CARB - BACSU - GREMLIN Contacts

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CARB - Carbamoyl-phosphate synthase pyrimidine-specific large chain

UniProt:	P25994	Sequences: MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEVILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVELSERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVSQIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEYEVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALGIEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEMMNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEESLLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHEFSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYSLRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQGVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDLEQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQPLGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQHPVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKKKIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLATKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKDSTLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAGYLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVENGVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	1071 (1048)
Sequences:	2857 (1170)
Seq/√Len:	36.1

ECOLI - CARB
BACSU - CARB CARY
HALSA - CARB
SULSO - CARB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
355_S	392_S	7.004	1.00
463_F	467_Q	5.549	1.00
226_D	273_R	4.724	1.00
9_K	45_I	4.621	1.00
9_K	43_E	4.582	1.00
288_D	291_S	4.448	1.00
555_M	591_V	4.401	1.00
698_S	723_E	4.320	1.00
82_R	111_C	4.275	1.00
69_L	98_L	4.234	1.00
676_E	810_G	4.216	1.00
104_E	124_Q	4.201	1.00
858_K	863_Q	4.152	1.00
659_E	669_K	4.142	1.00
552_K	628_M	4.097	1.00
940_L	954_A	3.692	1.00
192_V	204_C	3.646	1.00
155_A	192_V	3.636	1.00
615_I	619_M	3.562	1.00
437_E	441_R	3.501	1.00
138_E	274_A	3.442	1.00
398_R	617_D	3.425	1.00
288_D	293_Q	3.396	1.00
218_Y	233_N	3.390	1.00
914_D	919_K	3.290	1.00
10_I	42_Y	3.268	1.00
937_S	963_N	3.235	1.00
802_Q	806_A	3.218	1.00
790_Q	881_V	3.217	1.00
762_E	864_K	3.185	1.00
75_T	110_E	3.127	1.00
435_L	448_L	3.091	1.00
237_I	462_L	3.087	1.00
79_R	111_C	3.043	1.00
264_L	294_Y	3.039	1.00
78_I	111_C	3.014	1.00
956_R	1049_E	3.014	1.00
233_N	253_S	3.010	1.00
591_V	621_I	3.000	1.00
439_Y	459_L	2.993	1.00
145_E	208_K	2.958	1.00
75_T	79_R	2.921	1.00
468_F	488_L	2.912	1.00
704_V	744_I	2.908	1.00
864_K	867_A	2.886	1.00
42_Y	327_V	2.859	1.00
160_S	185_E	2.855	1.00
511_K	623_D	2.852	1.00
156_E	189_K	2.825	1.00
75_T	111_C	2.772	1.00
544_N	624_L	2.770	1.00
694_V	727_L	2.757	1.00
794_E	798_K	2.747	1.00
43_E	63_R	2.726	1.00
863_Q	867_A	2.708	1.00
446_E	456_V	2.695	1.00
439_Y	445_V	2.695	1.00
757_A	804_T	2.692	1.00
758_V	859_I	2.684	1.00
973_Y	977_A	2.611	1.00
393_L	432_L	2.605	1.00
421_E	447_D	2.601	1.00
958_H	980_P	2.576	1.00
555_M	622_I	2.563	1.00
4_R	114_E	2.562	1.00
185_E	189_K	2.555	1.00
685_K	699_D	2.530	1.00
130_D	134_T	2.527	1.00
149_I	158_F	2.522	1.00
10_I	327_V	2.506	1.00
702_Y	723_E	2.498	1.00
390_E	461_K	2.487	1.00
479_T	483_R	2.486	1.00
885_A	924_A	2.442	1.00
551_K	587_E	2.437	1.00
74_L	98_L	2.418	1.00
151_S	154_E	2.377	1.00
159_V	164_F	2.377	1.00
483_R	487_E	2.362	1.00
622_I	651_V	2.359	1.00
386_G	391_E	2.346	1.00
47_V	77_I	2.329	0.99
583_Q	854_N	2.317	0.99
71_P	101_E	2.314	0.99
680_P	803_Y	2.311	0.99
722_H	725_E	2.306	0.99
944_D	947_K	2.293	0.99
957_F	1045_L	2.291	0.99
733_A	737_N	2.291	0.99
685_K	696_I	2.281	0.99
864_K	868_F	2.278	0.99
971_A	981_A	2.277	0.99
75_T	105_R	2.276	0.99
805_I	809_K	2.254	0.99
951_L	973_Y	2.238	0.99
416_S	419_L	2.232	0.99
797_K	877_E	2.227	0.99
141_E	270_K	2.212	0.99
660_D	812_N	2.207	0.99
272_I	283_V	2.206	0.99
855_L	868_F	2.197	0.99
218_Y	253_S	2.193	0.99
39_E	324_K	2.190	0.99
471_E	484_R	2.181	0.99
555_M	621_I	2.179	0.99
142_P	293_Q	2.160	0.99
208_K	293_Q	2.151	0.99
443_Y	447_D	2.151	0.99
799_K	802_Q	2.149	0.99
164_F	185_E	2.148	0.99
242_I	427_A	2.143	0.99
1007_I	1041_A	2.142	0.99
150_H	203_Q	2.122	0.99
963_N	982_K	2.117	0.99
549_T	587_E	2.111	0.99
951_L	977_A	2.099	0.99
647_S	659_E	2.099	0.99
507_Y	619_M	2.094	0.99
394_L	490_F	2.080	0.99
481_V	485_A	2.080	0.99
439_Y	448_L	2.075	0.99
937_S	965_L	2.074	0.99
76_R	79_R	2.047	0.99
767_P	852_M	2.045	0.99
679_V	803_Y	2.042	0.99
147_E	161_Q	2.042	0.99
100_V	120_L	2.042	0.99
370_R	429_D	2.037	0.99
763_T	866_A	2.033	0.99
694_V	723_E	2.026	0.99
502_K	505_E	2.024	0.99
287_L	294_Y	2.012	0.98
375_Q	892_K	2.005	0.98
390_E	464_G	2.000	0.98
271_L	296_I	2.000	0.98
753_I	792_L	1.998	0.98
141_E	267_V	1.996	0.98
511_K	516_A	1.984	0.98
71_P	105_R	1.972	0.98
445_V	459_L	1.969	0.98
723_E	727_L	1.965	0.98
984_V	997_V	1.962	0.98
