GREMLIN Database
CARB - Carbamoyl-phosphate synthase pyrimidine-specific large chain
UniProt: P25994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1071 (1048)
Sequences: 2857 (1170)
Seq/√Len: 36.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
355_S392_S7.0041.00
463_F467_Q5.5491.00
226_D273_R4.7241.00
9_K45_I4.6211.00
9_K43_E4.5821.00
288_D291_S4.4481.00
555_M591_V4.4011.00
698_S723_E4.3201.00
82_R111_C4.2751.00
69_L98_L4.2341.00
676_E810_G4.2161.00
104_E124_Q4.2011.00
858_K863_Q4.1521.00
659_E669_K4.1421.00
552_K628_M4.0971.00
940_L954_A3.6921.00
192_V204_C3.6461.00
155_A192_V3.6361.00
615_I619_M3.5621.00
437_E441_R3.5011.00
138_E274_A3.4421.00
398_R617_D3.4251.00
288_D293_Q3.3961.00
218_Y233_N3.3901.00
914_D919_K3.2901.00
10_I42_Y3.2681.00
937_S963_N3.2351.00
802_Q806_A3.2181.00
790_Q881_V3.2171.00
762_E864_K3.1851.00
75_T110_E3.1271.00
435_L448_L3.0911.00
237_I462_L3.0871.00
79_R111_C3.0431.00
264_L294_Y3.0391.00
78_I111_C3.0141.00
956_R1049_E3.0141.00
233_N253_S3.0101.00
591_V621_I3.0001.00
439_Y459_L2.9931.00
145_E208_K2.9581.00
75_T79_R2.9211.00
468_F488_L2.9121.00
704_V744_I2.9081.00
864_K867_A2.8861.00
42_Y327_V2.8591.00
160_S185_E2.8551.00
511_K623_D2.8521.00
156_E189_K2.8251.00
75_T111_C2.7721.00
544_N624_L2.7701.00
694_V727_L2.7571.00
794_E798_K2.7471.00
43_E63_R2.7261.00
863_Q867_A2.7081.00
446_E456_V2.6951.00
439_Y445_V2.6951.00
757_A804_T2.6921.00
758_V859_I2.6841.00
973_Y977_A2.6111.00
393_L432_L2.6051.00
421_E447_D2.6011.00
958_H980_P2.5761.00
555_M622_I2.5631.00
4_R114_E2.5621.00
185_E189_K2.5551.00
685_K699_D2.5301.00
130_D134_T2.5271.00
149_I158_F2.5221.00
10_I327_V2.5061.00
702_Y723_E2.4981.00
390_E461_K2.4871.00
479_T483_R2.4861.00
885_A924_A2.4421.00
551_K587_E2.4371.00
74_L98_L2.4181.00
151_S154_E2.3771.00
159_V164_F2.3771.00
483_R487_E2.3621.00
622_I651_V2.3591.00
386_G391_E2.3461.00
47_V77_I2.3290.99
583_Q854_N2.3170.99
71_P101_E2.3140.99
680_P803_Y2.3110.99
722_H725_E2.3060.99
944_D947_K2.2930.99
957_F1045_L2.2910.99
733_A737_N2.2910.99
685_K696_I2.2810.99
864_K868_F2.2780.99
971_A981_A2.2770.99
75_T105_R2.2760.99
805_I809_K2.2540.99
951_L973_Y2.2380.99
416_S419_L2.2320.99
797_K877_E2.2270.99
141_E270_K2.2120.99
660_D812_N2.2070.99
272_I283_V2.2060.99
855_L868_F2.1970.99
218_Y253_S2.1930.99
39_E324_K2.1900.99
471_E484_R2.1810.99
555_M621_I2.1790.99
142_P293_Q2.1600.99
208_K293_Q2.1510.99
443_Y447_D2.1510.99
799_K802_Q2.1490.99
164_F185_E2.1480.99
242_I427_A2.1430.99
1007_I1041_A2.1420.99
150_H203_Q2.1220.99
963_N982_K2.1170.99
549_T587_E2.1110.99
951_L977_A2.0990.99
647_S659_E2.0990.99
507_Y619_M2.0940.99
