0.95
400_P	403_G	0.541	0.95
169_A	223_A	0.540	0.95
189_S	202_N	0.539	0.95
308_H	312_E	0.537	0.95
232_I	253_A	0.537	0.95
294_L	343_S	0.537	0.95
120_L	123_A	0.534	0.94
390_E	402_N	0.534	0.94
143_A	147_A	0.534	0.94
107_V	111_I	0.533	0.94
324_I	400_P	0.533	0.94
60_V	327_L	0.533	0.94
134_M	167_R	0.532	0.94
39_D	43_V	0.531	0.94
310_E	389_K	0.531	0.94
151_D	154_G	0.530	0.94
153_V	161_M	0.528	0.94
273_N	310_E	0.528	0.94
328_E	331_F	0.526	0.94
15_G	369_Q	0.526	0.94
79_A	327_L	0.525	0.94
29_I	372_Q	0.525	0.94
392_F	399_T	0.525	0.94
29_I	32_I	0.525	0.94
56_V	366_G	0.525	0.94
332_P	407_T	0.524	0.94
119_V	122_Y	0.524	0.94
73_I	114_T	0.523	0.94
288_A	291_E	0.521	0.94
117_V	123_A	0.521	0.94
97_V	129_Q	0.520	0.94
120_L	124_S	0.518	0.93
277_N	322_F	0.518	0.93
107_V	112_K	0.517	0.93
51_V	368_L	0.515	0.93
323_G	328_E	0.514	0.93
385_A	406_C	0.513	0.93
55_F	354_T	0.513	0.93
23_R	37_A	0.513	0.93
19_Q	34_K	0.512	0.93
64_E	72_T	0.511	0.93
136_N	140_L	0.511	0.93
87_T	366_G	0.509	0.93
274_Y	280_L	0.508	0.93
302_A	305_H	0.508	0.93
129_Q	153_V	0.507	0.93
303_T	308_H	0.507	0.93
14_N	369_Q	0.506	0.93
181_D	215_R	0.506	0.93
169_A	195_F	0.506	0.93
59_H	254_E	0.506	0.93
116_C	119_V	0.505	0.93
162_Y	207_V	0.505	0.93
335_Y	341_N	0.505	0.93
122_Y	129_Q	0.503	0.92
4_L	35_L	0.502	0.92
238_V	242_R	0.501	0.92
272_T	275_K	0.501	0.92
200_G	277_N	0.501	0.92
9_W	47_K	0.501	0.92
159_G	162_Y	0.500	0.92
22_I	376_I	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dc8A	3	0.9836	100	0.267	Contact Map
3mpgA	2	0.9953	100	0.267	Contact Map
2ftyA	3	0.9953	100	0.27	Contact Map
3griA	1	0.986	100	0.274	Contact Map
4lcqA	3	0.9953	100	0.28	Contact Map
3hm7A	2	0.979	100	0.287	Contact Map
2z00A	2	0.9813	100	0.289	Contact Map
1gkrA	3	0.9883	100	0.29	Contact Map
3sfwA	3	0.9953	100	0.293	Contact Map
2ftwA	3	0.9953	100	0.294	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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