504_S	648_A	1.961	0.98
644_D	648_A	1.953	0.98
435_L	454_I	1.946	0.98
164_F	184_N	1.945	0.98
417_D	441_R	1.935	0.98
971_A	983_V	1.923	0.98
795_D	826_G	1.917	0.98
689_S	692_Q	1.913	0.98
662_D	669_K	1.901	0.98
66_I	911_M	1.898	0.98
171_A	203_Q	1.896	0.98
75_T	107_V	1.891	0.98
662_D	710_Y	1.879	0.98
609_Y	625_E	1.879	0.98
182_C	191_I	1.879	0.98
755_V	804_T	1.875	0.98
40_E	324_K	1.874	0.98
184_N	187_E	1.873	0.98
509_L	513_A	1.869	0.98
150_H	154_E	1.867	0.98
47_V	74_L	1.866	0.97
733_A	742_V	1.864	0.97
78_I	113_V	1.857	0.97
584_A	858_K	1.845	0.97
583_Q	858_K	1.836	0.97
159_V	166_V	1.832	0.97
79_R	110_E	1.830	0.97
683_L	699_D	1.829	0.97
253_S	261_Y	1.821	0.97
733_A	736_I	1.817	0.97
695_S	699_D	1.816	0.97
103_S	120_L	1.809	0.97
680_P	827_E	1.799	0.97
516_A	623_D	1.786	0.97
388_T	541_E	1.782	0.97
759_S	809_K	1.763	0.96
147_E	158_F	1.760	0.96
9_K	63_R	1.759	0.96
687_A	696_I	1.756	0.96
554_V	654_L	1.747	0.96
151_S	202_H	1.744	0.96
1006_V	1027_S	1.739	0.96
992_P	996_D	1.738	0.96
444_T	447_D	1.735	0.96
449_H	459_L	1.734	0.96
470_K	473_K	1.731	0.96
492_D	510_R	1.731	0.96
673_A	807_L	1.730	0.96
728_H	732_N	1.720	0.96
135_L	274_A	1.714	0.96
508_S	512_Q	1.708	0.96
168_V	204_C	1.699	0.96
439_Y	462_L	1.685	0.95
753_I	823_L	1.676	0.95
424_I	438_A	1.668	0.95
196_L	202_H	1.668	0.95
793_T	796_I	1.662	0.95
793_T	826_G	1.660	0.95
734_V	742_V	1.655	0.95
382_V	399_S	1.651	0.95
436_A	440_R	1.644	0.95
124_Q	131_L	1.641	0.95
168_V	206_L	1.637	0.95
799_K	803_Y	1.636	0.95
183_S	187_E	1.630	0.94
393_L	407_L	1.629	0.94
615_I	645_E	1.624	0.94
753_I	800_I	1.620	0.94
103_S	109_A	1.620	0.94
946_D	1009_T	1.613	0.94
965_L	1003_A	1.612	0.94
86_I	113_V	1.599	0.94
436_A	462_L	1.596	0.94
495_I	499_W	1.594	0.94
757_A	817_L	1.590	0.94
260_E	292_F	1.587	0.94
133_R	137_N	1.579	0.93
125_Q	274_A	1.578	0.93
552_K	586_Y	1.577	0.93
584_A	861_L	1.576	0.93
465_I	490_F	1.569	0.93
673_A	810_G	1.565	0.93
73_F	77_I	1.562	0.93
683_L	746_R	1.562	0.93
1025_R	1029_E	1.561	0.93
531_S	534_P	1.561	0.93
164_F	188_L	1.561	0.93
405_Y	497_R	1.554	0.93
71_P	74_L	1.554	0.93
478_D	481_V	1.551	0.93
716_A	733_A	1.549	0.93
275_L	299_V	1.545	0.93
615_I	649_R	1.539	0.93
966_A	981_A	1.534	0.92
509_L	512_Q	1.532	0.92
389_L	457_F	1.530	0.92
581_I	588_A	1.527	0.92
464_G	488_L	1.527	0.92
789_P	797_K	1.525	0.92
753_I	828_V	1.524	0.92
823_L	828_V	1.524	0.92
798_K	801_E	1.523	0.92
680_P	799_K	1.520	0.92
986_K	1019_D	1.515	0.92
218_Y	268_S	1.512	0.92
168_V	188_L	1.511	0.92
796_I	826_G	1.504	0.92
503_E	507_Y	1.496	0.91
671_E	681_Q	1.495	0.91
799_K	828_V	1.493	0.91
71_P	98_L	1.492	0.91
225_Q	330_S	1.492	0.91
224_S	330_S	1.488	0.91
962_Y	1048_L	1.486	0.91
581_I	861_L	1.473	0.91
916_T	919_K	1.471	0.91
506_L	509_L	1.469	0.91
468_F	485_A	1.468	0.91
521_M	536_F	1.461	0.90
149_I	154_E	1.461	0.90
628_M	652_K	1.460	0.90
784_I	885_A	1.457	0.90
482_L	509_L	1.455	0.90
134_T	138_E	1.454	0.90
758_V	852_M	1.452	0.90
796_I	828_V	1.450	0.90
998_I	1032_V	1.448	0.90
237_I	248_I	1.437	0.90
549_T	553_S	1.437	0.90
443_Y	448_L	1.435	0.90
501_M	506_L	1.429	0.89
107_V	111_C	1.424	0.89
660_D	663_R	1.423	0.89
144_P	295_Y	1.421	0.89
796_I	823_L	1.415	0.89
669_K	710_Y	1.413	0.89
472_L	485_A	1.408	0.89
421_E	443_Y	1.406	0.89
674_L	830_V	1.406	0.89
449_H	453_A	1.405	0.89
631_V	857_T	1.403	0.89
511_K	620_H	1.398	0.88
397_V	432_L	1.396	0.88
554_V	861_L	1.392	0.88
801_E	875_Q	1.389	0.88
152_L	188_L	1.387	0.88
421_E	451_F	1.381	0.88
88_P	99_A	1.379	0.88
149_I	155_A	1.378	0.88
765_V	870_Y	1.378	0.88
237_I	435_L	1.377	0.88
417_D	447_D	1.375	0.88
697_A	702_Y	1.367	0.87
857_T	861_L	1.360	0.87
321_L	337_P	1.358	0.87
493_Q	503_E	1.351	0.87
863_Q	868_F	1.348	0.86
975_K	983_V	1.347	0.86
479_T	513_A	1.340	0.86
663_R	810_G	1.338	0.86
69_L	74_L	1.335	0.86
804_T	821_F	1.334	0.86
101_E	104_E	1.331	0.86
803_Y	828_V	1.329	0.86
152_L	156_E	1.327	0.86
439_Y	463_F	1.324	0.85
465_I	488_L	1.323	0.85
942_V	950_G	1.323	0.85
630_V	651_V	1.316	0.85
157_K	160_S	1.315	0.85
70_T	73_F	1.314	0.85
420_L	448_L	1.312	0.85
11_L	86_I	1.311	0.85
947_K	969_G	1.311	0.85
759_S	764_V	1.309	0.85
799_K	827_E	1.309	0.85
477_G	499_W	1.300	0.84
553_S	587_E	1.294	0.84
237_I	250_V	1.289	0.84
516_A	620_H	1.286	0.84
159_V	188_L	1.285	0.84
679_V	828_V	1.279	0.83
748_L	824_S	1.278	0.83
257_S	260_E	1.277	0.83
968_E	983_V	1.276	0.83
341_K	532_E	1.275	0.83
1046_R	1049_E	1.271	0.83
554_V	581_I	1.270	0.83
263_L	287_L	1.269	0.83
548_V	607_K	1.269	0.83
477_G	482_L	1.265	0.83
6_D	114_E	1.261	0.83
440_R	469_E	1.257	0.82
40_E	329_L	1.254	0.82
975_K	981_A	1.254	0.82
588_A	861_L	1.251	0.82
672_Q	676_E	1.251	0.82
461_K	464_G	1.245	0.82
972_G	976_E	1.244	0.82
394_L	465_I	1.240	0.81
546_S	624_L	1.239	0.81
146_S	207_E	1.237	0.81
221_M	321_L	1.235	0.81