394_L490_F2.0800.99
481_V485_A2.0800.99
439_Y448_L2.0750.99
937_S965_L2.0740.99
76_R79_R2.0470.99
767_P852_M2.0450.99
679_V803_Y2.0420.99
147_E161_Q2.0420.99
100_V120_L2.0420.99
370_R429_D2.0370.99
763_T866_A2.0330.99
694_V723_E2.0260.99
502_K505_E2.0240.99
287_L294_Y2.0120.98
375_Q892_K2.0050.98
390_E464_G2.0000.98
271_L296_I2.0000.98
753_I792_L1.9980.98
141_E267_V1.9960.98
511_K516_A1.9840.98
71_P105_R1.9720.98
445_V459_L1.9690.98
723_E727_L1.9650.98
984_V997_V1.9620.98
504_S648_A1.9610.98
644_D648_A1.9530.98
435_L454_I1.9460.98
164_F184_N1.9450.98
417_D441_R1.9350.98
971_A983_V1.9230.98
795_D826_G1.9170.98
689_S692_Q1.9130.98
662_D669_K1.9010.98
66_I911_M1.8980.98
171_A203_Q1.8960.98
75_T107_V1.8910.98
662_D710_Y1.8790.98
609_Y625_E1.8790.98
182_C191_I1.8790.98
755_V804_T1.8750.98
40_E324_K1.8740.98
184_N187_E1.8730.98
509_L513_A1.8690.98
150_H154_E1.8670.98
47_V74_L1.8660.97
733_A742_V1.8640.97
78_I113_V1.8570.97
584_A858_K1.8450.97
583_Q858_K1.8360.97
159_V166_V1.8320.97
79_R110_E1.8300.97
683_L699_D1.8290.97
253_S261_Y1.8210.97
733_A736_I1.8170.97
695_S699_D1.8160.97
103_S120_L1.8090.97
680_P827_E1.7990.97
516_A623_D1.7860.97
388_T541_E1.7820.97
759_S809_K1.7630.96
147_E158_F1.7600.96
9_K63_R1.7590.96
687_A696_I1.7560.96
554_V654_L1.7470.96
151_S202_H1.7440.96
1006_V1027_S1.7390.96
992_P996_D1.7380.96
444_T447_D1.7350.96
449_H459_L1.7340.96
470_K473_K1.7310.96
492_D510_R1.7310.96
673_A807_L1.7300.96
728_H732_N1.7200.96
135_L274_A1.7140.96
508_S512_Q1.7080.96
168_V204_C1.6990.96
439_Y462_L1.6850.95
753_I823_L1.6760.95
424_I438_A1.6680.95
196_L202_H1.6680.95
793_T796_I1.6620.95
793_T826_G1.6600.95
734_V742_V1.6550.95
382_V399_S1.6510.95
436_A440_R1.6440.95
124_Q131_L1.6410.95
168_V206_L1.6370.95
799_K803_Y1.6360.95
183_S187_E1.6300.94
393_L407_L1.6290.94
615_I645_E1.6240.94
753_I800_I1.6200.94
103_S109_A1.6200.94
946_D1009_T1.6130.94
965_L1003_A1.6120.94
86_I113_V1.5990.94
436_A462_L1.5960.94
495_I499_W1.5940.94
757_A817_L1.5900.94
260_E292_F1.5870.94
133_R137_N1.5790.93
125_Q274_A1.5780.93
552_K586_Y1.5770.93
584_A861_L1.5760.93
465_I490_F1.5690.93
673_A810_G1.5650.93
73_F77_I1.5620.93
683_L746_R1.5620.93
1025_R1029_E1.5610.93
531_S534_P1.5610.93
164_F188_L1.5610.93
405_Y497_R1.5540.93
71_P74_L1.5540.93
478_D481_V1.5510.93
716_A733_A1.5490.93
275_L299_V1.5450.93
615_I649_R1.5390.93
966_A981_A1.5340.92
509_L512_Q1.5320.92
389_L457_F1.5300.92
581_I588_A1.5270.92
464_G488_L1.5270.92
789_P797_K1.5250.92
753_I828_V1.5240.92
823_L828_V1.5240.92
798_K801_E1.5230.92
680_P799_K1.5200.92
986_K1019_D1.5150.92
218_Y268_S1.5120.92
168_V188_L1.5110.92
796_I826_G1.5040.92
503_E507_Y1.4960.91
671_E681_Q1.4950.91
799_K828_V1.4930.91
71_P98_L1.4920.91
225_Q330_S1.4920.91
224_S330_S1.4880.91
962_Y1048_L1.4860.91
581_I861_L1.4730.91
916_T919_K1.4710.91
506_L509_L1.4690.91
468_F485_A1.4680.91
521_M536_F1.4610.90
149_I154_E1.4610.90
628_M652_K1.4600.90
784_I885_A1.4570.90
482_L509_L1.4550.90
134_T138_E1.4540.90
758_V852_M1.4520.90
796_I828_V1.4500.90
998_I1032_V1.4480.90
237_I248_I1.4370.90
549_T553_S1.4370.90
443_Y448_L1.4350.90
501_M506_L1.4290.89
107_V111_C1.4240.89
660_D663_R1.4230.89
144_P295_Y1.4210.89
796_I823_L1.4150.89
669_K710_Y1.4130.89
472_L485_A1.4080.89
421_E443_Y1.4060.89
674_L830_V1.4060.89
449_H453_A1.4050.89
631_V857_T1.4030.89
511_K620_H1.3980.88
397_V432_L1.3960.88
554_V861_L1.3920.88
801_E875_Q1.3890.88
152_L188_L1.3870.88
421_E451_F1.3810.88
88_P99_A1.3790.88
149_I155_A1.3780.88
765_V870_Y1.3780.88
237_I435_L1.3770.88
417_D447_D1.3750.88
697_A702_Y1.3670.87
857_T861_L1.3600.87
321_L337_P1.3580.87
493_Q503_E1.3510.87
863_Q868_F1.3480.86
975_K983_V1.3470.86
479_T513_A1.3400.86
663_R810_G1.3380.86
69_L74_L1.3350.86
804_T821_F1.3340.86
101_E104_E1.3310.86
803_Y828_V1.3290.86
152_L156_E1.3270.86
439_Y463_F1.3240.85
465_I488_L1.3230.85
942_V950_G1.3230.85
630_V651_V1.3160.85
157_K160_S1.3150.85
70_T73_F1.3140.85
420_L448_L1.3120.85
11_L86_I1.3110.85
947_K969_G1.3110.85
759_S764_V1.3090.85
799_K827_E1.3090.85
477_G499_W1.3000.84
553_S587_E1.2940.84
237_I250_V1.2890.84
516_A620_H1.2860.84
159_V188_L1.2850.84
679_V828_V1.2790.83
748_L824_S1.2780.83
257_S260_E1.2770.83
968_E983_V1.2760.83
341_K532_E1.2750.83
1046_R1049_E1.2710.83
554_V581_I1.2700.83
263_L287_L1.2690.83
548_V607_K1.2690.83
477_G482_L1.2650.83
6_D114_E1.2610.83
440_R469_E1.2570.82
40_E329_L1.2540.82
975_K981_A1.2540.82
588_A861_L1.2510.82
672_Q676_E1.2510.82
461_K464_G1.2450.82
972_G976_E1.2440.82
394_L465_I1.2400.81
546_S624_L1.2390.81
146_S207_E1.2370.81
221_M321_L1.2350.81
807_L819_I1.2330.81
797_K801_E1.2320.81
520_K543_E1.2270.81
86_I108_L1.2270.81
631_V860_I1.2240.81
468_F481_V1.2240.81
125_Q138_E1.2230.81
671_E684_G1.2220.80
472_L498_E1.2190.80
985_G993_N1.2130.80
393_L462_L1.2120.80
956_R1045_L1.2060.80
619_M651_V1.2050.80
436_A466_V1.2010.79
394_L406_H1.1940.79
955_K959_A1.1920.79
100_V131_L1.1880.79
730_M734_V1.1860.78
443_Y451_F1.1840.78
184_N991_G1.1830.78
457_F461_K1.1830.78
417_D421_E1.1810.78
954_A964_I1.1760.78
126_A283_V1.1750.78
405_Y493_Q1.1690.77
131_L134_T1.1670.77
448_L462_L1.1660.77
472_L495_I1.1650.77
730_M733_A1.1610.77
769_I801_E1.1600.77
250_V355_S1.1580.77
764_V809_K1.1580.77