807_L	819_I	1.233	0.81
797_K	801_E	1.232	0.81
520_K	543_E	1.227	0.81
86_I	108_L	1.227	0.81
631_V	860_I	1.224	0.81
468_F	481_V	1.224	0.81
125_Q	138_E	1.223	0.81
671_E	684_G	1.222	0.80
472_L	498_E	1.219	0.80
985_G	993_N	1.213	0.80
393_L	462_L	1.212	0.80
956_R	1045_L	1.206	0.80
619_M	651_V	1.205	0.80
436_A	466_V	1.201	0.79
394_L	406_H	1.194	0.79
955_K	959_A	1.192	0.79
100_V	131_L	1.188	0.79
730_M	734_V	1.186	0.78
443_Y	451_F	1.184	0.78
184_N	991_G	1.183	0.78
457_F	461_K	1.183	0.78
417_D	421_E	1.181	0.78
954_A	964_I	1.176	0.78
126_A	283_V	1.175	0.78
405_Y	493_Q	1.169	0.77
131_L	134_T	1.167	0.77
448_L	462_L	1.166	0.77
472_L	495_I	1.165	0.77
730_M	733_A	1.161	0.77
769_I	801_E	1.160	0.77
250_V	355_S	1.158	0.77
764_V	809_K	1.158	0.77
329_L	334_M	1.156	0.77
607_K	625_E	1.152	0.76
584_A	863_Q	1.152	0.76
194_N	198_L	1.152	0.76
47_V	102_L	1.148	0.76
628_M	654_L	1.146	0.76
482_L	515_I	1.144	0.76
859_I	868_F	1.143	0.76
404_V	433_F	1.141	0.76
71_P	107_V	1.141	0.76
471_E	481_V	1.138	0.75
142_P	208_K	1.136	0.75
449_H	456_V	1.135	0.75
769_I	797_K	1.133	0.75
734_V	737_N	1.132	0.75
517_P	540_Y	1.130	0.75
803_Y	821_F	1.129	0.75
100_V	124_Q	1.128	0.75
13_I	69_L	1.127	0.75
125_Q	135_L	1.120	0.74
137_N	143_V	1.119	0.74
786_V	917_L	1.119	0.74
124_Q	172_Y	1.118	0.74
267_V	294_Y	1.117	0.74
170_P	179_G	1.113	0.74
71_P	75_T	1.112	0.74
19_I	177_T	1.110	0.74
340_G	532_E	1.109	0.74
155_A	206_L	1.103	0.73
34_C	60_M	1.103	0.73
390_E	488_L	1.101	0.73
133_R	207_E	1.098	0.73
501_M	505_E	1.095	0.73
101_E	105_R	1.093	0.72
258_D	262_Q	1.093	0.72
617_D	620_H	1.093	0.72
121_S	131_L	1.092	0.72
188_L	206_L	1.091	0.72
423_R	428_G	1.090	0.72
1021_F	1025_R	1.088	0.72
321_L	334_M	1.088	0.72
557_L	618_V	1.087	0.72
208_K	295_Y	1.086	0.72
991_G	996_D	1.085	0.72
579_W	604_I	1.085	0.72
424_I	452_S	1.084	0.72
437_E	440_R	1.082	0.72
423_R	434_Y	1.082	0.72
13_I	74_L	1.081	0.72
507_Y	649_R	1.081	0.72
99_A	115_V	1.081	0.72
965_L	982_K	1.079	0.71
620_H	623_D	1.075	0.71
382_V	396_A	1.068	0.71
207_E	210_I	1.068	0.71
388_T	488_L	1.066	0.71
221_M	272_I	1.065	0.70
578_V	605_S	1.064	0.70
262_Q	265_R	1.060	0.70
227_H	330_S	1.057	0.70
228_A	269_L	1.056	0.70
227_H	345_A	1.054	0.70
155_A	168_V	1.048	0.69
420_L	441_R	1.048	0.69
736_I	742_V	1.040	0.69
843_F	911_M	1.038	0.68
940_L	974_L	1.036	0.68
858_K	868_F	1.032	0.68
716_A	734_V	1.032	0.68
259_R	292_F	1.032	0.68
250_V	389_L	1.031	0.68
619_M	649_R	1.030	0.68
220_V	230_V	1.029	0.68
337_P	602_F	1.028	0.68
388_T	392_S	1.028	0.68
126_A	716_A	1.027	0.68
214_K	455_D	1.026	0.68
266_N	270_K	1.026	0.68
218_Y	228_A	1.025	0.67
804_T	819_I	1.022	0.67
404_V	408_E	1.022	0.67
986_K	1023_I	1.021	0.67
1005_F	1035_L	1.021	0.67
228_A	273_R	1.020	0.67
679_V	799_K	1.017	0.67
989_Q	993_N	1.016	0.67
189_K	193_E	1.016	0.67
192_V	206_L	1.016	0.67
809_K	812_N	1.015	0.67
417_D	443_Y	1.014	0.67
225_Q	332_D	1.014	0.67
13_I	95_G	1.012	0.66
613_L	642_L	1.009	0.66
141_E	296_I	1.008	0.66
727_L	731_K	1.006	0.66
191_I	195_G	1.006	0.66
987_I	995_L	1.005	0.66
38_K	60_M	1.005	0.66
290_D	453_A	1.002	0.66
720_V	742_V	1.002	0.66
445_V	460_H	1.002	0.66
814_V	859_I	0.999	0.65
882_F	913_K	0.998	0.65
228_A	272_I	0.998	0.65
387_R	541_E	0.997	0.65
164_F	189_K	0.997	0.65
964_I	981_A	0.997	0.65
438_A	443_Y	0.993	0.65
807_L	830_V	0.993	0.65
688_T	692_Q	0.991	0.65
578_V	588_A	0.987	0.65
1010_L	1020_G	0.986	0.64
710_Y	740_H	0.986	0.64
520_K	541_E	0.984	0.64
448_L	459_L	0.983	0.64
1007_I	1038_L	0.979	0.64
85_A	88_P	0.979	0.64
784_I	886_P	0.977	0.64
336_N	339_T	0.975	0.64
985_G	992_P	0.974	0.63
36_A	334_M	0.974	0.63
144_P	210_I	0.972	0.63
424_I	434_Y	0.972	0.63
159_V	192_V	0.971	0.63
445_V	463_F	0.968	0.63
460_H	463_F	0.968	0.63
387_R	520_K	0.968	0.63
730_M	737_N	0.966	0.63
141_E	283_V	0.966	0.63
918_E	1046_R	0.965	0.63
998_I	1026_E	0.963	0.63
789_P	792_L	0.963	0.63
880_G	913_K	0.963	0.63
218_Y	261_Y	0.960	0.62
496_S	506_L	0.960	0.62
107_V	110_E	0.960	0.62
262_Q	529_F	0.955	0.62
847_I	882_F	0.954	0.62
737_N	742_V	0.952	0.62
253_S	350_L	0.951	0.62
1_M	7_I	0.949	0.61
353_V	392_S	0.948	0.61
8_N	43_E	0.947	0.61
121_S	125_Q	0.946	0.61
262_Q	528_E	0.946	0.61
938_V	954_A	0.944	0.61
403_D	407_L	0.943	0.61
998_I	1023_I	0.942	0.61
988_G	993_N	0.942	0.61
775_R	1039_D	0.941	0.61
693_A	730_M	0.941	0.61
357_I	360_W	0.940	0.61
462_L	466_V	0.938	0.61
479_T	515_I	0.937	0.60
1044_I	1048_L	0.935	0.60
468_F	484_R	0.935	0.60
787_Y	844_L	0.934	0.60
950_G	974_L	0.934	0.60
4_R	42_Y	0.932	0.60
153_E	157_K	0.930	0.60
184_N	1000_N	0.930	0.60
464_G	468_F	0.928	0.60
412_A	434_Y	0.928	0.60
35_L	603_S	0.926	0.60
449_H	454_I	0.923	0.59
468_F	471_E	0.922	0.59
674_L	678_G	0.922	0.59
998_I	1030_N	0.922	0.59
234_M	249_V	0.921	0.59
690_V	727_L	0.921	0.59
933_P	936_G	0.920	0.59
938_V	1007_I	0.919	0.59
156_E	164_F	0.916	0.59
164_F	627_P	0.915	0.59
734_V	740_H	0.914	0.58
156_E	185_E	0.913	0.58
24_A	562_I	0.910	0.58
965_L	997_V	0.909	0.58
587_E	607_K	0.907	0.58
586_Y	628_M	0.907	0.58
166_V	188_L	0.906	0.58
634_F	856_A	0.906	0.58
517_P	620_H	0.905	0.58
168_V	192_V	0.904	0.58
342_T	346_F	0.904	0.58
320_K	337_P	0.904	0.58
154_E	157_K	0.900	0.57
402_A	433_F	0.900	0.57
771_E	791_S	0.898	0.57
11_L	78_I	0.898	0.57
964_I	979_I	0.897	0.57
934_N	1048_L	0.892	0.57
180_G	191_I	0.892	0.57
577_S	631_V	0.891	0.57
408_E	497_R	0.888	0.56
145_E	293_Q	0.887	0.56
45_I	77_I	0.886	0.56
258_D	529_F	0.883	0.56
575_V	1021_F	0.882	0.56
286_A	295_Y	0.881	0.56
750_G	822_V	0.879	0.56
268_S	285_L	0.879	0.56
221_M	229_I	0.879	0.56
947_K	970_T	0.878	0.55
755_V	800_I	0.878	0.55
505_E	508_S	0.878	0.55
765_V	850_I	0.877	0.55
764_V	805_I	0.877	0.55
262_Q	346_F	0.875	0.55
404_V	410_K	0.875	0.55
265_R	347_E	0.874	0.55
2_P	333_E	0.871	0.55
357_I	396_A	0.871	0.55
765_V	875_Q	0.868	0.55
248_I	432_L	0.868	0.55
213_Y	295_Y	0.867	0.54
394_L	494_Y	0.867	0.54
482_L	506_L	0.862	0.54
379_T	562_I	0.861	0.54
773_I	786_V	0.860	0.54
948_E	952_A	0.860	0.54
207_E	613_L	0.858	0.54
646_L	651_V	0.857	0.54
1006_V	1023_I	0.857	0.54
133_R	148_I	0.857	0.54
210_I	240_V	0.856	0.54
471_E	475_N	0.855	0.53
157_K	161_Q	0.855	0.53
800_I	823_L	0.854	0.53
800_I	804_T	0.854	0.53
271_L	627_P	0.852	0.53
1035_L	1044_I	0.851	0.53
515_I	540_Y	0.850	0.53
346_F	528_E	0.850	0.53
47_V	69_L	0.850	0.53
942_V	954_A	0.849	0.53
128_D	203_Q	0.849	0.53
447_D	450_E	0.849	0.53
644_D	647_S	0.848	0.53
166_V	206_L	0.848	0.53
937_S	982_K	0.847	0.53
730_M	742_V	0.846	0.53
482_L	510_R	0.846	0.53
226_D	230_V	0.846	0.53
218_Y	254_Q	0.844	0.52
394_L	457_F	0.844	0.52
450_E	453_A	0.844	0.52
518_V	541_E	0.842	0.52
167_I	181_I	0.841	0.52
267_V	271_L	0.840	0.52
4_R	10_I	0.839	0.52
145_E	161_Q	0.838	0.52
371_K	426_K	0.837	0.52
265_R	346_F	0.837	0.52
848_T	870_Y	0.836	0.52
615_I	642_L	0.835	0.52
341_K	531_S	0.833	0.52
391_E	489_G	0.832	0.51
74_L	77_I	0.832	0.51
975_K	980_P	0.832	0.51
940_L	950_G	0.832	0.51
554_V	586_Y	0.830	0.51
759_S	817_L	0.829	0.51
681_Q	716_A	0.828	0.51
682_P	712_L	0.828	0.51
369_N	429_D	0.827	0.51
557_L	613_L	0.827	0.51
383_M	610_F	0.826	0.51
967_T	970_T	0.825	0.51
555_M	628_M	0.825	0.51
281_C	299_V	0.824	0.51
168_V	191_I	0.824	0.51
336_N	523_D	0.824	0.51
937_S	1004_Q	0.820	0.50
19_I	242_I	0.818	0.50
588_A	857_T	0.817	0.50
724_E	727_L	0.816	0.50
663_R	673_A	0.815	0.50
691_N	695_S	0.815	0.50
94_T	174_L	0.815	0.50
421_E	448_L	0.815	0.50
482_L	513_A	0.815	0.50
420_L	438_A	0.815	0.50
102_L	108_L	0.814	0.50
379_T	593_N	0.814	0.50
1037_S	1040_T	0.813	0.50
177_T	892_K	0.812	0.50
575_V	579_W	0.812	0.50
573_A	853_A	0.811	0.50
242_I	426_K	0.810	0.50
234_M	299_V	0.809	0.49
971_A	975_K	0.809	0.49
943_A	946_D	0.809	0.49
354_V	385_I	0.808	0.49
5_V	42_Y	0.808	0.49
986_K	989_Q	0.805	0.49
712_L	843_F	0.805	0.49
695_S	698_S	0.804	0.49
1019_D	1023_I	0.803	0.49
806_A	810_G	0.802	0.49
536_F	546_S	0.802	0.49
346_F	533_T	0.801	0.49
476_A	499_W	0.797	0.48
262_Q	525_C	0.795	0.48
152_L	155_A	0.795	0.48
119_K	224_S	0.793	0.48
969_G	986_K	0.793	0.48
439_Y	443_Y	0.792	0.48
671_E	705_L	0.792	0.48
494_Y	498_E	0.792	0.48
141_E	294_Y	0.791	0.48
133_R	205_L	0.790	0.48
60_M	64_V	0.790	0.48
807_L	817_L	0.790	0.48
156_E	168_V	0.787	0.48
668_D	686_T	0.787	0.48
562_I	593_N	0.787	0.48
218_Y	272_I	0.787	0.48
754_E	767_P	0.786	0.47
156_E	159_V	0.785	0.47
246_D	372_L	0.783	0.47
230_V	338_V	0.782	0.47
668_D	688_T	0.781	0.47
823_L	826_G	0.781	0.47
234_M	294_Y	0.780	0.47
797_K	804_T	0.780	0.47
974_L	981_A	0.779	0.47
446_E	450_E	0.779	0.47
177_T	375_Q	0.778	0.47
166_V	192_V	0.778	0.47
504_S	649_R	0.777	0.47
784_I	925_L	0.777	0.47
824_S	827_E	0.776	0.47
85_A	116_L	0.776	0.47
758_V	870_Y	0.775	0.46
765_V	871_T	0.774	0.46
967_T	1023_I	0.773	0.46
886_P	924_A	0.772	0.46
399_S	612_P	0.770	0.46
201_V	531_S	0.770	0.46
845_S	852_M	0.769	0.46
184_N	999_R	0.769	0.46
934_N	962_Y	0.769	0.46
673_A	811_L	0.768	0.46
937_S	997_V	0.768	0.46
577_S	857_T	0.768	0.46
206_L	264_L	0.767	0.46
213_Y	603_S	0.767	0.46
234_M	379_T	0.767	0.46
290_D	456_V	0.766	0.46
968_E	989_Q	0.766	0.46
183_S	211_A	0.766	0.46
730_M	736_I	0.766	0.46
580_A	854_N	0.765	0.46
149_I	204_C	0.765	0.46
579_W	583_Q	0.765	0.46
525_C	529_F	0.763	0.45
58_T	849_G	0.761	0.45
221_M	323_A	0.761	0.45
47_V	107_V	0.761	0.45
79_R	82_R	0.760	0.45
346_F	529_F	0.760	0.45
152_L	159_V	0.760	0.45
345_A	577_S	0.759	0.45
982_K	1002_E	0.759	0.45
10_I	853_A	0.757	0.45
233_N	261_Y	0.756	0.45
31_T	60_M	0.755	0.45
265_R	523_D	0.755	0.45
715_R	734_V	0.755	0.45
960_I	1049_E	0.754	0.45
800_I	828_V	0.753	0.45
347_E	523_D	0.753	0.45
549_T	607_K	0.752	0.44
771_E	790_Q	0.752	0.44