329_L334_M1.1560.77
607_K625_E1.1520.76
584_A863_Q1.1520.76
194_N198_L1.1520.76
47_V102_L1.1480.76
628_M654_L1.1460.76
482_L515_I1.1440.76
859_I868_F1.1430.76
404_V433_F1.1410.76
71_P107_V1.1410.76
471_E481_V1.1380.75
142_P208_K1.1360.75
449_H456_V1.1350.75
769_I797_K1.1330.75
734_V737_N1.1320.75
517_P540_Y1.1300.75
803_Y821_F1.1290.75
100_V124_Q1.1280.75
13_I69_L1.1270.75
125_Q135_L1.1200.74
137_N143_V1.1190.74
786_V917_L1.1190.74
124_Q172_Y1.1180.74
267_V294_Y1.1170.74
170_P179_G1.1130.74
71_P75_T1.1120.74
19_I177_T1.1100.74
340_G532_E1.1090.74
155_A206_L1.1030.73
34_C60_M1.1030.73
390_E488_L1.1010.73
133_R207_E1.0980.73
501_M505_E1.0950.73
101_E105_R1.0930.72
258_D262_Q1.0930.72
617_D620_H1.0930.72
121_S131_L1.0920.72
188_L206_L1.0910.72
423_R428_G1.0900.72
1021_F1025_R1.0880.72
321_L334_M1.0880.72
557_L618_V1.0870.72
208_K295_Y1.0860.72
991_G996_D1.0850.72
579_W604_I1.0850.72
424_I452_S1.0840.72
437_E440_R1.0820.72
423_R434_Y1.0820.72
13_I74_L1.0810.72
507_Y649_R1.0810.72
99_A115_V1.0810.72
965_L982_K1.0790.71
620_H623_D1.0750.71
382_V396_A1.0680.71
207_E210_I1.0680.71
388_T488_L1.0660.71
221_M272_I1.0650.70
578_V605_S1.0640.70
262_Q265_R1.0600.70
227_H330_S1.0570.70
228_A269_L1.0560.70
227_H345_A1.0540.70
155_A168_V1.0480.69
420_L441_R1.0480.69
736_I742_V1.0400.69
843_F911_M1.0380.68
940_L974_L1.0360.68
858_K868_F1.0320.68
716_A734_V1.0320.68
259_R292_F1.0320.68
250_V389_L1.0310.68
619_M649_R1.0300.68
220_V230_V1.0290.68
337_P602_F1.0280.68
388_T392_S1.0280.68
126_A716_A1.0270.68
214_K455_D1.0260.68
266_N270_K1.0260.68
218_Y228_A1.0250.67
804_T819_I1.0220.67
404_V408_E1.0220.67
986_K1023_I1.0210.67
1005_F1035_L1.0210.67
228_A273_R1.0200.67
679_V799_K1.0170.67
989_Q993_N1.0160.67
189_K193_E1.0160.67
192_V206_L1.0160.67
809_K812_N1.0150.67
417_D443_Y1.0140.67
225_Q332_D1.0140.67
13_I95_G1.0120.66
613_L642_L1.0090.66
141_E296_I1.0080.66
727_L731_K1.0060.66
191_I195_G1.0060.66
987_I995_L1.0050.66
38_K60_M1.0050.66
290_D453_A1.0020.66
720_V742_V1.0020.66
445_V460_H1.0020.66
814_V859_I0.9990.65
882_F913_K0.9980.65
228_A272_I0.9980.65
387_R541_E0.9970.65
164_F189_K0.9970.65
964_I981_A0.9970.65
438_A443_Y0.9930.65
807_L830_V0.9930.65
688_T692_Q0.9910.65
578_V588_A0.9870.65
1010_L1020_G0.9860.64
710_Y740_H0.9860.64
520_K541_E0.9840.64
448_L459_L0.9830.64
1007_I1038_L0.9790.64
85_A88_P0.9790.64
784_I886_P0.9770.64
336_N339_T0.9750.64
985_G992_P0.9740.63
36_A334_M0.9740.63
144_P210_I0.9720.63
424_I434_Y0.9720.63
159_V192_V0.9710.63
445_V463_F0.9680.63
460_H463_F0.9680.63
387_R520_K0.9680.63
730_M737_N0.9660.63
141_E283_V0.9660.63