716_A	736_I	0.750	0.44
130_D	148_I	0.750	0.44
357_I	432_L	0.749	0.44
963_N	980_P	0.749	0.44
657_S	812_N	0.749	0.44
155_A	205_L	0.748	0.44
496_S	502_K	0.747	0.44
386_G	489_G	0.747	0.44
242_I	371_K	0.747	0.44
1025_R	1028_V	0.746	0.44
618_V	642_L	0.746	0.44
336_N	533_T	0.746	0.44
947_K	986_K	0.746	0.44
258_D	265_R	0.746	0.44
720_V	733_A	0.746	0.44
995_L	1026_E	0.745	0.44
813_I	817_L	0.744	0.44
680_P	828_V	0.742	0.44
391_E	539_T	0.742	0.44
762_E	809_K	0.740	0.43
177_T	914_D	0.740	0.43
57_D	572_Y	0.738	0.43
339_T	523_D	0.736	0.43
974_L	979_I	0.736	0.43
733_A	738_P	0.734	0.43
885_A	925_L	0.734	0.43
221_M	231_V	0.733	0.43
994_L	1023_I	0.733	0.43
721_Y	945_K	0.733	0.43
545_E	548_V	0.732	0.43
424_I	924_A	0.731	0.43
420_L	434_Y	0.729	0.43
753_I	888_F	0.729	0.43
773_I	950_G	0.728	0.42
706_V	804_T	0.727	0.42
765_V	855_L	0.726	0.42
249_V	299_V	0.726	0.42
335_M	343_Y	0.726	0.42
124_Q	399_S	0.725	0.42
162_I	167_I	0.724	0.42
90_L	210_I	0.724	0.42
817_L	833_V	0.721	0.42
249_V	294_Y	0.721	0.42
218_Y	229_I	0.721	0.42
722_H	744_I	0.720	0.42
346_F	523_D	0.720	0.42
729_Y	734_V	0.720	0.42
361_P	379_T	0.720	0.42
339_T	533_T	0.720	0.42
486_K	616_E	0.720	0.42
850_I	855_L	0.719	0.42
239_P	453_A	0.718	0.42
149_I	831_L	0.718	0.42
550_D	553_S	0.718	0.42
66_I	568_V	0.718	0.42
180_G	195_G	0.717	0.41
751_K	791_S	0.717	0.41
168_V	195_G	0.717	0.41
148_I	171_A	0.716	0.41
336_N	347_E	0.715	0.41
389_L	461_K	0.715	0.41
693_A	733_A	0.715	0.41
530_E	534_P	0.714	0.41
231_V	253_S	0.714	0.41
690_V	731_K	0.713	0.41
86_I	979_I	0.713	0.41
12_V	44_V	0.712	0.41
360_W	402_A	0.712	0.41
675_G	681_Q	0.712	0.41
967_T	1019_D	0.711	0.41
231_V	585_G	0.710	0.41
229_I	593_N	0.709	0.41
234_M	562_I	0.709	0.41
751_K	796_I	0.709	0.41
258_D	339_T	0.708	0.41
233_N	254_Q	0.707	0.41
831_L	1021_F	0.706	0.41
948_E	973_Y	0.706	0.41
507_Y	620_H	0.706	0.41
993_N	996_D	0.705	0.40
5_V	10_I	0.705	0.40
31_T	55_M	0.705	0.40
765_V	848_T	0.703	0.40
953_I	1045_L	0.703	0.40
152_L	192_V	0.703	0.40
557_L	632_V	0.703	0.40
967_T	986_K	0.701	0.40
7_I	1043_A	0.700	0.40
149_I	206_L	0.700	0.40
966_A	970_T	0.700	0.40
166_V	182_C	0.700	0.40
863_Q	866_A	0.699	0.40
250_V	813_I	0.699	0.40
494_Y	497_R	0.698	0.40
367_S	905_K	0.697	0.40
162_I	962_Y	0.696	0.40
288_D	295_Y	0.696	0.40
754_E	889_S	0.696	0.40
78_I	107_V	0.694	0.40
753_I	769_I	0.693	0.39
261_Y	346_F	0.692	0.39
170_P	173_T	0.692	0.39
859_I	864_K	0.692	0.39
556_V	588_A	0.692	0.39
556_V	581_I	0.690	0.39
234_M	325_I	0.690	0.39
424_I	451_F	0.689	0.39
141_E	299_V	0.687	0.39
258_D	336_N	0.687	0.39
776_A	822_V	0.686	0.39
650_G	761_G	0.686	0.39
77_I	325_I	0.684	0.39
213_Y	293_Q	0.684	0.39
177_T	198_L	0.684	0.39
160_S	164_F	0.683	0.39
496_S	501_M	0.683	0.39
940_L	964_I	0.683	0.39
339_T	347_E	0.682	0.39
632_V	653_I	0.682	0.39
258_D	347_E	0.682	0.39
405_Y	408_E	0.681	0.38
417_D	437_E	0.681	0.38
162_I	166_V	0.680	0.38
997_V	1002_E	0.680	0.38
73_F	926_I	0.680	0.38
104_E	516_A	0.680	0.38
795_D	799_K	0.680	0.38
415_I	419_L	0.680	0.38
271_L	283_V	0.679	0.38
886_P	889_S	0.678	0.38
337_P	603_S	0.678	0.38
797_K	828_V	0.678	0.38
690_V	730_M	0.678	0.38
973_Y	976_E	0.677	0.38
321_L	340_G	0.677	0.38
696_I	733_A	0.676	0.38
688_T	734_V	0.676	0.38
224_S	278_E	0.675	0.38
78_I	102_L	0.674	0.38
807_L	811_L	0.674	0.38
1008_N	1023_I	0.673	0.38
951_L	974_L	0.672	0.38
720_V	726_L	0.672	0.38
642_L	769_I	0.672	0.38
506_L	514_G	0.672	0.38
12_V	34_C	0.672	0.38
943_A	1020_G	0.671	0.38
299_V	379_T	0.670	0.38
403_D	406_H	0.670	0.38
55_M	246_D	0.669	0.37
173_T	199_S	0.669	0.37
748_L	808_A	0.668	0.37
134_T	137_N	0.668	0.37
555_M	651_V	0.668	0.37
242_I	432_L	0.668	0.37
207_E	821_F	0.667	0.37
385_I	522_V	0.667	0.37
486_K	540_Y	0.666	0.37
562_I	893_L	0.666	0.37
972_G	975_K	0.666	0.37
268_S	335_M	0.665	0.37
953_I	1038_L	0.665	0.37
748_L	823_L	0.665	0.37
691_N	727_L	0.665	0.37
986_K	990_D	0.663	0.37
519_F	538_S	0.663	0.37
265_R	528_E	0.662	0.37
499_W	506_L	0.662	0.37
822_V	889_S	0.662	0.37
24_A	379_T	0.661	0.37
133_R	146_S	0.661	0.37
910_V	927_A	0.660	0.37
968_E	972_G	0.660	0.37
406_H	573_A	0.660	0.37
555_M	588_A	0.659	0.37
131_L	264_L	0.659	0.37
1042_E	1046_R	0.659	0.37
173_T	179_G	0.659	0.37
447_D	527_A	0.658	0.37
152_L	168_V	0.657	0.37
698_S	702_Y	0.656	0.36
143_V	210_I	0.656	0.36
249_V	281_C	0.654	0.36
986_K	996_D	0.653	0.36
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706_V	726_L	0.652	0.36
802_Q	805_I	0.651	0.36
528_E	533_T	0.651	0.36
47_V	71_P	0.651	0.36
492_D	507_Y	0.650	0.36
172_Y	807_L	0.649	0.36
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249_V	562_I	0.649	0.36
696_I	699_D	0.649	0.36
277_I	557_L	0.649	0.36
397_V	401_E	0.648	0.36
672_Q	678_G	0.648	0.36
763_T	805_I	0.648	0.36
249_V	379_T	0.648	0.36
1030_N	1033_A	0.647	0.36
153_E	474_A	0.646	0.36
349_A	527_A	0.646	0.36
401_E	561_P	0.645	0.36
578_V	683_L	0.645	0.36
801_E	805_I	0.644	0.35
940_L	1007_I	0.643	0.35
316_Y	893_L	0.642	0.35
947_K	1008_N	0.642	0.35
29_A	95_G	0.642	0.35
589_I	609_Y	0.642	0.35
693_A	697_A	0.642	0.35
556_V	913_K	0.641	0.35
591_V	622_I	0.641	0.35
918_E	1050_S	0.641	0.35
230_V	273_R	0.641	0.35
153_E	186_T	0.640	0.35
938_V	1005_F	0.640	0.35
401_E	563_R	0.640	0.35
171_A	747_Y	0.640	0.35
816_L	853_A	0.640	0.35
114_E	119_K	0.640	0.35
699_D	806_A	0.639	0.35
950_G	973_Y	0.639	0.35
647_S	658_L	0.639	0.35
408_E	436_A	0.639	0.35
800_I	861_L	0.639	0.35
342_T	528_E	0.638	0.35
265_R	336_N	0.638	0.35
878_Q	882_F	0.638	0.35
686_T	730_M	0.637	0.35
942_V	946_D	0.637	0.35
139_L	744_I	0.637	0.35
574_T	853_A	0.637	0.35
422_K	426_K	0.636	0.35
985_G	990_D	0.636	0.35
6_D	42_Y	0.636	0.35
572_Y	576_H	0.635	0.35
719_I	730_M	0.635	0.35
95_G	514_G	0.635	0.35
339_T	342_T	0.635	0.35
995_L	998_I	0.635	0.35
654_L	860_I	0.635	0.35
674_L	738_P	0.635	0.35
82_R	659_E	0.634	0.35
100_V	104_E	0.634	0.35
803_Y	806_A	0.633	0.35
668_D	672_Q	0.633	0.35
42_Y	85_A	0.633	0.35
186_T	471_E	0.633	0.35
278_E	575_V	0.632	0.35
128_D	131_L	0.632	0.35
808_A	817_L	0.632	0.35
507_Y	511_K	0.632	0.35
536_F	593_N	0.631	0.34
690_V	694_V	0.631	0.34
715_R	733_A	0.631	0.34
249_V	893_L	0.629	0.34
507_Y	623_D	0.629	0.34
323_A	614_T	0.628	0.34
986_K	992_P	0.628	0.34
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452_S	609_Y	0.627	0.34
539_T	769_I	0.627	0.34
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261_Y	527_A	0.626	0.34
447_D	451_F	0.625	0.34
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415_I	423_R	0.625	0.34
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938_V	957_F	0.625	0.34
554_V	629_G	0.625	0.34
755_V	828_V	0.625	0.34
520_K	539_T	0.624	0.34
248_I	462_L	0.624	0.34
296_I	946_D	0.623	0.34
510_R	540_Y	0.623	0.34
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218_Y	249_V	0.622	0.34
388_T	539_T	0.622	0.34
237_I	389_L	0.622	0.34
159_V	168_V	0.622	0.34
378_A	750_G	0.622	0.34
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338_V	347_E	0.621	0.34
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785_A	1037_S	0.620	0.34
445_V	449_H	0.620	0.34
7_I	938_V	0.620	0.34
347_E	528_E	0.620	0.34
589_I	607_K	0.619	0.34
986_K	993_N	0.619	0.34
49_S	66_I	0.618	0.33
1025_R	1041_A	0.618	0.33
167_I	182_C	0.617	0.33
34_C	38_K	0.617	0.33
518_V	543_E	0.617	0.33
452_S	586_Y	0.616	0.33
188_L	200_P	0.615	0.33
85_A	386_G	0.615	0.33
86_I	107_V	0.614	0.33
770_M	787_Y	0.614	0.33
850_I	859_I	0.614	0.33
696_I	744_I	0.614	0.33
941_T	967_T	0.613	0.33
428_G	434_Y	0.613	0.33
621_I	624_L	0.612	0.33
234_M	275_L	0.612	0.33
203_Q	283_V	0.612	0.33
504_S	508_S	0.611	0.33
227_H	265_R	0.611	0.33
716_A	1010_L	0.611	0.33
584_A	857_T	0.611	0.33
633_Q	831_L	0.610	0.33
474_A	691_N	0.610	0.33
657_S	660_D	0.610	0.33
256_L	322_A	0.610	0.33
293_Q	397_V	0.609	0.33
152_L	193_E	0.609	0.33
267_V	270_K	0.608	0.33
495_I	506_L	0.608	0.33
424_I	448_L	0.607	0.33
1013_G	1016_P	0.607	0.33
86_I	99_A	0.607	0.33
898_I	1025_R	0.607	0.33
156_E	160_S	0.607	0.33
966_A	971_A	0.606	0.33
119_K	276_G	0.606	0.33
663_R	676_E	0.605	0.32
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118_T	249_V	0.605	0.32
762_E	866_A	0.605	0.32
130_D	207_E	0.605	0.32
258_D	338_V	0.604	0.32
7_I	607_K	0.604	0.32
702_Y	940_L	0.603	0.32
632_V	650_G	0.603	0.32
471_E	916_T	0.603	0.32
94_T	386_G	0.603	0.32
736_I	740_H	0.603	0.32
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561_P	593_N	0.602	0.32
1026_E	1032_V	0.602	0.32
338_V	602_F	0.602	0.32
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183_S	991_G	0.602	0.32
478_D	509_L	0.602	0.32
361_P	905_K	0.602	0.32
419_L	422_K	0.602	0.32
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465_I	651_V	0.601	0.32
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388_T	699_D	0.600	0.32
322_A	384_A	0.600	0.32
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804_T	817_L	0.600	0.32
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922_Y	1051_M	0.599	0.32
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234_M	893_L	0.598	0.32
716_A	737_N	0.598	0.32
262_Q	347_E	0.598	0.32
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265_R	339_T	0.597	0.32
336_N	528_E	0.597	0.32
262_Q	266_N	0.596	0.32
726_L	733_A	0.596	0.32
853_A	857_T	0.596	0.32
787_Y	921_L	0.595	0.32
510_R	515_I	0.595	0.32
112_G	257_S	0.595	0.32
361_P	562_I	0.595	0.32
448_L	452_S	0.595	0.32
953_I	1041_A	0.594	0.32
481_V	515_I	0.594	0.32
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379_T	639_A	0.594	0.32
415_I	420_L	0.594	0.32
956_R	1042_E	0.594	0.32
778_V	975_K	0.594	0.32
404_V	409_L	0.593	0.32