918_E1046_R0.9650.63
998_I1026_E0.9630.63
789_P792_L0.9630.63
880_G913_K0.9630.63
218_Y261_Y0.9600.62
496_S506_L0.9600.62
107_V110_E0.9600.62
262_Q529_F0.9550.62
847_I882_F0.9540.62
737_N742_V0.9520.62
253_S350_L0.9510.62
1_M7_I0.9490.61
353_V392_S0.9480.61
8_N43_E0.9470.61
121_S125_Q0.9460.61
262_Q528_E0.9460.61
938_V954_A0.9440.61
403_D407_L0.9430.61
998_I1023_I0.9420.61
988_G993_N0.9420.61
775_R1039_D0.9410.61
693_A730_M0.9410.61
357_I360_W0.9400.61
462_L466_V0.9380.61
479_T515_I0.9370.60
1044_I1048_L0.9350.60
468_F484_R0.9350.60
787_Y844_L0.9340.60
950_G974_L0.9340.60
4_R42_Y0.9320.60
153_E157_K0.9300.60
184_N1000_N0.9300.60
464_G468_F0.9280.60
412_A434_Y0.9280.60
35_L603_S0.9260.60
449_H454_I0.9230.59
468_F471_E0.9220.59
674_L678_G0.9220.59
998_I1030_N0.9220.59
234_M249_V0.9210.59
690_V727_L0.9210.59
933_P936_G0.9200.59
938_V1007_I0.9190.59
156_E164_F0.9160.59
164_F627_P0.9150.59
734_V740_H0.9140.58
156_E185_E0.9130.58
24_A562_I0.9100.58
965_L997_V0.9090.58
587_E607_K0.9070.58
586_Y628_M0.9070.58
166_V188_L0.9060.58
634_F856_A0.9060.58
517_P620_H0.9050.58
168_V192_V0.9040.58
342_T346_F0.9040.58
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31_T771_E0.5090.26
336_N531_S0.5090.26
361_P575_V0.5090.26
262_Q336_N0.5090.26
166_V593_N0.5090.26
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80_K1044_I0.5050.25
687_A737_N0.5050.25
750_G921_L0.5050.25
806_A837_S0.5040.25
142_P145_E0.5040.25
994_L1022_R0.5040.25
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523_D531_S0.5030.25
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536_F786_V0.5030.25
830_V932_I0.5020.25
229_I283_V0.5020.25
338_V523_D0.5020.25
475_N478_D0.5020.25
460_H467_Q0.5020.25
642_L789_P0.5020.25
204_C428_G0.5020.25
189_K678_G0.5020.25
473_K589_I0.5020.25
181_I211_A0.5020.25
418_E480_D0.5020.25
261_Y347_E0.5020.25
258_D533_T0.5010.25
43_E254_Q0.5010.25
439_Y973_Y0.5010.25
500_K666_D0.5010.25
213_Y288_D0.5010.25
79_R107_V0.5010.25
10_I444_T0.5010.25
694_V698_S0.5010.25
67_E81_E0.5010.25
562_I639_A0.5010.25
883_V920_A0.5010.25
124_Q201_V0.5000.25
793_T823_L0.5000.25
987_I993_N0.5000.25
699_D952_A0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jrxA 1 0.3884 100 0.897 Contact Map
3glkA 1 0.3697 100 0.897 Contact Map
3orqA 2 0.3371 100 0.9 Contact Map
2vpqA 2 0.3866 100 0.902 Contact Map
1ulzA 2 0.3922 100 0.902 Contact Map
3q2oA 2 0.338 100 0.905 Contact Map
2dzdA 2 0.3866 100 0.905 Contact Map
1w96A 1 0.3884 100 0.905 Contact Map
2dwcA 4 0.3483 100 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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