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398_R	491_S	0.592	0.31
171_A	180_G	0.591	0.31
408_E	494_Y	0.591	0.31
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754_E	821_F	0.591	0.31
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15_S	69_L	0.588	0.31
502_K	676_E	0.588	0.31
112_G	514_G	0.588	0.31
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143_V	272_I	0.587	0.31
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353_V	388_T	0.587	0.31
641_N	715_R	0.586	0.31
847_I	852_M	0.586	0.31
213_Y	573_A	0.586	0.31
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553_S	589_I	0.585	0.31
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299_V	562_I	0.584	0.31
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632_V	661_L	0.583	0.31
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960_I	1003_A	0.581	0.31
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435_L	439_Y	0.581	0.31
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242_I	991_G	0.581	0.31
194_N	706_V	0.580	0.31
283_V	624_L	0.580	0.31
591_V	1004_Q	0.580	0.31
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75_T	116_L	0.579	0.30
506_L	994_L	0.578	0.30
173_T	195_G	0.578	0.30
958_H	964_I	0.578	0.30
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718_E	1014_K	0.577	0.30
949_E	1042_E	0.576	0.30
958_H	979_I	0.576	0.30
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355_S	389_L	0.575	0.30
1010_L	1017_A	0.575	0.30
491_S	515_I	0.575	0.30
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439_Y	464_G	0.575	0.30
792_L	797_K	0.575	0.30
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517_P	617_D	0.574	0.30
514_G	867_A	0.574	0.30
831_L	1040_T	0.574	0.30
272_I	299_V	0.574	0.30
269_L	1031_G	0.573	0.30
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423_R	863_Q	0.572	0.30
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799_K	826_G	0.570	0.30
768_G	844_L	0.570	0.30
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798_K	805_I	0.569	0.30
1008_N	1013_G	0.569	0.30
265_R	529_F	0.569	0.30
770_M	785_A	0.568	0.30
763_T	809_K	0.568	0.30
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525_C	533_T	0.568	0.30
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800_I	898_I	0.567	0.30
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721_Y	1013_G	0.567	0.30
234_M	281_C	0.566	0.30
548_V	624_L	0.566	0.30
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485_A	740_H	0.566	0.30
340_G	465_I	0.566	0.30
439_Y	449_H	0.566	0.30
133_R	210_I	0.565	0.29
321_L	651_V	0.565	0.29
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747_Y	918_E	0.565	0.29
969_G	1008_N	0.564	0.29
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622_I	646_L	0.563	0.29
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425_K	451_F	0.563	0.29
439_Y	465_I	0.562	0.29
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523_D	533_T	0.557	0.29
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553_S	625_E	0.557	0.29
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468_F	472_L	0.554	0.29
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664_A	757_A	0.553	0.29
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538_S	604_I	0.551	0.28
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587_E	758_V	0.547	0.28
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467_Q	470_K	0.546	0.28
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216_I	249_V	0.545	0.28
316_Y	343_Y	0.545	0.28
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653_I	658_L	0.545	0.28
739_Q	742_V	0.545	0.28
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339_T	529_F	0.544	0.28
805_I	870_Y	0.544	0.28
57_D	362_F	0.544	0.28
544_N	548_V	0.543	0.28
415_I	441_R	0.543	0.28
1007_I	1023_I	0.543	0.28
994_L	997_V	0.542	0.28
844_L	852_M	0.542	0.28
700_I	704_V	0.542	0.28
248_I	384_A	0.542	0.28
428_G	654_L	0.542	0.28
72_E	101_E	0.541	0.28
290_D	449_H	0.541	0.28
968_E	985_G	0.541	0.28
676_E	762_E	0.540	0.28
141_E	275_L	0.540	0.28
484_R	488_L	0.539	0.28
233_N	281_C	0.539	0.28
225_Q	799_K	0.539	0.28
67_E	78_I	0.539	0.28
660_D	810_G	0.538	0.28
258_D	528_E	0.538	0.28
546_S	549_T	0.538	0.28
531_S	882_F	0.538	0.28
90_L	786_V	0.537	0.27
720_V	914_D	0.537	0.27
672_Q	975_K	0.537	0.27
2_P	329_L	0.537	0.27
483_R	699_D	0.537	0.27
201_V	360_W	0.536	0.27
336_N	527_A	0.536	0.27
770_M	783_S	0.536	0.27
477_G	513_A	0.536	0.27
576_H	947_K	0.536	0.27
999_R	1030_N	0.535	0.27
73_F	927_A	0.535	0.27
90_L	522_V	0.535	0.27
933_P	1005_F	0.534	0.27
115_V	120_L	0.534	0.27
447_D	964_I	0.533	0.27
690_V	739_Q	0.533	0.27
681_Q	684_G	0.533	0.27
357_I	382_V	0.533	0.27
992_P	1000_N	0.532	0.27
120_L	329_L	0.532	0.27
483_R	516_A	0.532	0.27
67_E	108_L	0.532	0.27
551_K	606_D	0.531	0.27
133_R	771_E	0.531	0.27
748_L	817_L	0.531	0.27
806_A	809_K	0.531	0.27
1_M	333_E	0.531	0.27
75_T	86_I	0.531	0.27
687_A	753_I	0.531	0.27
346_F	531_S	0.531	0.27
652_K	860_I	0.530	0.27
19_I	886_P	0.530	0.27
213_Y	457_F	0.529	0.27
66_I	913_K	0.529	0.27
115_V	133_R	0.529	0.27
444_T	449_H	0.529	0.27
486_K	510_R	0.529	0.27
936_G	962_Y	0.528	0.27
941_T	970_T	0.528	0.27
143_V	221_M	0.528	0.27
949_E	1038_L	0.528	0.27
149_I	425_K	0.527	0.27
742_V	927_A	0.527	0.27
1005_F	1042_E	0.527	0.27
424_I	828_V	0.527	0.27
764_V	802_Q	0.527	0.27
554_V	857_T	0.527	0.27
90_L	536_F	0.526	0.27
273_R	387_R	0.526	0.27
226_D	272_I	0.526	0.27
7_I	42_Y	0.526	0.27
80_K	773_I	0.525	0.27
831_L	918_E	0.525	0.27
287_L	291_S	0.525	0.27
261_Y	350_L	0.525	0.27
555_M	627_P	0.524	0.27
145_E	295_Y	0.524	0.27
716_A	929_G	0.524	0.27
750_G	889_S	0.524	0.27
149_I	188_L	0.524	0.27
471_E	621_I	0.523	0.26
664_A	682_P	0.523	0.26
36_A	323_A	0.523	0.26
120_L	124_Q	0.523	0.26
261_Y	355_S	0.522	0.26
389_L	393_L	0.522	0.26
194_N	828_V	0.522	0.26
375_Q	924_A	0.522	0.26
948_E	977_A	0.522	0.26
182_C	204_C	0.522	0.26
546_S	607_K	0.521	0.26
57_D	67_E	0.521	0.26
440_R	494_Y	0.521	0.26
339_T	528_E	0.521	0.26
622_I	627_P	0.521	0.26
4_R	327_V	0.521	0.26
677_L	800_I	0.521	0.26
382_V	400_L	0.520	0.26
45_I	645_E	0.520	0.26
272_I	534_P	0.520	0.26
525_C	534_P	0.520	0.26
436_A	593_N	0.520	0.26
391_E	853_A	0.519	0.26
456_V	459_L	0.519	0.26
3_K	7_I	0.519	0.26
210_I	296_I	0.519	0.26
928_S	932_I	0.519	0.26
142_P	370_R	0.519	0.26
435_L	459_L	0.518	0.26
87_L	99_A	0.518	0.26
204_C	211_A	0.518	0.26
234_M	361_P	0.518	0.26
157_K	550_D	0.517	0.26
452_S	828_V	0.517	0.26
602_F	899_T	0.517	0.26
143_V	283_V	0.517	0.26
83_P	831_L	0.517	0.26
619_M	630_V	0.517	0.26
90_L	485_A	0.517	0.26
445_V	456_V	0.516	0.26
999_R	1003_A	0.516	0.26
641_N	817_L	0.516	0.26
957_F	1016_P	0.516	0.26
179_G	203_Q	0.516	0.26
980_P	983_V	0.516	0.26
525_C	528_E	0.516	0.26
254_Q	433_F	0.516	0.26
720_V	734_V	0.516	0.26
294_Y	299_V	0.515	0.26
263_L	294_Y	0.515	0.26
98_L	704_V	0.515	0.26
133_R	485_A	0.514	0.26
527_A	723_E	0.514	0.26
256_L	455_D	0.514	0.26
263_L	292_F	0.514	0.26
556_V	719_I	0.514	0.26
995_L	1023_I	0.514	0.26
258_D	346_F	0.513	0.26
152_L	196_L	0.513	0.26
943_A	950_G	0.512	0.26
733_A	910_V	0.512	0.26
470_K	493_Q	0.512	0.26
59_E	851_P	0.512	0.26
916_T	1050_S	0.512	0.26
876_P	1028_V	0.512	0.26
112_G	160_S	0.512	0.26
2_P	6_D	0.512	0.26
229_I	272_I	0.512	0.26
44_V	984_V	0.511	0.26
280_G	303_V	0.511	0.26
754_E	847_I	0.511	0.26
689_S	1006_V	0.511	0.26
17_P	49_S	0.511	0.26
166_V	207_E	0.511	0.26
562_I	684_G	0.511	0.26
361_P	429_D	0.511	0.26
47_V	80_K	0.510	0.26
917_L	1043_A	0.510	0.26
509_L	515_I	0.510	0.26
206_L	448_L	0.510	0.26
191_I	942_V	0.510	0.26
793_T	828_V	0.510	0.26
523_D	528_E	0.510	0.26
171_A	179_G	0.510	0.26
152_L	181_I	0.510	0.26
31_T	771_E	0.509	0.26
336_N	531_S	0.509	0.26
361_P	575_V	0.509	0.26
262_Q	336_N	0.509	0.26
166_V	593_N	0.509	0.26
421_E	424_I	0.508	0.25
214_K	524_T	0.508	0.25
227_H	527_A	0.508	0.25
15_S	1010_L	0.508	0.25
143_V	146_S	0.507	0.25
152_L	268_S	0.507	0.25
769_I	800_I	0.507	0.25
1010_L	1016_P	0.507	0.25
345_A	1034_C	0.507	0.25
952_A	1046_R	0.506	0.25
233_N	350_L	0.506	0.25
1010_L	1013_G	0.506	0.25
931_Q	979_I	0.506	0.25
149_I	156_E	0.506	0.25
937_S	940_L	0.505	0.25
258_D	525_C	0.505	0.25
80_K	1044_I	0.505	0.25
687_A	737_N	0.505	0.25
750_G	921_L	0.505	0.25
806_A	837_S	0.504	0.25
142_P	145_E	0.504	0.25
994_L	1022_R	0.504	0.25
580_A	584_A	0.503	0.25
523_D	531_S	0.503	0.25
261_Y	528_E	0.503	0.25
147_E	157_K	0.503	0.25
724_E	863_Q	0.503	0.25
953_I	973_Y	0.503	0.25
143_V	207_E	0.503	0.25
536_F	786_V	0.503	0.25
830_V	932_I	0.502	0.25
229_I	283_V	0.502	0.25
338_V	523_D	0.502	0.25
475_N	478_D	0.502	0.25
460_H	467_Q	0.502	0.25
642_L	789_P	0.502	0.25
204_C	428_G	0.502	0.25
189_K	678_G	0.502	0.25
473_K	589_I	0.502	0.25
181_I	211_A	0.502	0.25
418_E	480_D	0.502	0.25
261_Y	347_E	0.502	0.25
258_D	533_T	0.501	0.25
43_E	254_Q	0.501	0.25
439_Y	973_Y	0.501	0.25
500_K	666_D	0.501	0.25
213_Y	288_D	0.501	0.25
79_R	107_V	0.501	0.25
10_I	444_T	0.501	0.25
694_V	698_S	0.501	0.25
67_E	81_E	0.501	0.25
562_I	639_A	0.501	0.25
883_V	920_A	0.501	0.25
124_Q	201_V	0.500	0.25
793_T	823_L	0.500	0.25
987_I	993_N	0.500	0.25
699_D	952_A	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3jrxA	1	0.3884	100	0.897	Contact Map
3glkA	1	0.3697	100	0.897	Contact Map
3orqA	2	0.3371	100	0.9	Contact Map
2vpqA	2	0.3866	100	0.902	Contact Map
1ulzA	2	0.3922	100	0.902	Contact Map
3q2oA	2	0.338	100	0.905	Contact Map
2dzdA	2	0.3866	100	0.905	Contact Map
1w96A	1	0.3884	100	0.905	Contact Map
2dwcA	4	0.3483	100	0.908	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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